Motor neuron disease is a rare disease it doesn't have any cure here in this video I have tried playing what is mnd its types causes how to diagnose and its management plan
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
amyotrophic lateral sclerosis & Gehrig's disease & moror neuron disease Medical Students
Gehrig's disease ALS motor neurone disease (MND), or Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.
Diabetic polyneuropathy
Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction. There are three main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress, and mitochondrial dysfunction.
amyotrophic lateral sclerosis & Gehrig's disease & moror neuron disease Medical Students
Gehrig's disease ALS motor neurone disease (MND), or Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.
Diabetic polyneuropathy
Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction. There are three main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress, and mitochondrial dysfunction.
neurobiology of brain and everyday behavioursakshipalod04
This is the final project for the course neurobiology of brain and behaviour. This consists analysis of the neurodegenerative disease- Amyotrophic lateral sclerosis (ASL)
Paralysis is caused by a malfunction of the nervous system. Nerves that are not harmed provide signals to muscles. Muscles move as a result of these impulses.
a summary of Amyotrophic lateral sclerosis, a disease of the nervous system, its causes, symptoms, and complications, and how it affects the quality of life, as well as one of the famous sport figures that died from the disease.
Review of the Diagnosis and Treatment of ParalysisYogeshIJTSRD
Paralysis is a complete loss of motor power in any muscle group. When paralysis affects all four extremities, it is called quadriplegia when it affects only the lower extremities, paraplegia and when it affects the extremities on one side of the body, hemiplegic. For this reason, the term paralysis is generally reserved for more focal, less stereotyped weakness, for instance, affecting all the muscles innervated by a peripheral nerve. Many different anatomical lesions and etiologies can cause paralysis and determine its treatment. Bikash Debsingha | Dr. Gourav Kr. Sharma | Dr. Kausal Kishore Chandrul "Review of the Diagnosis and Treatment of Paralysis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45108.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmacology-/45108/review-of-the-diagnosis-and-treatment-of-paralysis/bikash-debsingha
Multiple sclerosis (MS) is a chronic, sometimes disabling, disease of the central nervous system affecting approximately 400,000 people in the United States, according to the National Multiple Sclerosis Society. It affects two to three times as many women as men
Gallbladder cancer is cancer that begins in the gallbladder. Your gallbladder is a small, pear-shaped organ on the right side of your abdomen, just beneath your liver. The gallbladder stores bile, a digestive fluid produced by your liver. Gallbladder cancer is uncommon. It is possible to cure gallbladder cancer when tumors are treated surgically at an early stage.
Many often we need to make videos from PowerPoint presentations May be for making YouTube video or lectures. but we find it difficult to make video from PPT file so here is a very simple technique how to convert MP4 from a PPT file
this is my first try. recommend me for better ways in future
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
3. What is motor neuron disease?
Motor neuron disease (MND) is a neurodegenerative condition caused by
loss of upper and lower motor neurons in the spinal cord, cranial nerve
nuclei and motor cortex.
It affects the human motor system
It is a broad term which contains multiple conditions according to the site
where it affects
It is difficult to diagnose and till now there is no cure but therapy can improve
lifestyle
Motor neuron disease means disease of the motor neurons
4. What are the motor neurons?
Neuron that passes from the central nervous system toward or to a muscle
and conducts a nerve impulse is called motor neuron
NERVE IMPULSE
5. Types of motor neuron?
According to the site of origin and ending motor neurons are two types. These
are
.. Upper motor neuron
.. Lower motor neuron
Upper motor neuron: A neuron that starts in the motor cortex of the brain and
terminates within the medulla (another part of the brain) or within the spinal
cord up to anterior horn cell
Lower motor neuron: A nerve cell that goes from the anterior horn cell spinal
cord to a muscle
7. Etiology of MND
..Most of the cases are sporadic only10% cases are hereditary
..The exact causes are unclear
..There are some theories explaining the causes. These may include
--Exposure to viruses
--Exposure to certain toxins and chemicals
--Genetic factors
--Immune system response
--Nerve growth factors
--Growth, repair and ageing of motor neurons
8. Types of motor neuron disease
Motor neuron disease can be classified according to the neurons that are affected
..Only upper motor neuron lesion: Primary lateral sclerosis, Pseudobulbar palsy
..Only lower motor neuron lesion: progressive muscular atrophy, Monomelik
amyotrophy
..Both upper motor and lower motor neuron lesion: amyotrophic lateral sclerosis,
progressive bulbar palsy
9. Signs and symptoms of upper motor neuron lesion
..Muscle weakness
..Muscle tightness or spastic paralysis
..Overactive reflex
..Clonus
..Babinski response
10. Signs and symptoms of lower motor neuron lesion
..Muscle weakness
..Muscle wasting
..Flaccid paralysis
..Fasciculation
..Hypotonia or atonia
..Hyporeflexia
11. Among different types of MND there are four main types
..Amyotrophic lateral sclerosis (ALS): 60-70%
..Progressive bulbar palsy (PBP)
..Progressive muscular atrophy (PMA)
..Primary lateral sclerosis (PLS)
12. Commonly known as "Lou
Gehrig's disease," named after
the famous New York Yankees
baseball player who was
forced to retire after
developing the disease in
1939 and died 1941
Amyotrophic Lateral Sclerosis (ALS)
Lou Gehrig's disease
13. Amyotrophic Lateral Sclerosis (ALS)
..This is the commonest type of motor neuron disease
..Here both upper and lower motor neurons are affected
..As both upper and lower motor neurons are affected so symptoms of both upper
motor and lower motor neuron lesion are present. They are discussed in previous
slides
..Signs and symptoms might include:
-Difficulty walking or doing normal daily activities
-Tripping and falling
-Weakness in your leg, feet or ankles
-Hand weakness or clumsiness
-Slurred speech or trouble swallowing
-Muscle cramps and twitching in your arms, shoulders and tongue
Inappropriate crying, laughing or yawning
-Cognitive and behavioral changes
14. Amyotrophic Lateral Sclerosis (ALS)
..The earliest symptoms of ALS are muscle weakness or muscle atrophy. Other
presenting symptoms include trouble swallowing or breathing, cramping, or stiffness
of affected muscles; muscle weakness affecting an arm or a leg; or slurred and nasal
speech. It depends on the site of the neurons that are affected.
