Ophthalmologic causes of visual impairment include retinal issues like retinal artery occlusion, retinal detachment, and macular degeneration as well as optic nerve problems like glaucoma. Cataracts, refractive errors, and diabetic retinopathy are also common causes of visual loss. Visual impairment can be gradual and painless from conditions like cataracts and macular degeneration or sudden from retinal detachments or artery occlusions. Treatment depends on the underlying problem but may include eyeglasses, surgery, laser treatment, or medication.
This presentation describes the background of the cornea and the corneal diseases in general, also it describes in detailed manner how to manage the corneal ulcer with its different causes
This presentation describes the background of the cornea and the corneal diseases in general, also it describes in detailed manner how to manage the corneal ulcer with its different causes
This presentation gives a brief idea about angle of anterior chamber along with its structures and diagnostic methods to grade and visualize the structures.
Congenital Glaucoma is one of the most common causes of irreversible childhood blindness. This presentation covers this topic in detail that can aid physicians in effective patient care.
PS: The slides in the preview look skewed, download the presentation to view the font used in Office 2012 and upwards.
This presentation gives a brief idea about angle of anterior chamber along with its structures and diagnostic methods to grade and visualize the structures.
Congenital Glaucoma is one of the most common causes of irreversible childhood blindness. This presentation covers this topic in detail that can aid physicians in effective patient care.
PS: The slides in the preview look skewed, download the presentation to view the font used in Office 2012 and upwards.
Glaucoma: the “silent thief of sight”
Glaucoma is a leading cause of preventable sight loss. Vision can often be preserved with early identification, good adherence to treatment and long-term monitoring.
This is a topic of sensory organ and this is detailed topic and can be refered by all nursing students bsc, msc and gnm which give you overall idea and things related to cataractwhich include definition, anat and physio, risk factor, pathophysiology, clinical menifestation, diagnostic evaluation, and management
A cataract is a dense, cloudy area that forms in the lens of the eye. A cataract begins when proteins in the eye form clumps that prevent the lens from sending clear images to the retina. The retina works by converting the light that comes through the lens into signals. It sends the signals to the optic nerve, which carries them to the brain.
CONCEPT OF NODOPATHIES AND PARANODOPATHIES.pptxNeurologyKota
emergence of autoimmune neuropathies and role of nodal and paranodal regions in their pathophysiology.
Peripheral neuropathies are traditionally categorized into demyelinating or axonal.
dysfunction at nodal/paranodal region key for better understanding of patients with immune mediated neuropathies.
antibodies targeting node and paranode of myelinated nerves have been increasingly detected in patients with immune mediated neuropathies.
have clinical phenotype similar common inflammatory neuropathies like Guillain Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
they respond poorly to conventional first line immunotherapies like IVIG
This presentation briefs out the approach of dementia assessment in line with consideration of recent advances. Now the pattern of assessment has evolved towards examining each individual domain rather than lobar assessment.
This presentation contains information about Dementia in Young onset. Also it describes the etiologies, clinical feature of common YOD & their management.
Entrapment Syndromes of Lower Limb.pptxNeurologyKota
This presentation contains information about the various Entrapment syndromes of Lower limb in descending order of topography. It also contains information about etiology, clinical features and management of each of these entrapment syndromes with special emphasis on electrodiagnostic confirmation.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Dehradun #ℂall #gIRLS Oyo Hotel 9719300533 #ℂall #gIRL in Dehradun
Overview of ophthalmologic causes of visual impairment
1. Overview of Ophthalmologic Causes
of Visual Impairment
Dr. Nishtha Jain
Senior Resident
Department of Neurology
GMC, Kota.
2. Visual Impairment
• A functional limitation of the eye(s) or visual system and
can manifest as reduced visual acuity or contrast
sensitivity, visual field loss, photophobia, diplopia, visual
distortion, visual perceptual difficulties, or any
combination.
4. Sudden Painless Loss of
Vision
Central retinal Artery Occlusion
Massive Vitreous Haemorrhage
Retinal Detachment Involving
Macular Area
Ischemic Central Retinal Vein
Occlusion
5. Sudden Painful Loss of
Vision
Acute Iridocyclitis
Acute Congestive Glaucomas
Chemical injuries to eyeball
Mechanical injuries to eyeball
6. Gradual Painful Loss of
Vision
Chronic Iridocyclitis
Corneal Ulceration
Chronic Simple Glaucoma
7. Gradual Painless Loss
of Vision
Progressive Pterygium
Corneal Degeneration
Corneal Dystrophies
Develepmental Cataract
Senile Cataract
Optic Atrophy
Chorioretinal
Degeneration
Age Related Macular
Degeneration
Diabetic Retinopathy
Refractive Errors
21. Myopia (Short-sightedness)
• With the accommodation at rest, the incident parallel rays of
light come to a focus anterior to the light sensitive layer of the
retina.
