These are the slides I made for the Micro Systems and Nano technology course that I gave for Mikro centrum for some years, a little old but not outdated i think. Already the current converge of hardware technology, software technology and biology becomes visible.
2. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
2Jan Eite Bullema
3. Reference Books
Reader:
Introduction Micro- and Nano Technology, J.E. Bullema
Further reading:
An Introduction to Micro Electro Mechanical Systems Engineering,
Nadim Maluf, ISBN 0-89006-581-0, 2004
Comprehensive Microsystems, Yogesh B.Gianchandani , 2007
Fundamentals of Micro System Packaging, Rao Tummala, 2001
Micro and Nanomanufacturing, Mark Jackson, 2010
Micro Systems Technology, Wolfgang Menz, 2001
Nano-Bio- Electronic, Photonic and MEMS Packaging, C.P. Wong 2010
3Jan Eite Bullema
4. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
4Jan Eite Bullema
5. Definition of Micro Systems Technology
MEMS/ Micro Systems Technology is simultaneously a toolbox, a
physical product, and a methodology, all in one:
• It is a portfolio of techniques and processes to design and create
miniature systems.
• It is a physical product often specialized and unique to a final
application one can seldom buy a generic MEMS / MST product at
the neighborhood electronics store.
• “MEMS / MST is a way of making things,” reports the Microsystems
Technology Office of the United States DARPA. These “things”
merge the functions of sensing and actuation with computation and
communication to locally control physical parameters at the
microscale, yet cause effects at much grander scales.
5Jan Eite Bullema
6. Definition of Nanotechnology
The U.S. National Nanotechnology Initiative gives the following defining
features of nanotechnology:
1. Nanotechnology involves research and technology development at
the 1nm-to-100nm range.
2. Nanotechnology creates and uses structures that have novel
properties because of their small size.
3. Nanotechnology builds on the ability to control or manipulate at the
atomic scale.
6Jan Eite Bullema
7. The Micro and Nano meter domain
7Jan Eite Bullema
Hair Flake EggLouse
Diode
Solder-
line
Digital
Mirror
Transistor
IC line
(157 nm))
Pore
1 mm 0,1mm 0,01mm 1mu 0,1mu
Atom
(Co on Pt)
Back Finger Nail Bacteria DNA
PCB ICTelevision
Quantum
structure
Buckey
Ball
Semen
1m 0,1m 0,01mu 1nm 0,1nm0,01m
BIOLOGICAL Scale
TECHNOLOGICAL Scale
8. History Micro and Nano Technology: Feynman
The origin of the concept of micro and nano technology is the speech
‘There is plenty of room at the bottom’ given by Richard Feynman for
the American Society of Physics on December 29, 1959.
Feynman argued in his lecture that one would be able to do amazing
things by decreasing the size.
• Why cannot we write the entire 24 volumes of the Encyclopedia
Brittanica on the head of a pin?
• He also presented the "weird possibility" of "swallowing the doctor"
This concept involved building a tiny, swallowable surgical robot by
developing a set of one-quarter-scale manipulator hands slaved to
the operator's hands to build one-quarter scale machine tools
analogous to those found in any machine shop.
8Jan Eite Bullema
9. History Micro and Nano Technology: Taniguchi
"‘Nano-technology’ mainly consists of the processing of separation,
consolidation, and deformation of materials by one atom or one
molecule."
9Jan Eite Bullema
10. History Micro and Nano Technology: Drexler
Eric Drexler, a student of Feynman, wrote in 1986, Engines of Creation:
The Coming Era of Nanotechnology. Describing self-replicating nano-
assemblers building objects one atom at a time.
10Jan Eite Bullema
11. History MNT: Binning and Rohrer
Binnig and Rohrer at IBM Zurich invented the scanning tunneling
microscope (STM) the first instrument to generate real-space images of
surfaces with atomic resolution. This discovery opened up the
important new field of nanotechnology and was recognized by the 1986
Nobel Prize in Physics. Subsequently, the atomic force microscope
(AFM) was developed. STM and AFM enabled not only the imaging of
individual atoms, but also the manipulation of a single atom.
11Jan Eite Bullema
12. History Micro and Nano Technology: Smalley
Richard Smalley, is one of the scientists that is credited with
discovering buckyballs. Smalley and his co-workers, produced the
buckyballs in a device by vaporizing carbon with a laser and allowing
the carbon atoms to condense.
12Jan Eite Bullema
13. History Micro and Nano Technology: Geim
Andre Geim and Konstatin Novoselov discovered graphene.
