An operational amplifier, or op-amp, is a high gain differential amplifier with very high input impedance and very low output impedance. It has five ideal characteristics: infinite input impedance, zero output impedance, infinite open-loop gain, infinite bandwidth, and infinite slew rate. There are three main op-amp configurations - inverting, non-inverting, and summing. The inverting configuration inverts the output signal phase. The non-inverting configuration maintains the output signal phase. The summing amplifier combines multiple input voltages into a single output voltage proportional to the algebraic sum of the inputs.
The OPerational AMPlifier or OPAMP is a versatile analog Integrated Circuit (IC) that is capable of producing a very high gain.
An amplifier is a circuit that receives a signal at its input and delivers an undistorted larger
version of the signal at its output. The operational amplifier is a high gain amplifier to which feedback is added to control its overall response characteristic.
In closed loop connection, an external resistance is connected between the output and the negative (inverting) input terminal as a negative feedback. Here, the gain can be controlled by changing the values of the resistors.
this presentation is based on basic description of inverting and non-inverting amplifiers using op-amps and their medical use, hope it helps students :)
The OPerational AMPlifier or OPAMP is a versatile analog Integrated Circuit (IC) that is capable of producing a very high gain.
An amplifier is a circuit that receives a signal at its input and delivers an undistorted larger
version of the signal at its output. The operational amplifier is a high gain amplifier to which feedback is added to control its overall response characteristic.
In closed loop connection, an external resistance is connected between the output and the negative (inverting) input terminal as a negative feedback. Here, the gain can be controlled by changing the values of the resistors.
this presentation is based on basic description of inverting and non-inverting amplifiers using op-amps and their medical use, hope it helps students :)
Introduction to operational Amplifier. For A2 level physics (CIE). Discusses characteristics of op amp, inverting and non inverting amplifier, and voltage follower, and transfer characetristics, virtual earth , etc
Introduction to operational Amplifier. For A2 level physics (CIE). Discusses characteristics of op amp, inverting and non inverting amplifier, and voltage follower, and transfer characetristics, virtual earth , etc
Block diagram of a typical op-amp – characteristics of ideal and practical op-amp - parameters of opamp – inverting and non-inverting amplifier configurations - frequency response - circuit stability.
Introduction to Linear ICs– BJT differential amplifier-Operational amplifier IC 741–Block diagram and Characteristics - Inverting, non inverting and difference amplifier – Adder, Subtractor, Integrator, Differentiator-Comparator- Window detector- Regenerative comparator (Schmitttrigger) - Precision rectifier- Current to voltage converter – Voltage to current converter
-Log and antilog amplifiers- Instrumentation amplifiers.
The term isolation refers to the separation of a strain from a natural, mixed population of living microbes, as present in the environment. It becomes necessary to maintain the viability and purity of the microorganism by keeping the pure culture free from contamination.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
1. Part 01
Operational Amplifier
Dr. Krishna Jibon Mondal
Assistant Professor and Head
Department of Physics and Electronics
Shri Shankaracharya Mahavidyalaya, Bhilai
2. Introduction
An operational amplifier commonly known
as op-amp is a two-input single-output
differential voltage amplifier which is
characterized by
high input impedance
low output impedance
high gain
3. Characteristics of Operational amplifier
Input Impedance (Zin): An ideal op-amp has infinite
input impedance
Output Impedance (Zout): An ideal op-amp has zero
output impedance
Open-Loop Gain (AVO): An ideal op-amp, the gain
will be infinite
Bandwidth (BW):An ideal op-amp, the bandwidth
will be infinite
Slew Rate:An ideal op-amp will have an infinite
slew rate
Offset Voltage (VIO) : An Ideal op-amp will have
zero offset voltage
CMRR (Common Mode Rejection Ratio): An ideal
op-amp will have infinite CMRR
5. Then, the Closed-Loop Voltage Gain of an Inverting
Amplifier is given as.
Linear Output
The negative sign in the equation indicates an
inversion of the output signal with respect to the
input as it is 180 degree out of phase. This is due
to the feedback being negative in value.
6. Non-inverting Operational
AmplifierIn this configuration, the input voltage signal, ( VIN ) is applied directly to the
non-inverting ( + ) input terminal which means that the output gain of
the amplifier becomes “Positive” in value in contrast to the “Inverting
Amplifier”.
7. Then the closed loop voltage gain of a Non-
inverting Operational Amplifier will be given
as:
8. Summing Amplifier
The Summing Amplifier is another type of operational
amplifier circuit configuration that is used to combine the
voltages present on two or more inputs into a single output
voltage.
9. However, if all the input impedances, ( RIN ) are
equal in value, we can simplify the above
equation to give an output voltage of:
Thus, an output voltage signal is proportional to
the algebraic “SUM” of the three individual
input voltages V1, V2 and V3
