This document discusses the selection and evaluation of pharmaceutical packaging materials. It begins by defining packaging and its purposes of providing protection, identification, convenience, and compliance for products. Key factors in selecting packaging materials include the type of container, product characteristics, and characteristics of the materials themselves like barrier properties and FDA approval. Common container materials like glass, plastic, and metal are described along with their advantages. The document also discusses evaluating packaging materials through tests like leakage tests, collapsibility tests, and permeability tests to ensure suitability for drug products.
this presentation mainly based on the regulatory aspects of packaging and gives all significance about packaging regulations,help in pharma or biotechnology .
Review of pharmaceutical product, packaging and ichDeepak Shukla
Review of stability of packaged material like containers and closures.
The whole ppt is regarding the test perform to know the stability of a container which is used for product storage.
It also contain the guidelines of ICH.
Different types of dosage forms have different properties so according to their handling and storage conditions we have to select containers accordingly
This presentation contains
Introduction, Advantages & Disadvantages, Process of manufacturing, Evaluation and defects in Blister, strip & ALU ALU Packaging. Useful for pharmacy students to understand the concept of blister & strip packaging
this presentation mainly based on the regulatory aspects of packaging and gives all significance about packaging regulations,help in pharma or biotechnology .
Review of pharmaceutical product, packaging and ichDeepak Shukla
Review of stability of packaged material like containers and closures.
The whole ppt is regarding the test perform to know the stability of a container which is used for product storage.
It also contain the guidelines of ICH.
Different types of dosage forms have different properties so according to their handling and storage conditions we have to select containers accordingly
This presentation contains
Introduction, Advantages & Disadvantages, Process of manufacturing, Evaluation and defects in Blister, strip & ALU ALU Packaging. Useful for pharmacy students to understand the concept of blister & strip packaging
Complete Information and knowledge about the selection criteria for packaging material and different test used for them .
All this material data is , Collected for seminar in QA SEM 2 , in the Subject of Pharmaceutical Manufacturing Technology .
Which also explain the How Quality control for Filling an pharmaceutical equipment is done.
PACKAGING MATERIAL QUALITY CONTROL TEST AND OPERATION.pdfMayuriPawar98
packaging operation in pharmaceutical industry and material used types and quality control tests,types of container closure system ,recent trends in pharmaceutical packaging
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with "Quality control of packaging materials."
Thank you for reading.
we hope it was helpful to you.
UIPS,PU team
Containers are in intimate contact with the product. No container presently available is totally non reactive, particularly with aqueous solutions . Both the chemical and physical characteristics are given primary consideration in the selection of a protective container . Glass containers traditionally have been used for sterile products , many of which are closed with rubber stoppers. Interest in plastic containers for parenterals is increasing and such containers are being used for commercial ophthalmic preparations and IV solutions.
SELECTION AND EVALUATION OF PHARMACEUTICAL PACKAGING TECHNIQUE.pdfShankar Maind Patil
Many pharmaceutical products are sell out in the market from its site to customer site covering miles of distance but .
Its necessary for them to keep their inner content intact throughout their use period .
That's how Packing involved in it.
Different materials like
Glass
Metal
Rubber
Plastic
Have been used for it .
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. PACKAGING :
Packaging Can Be Defined As An Economical Means Of Providing Presentation,
Protection, Identification Information, Convenience And Compliance For A Product
During Storage, Carriage, Display And Until The Product Is Consumed.
Packaging Must Provide Protection Against Climatic Conditions Biological, Physical And
Chemical Hazards And Must Be Economical. The Package Must Ensure Adequate
Stability Of The Product Throughout The Shelf Life.
2
3. SELECTION OF PACKAGING
MATERIALS ACCORDING TO
CONTAINERS :
Selection Of Packaging Materials According To Containers Glass &
Plastic
Selection Of Packaging Materials According To Containers
Metal,Closures
Selection Of Packaging Materials According To Product Characteristics
3
4. CHARACTERISTICS OF PACKAGING
MATERIALS:-
They must protect the preparation from
environmental conditions.
They must not be reactive with the product.
They must not impart to the product tastes or
odours.
They must be nontoxic.
4
5. CHARACTERISTICS OF PACKAGING
MATERIALS:-
They must be FDA approved.
They must meet applicable tamper-resistance
requirements.
They must be adaptable to commonly employed high
speed packaging equipment.
5
6. SELECTION OF THE PACKAGING MATERIALS
On the facilities available, for example, pressurized dispenser requires special filling equipment.
On the ultimate use of product. The product may be used by skilled person in hospital or may need to
be suitable for use in the home by a patient.
On the physical form of the product. For example, solid, semi-solid, liquids or gaseous dosage form.