Graphene is a 2D mono layer of carbon, with remarkable physical
properties. Extreme mechanical strength, optical transparent, hermetic,
excellent electrical conduction. Graphene is already produced in
industrial quantities for display applications. As graphene is electrical
conductive and transparent (98% per carbon layer)
13Jan Eite Bullema
17. MEMS and Sensors in Mobile Phones
(Source Yole August 2011
17Jan Eite Bullema
18. Market Expectations: Medical MNT Devices
The total market for Medical Devices is estimated as follows:
Drugs and drug delivery 80 B USD
Blood Analyis 22 B USD
Heart Pacemakers & other implants 16 B USD
Endoscopes and MIS tools 5 B USD
Hearing Aids 4 B USD
DNA & Lab on a Chip 1,2 B USD
Micro and Nano Technology based Products accounts for an estimated
7 B USD, components account for 326 M USD.
www.tft-ltd.co.uk
18Jan Eite Bullema
19. Market Expectations: Dutch MNT Companies
Company Product / Service
Aquamarijn Micro sieves
ASMI Various equipment
ASML Wafer stepper
Bronkhorst High Tech Flowsensors
C2V / Thermo fisher micro Gas chromatography
Cavendish Kinetics Non volatile memory
Cytocentrics Patch Clamping
Chemtrix Process intensification
EPCOS RF Switches
Fei Company Electron microscopy
Fluxxion Micro sieves
19Jan Eite Bullema
20. Market Expectations: Dutch MNT Companies
Company Product / Service
Friesland Foods Application of micro fluidics in foods
Holst Institute System in Package development
IMS Micro Assembly Equipment
Levitor ALD Equipment
Lionix Development of technologies
Mapper Lithographic Equipment
Medspray Aerosol dispensing
Medtronic Maastricht Medical equipment , pacemakers
Microflown Acoustic pressure measurement
Mikronit Lab-on-a-chip
Miplazza Open innovation research facility
20Jan Eite Bullema
21. Market Expectations: Dutch MNT Companies
Company Product / Service
Nanomi Functional Emulsions
NT MDT Scientific Equipment for Nanotechnology
NTS Ter Strake Equipment for Large Area Printing
NXP Oscillators, BAW filters
Oce Ink jet printing
Phoenix Software
Philips Electronics Various applications
Pie Medical Ultrasonic imaging
Sensata Pressure sensors
Sentron Solid State pH sensor
SolayTech ALD Equipment
21Jan Eite Bullema
22. Market Expectations: Dutch MNT Companies
Company Product / Service
Solmates Pulsed Laser Deposition
Tempress Production Equipment, ovens
TNO Development of technology
Wetsus Sustainable water technology
XiO Photonics Optical switching
Xensor Integration Hall sensors
MinacNed is a Dutch interest group that brings companies together in this
field. Regular meetings are organized for interested parties. A yearly
conference Micro Nano Conference is organized, mostly in November of a
year.
http://www.minacned.nl/home.html
22Jan Eite Bullema
23. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
23Jan Eite Bullema
24. MEMS: Materials and Material Properties
Silicon
Silicon Oxide and Nitride
Thin metal films
Polymers
Other materials and substrates
Silicon Carbide, Gallium Arsenide, Shape Memory Alloys
Important properties and physical effects
Piezoresistivity, Piezoelectricity, Thermoelectricity, Hall Effect
24Jan Eite Bullema
25. Silicon as a Mechanical Material
Kurt Petersen 1982
25Jan Eite Bullema
26. Mechanical Properties of Crystalline Silicon
Silicon is hard and brittle.
Yield strength of 7 G Pa
(equivalent to 700 kg on 1 square millimetre)
Young modulus is dependent on the crystal orientation.
Average 160 GPa (for a (100) wafer E110 = 169 GPa E100 = 130
GPa)
Mechanical properties are influenced by dopants
(e.g. introduction of internal stress)
26Jan Eite Bullema
28. Silicon is a Semiconductor
A semiconductor is a material with an electrical conductivity that is
intermediate between that of an insulator and a conductor.
A semiconductor behaves as an insulator at very low temperature, and
has an appreciable electrical conductivity at room temperature although
much lower conductivity than a conductor.
Bandgap
Diamont (C) 5,9 eV
Gallium Arsenide (GaAs) 1,42 eV
Silicon (Si) 1,14 eV
Germanium (Ge) 0,7 eV
Tin (Sn) 0,01 eV
Grafeen (C) 0 eV (halfmetal)
A bandgap below 3 eV is associated with a semiconductor
28Jan Eite Bullema
29. Impurity Doping
Impurity doping. Introducing into a semiconductor material impurities of
foreign atoms (dopants) in relative dilute concentrations
Relative dilute is 10 13 - 10 20 foreign atoms / cm3
The impurities alter the electrical properties of the semiconductor. At
room temperature the carrier concentration is nearly equal to the
dopant concentration.
