This document proposes developing protein-based nanomachines and robots for space applications over the next 50 years. In Phase I, the team will identify proteins for nanoscale mechanisms, develop computational models, and perform experiments to assemble and test components like viral protein linear motors and DNA joints. The long term vision is to develop self-sustaining nanorobotic assemblies capable of space colonization tasks like remote sensing and signal transmission.
Nanomaterials in biomedical applicationsumeet sharma
An introduction to emerging technology in medicinal science, "nanodrugs" a fruitful combination of nano-science and medical science. In this presentation, use of nano shells for delivery of drugs to targeted cancer cells has been explained. along with In Vivo and In Vitro studies on use of nanomaterials for biomedical application. For any information please feel free to contact me or refer to the references.
This presentation is a simple explain of Bionanoimaging which introduce this area completely. You can use this PPTx File to present in your class and seminars as well. I prepare this file to present in Tabriz University of Medical Sciences when I was a MSc Medical Nanotechnology student. It will be useful for you too.
Nanomaterials in biomedical applicationsumeet sharma
An introduction to emerging technology in medicinal science, "nanodrugs" a fruitful combination of nano-science and medical science. In this presentation, use of nano shells for delivery of drugs to targeted cancer cells has been explained. along with In Vivo and In Vitro studies on use of nanomaterials for biomedical application. For any information please feel free to contact me or refer to the references.
This presentation is a simple explain of Bionanoimaging which introduce this area completely. You can use this PPTx File to present in your class and seminars as well. I prepare this file to present in Tabriz University of Medical Sciences when I was a MSc Medical Nanotechnology student. It will be useful for you too.
Controlling and manipulating matter on the nanometer-length scale (1-100 nm), and
Exploiting novel phenomena and properties (physical, chemical, biological, mechanical, electrical) at the nanoscale.
Introduction
Definition
History
Advantages of nanobiotechnology
Applications of nanobiotechnology
Drawback of nanobiotechnology
New features in the nanobiotechnology
Conclusion
References
Nanotechnology & nanobiotechnology by kk sahuKAUSHAL SAHU
Introduction &definition
a) Nanotechnology
b) Nanobiotechnology
History
Terms related to Nanotechnology
Nanoscale technology
Some Nanoscale related terms
What are Nanosensors
How nanosensors work
DNA Nanotechnology
How Nanotechnology works in different fields
Advantages & application of Nanotechnology
Disadvantages
Conclusion
References
Review paper on the applications and challenges of gold nanoparticles in medicine and dentistry.
Gold nanoparticles is a game-changer in delivering patient care. Its versatility can be put to use in diagnosis, imaging and treatment of various conditions. It relatively recent innovation although gold is a metal that has had a lot of meaning in human civilisation.With a lot of potential left unexplored one has to what and watch the miracles this breakthrough has in store for medical science.
Introduction
Nanoparticle characterization techniques
Electron Microscope
Scanning electron microscope
Transmission electron Microscope
X-ray powder diffraction
Nuclear Magnetic Resonance
Controlling and manipulating matter on the nanometer-length scale (1-100 nm), and
Exploiting novel phenomena and properties (physical, chemical, biological, mechanical, electrical) at the nanoscale.
Introduction
Definition
History
Advantages of nanobiotechnology
Applications of nanobiotechnology
Drawback of nanobiotechnology
New features in the nanobiotechnology
Conclusion
References
Nanotechnology & nanobiotechnology by kk sahuKAUSHAL SAHU
Introduction &definition
a) Nanotechnology
b) Nanobiotechnology
History
Terms related to Nanotechnology
Nanoscale technology
Some Nanoscale related terms
What are Nanosensors
How nanosensors work
DNA Nanotechnology
How Nanotechnology works in different fields
Advantages & application of Nanotechnology
Disadvantages
Conclusion
References
Review paper on the applications and challenges of gold nanoparticles in medicine and dentistry.
Gold nanoparticles is a game-changer in delivering patient care. Its versatility can be put to use in diagnosis, imaging and treatment of various conditions. It relatively recent innovation although gold is a metal that has had a lot of meaning in human civilisation.With a lot of potential left unexplored one has to what and watch the miracles this breakthrough has in store for medical science.
