Topical drug delivery involves application of medications to the skin or mucous membranes for local or systemic effects. It has advantages like avoidance of first-pass metabolism and convenient self-administration. The skin is made of three layers - epidermis, dermis and hypodermis. Drugs can penetrate the skin via trans-epidermal or trans-follicular routes. Evaluation of topical dosage forms includes testing for drug content and release, absorption, irritation potential, rheological properties, and stability. Common topical dosage forms are solids, liquids, semi-solids and patches which are evaluated using methods specific to the product type and administration route.
Antiperspirant & Deodorant:A deodorant is a substance applied to the body to prevent body odor caused by the bacterial breakdown of perspiration in armpits, feet, and other areas of the body. A subgroup of deodorants, antiperspirants, affect odor as well as prevent sweating by affecting sweat glands.
Antiperspirants are typically applied to the underarms, while deodorants may also be used on feet and other areas in the form of body sprays. In the United States, the Food and Drug Administration classifies and regulates most deodorants as cosmetics, but classifies antiperspirants as over-the-counter drugs.
Mechanism perspiration control
Sweating allows the body to regulate its temperature. Sweating is controlled from a center in the periotic and anterior regions of the brain's hypothalamus, where thermo sensitive neurons are located. The heat-regulatory function of the hypothalamus is also affected by inputs from temperature receptors in the skin.
Antiperspirant & Deodorant:A deodorant is a substance applied to the body to prevent body odor caused by the bacterial breakdown of perspiration in armpits, feet, and other areas of the body. A subgroup of deodorants, antiperspirants, affect odor as well as prevent sweating by affecting sweat glands.
Antiperspirants are typically applied to the underarms, while deodorants may also be used on feet and other areas in the form of body sprays. In the United States, the Food and Drug Administration classifies and regulates most deodorants as cosmetics, but classifies antiperspirants as over-the-counter drugs.
Mechanism perspiration control
Sweating allows the body to regulate its temperature. Sweating is controlled from a center in the periotic and anterior regions of the brain's hypothalamus, where thermo sensitive neurons are located. The heat-regulatory function of the hypothalamus is also affected by inputs from temperature receptors in the skin.
PHARMACOKINETICS AND PHARMACODYNAMICS OF
ANAESTHETIC DRUGS IN PAEDIATRICS (based on the article that came up in INDIAN JOURNAL OF ANAESTHESIA, OCTOBER 2004)
Dissolution is mass transfer process.
Dissolution is mainly depend on aqueous solubility of drug.
It is process in which solid mass transfer in liquid medium.
Dissolution based on four process – 1. wetting 2. solubility 3. Swelling 4. diffusion.
Particle size, shape, surface area is important factor can affect the rate of dissolution of drug.
The aqueous solubility is increases, increases rate of dissolution drug
Penetration Enhancers in Transdermal Drug Delivery SystemSimranDhiman12
Penetration Enhancers in Transdermal Drug Delivery System
Permeation enhancers are substances that reduce the skin barrier's ability to make skin more permeable and allow drug molecules to cross the skin at a faster rate
advantages and disadvantages
types of penetration enhancers
techniques
physical and chemical enhancers
transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality. Third-generation delivery systems target their effects to skin’s barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound. Microneedles and thermal ablation are currently progressing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase impact on medicine.
Semisolid dosage forms: Definitions, classification, mechanisms and factors influencing dermal penetration of drugs. Preparation of ointments, pastes, creams and gels. Excipients used in semi solid dosage forms. Evaluation of semi solid dosages forms
Transdermal Drug Delivery System (TDDS) is the one of the novel technology to deliver the molecules through the skin for long period of time.
Transdermal Drug Delivery System (TDDS) are defined as self contained, discrete dosage forms which are also known as “patches” 2, 3 when patches are applied to the intact skin, deliver the drug through the skin at a controlled rate to the systemic circulation
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. Introduction
Definition:
Topical delivery is an attractive route for local
and systemic treatment. The delivery of drugs onto the skin is
recognized as an effective means of therapy for local
dermatologic diseases. It can penetrate deeper into skin and
hence give better absorption.
Topical delivery includes two basic types of product:
1. External topicals that are spread, sprayed, or
otherwise dispersed on to cutaneous tissues to cover the
affected area.