If the dopant is n-type (Arsenic, Phosphorus) there is an excess of
electrons. For p-type there is an excess of holes (dopant Boron)
29Jan Eite Bullema
32. Availability of Silicon
Three forms of Silicon are relevant for MEMS
- Crystalline
- Poly Crystalline / poly silicon
- Amorphous
Crystalline silicon is available in circulair wafers
100 mm (4''), 150 mm (6''), 200 mm (8'') and 300 mm (12")
450 mm is expected in the near future
100 mm wafer has a thickness of 525 micron
150 mm wafer has a thickness of 650 micron
32Jan Eite Bullema
33. Miller Indices
Orientations in planes are often described in so-called Miller indices
[100] x,y,z vector orientation
<100> 6 directions +x,-x,+y,-y,+z,-y
(111) a plane on the [111] vector
{111} describes all 8 equivalent (111) planes
Planes and there orientations
33Jan Eite Bullema
34. Anisotropic Properties of Silicon
34Jan Eite Bullema
(a) face view (100); (b) edge view (110); (c) vertex view (111).
Three crystallographic planes and their Miller indexes
Four of the eight equivalent (111) planes in the {111} family.
36. Silicon Wafers
Material manufacturers cut thin circular
wafers from silicon boules along specific
crystal planes. The cut plane - the top
surface of the wafer - is known as the
orientation cut, and is encoded on the
wafer itself in the form of a primary and
a secondary flat located on the side of
the wafer.
Commercially available wafers are predominantly of {100} orientation,
which is the preferred orientation cut for CMOS technology. In addition
to the cut impurity doping (p or n) and electrical resistivity
(in Ohm m) are specified by the supplier
36Jan Eite Bullema
37. KOH Etch of Silicon
37Jan Eite Bullema
The etch rate of silicon
with KOH depends on:
- the concentration
of the KOH solution
- the temperature
- the Si crystal orientation
38. Poly Silicon
Usually deposited as layer or thin film (5 micron) on a surface.
It is used as:
- micromechanical structure (e.g in accelerometer of Analog Devices)
- electrical interconnect
- thermocouples
- p-n junction
Mature technology to create planar micro mechanical structures
38Jan Eite Bullema
39. Poly Silicon an Amorphous Silicon
The mechanical properties vary with deposition conditions, but in
general they are the same as for single-crystal silicon
Normally both suffer from intrinsic stress (hundreds of M Pa) which
requires annealing at elevated temperatures (> 900 °C)
Beams of poly silicon or amorphous silicon that have not been
subjected to a careful stress annealing step can curl up under the effect
of intrinsic stress
39Jan Eite Bullema
41. Interesting Properties of Silicon
Silicon conducts heat circa 100 times better than glass.
Silicon does not function as a Laser (as GaAs for instance does), but
can interact with light and function as a detector.
Silicon is transparent above wavelengths of 1,1 micron.
Silicon reflects light below circa 400 nm (Bleu) at 60 %
Above 500 degrees °C Silicon becomes soft,
plastic deformation sets in.
41Jan Eite Bullema
42. Interesting Properties of Silicon
Silicon is resistant to most chemicals (e.g freon or brake fluids)
Interaction with gasses, chemicals, biological fluids, and enzymes
remains subject of studies
In medicine and biology there are on-going studies to evaluate silicon
for chronic medical implants. Preliminary medical evidence indicates
that silicon is benign in the body and does not release toxic substances
42Jan Eite Bullema
45. Properties of Silicon Oxide
SiO2 Softens above 700 degrees Celsius.
Important that it is electrically insulating, unlike germanium oxide which
oxide is also soluble in water. Gallium Arsenide which oxide can not be
grown appreciably.
Various forms of SiO2 and SiOx, silicate glass are used in
micromachining due to their excellent electrical and thermal insulation
properties.
Also often used as sacrificial layer in surface micromachining
processes, because they can be preferentially etched with hydrofluoric
acid (HF) which is selective to Silicon
45Jan Eite Bullema
46. Etching of SiO2 in KOH
KOH etching of silicon dioxide is observable. The etch rates are
considerably slower (1-2 orders of magnitude) than that of silicon but
should be considered when deep etching is being done.
46Jan Eite Bullema
47. Silicon On Insulator (SOI)
SOI wafer, where the top single crystalline silicon layer (device layer)
on an oxide film(buried oxide) is fabricated on a silicon wafer (handle
wafer), is widely used in microsystems as well as in semiconductor
devices.
In microsystems, the most attractive feature is that the single crystalline
silicon can be used as structural materials. In surface micromachined
devices.
Relatively thick SOI wafers, whose device layer thickness is more than
a few microns, are widely used in accelerometers, vibrating
gyroscopes, and micromirrors.
