Cancer is a major cause of death worldwide. The document discusses the etiology and pathogenesis of various cancers. It provides data on the most common cancers globally and lists lifestyle risk factors. The key mechanisms of carcinogenesis include chemical, physical, and infectious causes. Chemical carcinogens can be direct or require metabolic activation. Various epidemiological factors influence cancer risk such as genetics, environment, age, and hormones. Physical carcinogens like radiation and asbestos can also cause cancer development. Certain viruses are associated with different cancer types.
Neoplasia - Characteristics & Classification of Neoplasm Chhavi Singh
This power point presentation take a detail note on neoplasm (cancer), types of neoplasm, stages of neoplasm, various kinds of carcinogens. This presentation also take interest in the classification and characteristics of the tumor & difference between the normal cells and tumor cells.
Neoplasia - Characteristics & Classification of Neoplasm Chhavi Singh
This power point presentation take a detail note on neoplasm (cancer), types of neoplasm, stages of neoplasm, various kinds of carcinogens. This presentation also take interest in the classification and characteristics of the tumor & difference between the normal cells and tumor cells.
Cancer is a degenerative disease that can be prevented and managed by following proper nutritional considerations however the prognosis highly depends on the stage of diagnosis.
It is all about cancer , risk factors of cancer now days based on strong evidences , it's way of prevention and also includes a new research on melatonin effect on reduction and prevention of many cancers including: Breast, prostate , lung , solid tumor ...etc
Bladder cancer is a disease of urinary bladder in which cells grow abnormally and have the potential to spread to other parts of the body. This is one of four parts of presentations on Bladder cancer. Please do go through the rest of the presentations too.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
2. Cancer incidence
• World wide cancer related death – 20 %
• In US- cancer is second most common cause of death
• Most common cancer in developed countries are
lung, breast, prostate and colorectal
• Most common cancer in developing countries are
liver, cervical and oesophageal.
• Following life-style factor attributing cancer worldwide:
tobacco use, alcohol abuse, obesity, physical
inactivity, low fiber diet, unprotected sex, polluted
air, indoor household smoke and contaminated
injections.
3. Cancer incidence
Five most common primary cancers in the world (descending order)
S.No Men
Women
Children (under 20)
1
Lung
Breast
Acute leukaemia
2
Prostate
Lung
CNS tumour
3
Colorectal
Colorectal
Bone sarcoma
4
Urinary bladder
Endometrial
Endocrine
5
Lymphoma
Lymphoma
Soft tissue sarcoma
4. Epidemiologic factors
1. Predisposing factors
a)
b)
c)
d)
Familial and genetic factors
Racial and geographic factors
Environmental and cultural factors
Age and gender
2. Chronic non-neoplastic (pre-malignant) conditions
a)
b)
c)
Carcinoma in situ
Benign tumour
Miscellaneous conditions
3. Role of hormones in cancer
a)
b)
c)
d)
Oestrogen
Contraceptive hormones
Anabolic steroids
Hormone-dependent tumor
5. Epidemiologic factors
1. Predisposing factors
a)
Familial and genetic factors:
– Risk of developing first degree relatives of cancer patient is 3
times higher as compare to control
– Genetic cancer comprise not greater than 5 % of all cancer. E.g.:
49% of retinoblastoma are inheritance (missing of RB gene in
chromosome 13), 100% of familial Polyposis coli develop cancer
of the colon, neurofibromatosis or von Recklinghausen’s
disease (50% inheritance), cancer of breast (2-6 times higher
risk than normal; inherited breast cancer- 5-10%,; mutant
genes- BRCA-1 and BRCA-2.)
6. Epidemiologic factors
1. Predisposing factors
b)
Racial and geographic factors
White Europeans and
Americans
Lungs, breast and colon;
Breast cancer common in Americans
but uncommon in Japanese
Black Africans
Skin, penis, cervix and liver
Japanese
5 times higher incidence of carcinoma
of the stomach than the Americans
South-East Asians
Chinese- nasopharyngeal cancer
Indians
Higher incidence of carcinoma of the
oral cavity and upper aerodigestive
tract; female- carcinoma of uterine
cervix, breast. Cancer of liver (HBV and
HCV viral hepatitis)
7. Epidemiologic factors
1. Predisposing factors
c) Environmental and cultural factors
–
–
–
–
–
–
Cigarette smock: cancer of oral
cavity, pharynx, larynx, oesophagus, lungs, pancreas and
urinary bladder
Alcohol and tobacco together: risk of developing cancer of the
upper aerodigestive track
Cancer of cervix: age at first coitus, frequency of
coitus, multiplicity of partners and parity
Penile cancer: rare in the Jews and Muslims.