..As the disease progress patient is unable to walk or do normal works. Later they
are unable to talk eat or move. They have difficulty in breathing.
.. The most common cause of death for people with ALS is respiratory failure when
the respiratory muscles are paralyzed.
15.
16. Primary Lateral Sclerosis (PLS)
..Primary lateral sclerosis (PLS) is a type of motor neuron disease that causes
nerves within the brain(UMN) to slowly break down. This makes the nerves unable
to activate the motor neurons in the spinal cord, which control muscles.
..PLS causes weakness in your voluntary muscles, such as those you use to control
your legs, arms and tongue.
..Primary lateral sclerosis progresses more slowly than ALS, and in most cases isn't
fatal.
17. Progressive Bulbar Palsy (PBP)
..Progressive Bulbar Palsy involves both upper and lower motor neurons
..PBP involves mainly the brain stem. The brain stem is the part of the brain
needed for swallowing, speaking, chewing, and other functions.
.. Signs and symptoms of progressive bulbar palsy include difficulty swallowing,
weak jaw and facial muscles, progressive loss of speech, and weakening of the
tongue.
18. Progressive muscular atrophy (PMA)
..Progressive muscular atrophy (PMA) is clinically characterized solely by signs of
lower motor neuron (LMN) dysfunction.
..Symptoms of PMA include:
atrophy
fasciculations
muscle weakness
..It is a sibling condition to amyotrophic lateral sclerosis (ALS), which affects both
the upper and lower motor neurons.
19. Onset and Prognosis
..The onset of symptoms varies but most commonly the disease is first recognized
between 20 and 40 years of age.
..Symptoms often develop very slowly over a number of years. At some stage,
symptoms are likely to affect a person's daily life. Everyone's experience
and progression will be different but most people will experience increasing
disability
.. Life expectancy for about half of those with the condition is three years from the
start of symptoms. However, some people may live for up to 10 years, and in rarer
circumstances even longer.
20. Diagnosis of MND
..Diagnosing motor neuron disease is often a difficult and lengthy process
..It is mainly diagnosed from physical examination and observing symptoms
..There are no single test to diagnose rather investigations are done to exclude
differentials.
..Tests may include blood test, electromyography(EMG), nerve conduction
test(NCS), MRI, muscle biopsy, lumbar puncture
21. Treatment of MND
..There is no cure for motor neuron disease
Symptomatic treatment
..Treatment is given to reduce symptoms and improve the quality of life
..Botox and some muscle relaxants may be used for muscle cramp and muscle
twitching
..Painkillers are used to relieve pain
..Antidepressants are used to improve psychological upset
Recent drug
..Riluzole is a drug that is being used in some countries in patient with MND. It can
reduce disease progression and increase life expectancy
22. Treatment of MND
Therapy
..Speech and language therapy can help with communication and swallowing.
..Physical and occupational therapy can help maintain mobility and function and
encourage people to find new ways to do specific tasks.
Assisted device and others
..In some cases and in last stage some assisted device may be required which will
help the patient to move, feed, breath and communicate with others
Mnd patient suffer from breathing difficulty for which breathing and ventilatory
support may be needed. Tube feeding maybe required who are unable to feed
23. Carers of MND
Taking on the role of caregiver for a loved one with Motor Neuron Disease was
likely profoundly unexpected and a role that you may not feel adequately prepared
for.
But without the right support, the personal cost of caring can be high, with many
carers experiencing poor health, poverty and disadvantage.
Good outcomes for carers occur when:
--the carer is able to cope with their caring role,
--the carer gets a regular break from caring,
--the carer is informed and knowledgeable about their caring role and the needs
of the person they care for, and
--the carer feels valued, supported and listened to
24. Life is a mystery
box. Never lose
hope. Never give
up. Keep faith. You
never know what’s
coming