47Jan Eite Bullema
48. Properties of Silicon Nitride
Si3N4, SiyNx is also widely used as an insulation thin film, it has also
excellent properties as a barrier against mobile ion diffusion. In
particular sodium and potassium ions as found in biological
environments
Its Young modulus is higher than that of silicon and can be controlled
by the specifics of the deposition process
Silicon nitride is an effective masking material in many alkaline etching
solution
48Jan Eite Bullema
49. Etching of Silicon Nitride in KOH
KOH etching of silicon nitride was not observed in the study.
Therefore, the silicon nitride etch rate is under 1 nanometer per hour if
it etches at all. If silicon nitride is being used as a mask for silicon
etching, potential etching of the silicon nitride need not be taken into
consideration.
J. Electrochem. Soc. Vol 137, 11, Nov 1990, 3612-3632.
49Jan Eite Bullema
50. Thin Metal Films
Metal .cm) Typical Areas of Application
Ag 1.58 Electrochemistry
Al 2.7 Electrical Inteconections
Optical reflection visible & infrared
Au 2.4 High Temp. Electrical Interconnect
Optical reflection infrared
Electrochemistry
Cr 12.9 Intermdiate Adhesion Layer
Cu 1.7 Low Resisitivity Interconnects
ITO 300 - 3000 Transparent Conductive Layer
W 5.5 High Temperature Interconnects
50Jan Eite Bullema
51. Thin Metal Films
Metal .cm) Typical Areas of Application
Pd 10.8 Electrochemistry
Solder Wetting layer
Permalloy - Magnetic Transducing
Pt 10,6 Electrochemistry
Electrodes for Bio-potential
SiCr 2000 Thin Laser Trimmed Resistor
SnO2 5000 Chemo-resistance Gas Sensors
TaN 300 - 500 Negative TCR
TiNi 80 Shape Memory Alloy
TiW 75 - 200 Intermediate Adhesion Layer
Near Zero TCR
51Jan Eite Bullema
52. Thin Metal Films
Metal .cm) Typical Areas of Application
Ir 5.1 Electrochemistry
Micro Electrodes Bio-potential
Ni 6.8 Magnetic Transducing
NiCr 200 - 500 Laser-trimmed resistor
52Jan Eite Bullema
53. Polymers (SU8)
In silicon micromaching polymers are often deposited in thin layers
from a few nanometers to hundreds of microns
Special photoresists (e.g. SU-8) can be brought up to 1000 micron
thick.
Hardening under UV light produces rigid structures.
Spin on organic polymers are general limited in their application
due to shrinkage due to solvent evaporation
53Jan Eite Bullema
54. SU8
SU-8 is a negative-tone photoresist chemically amplified resist
system with excellent sensitivity and high aspect ratios. The
primary applications are micro fabricated mechanical structures
(MEMS) and other microsystems.
Examples are sensors, microfluidic components, electronic coils, inkjet
print head nozzles, MR and GMR heads, multichip modules, actuators,
LCD spacers and moulds for plastic, stamps for hot embossing
and electroplating
54Jan Eite Bullema
55. PolyDiMethylSiloxane (PDMS)
Polydimethylsiloxane is one of the most widely used polymers in
MEMS, especially in microfluidic and bioMEMS. It belongs to a class of
polymers called silicones, which are synthetic polymers containing a
Si–O backbone.
Silicones are different from most other polymers in that the backbone
chain of atoms is silicon rather than carbon. Silicones are very
compliant and have been used as the deformable membrane in valves,
as well as being a common die-attach material in packaging.
55Jan Eite Bullema
56. Glass, Quartz
Glass and silicon fit together well.
Close match of CTE and suitable for anodic bonding
Quartz has as an extra advantage that it shows piezo electrical
behaviour
Machining can be done by:
- HF etching,
- ultrasonic machining or
- powder blasting
56Jan Eite Bullema
57. Silicon Carbide and Diamond
Both materials offer extraordinary hardness and resistance to harsh
environments. Micro machining of both materials is still in its infancy
Both materials demonstrate piezoresistive properties
Silicon carbide is sometimes used as a coating material for harsh
environments
Bandgap of SiC is 3,03 eV
57Jan Eite Bullema
58. III-V Semiconductors
Very well suitable for manufacture of lasers and other optical devices
Use in RF devices and high speed electronics. GaN is becoming more
important in LED applications and power electronic applications.
• GaAs
• InP
• AlGaAs
• GaN
• InGaN
58Jan Eite Bullema
59. Smart Memory Alloys
Invented in 1951 AuCd alloy
The material remembers its original form after being strained and
deformed. Alloys:
• TiNi
• Cu Al Ni
• FeNi
• Fe Pt
Practical limitation lies in the transition temperature.