Carcinogenic compound smegma plays a role in etiology of
cancer
Betel nut cancer: common in some part of India due to
habitual of keeping the bolus of pann in particular place of
mouth for a long time
8. Epidemiologic factors
1.
Predisposing factors
d) Age and gender
–
–
–
–
–
–
Age is most significant factor for cancer (two-third of all
cancer occur above 65 yr of age)
Cancer in advanced age may be due to alterations in the cells
of host, longer exposure to the effect of carcinogen, or
decreased ability of the host immunity
Tumours in infancy and childhood:
Neuroblastoma, nephroblastoma, rhabdomyosarcoma, Ewing’
s sarcoma, teratoma and CNS tumours.
Apart form malignant tumours, most tumours are common
for men than in women except cancer of the breast
Breast cancer: throughout the world common for women
Lung cancer: common for men
9. Epidemiologic factors
2. Chronic non-neoplastic (pre-malignant) conditions
a)
Carcinoma in situ
–
–
b)
Benign tumour
–
c)
Malignancy are present in epithelium without invasion across the
basement membrane
Common sites for carcinoma in situ are uterine cervix, Bowen’s
disease of the skin, oral leukoplakia, intralobular and intraepithelial
carcinoma of the breast
Benign tumour not become malignant excepts multiple villous
adenomas of the large intestine
(adenocarcinoma), neurofibromatosis (neurofibrosarcoma)
Miscellaneous conditions
–
–
–
–
Patients of long standing ulcerative colitis colorectal cancer
Cirrhosis of liver hepatocellular carcinoma
Chronic bronchitis in heavy cigarette cancer of bronchus
Old burn scar (Marjolin’s ulcer) squamous cell carcinoma
10. Epidemiologic factors
3. Role of hormones in cancer
Hormone sensitive tissues developing tumour are the
breast, endometrium, myometrium, vagina, thyroid, liver, p
rostate and testis.
a)
b)
c)
Oestrogen therapy increase the risk of developing endometrial
carcinoma
Oral contraceptives increase the risk of developing breast cancer
Anabolic steroids increase the risk of developing benign and
malignant tumours
12. Causes/ pathogenesis of cancer
Carcinogenesis/ oncogenesis or tumorigenesis : mechanism of
induction of tumours
Three major type of carcinogens
• Chemical carcinogenesis
– Mutagens
– Chemical carcinogenesis and their metabolism
• Physical carcinogenesis (radiation)
– Ultraviolet radiation, Asbestos
• Infectious Pathogens (Viral)
– Human T-cell leukemia viruses, DNA viruses, Human papillomaviruses
– Epstein-Barr virus, Hepatitis B virus
13. Chemical carcinogenesis/ mutagens
• Two-step/ multistep process
– Initiation : causes permanent DNA damage
(Mutation)
– Promotion (Proliferation)
INITIATORS
• Direct acting compounds: Direct acting carcinogens are
bind covalently to cellular macromolecules. E.g. nitrogen
mustard, bis(chloro-methyl) ether, benzyl chloride, Epoxides
• Indirect acting carcinogen (Procarcinogens): Require
metabolic conversion to form ultimate active carcinogen.
PROMOTERS
• Can cause cellular proliferation & induce tumors in
initiated cells, e.g estrogen but they are non tumorigenic
by themselves.
•
Proliferation of a mutated cell may lead to accumulation of
additional mutations.
14. Chemical carcinogenesis/ mutagens
E.g. for indirect-acting chemical carcinogens (procarcinogens)
– Polycyclic aromatic hydrocarbons cigarette smoke lung
cancer
– Aflatoxin B1 Fungi Aspergillus flavus (contamination of veg.
food, peanuts) liver cancer (Africa and Asia regions)
– Aromatic amines and Azo dues bladder (aniline dye) and liver
tumors.
– Nitrosamines: Nitrosamines (nitrosamine, dimethyl nitrosamine)
are potent carcinogen, produce kidney, liver tumor and
gastrointestinal cancers.
– Metals: Ni2+, Pb2+, Cd2+, Co2+ and Be2+.
15. Test for chemical carcinogenesis
• Experimental induction
– Rodents are used
– Chemical (investigational product) administration promoting agents
administration after study period animals are autopsied and results
obtained.
• Test for mutagenicity (AMES’ test)
– Check the mutation ability of a chemical to induce mutation in the
mutant strain of Salmonella typhimurium
16. Factors influencing chemical carcinogenesis
• Metabolism of carcinogens: Most of the chemical carcinogen
required metabolic activation. If carcinogen augmenting the
detoxification pathways, reduce incidence of cancer.