Introduction
Nanoparticle characterization techniques
Electron Microscope
Scanning electron microscope
Transmission electron Microscope
X-ray powder diffraction
Nuclear Magnetic Resonance
20091116-17
Curso de Genómica Aplicada a la Medicina Clínica (MADRID)
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Las macromoléculas se comportan como diminutas máquinas para realizar sus funciones biológicas dentro de las células.
Si bien la estructura (en los diferentes niveles) viede dada por la secuencia de las proteínas, la función más que a la propia estructura la deben a las diferentes conformaciones que pueden adoptar.
Tanto la difracción de rayos X, como las técnicas de microscopía electrónica son capaces de resolver las estructuras 3D de un amplio rango de biomoleculas. Combinandolas obtenemos "modelos híbridos" que se benefician de las mejores caracteristicas de estas técnicas que se complementan.
PeppeR es una aplicación de integración de datos, que permite ver los modelos híbridos almacenados en EMDB, junto con anotaciones de otras muchas bases de datos de genomica, proteomica, etc.
The cellular cytoskeleton is essential in proper cell function as well as in organism development. These polymers provide the elaborate roads along which most intracellular protein transport occurs. I will discuss several examples where mathematical modeling, analysis, and simulation tools help us study and understand the interactions between these filaments roads and motor proteins in cells. In neurons, neurofilaments navigate axons and their constrictions to maintain a healthy speed of neuronal communication. We develop stochastic models that may provide insights into transport mechanisms through axonal constrictions. In the reproductive system of the worm C. elegans, we use agent - based modeling to study how myosin motors interact with actin filaments to maintain contractile rings that allow passage and nutrient transport for developing egg cells. In addition, we have recently become interested in using topological data analysis tools to assess maintenance and establishment of these ring structures.
Dr. Patrick Bradshaw presents an overview of his program, Human Performance and Biosystems, at the AFOSR 2013 Spring Review. At this review, Program Officers from AFOSR Technical Divisions will present briefings that highlight basic research programs beneficial to the Air Force.
The Wonderful World of Scanning Electrochemical Microscopy (SECM)InsideScientific
To watch the webinar, go to:
https://insidescientific.com/webinar/the-wonderful-world-of-scanning-electrochemical-microscopy-secm/
In this webinar, Dr. Janine Mauzeroll discusses the fundamentals, critical experimental parameters and recent applications for scanning electrochemical Microscopy (SECM).
In its simplest form, SECM is a scanning probe technique in which a small-scale electrode is scanned across an immersed substrate while recording the current response. This response is dependent on both the surface topography and the electrochemical activity of the substrate. Consequently, using an array of operational modes, a wide variety of substrates and experimental systems can be characterized. The strength of SECM lies in its ability to quantify material flux from a surface with a high spatial and temporal resolution. It has been used in a variety of applications fields.
Dr. Janine Mauzeroll describes the fundamentals of SECM, including the required instrumentation and the principles of the most frequently used operational modes. Following this basic understanding of SECM principles, she then moves towards a comprehensive summary of the critical parameters for any SECM experiment. Specifically, she discusses in detail redox mediators, probes, and solvent systems that are used in SECM experiments. Finally, she presents recent applications of SECM with an emphasis on her work in the last five years related to material characterization, corrosion and batteries.
Nanotechnology refers to research and technology development at the atomic, molecular, and macromolecular scale, leading to the controlled manipulation and study of structures and devices with length scales in the 1- to 100-nanometers range.
1. 1
PROTEIN BASED NANO
MACHINES FOR SPACE
APPLICATIONS
Dr. Constantinos Mavroidis, Associate Professor
Department of Mechanical and Aerospace Engineering
Rutgers, The State University of New Jersey
NIAC Phase I Grant
2. 2
THE TEAM
Dr. C. Mavroidis
Associate Professor
Mechanical Engineering,
Rutgers University
Dr. M. Yarmush
Chair, Biomedical
Engineering, Rutgers
University
Dr. M. S. Tomassone
Assistant Professor,
Biochemical Engineering
Rutgers University
Dr. F. Papadimitrakopoulos
Associate Professor Department of
Chemistry University of Connecticut
Dr. B. Yurke
Researcher, Bell
Laboratories, Lucent
Technologies Inc.