2. Internal topicals that are applied to the mucous
membrane orally, vaginally or on anorectal tissues for local
activity.
2
3. ADVANTAGES OF TOPICAL DRUG DELIVERY SYSTEMS
Avoidance of first pass metabolism.
Convenient and easy to apply.
Avoidance of the risks and inconveniences of intravenous
therapy and of the varied conditions of absorption, like pH
changes, presence of enzymes, gastric emptying time etc.
Achievement of efficacy with lower total daily dosage of
drug by continuous drug input.
Avoids fluctuation in drug levels, inter- and intrapatient
variations.
Provide suitability for self-medication.
3
4. Ability to easily terminate the medications, when
needed.
A relatively large area of application in comparison
with buccal or nasal cavity
Ability to deliver drug more selectively to a specific site.
Avoidance of gastro-intestinal incompatibility.
Providing utilization of drugs with short biological half-
life, narrow therapeutic window.
Improving physiological and pharmacological response.
Improve patient compliance.
ADVANTAGES OF TOPICAL DRUG DELIVERY SYSTEMS
4
5. Disadvantages of Topical Drug Delivery Systems
Skin irritation of contact dermatitis may occur due
to the drug and/or excipients.
Poor permeability of some drugs through the skin.
Possibility of allergenic reactions.
Can be used only for drugs which require very small
plasma concentration for action
Enzyme in epidermis may denature the drugs
Drugs of larger particle size not easy
to absorb through the skin
5
6. 6
Structure of skin
The skin is a large multi- layered organ, skin serves as a
barrier against physical, chemical attack.
Some materials, such as nickel ions, mustard gas,
oleoresins from Rhus toxicodendron, commonly known as
poison ivy, can penetrate the barrier, but most of the
substance cannot.
The skin act as thermostat in maintain body temperature,
shields the body from invasion by micro-organism, protects
against ultra-violet rays, and play a role in the regulation of
blood pressure.
Layers of skin
1. Epidermis 2. Dermis 3. Hypodermis
10. 10
Definition of dermal absorption
Dermal(Percutaneous, skin) absorption is a global
term that describes the transport of chemicals from the
outer surface of the skin to the systemic circulation. This
often divided in to,
1. Penetration:
which is the entry of a substance into a particular
layer (or) structure, such as the entrance of a compound
into the stratum corneum.
2. Permeation:
which is penetration through one layer into s second
layer that is both functionally and structurally different
from first layer.
3. Resorption:
which is the uptake of a substance into the skin
lymph and local vascular system and in most cases will lead
to entry into systemic circulation.
11. 11
Percutaneous absorption
Drug dissolution in vehicle
Drug diffusion through
vehicle to skin
Partitioning into
Stratum corneum
Partitioning into
Sebaceous gland
Partitioning into viable
epidermis
Diffusion through viable epidermis
Diffusion through upper epidermis
Systemic circulation
Trans follicular route Trans epidermal route
19. Evaluation of paste Abrasiveness
Particle size
Cleaning property
pH of the product
Limit test for arsenic and lead
Non-volatile matters and moisture
Effect of special ingredients
EVALUATION OF TOPICAL DOSAGE FORM
19
20. Evaluation of powder
Shade control and lighting
Moisture content
Bulk density
Flow property
Particle size and abrasiveness
Dispersion of color
EVALUATION OF TOPICAL DOSAGE FORM
20
22. EVALUATION OF TOPICAL DOSAGE FORM
Evaluation of
patch's
21-day cumulative
irritancy patch test
Kligman
“maximization”
test
Draize-shelanski
repeat-insult patch
test
22
26. 26
Reference
1. Industrial Pharmacy, lachman / liberman’s, Fourth
edition. 714-756.
2. http://pharmaceuticalintelligence.com/tag/transcellular
-pathway/
3. https://en.wikipedia.org/wiki/Transdermal
4. http://www.ncbi.nlm.nih.gov/pmc/articles
5. http://www.pharmainfo.net/evaluation-ointments
6. The Principle and Practice of Modern Cosmetics: 45-48
7. Remington: The Science and Practice of Pharmacy
8. Pharmaceutical dosage form and drug delivery system.
Ansel’s.