59Jan Eite Bullema
60. Jan Eite Bullema 60
Shape Memory Alloys
A shape memory alloy (SMA) (also known as memory metal or smart
wire) is a metal that remembers its geometry. After it is deformed, it
regains its original geometry by itself during heating (one-way effect)
or, at higher ambient temperatures, simply during unloading
Jan Eite Bullema 60
61. Jan Eite Bullema 61
Important Physical Effects
Piezoresistivity
Piezo electricity
Thermoelectricity
Hall-Effect
Jan Eite Bullema 61
62. Jan Eite Bullema 62
Strain Gauge
A strain gauge is a device used
to measure deformation (strain)
of an object. The most common
type of strain gage consists of a
flexible backing which supports a
metallic foil pattern etched onto
the backing.
As the object is deformed, the
foil pattern is deformed, causing
its electrical resistance to
change. This resistance change,
usually measured using a
Wheatstone bridge circuit
Jan Eite Bullema 62
63. Jan Eite Bullema 63
Piezo electricity
Certain classes of crystals exhibit the peculiar property of producing
an electrical field when subjected to an external force
They are attractive to MEMS because they can be used as well as
sensors as well as actuators and they can be deposited as thin film
on silicon
Jan Eite Bullema 63
64. Jan Eite Bullema 64
Piezo electric coefficients
Jan Eite Bullema 64
66. Jan Eite Bullema 66
Thermo electricity
The Seebeck effect is the conversion of heat differences directly into
electricity.
The Peltier effect is the reverse of the Seebeck effect; a creation of a
heat difference from an electric voltage
Thomson effect, describes the heating or cooling of a current-carrying
conductor with a temperature gradient. Any current-carrying conductor,
with a temperature difference between two points, will either absorb or
emit heat, depending on the material.
Seebeck is most used, in thermocouples to measure temperature
differences
Jan Eite Bullema 66
67. Jan Eite Bullema 67
Seebeck coefficients relative to Pt
Jan Eite Bullema 67
68. Jan Eite Bullema 68
Hall Effect
(www.sensedu.com)
Jan Eite Bullema 68
69. Jan Eite Bullema 69
Some Sensing methods
Piezo resistive
Capacitive
Electromagnetic
Thermoelectric
Jan Eite Bullema 69
70. Jan Eite Bullema 70
Capacitive sensing
Capacitive sensing relies on an external physical
parameter changing spacing or dielectric constant
Advantage of capacitate measurement are
(1) that it requires little energy
(2) it is relative temperature insensitive
(3) it gives the possibility to closed loop feedback
Disadvantages are
(1) Capacitive sensing requires large electronics
Measurements can be done down to pF level
Jan Eite Bullema 70
71. Jan Eite Bullema 71
Piezo Electric actuation
Piezo Electric actuation can provide relative large forces
Thick Piezo electric films are used up to a few Newton's with a few
hundred Volts applied
Thin films ( < 5 micron) only a few milli Newton's
Jan Eite Bullema 71
72. Jan Eite Bullema 72
Actuators
A complete paradigm change is necessary when thinking of actuating at a
micro scale. A four stroke engine is not scalable
Electrostatic Actuation
Piezo Electric Actuation
Thermal Actuation
Magnetic Actuation
Shape Memory alloys
Jan Eite Bullema 72
73. Jan Eite Bullema 73
Thermal Actuation
Thermal actuation consumes more power than electrostatic or piezo electric
actuation. But it can provide, despite its gross inefficiencies, actuation to
hundreds of milli Newton's or higher
- Traditional bimetal
- Thermo pneumatic
- Suspended beam heating
Notice: First two methods are ambient temperature dependent
Jan Eite Bullema 73
74. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
74Jan Eite Bullema
75. Jan Eite Bullema 75
MEMS Processes
Basic Process Tools:
Epitaxy, Oxidation, Sputter deposition, Evaporation,
Chemical Vapor Deposition
Spin-on methods, Lithography, Etching
Advanced Process Tools:
Anodic bonding, silicon fusion bonding, grinding polishing and
Electrochemical polishing, Sol-gel deposition methods
Bosch Process: DRIE
Jan Eite Bullema 75
77. Jan Eite Bullema 77
Epitaxy
General method to grow a crystaline layer of silicon on a
silicon wafer, with use of dopants specific properties can be
given {AsH3, PH3 (n-type), B2H6 (p-type)}
- layer thickness 1- 20 micron
- same crystaline orientation as wafer
- much used in CMOS (efficient p-n junctions)
- Temperature (> 800 °C) with SiH4, SiH2Cl2, SiCl4
- grow speeds 0,2 - 1,5 micron per minute
Jan Eite Bullema 77
78. Jan Eite Bullema 78
Epitaxy: Silicon on Safire
So called hetero epitaxy, were two different materials are grown.