Mr. Atul Dubey
Graduate Student
Rutgers University
Ms. Angela Thornton
Graduate Student Rutgers
University
Mr. Kevin Nikitczuk
Undergraduate Student Rutgers
University
3. OUR VISION
To Develop Protein Based NanoMachines and Robots
Novel
Biological
Multi-Degree of Freedom
Apply Forces
Manipulate Objects
Move From Nano to Macro
Lightweight / Efficient
Self-Assembling
Self-Reproducing
3
4. 4
APPLICATIONS
Outer Space and Planetary Missions
Colonization
Workstations
Manufacturing
Military
Medical
6. 6
0-10 YEARS: DEVELOPMENT
OF BIO NANO COMPONENTS
DNA VPL Motor Bacteriorhodopsin
DNA – Structural Member, Power Source
VPL – Protein Based Actuator
Bacteriorhodopsin, HSF – Nano Sensors
7. 7
MACRO-NANO EQUIVALENCE
Structural Elements
Metal, Plastic Polymer DNA, Nanotubes
Power Sources
Electric Motors,
Pneumatic Actuators,
Smart Materials, Batteries,
etc.
ATPase, VPL Motor, DNA
8. 8
MACRO-NANO EQUIVALENCE
Compliance Devices
Springs
Various Types of Gears,
Belts, Chains etc.
β-Sheets
VPL Platforms,
DNA Double
Crossover
Molecules
Transmission Elements
9. 9
MACRO-NANO EQUIVALENCE
Sensors
Light sensors, force sensors,
position sensors, temperature
sensors
Actuated Joints
Revolute, Prismatic,
Spherical Joints etc.
Rhodopsin,
Heat Shock
Factor
DNA
Nanodevices,
Nanojoints
10. 10
10-20 YRS: NANOROBOTIC
ASSEMBLIES
ATPase Motor Propelled
Structure – Nanotubes
Legs – Helical Proteins
Vision of a Nano Robot
12. Space Colonization
Non-living Robots
Bio Mimetic
Remote Sensing
Signal Transmission
12
30-50 YRS – DEPLOYMENT
FOR SPACE COLONIZATION
Courtesy: http://members.cox.net/kableguy/bryceworks/
13. 13
SPECIFIC AIMS FOR PHASE I
Identify Proteins for Use in Nanoscale Mechanisms
Develop Concepts for Bio NanoMachine components
Develop Dynamic Models and Realistic Simulations
Perform a Series of Biomolecular Experiments
Assembly and Interface NanoMachine Components
14. 14
VPL MOTOR CONCEPT
Viral Membrane Peptides
pH Dependent
15. 15
VPL ACTUATED PLATFORMS
Viral Protein Linear Motor Actuated Parallel
Platforms with Controllable Motion
16. VPL OUTPUT MULTIPLICATION
16
VPL Motors in Parallel –
Force Multiplication
VPL Motors in Series –
Displacement Multiplication
17. 17
BIOSENSOR SYSTEM
HSF Protein in Organisms
Responds to Stimuli – Trimerises
Binds to DNA
Color Change
Signal Transmission
18. 18
MULTI- DOF DEVICES
3 VPL Actuators
Nanotubes
DNA Joints
Response to pH Changes
19. COMPUTATIONAL STUDIES
Model Reversible Folding of VPL Motor Protein
Estimate Forces, Displacements etc. Through Energy
Software Usage - CHARMM
Input – Structure Files in .pdb Format
Output – Simulated Energy and Displacements
Microsecond Modeling – Assumptions, Targeted MD
Parallel Processing Facilities at CAIP (Teal)
Comparison with Experimental Observations
19
20. 20
EXPERIMENTAL WORK
Peptide Selection
Protein Expression
Protein Purification
Protein Conformation as a Function of pH
Calculate Force Expended upon Extension
Reversibility
Different Sequence - Different Designs
23. OUTREACH ACTIVITIES
High School Students in Research
Minority Students in Research
Undergraduate Students Employed
Technology Transfer
International and Industry Collaboration
Colloquiums, Symposia and Journal Clubs
Interdepartmental Course on Bio Nano Technology
23
24. 24
ACKNOWLEDGEMENTS
NASA Institute of Advanced Concepts (NIAC)
SROA Program and Rutgers University, NJ
NSF Nanomanufacturing Program