• Person is near-sighted i.e. the person can see near things
clearly but has difficulty in seeing distant objects.
• Causes-Anteroposterior diameter of the eye is longer than
normal.
• Distance too great from the lens to the retina.
• Correction - Needs a concave or minus corrective lens
22. Hypermetropia (Far-sightedness)
• With the accommodation at rest, incident parallel rays
come to a focus posterior to the light sensitive layer of
the retina.
• Causes: Antero-posterior diameter of the eye is shorter
than normal, Distance too short from the lens to the
retina.
• A predisposing cause for convergent squint.
• Correction - Prescribing convex or plus corrective lenses
23. Astigmatism
• In this condition, the eye has a misshapen curve referred
as curvature ametropia.
• It produces a distorted image on the retina.
• Correction - Glasses with cylindrical lenses
24. Presbyopia
• The crystalline lens becomes rigid so during
accommodation, even though the ciliary muscles are
contracting, it is unable to change its shape to focus near
objects.
• Light is formed behind the retina.
• Symptoms - Difficulty in reading, sewing or near work.
• Correction - convex lenses for doing near work.
25. Buphthalmos
• It is infantile glaucoma.
• Failure of development of
tissues in region of
anterior chamber.
• Results into excessive
watering, photophobia &
cornea becomes cloudy.
• Due to altered shape of
eye, refractive errors may
occur.
26. Albinism
• This is a hereditary condition involving defective
development of pigment in hair, skin & eye.
• In ‘ocular albinism’, only eyes are affected.
• Associated with photophobia, decreased visual acuity,
nystagmus and refractive errors.
• Difficult going outside on a bright day
• Any glare would cause difficulty
27. Precautions
• Such children not to be
seated near windows
• Level of lighting may be
adapted
• Need glasses to help
their distant vision
28. Retinitis Pigmentosa
• Hereditary slow degenerative disease of the retina.
• Affects the peripheral area of retina.
• Result into night blindness, tunnel vision and inability to
see in dark.
• Progressive and results into blindness in middle or
advanced age.
• The field of vision is so poor that the person falls in the
category of blindness.
29.
30. Retinoblastoma
• Malignant tumour of the retina.
• Generally confined to infants, probably always congenital
and some cases are heredity.
• Often a bilateral condition.
• Treated by surgery and radiation or photo-coagulation.
• Genetic counselling is desirable.
31.
32. Retrolental Fibroplasia
• Associated with pre-mature birth children who have been
given high concentration of oxygen.
• Caused due to formation of new vessels and proliferation
of fibrous tissue in the retina.
• Results into formation of a membrane in the back of the
lens of the eye.
• Usually a bilateral condition.
33. Trachoma
• Caused by an organism chlamydia trachomatis.
• Unhygienic and crowded unhealthy environment
• Primary infection is epithelial and involves both
conjunctiva and cornea.
• Symptoms- Redness, Itching, Tearing, Irritations
• Signs : Diffused conjunctival inflammation characterized
by congestion, formation of follicles on the inner aspect
of the upper lid.
• Vascularisation of the upper margin of cornea and
corneal ulcers
34. Treatment
• Clean the eyes if there is discharge
• Sulphacetamide eye drops 10% or 20% to be instilled at
least 4 times a day for 6 weeks.
• Advise on personal hygiene and daily washing of face.
• Check other members of the family for trachoma
• Never use medicines containing steroids.
35. • Trichiasis : distortion of the lids.
• The shape of lids, especially upper lid, is altered and
may be turned inwards, leading to entropion.
• This causes the lids to rub against the cornea.
• Symptoms – Irritation, Photophobia, Tearing, Poor vision
36. • Remove misdirected eyelashes
• Topical treatment with Erythromycin ointment,
Tetracycline or Rifampicin is far more effective than
Sulfonamides.
• This treatment must be persistent for 5 consecutive days
a month for 12 months.
• Oral Doxycycline 5mg/kg body weight one per month is
easy to administer and is as effective as topical
Tetracycline.
37.