In this case Silicon on Safire (Al2O3)
Process is called SOS
Due to crystalline structure the layers of silicon on safire have to
stay thin (due to increasing defects the electrical properties of
silicon degrade)
SOS is used when optical or electrical properties require this
Jan Eite Bullema 78
79. Jan Eite Bullema 79
Oxidation
Silicon dioxide is obtained by oxidizing silicon with dry oxygen or
steam at 850 - 1100 °C
Very well known process. Oxidation introduces compression
stress in the material because SiO2 needs more volume than
Silicon
The compression stress can be several hundreds MPa
Stress in a layer can lead to warping and curling
Jan Eite Bullema 79
80. Jan Eite Bullema 80
Sputtering
In sputtering a target material is bombarded with inert ions (e.g. Argon
or Helium) Some material of the target is released and deposited on a
wafer
Three basic forms
- DC glow discharge
- Planar RF
- Cylindrical Magnetron or S-gun
Large range of materials: Al, Ti, Cr, Pt, Pa, Si, glass, Piezomaterial.
Jan Eite Bullema 80
81. Jan Eite Bullema 81
Sputtering
Schematic illustration of a sputtering apparatus.
In the sputtering process, positively charged
argon ions strike the target biased negatively
and remove target atoms. These sputtered
atoms condense on the substrate to form a thin
film.
Sputtering parameters such as substrate
temperature, sputter gas pressure, target-to-
substrate distance, and target power play an
important role in the structure and composition
of deposited films.
Jan Eite Bullema 81
82. Jan Eite Bullema 82
Sputtering
Depending on target size a good step covering can be obtained.
The film has a fine granular structure
Depending on the sputtering pressure the stress in the layer goes from
tensile (low pressures 0,1 - 1.0 Pa) to compressive (1 - 10 Pa) Good
pressure control is necessary for controlling stress
Advantage of sputtering is the relative low temperature (150 C)
Jan Eite Bullema 82
83. Jan Eite Bullema 83
Evaporation
Local heating of target material with subsequent condensation on a
substrate. Nearly any material is suitable: Al, Si, Ti, Mo, glass, Al2O3,
etc
Inclusive refractory materials: W, Au, Cr, Pd, Pt as long as the vapor
pressure is higher than the background pressure
Important is that the carrier (mostly W) does not evaporate
Stress in the layer can become very large (depending on the
temperature) in W up to 500 MPa
Jan Eite Bullema 83
85. Jan Eite Bullema 85
Chemical Vapour Deposition
Chemical Vapour Deposition is mostly a process at elevated
temperatures (> 300 °C)
Materials that can be deposited are:
- silicon,
- poly silicon
- amorf silicon
- SiO2
- Si3N4
- Cu and low r material
Jan Eite Bullema 85
87. Jan Eite Bullema 87
Chemical Vapour Deposition
There two important forms of CVD:
- Low pressure Chemical Vapour Deposition (LPCVD)
- Plasma Enhanced Chemical Vapour Deposition (PECVD)
LPCVD temperatures > 800 °C
PECVD temperatures ~ 300 °C
Many layer properties can be controlled with deposition parameters
(pressure, temperature, gas flow, dopants, power and plasma
excitation)
Jan Eite Bullema 87
88. Jan Eite Bullema 88
Example PE- CVD Equipment
The Plasma Enhanced Chemical Vapor
Deposition (PECVD) machine is used to
deposit thin dielectric films. It combines up
to four gases at pressures between
0.1 and 1 Torr and uses an RF source
of up to 200 Watts to ionize the resultant
gas mixture, causing film deposition on
a heated substrate.
Films deposited with the system include:
SiO2, SiOxNy, and Si3N4.
Jan Eite Bullema 88
89. Jan Eite Bullema 89
Polysilicon with CVD
Polysilicon deposition on a wafer can be done from tens of nm to
several microns thickness on a silicon wafer
Easy to apply by pyrolysis of Silane (SiH4) with LPCVD at 550 - 750
°C. PECVD is also possible.
Depending on process conditions amorphous or crystalline silicon is
obtained.
Good step covering
Stress can be reduced by annealing > 900 °C
Jan Eite Bullema 89
90. Jan Eite Bullema 90
Silicon dioxide with CVD
Silane and oxygen in a CVD reactor result in on SiO2 layer
Boron and or phosphorus can be build in to obtain specific properties.