On the route of administration. For example, oral, parenteral, external, etc. 9
6
7. SELECTION OF THE PACKAGING MATERIALS
On the stability of the material. For example , moisture, oxygen, carbon di oxide, light, trace metals,
temperature or pressure or fluctuation of these may have a deleterious effect on the product.
On the contents. The product may react with the package such as the release of alkali from the glass or
the corrosion of the metals and intern the product is affected.
On the cost of the product. Expensive products usually justify expensive packaging
7
10. CONTAINERS
Container is one in which the
product is placed.
A pharmaceutical container is
defined as a device that holds
the drugs and is or may be in
direct contact with the
preparation.
10
11. IDEAL REQUIREMENTS OF
CONTAINERS
Able to withstand changes in pressure and temperature.
Must be non-toxic.
Can be labelled easily.
Pharmaceutically elegant appearance.
11
12. TYPES OF CONTAINERS
Well-closed containers
Single dose containers
Multi dose containers
Light-resistant containers
Air-tight containers
Aerosol containers
12
13. MATERIALS USED FOR MAKING OF
CONTAINERS
1. Glass
2. Plastic
3. Metal
4. Paper and board
13
14. ADVANTAGES OF GLASS
CONTAINERS :
They Are Transparent.
They Are Available In Various Shapes And Sizes.
They Can Withstand The Variation In Temperature And Pressure During
Sterilization.
They Are Economical And Easily Available.
They Can Protect The Photosensitive Medicaments From Light During Their
Storage.
They Have Good Protection Power.
They Can Be Easily Labelled.
14
16. EVALUATION OF GLASS CONTAINERS
ARSENIC TEST : Washed the inner and outer surface of container with fresh distilled water for 5min.
Prep test as described in the test for hydrolytic resistance for an adequate no. of samples to produce
50ml. pipette out 10ml solution from combined contents of all ampoules to the flask. Add 10ml of HNO3
to dryness on the water bath, dry the residue in an oven at 130⁰C for 30min cool.
Swirl to dissolve and heat under water bath and reflux for 25min. Cool to room temp and determine the
absorbance at 840nm.
The absorbance of the test solution should not exceed the absorbance obtained by repeating the
determination using 0.1ml of arsenic standard solution (10ppm) in place of test solution
16
17. ADVANTAGES OF PLASTIC
CONTAINERS
They are light in weight and can be handled easily.
They are poor conductor of heat.
They can be transported easily.
They are unbreakable.
They are available in various shapes and sizes.
They have good protection power.
17
19. EVALUATION OF PLASTICS:-
1.Leakage Test : Fill 10 containers with water, fit with intended closures and
keep them inverted at room temperature for 24hr.
The test is said to be passed if there is no signs of leakage from any
container.
2. Collapsibility Test : This test is applicable to the containers which are to
be squeezed for removing the contents.
A container by collapsing inward during use, yield at least 90% of its normal
contents at the required rate of flow at ambient temperature.
19
20. EVALUATION OF PLASTICS:-
3.Water Vapour Permeability Test : Fill 5 containers with normal volume of
water and heat seal the bottles with an aluminium foil.
Weigh accurately each container and allowed to stand for 14days at
temperature between 20 and 25⁰C.
Reweigh the containers.
20
21. ADVANTAGES OF METAL
CONTAINERS
They are sturdy.
They are impermeable to light, moisture and gases.
They can be made into rigid unbreakable containers by impact extrusion.
They are light in weight as compared to glass containers
21
22. CLOSURES
Closures are the devices by means of which containers can be opened and
closed.
It prevents loss of material by spilling or volatilization.
It avoids contamination of the product from dirt, micro- organism or insects.
It prevents deterioration of the product from the effect of the environment such as
moisture, oxygen or carbon dioxide.
22
24. EVALUATION OF CLOSURES:-
1.FRAGMENTATION TEST (IP 1996) :
Place A Volume Of Water Corresponding To Nominal Volume-4ml In Each Of 12 Clean Vials, Close Vial With
Closure And Secure Caps For 16hrs.
Pierce The Closure With Number 21 Hypodermic Needle and Inject 1ml Water And Remove 1ml Air
Repeat The Above Operation 4 Times For Each Closure
Count The Number Of Fragments Visible To Naked Eye
Total Number Of Fragments Should Not Be More Than 10.
24
25. EVALUATION OF CLOSURES:-
2.SELF SEALABILITY TEST FOR RUBBER CLOSURES :
Fill 10 Vials With Water To Small Volume And Close The Vials With Closures, Pierce The Cap And
Closures 10 Times At Different Places With No 21 Syringe Needle.
Immerse The Vials In 0.1 %W/V Solution Of Methylene Blue Under Reduced Pressure, Restore The
Nominal Pressure And Keep The Container For 30 Min And Wash The Vials. None Of The Vial Should
Contain Traces Of Colored Solution.
25