• Sex and hormonal status:
– Pregnancy is associated with a decreased incidence of cancers of the
breast, endometrium and ovary.
– Women who are borne children at an early age are at a lesser risk than
nulliparous woman for cancers of the breast, endometrium and ovary.
– Early menarche, late menopause and later age of first pregnancy all
increase the risk of breast cancer.
• Diet: Low-protein diet reduce the hepatic activity and decreased
sensitivity to hepatocarcinogens. Obesity is associated with an increased
number of tumors.
18. Physical carcinogenesis
• Radiation- Ultraviolet light
– Causes: mutation, inhibits cell division and cell death
– MOA: formation of pyrimidine dimer
– Main source of UV light is sunlight, UV lamp and welder’s arcs
– Penetration of UV light protected by melanin pigmentation of
the skin.
• Sun light white race basal cell carcinoma, squamous
carcinoma and malignantmelanoma
• Sun light darker races protected by melanin
pigment, which absorbs UV radiation
• Lifetime risk of 1 rad of whole-body x-ray or gamma-ray
radiation is one excess cancer death per 10,000 person
19. Physical carcinogenesis
• Radiation- Ionising radiation
• X-rays, α-, β- and γrays, radioactive
isotopes, protons and
neutrons can cause cancer
Image form ‘Essential Pathology for Dental Students’ by Harsh Mohan and Sugandha Mohan, 4th ed. India
20. Physical carcinogenesis
• Non-radiation Physical Carcinogenesis
– Asbestos: A fibrous amphibole; used for making
fireproof articles
– Inhaling asbestos can cause lung cancer
– Source of inhalation:
•
•
•
•
•
mining and manufacturing of asbestos
installation of asbestos insulation
air in the vicinity of asbestos plants
contaminated air in buildings undergoing repair or demolition
clothing of asbestos workers
21. Infectious Pathogens
• Virus
Viral infection is responsible for 20% of human cancer
worldwide
– RNA retrovirus HTLV-I T-cell leukemia/ lymphoma (endemic in
Japan, Africa, the Caribbean basin and southeastern United
States)
– Human papillomavirus (DNA) squamous carcinoma of the
cervix
– Hepatitis B and C viruses primary hepatocellular carcinoma
– Epstein-Barr virus (EBV) lymphoma and nasopharyngeal
carcinoma
– Human herpesvirus 8 kaposi sarcoma
22. Infectious Pathogens
Bacteria
• Helicobacter Pylori (Gastric lymphoma, Mucosal Associated
Lymphoid Tumor (MALT) & Gastric carcinoma)
Fungi
• aflatoxins produced by Aspergillus flavus - hepatocellular
carcinoma
Parasites
• Schistosoma and Clonorchis sinensis
Cancer inheritance
•
Cancer inheritance: Genetic basis. E.g., Breast cancer
(associated genes are BRCA-1 and BRCA-2)
24. Tobacco-Related Cancers
• Lung cancer estimates for 2013 (Source: Cancer Facts & Figures
2013):
– New cases of lung cancer: 228,190
Males: 118,080
Females: 110,110
– Deaths from lung cancer: 159,480
Males: 87,260
Females: 72,220
• Tobacco use also increases the risk for cancers of the mouth, lips, nasal
cavity (nose) and sinuses, larynx (voice box), pharynx (throat), esophagus
(swallowing tube), stomach, pancreas, kidney, bladder, uterus, cervix,
colon/rectum, ovary (mucinous), and acute myeloid leukemia.
• Tobacco use is responsible for nearly 1 in 5 deaths in US
• Tobacco use accounts for at least 30% of all cancer deaths and 87% of lung
cancer deaths
Back
25. Cancer induced by alcohol abuse:
•
•
•
•
•
•
•
Mouth cancer
Pharyngeal cancer (upper throat)
Oesophageal cancer (food pipe)
Laryngeal cancer (voice box)
Breast cancer
Bowel cancer
Liver cancer
Back
26. Cancer induced by obesity:
• 49 % of endometrial cancers are caused by excess body fat.
–
–
–
–
–
–
esophageal cancer
pancreatic cancer
kidney cancer
gallbladder cancer cases
breast cancer cases
colorectal cancer cases
Back
27. Cancer induced by unprotected sex :
• HPV is a virus that's transmitted through sexual
contact -- genital or oral
Back
Editor's Notes
Inhabitants of Australia and New Zealand living close to the equator who receive more sunlight, and in farmers and outdoor workers due to the effect of actinic light radiation.
Inhabitants of Australia and New Zealand living close to the equator who receive more sunlight, and in farmers and outdoor workers due to the effect of actinic light radiation.