E.g. Low Temperature Oxide (LTO) which can be used to obtain an
excellent step coverage of the SiO2 layer by heating to 1000 °C
Silicon oxide also can be obtained by pyrolysis of [Si(OC2H5)4]
TEOS (tetra ethoxy silane) in LPCVD at 650 - 700 °C
Jan Eite Bullema 90
91. Jan Eite Bullema 91
Silicon Nitride with CVD
Silicon nitride is good for passivation and an excellent barrier for water
and sodium ions. For MEMS it is an excellent mask for etching with
KOH
Stoichiometric Si3N4 is obtained by atmospheric CVD of SiH4 and NH3
or SiCl2H2 and NH3 at 700 - 900 °C
H2 is absorbed in the layer which lead too large tensile stresses
(e.g. 1000 MPa)
Jan Eite Bullema 91
92. Jan Eite Bullema 92
Spin on methods
With spin on methods layers of dielectric insulators and organic
materials can be applied
A table spins with typical 500 - 5000 rpm
Thicknesses are 0,5 - 20 micron
For SU-8 epoxy it can be 1 up to 1000 micron
Glasses also can be applied
Jan Eite Bullema 92
93. Jan Eite Bullema 93
Lithography
Lithography has three essential steps:
- application of photoresist with a photosensitive emulsion layer
- optical exposure to print an image of the mask into the resist
- immersion in an aqueous development solution to dissolve exposed
resist and render visible the latent image
Jan Eite Bullema 93
94. Jan Eite Bullema 94
Lithography
There are three main forms of lithography
- Contact
- Proximity
- Projection
Jan Eite Bullema 94
95. Jan Eite Bullema 95
Lithography
Resolution:
- contact 1 - 2 micron
- proximity 5 micron (Fresnel limitation)
- projection (better than 1 micron)
Depth of Focus is sometimes limiting for thicker structures
Jan Eite Bullema 95
97. Jan Eite Bullema 97
Example Lithography Equipment
The Canon Parallel Light Mask Aligner
is a machine used in the process of
lithography. The shown machine allows
for the use of 4-5 inch photomasks
and can handle 2-5 inch wafers.
Both the mask and wafer can be brought
into sharp focus, facilitating the proper
alignment of mask and wafer for
maximum exposure accuracy.
.The maximum print diameter is 5 inches, which is a relatively large exposure area.
As such, the number of devices per wafer and throughput is increased. This Canon
Aligner is also equipped with an auto feeder, allowing hands-off loading and
unloading of the wafer
Jan Eite Bullema 97
98. Jan Eite Bullema 98
Double Sided Lithography
Jan Eite Bullema 98
99. Jan Eite Bullema 99
Thick resist
With multiple spin on process a thick resist layer can be obtained.
Due to height differences (topological height variations) some
processes become very difficult.
Jan Eite Bullema 99
100. Jan Eite Bullema 100
Etching
Etching processes in MEMS are derived from traditional etch processes
for semiconductor processes.
‘Underpinning is in science, much remains an art’
The objective is to selectively remove material using imaged
photoresist as a masking template.
Jan Eite Bullema 100
106. Jan Eite Bullema 106
Deep Reactive Ion Etching (Bosch Process)
Jan Eite Bullema 106
107. Jan Eite Bullema 107
Deep Reactive Ion Etching (Bosch Process)
Jan Eite Bullema 107
108. Jan Eite Bullema 108
Deep Reactive Ion Etching (Bosch Process)
Jan Eite Bullema 108
109. 109
Isotropic wet Etching
Common wet etchant is HNA also known as poly etch
H = Hydrofluoric Acid (HF)
N = Nitric Acid (HNO3)
A = Acetic Acid (CH3COOH)
Nitric acid oxidizes silicon which is removed by HF
Etch depth and surface condition are mostly difficult to control (Etch
rate up to 20 micron)
Jan Eite Bullema 109
110. Jan Eite Bullema 110
Anisotropic wet etching
Anisotropic wet etchants include the hydroxides of alkali metals (KOH,
NaOH, CsOH, etc), simple and quaternary ammonium hydroxides
(NH4OH, (CH3)4NOH)
Potassium hydroxide is the most common
KOH etches the {111} planes 100 times faster than the {100} planes.
This feature is routinely used to make V shaped grooves that are
precisely delineated by the {111} crystallographic planes
Jan Eite Bullema 110
111. Jan Eite Bullema 111
Anodic bonding
Bonding of silicon and sodium containing glass (Pyrex 7740 and 7070
or Schott 8330 and 8329) It is fundamental to manufacture of a wide
variety of sensors, including pressure sensors, because it provides a
rigid support in the form of a glass substrate rather than the fragile
silicon
bonding at 200 - 500 °C in vacuum, air or inert
application of a voltage 500 - 1500 V across the two substrates
Jan Eite Bullema 111
113. Jan Eite Bullema 113
Silicon fusion bonding
Silicon fusion bonding, also known as direct wafer bonding is a process
capable of securely joining two silicon substrates
The bonding mechanism is not well understood but it is widely believed
that it occurs at a molecular level.