38. Vitamin A Deficiency
• Also known as: Xerophthalmia, Blinding malnutrition,
Disease of darkness.
• Causes-Insufficient and unbalanced food intake by the
mothers and the children, Low absorption due to
diarrhoea or malnutrition, Increased demand of Vitamin A
during and after measles infection.
• Leads to: Xerosis of the conjunctiva, Keratomalacia and
Night blindness.
39. Signs
• A line or spot on the conjunctiva
• Thick white spots on both sides of the cornea
• Conjunctiva becomes wrinkled
• Scar forms over cornea
40. • Immediately- give oral 200,000 IU vitamin A
• Apply antibiotic ointment (twice daily)
• Apply a protective eye shield
• Next day give a further dose of oral vitamin A, 200,000
IU, and again two weeks later (same dose)
41.
42. Cataract
• Loss of transparency of the lens due to altered physio-
chemical processes within tissues.
• Usually associated with advanced age.
• If present at birth, it is referred as congenital cataract.
• Complaint - Gradual loss of vision over a long period of
time
• Feels as if looking through a dirty window
43. Examination and findings
• Gray or white pupils
• Usually both eyes are affected
• Usually found in old people
Refer for further examination and possible operation if:
• patient can not perform daily activities
• vision is worse than 6/60 or finger counting at 6 meters
in both eyes
44. Age-Related Macular Degeneration
• Characterized by degeneration of the macula.
• Risk factors for AMD - Advancing age, family history of
AMD and cardiovascular risk factors such as
hypertension and cigarette smoking.
• AMD can be divided into two categories: nonexudative
(or “dry”) AMD and exudative (or “wet”) AMD.
45. • 90 percent of persons with AMD have the nonexudative
form of the disease.
• Types of nonexudative AMD include drusen and
geographic atrophy.
47. • Approximately 10 percent
of persons with AMD
develop the exudative
form of the disease.
• Characterized by growth
of abnormal vessels from
the choroidal circulation
to the subretinal space.
• These abnormal vessels
leak fluid and blood in the
macula, resulting in
blurred or distorted
central vision.
48. Glaucoma
• Caused by an obstruction in aqueous outflow channels
at angle of anterior chamber.
• Results in the rise in intraocular pressure which is
detrimental to the eye.
• It is usually a hereditary, symptomatic condition.
• Acute glaucoma strikes suddenly with intense
pain,nausea and blurred vision.
49. • Treatment is aimed at lowering the internal pressure in
the eye
• Special eye drops used regularly would maintain the
internal pressure at the proper level
• In some instances, surgery may be required.
50. Risk factors
• age over 35 years of age
• have blood relatives who have Glaucoma
• have diabetes
• asthmatic and patient of arthritis on long term oral
“Corticosteroids”
• have rainbow rings around bulbs, lights or candles
• pain or blurring of sight in the evenings
• children with large eye
51. Diabetic Retinopathy
• Diabetic macular oedema occurs in approximately 10
percent of all diabetics.
• In patients with diabetes for 20 or more years, incidence
increases to 25 percent.
• Macular oedema is defined as any retinal thickening of
or deposition of hard exudates within one disc diameter
of the centre of the macula.
52. It is termed significant if any of the following three
characteristics are present:
• Thickening of the retina at or within 500 u of the centre
of fovea
• Deposition of hard exudates associated with the area of
adjacent retinal thickening at or within 500 u of the foveal
centre
• Development of a zone of retinal thickening one disc
diameter or larger
53. • The decision to treat diabetic macular oedema is based
entirely on clinical and angiographic findings,
independent of patient’s visual acuity.
• Focal treatment consists of directing only green argon
photocoagulation to all leaking microaneurysms.
54.
55. To conclude
• Developing countries having major burden of visual
impairment.
• Low socioeconomic status/rural population more prone.
• Main cause in adults- cataract, RE, AMD, Glaucoma,
Diabetic Retinopathy
• Main cause in children- Develepmental disorders,
cataract, vitamin A deficiency.
56. Referrences
• Bradley’s Neurology in Clinical Practice, Sixth Edition.
• Causes, Prevention And Cure Of Visual Impairment. Dr.
Vandana Nath.
• Prevalence and Causes of Visual Impairment and
Blindness in an Urban Indian Population: The Singapore
Indian Eye Study. Zheng et al. Ophthalmology
2011;118:1798–1804.
• Global Data On Visual Impairment. World Health
Organization 2012.