Formation of OH groups on the surface and cleanliness are important.
A temperature anneal at 800 - 1000 °C promotes and strengthen the
bond reaction
Jan Eite Bullema 113
116. Jan Eite Bullema 116
SU-8 Epoxy
SU-8 Epoxy Structures
Examples of SU-8 epoxy structures that are available as foundry
processes. Structure heights from 1 micron to 1 millimeter are possible
and side-wall angle can also be controlled for various geometries.
Jan Eite Bullema 116
118. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
118Jan Eite Bullema
119. Jan Eite Bullema 119
MEMS Products
Pressure Sensor
Accelerometer
Mass Flow Sensors
Digital Micro mirror Device
Angular Rate Sensors
Fluid Nozzles, inkjet print nozzles, micro filtration
Micro machined valves
Jan Eite Bullema 119
120. Jan Eite Bullema 120
Relative Merits different sensing principles
Jan Eite Bullema 120
126. Jan Eite Bullema 126
Pressure sensor
The machined silicon-structure is protected in an elektronics package
Jan Eite Bullema 126
127. Jan Eite Bullema 127
Nano Probe
Beams of the Silicon part
are 20 – 30 m thick, the
function of the nano probe
requires thin beams
For assembly thin beams
are challenging
Jan Eite Bullema 127
128. Jan Eite Bullema 128
Flow Sensor
Gas flow cools the upstream heater and heats the downstream heater.
Temperature-sensitive resistors are used to measure the temperature of each
heater and consequently infer the flow rate. The etched pit underneath the
heater provides exceptional thermal isolation to the silicon support frame.
Jan Eite Bullema 128
129. Jan Eite Bullema 129
Accelerometer
Acceleration
(1) Front and side airbag crash sensing (2) Electrically controlled car
suspension. (3) Safety belt pretensioning . (3) Vehicle and traction control
systems. (4) Inertial measurement, (5) object positioning, and navigation
(6) Human activity for pacemaker control
Vibration
(1) Engine management (2) Condition-based maintenance of engines
and machinery (3) Security device (4) Shock and impact monitoring
(5) Monitoring of seismic activity
Angles of inclination
(1) Inclinometers and tilt sensing (2) Vehicle stability and roll (3) Computer
peripherals (e.g., joystick,head mounted displays … ) (4) Handwriting recognition
(e.g., SmartQuill from British Telecom) (5) Bridges, ramps, and construction
Jan Eite Bullema 129
130. Jan Eite Bullema 130
Acclerometer: Principle
Jan Eite Bullema 130
131. Jan Eite Bullema 131
Differences in G measurements
Airbag 50 G Bandwidth 1 k Hz
Motor sensor: 1 G resolution 100 micro G Bandwidth > 10 kHz
Hart sensor: 2 G Bandwidth 50 Hz
ultra low power consumption
Military sensor: 1000 G
Drop test: 10 000 G
Jan Eite Bullema 131
132. Jan Eite Bullema 132
Accelerometer
Illustration of a piezoresistive accelerometer from Endevco Corporation fabricated
using anisotropic etching in {110} wafers. The middle core contains the inertial
mass suspended from a hinge. Two piezoresistive sense elements measure the
deflection of the mass. The axis of sensitivity is in the plane of the middle core.
Jan Eite Bullema 132
133. Jan Eite Bullema 133
Bulk micro machined PZR sensor
Proof mass typical 100 micro grams
PZR (Boron doped Silicon) 0,6 micro thick 3,4 micron broad
Signal in Wheatstone bridge typical 1 G / 25 mV over 10 V
Measurement until 6000 G
Shock proof 10000 G
Bandwidth 28 k Hz
Jan Eite Bullema 133
134. Jan Eite Bullema 134
Accelerometer
Capacitive bulk-micromachined accelerometer. The inertial mass in the middle
wafer forms the movable electrode of a variable differential capacitive circuit.
Adapted from the accelerometer product catalog
Jan Eite Bullema 134
135. Jan Eite Bullema 135
Accelerometer
Process steps to fabricate the middle wafer containing the hinge and the
inertial mass of a capacitive bulk-micromachined accelerometer
Jan Eite Bullema 135
136. Jan Eite Bullema 136
Bulk Micro Machined Capacitive Sensor
Proof mass typical 100 micro grams
Capicitance translated to + - 2,5 V
Measurement 1.5 to 50 G
Shock proof 20000 G
Bandwidth 400 Hz
Jan Eite Bullema 136
137. Jan Eite Bullema 137
Accelerometer
Basic structure of the ADXL family of surface- micromachined accelerometers.
A comb-like structure suspended from springs forms the inertial mass.
Displacements of the mass are measured capacitively with respect to two
sets of stationary finger-like electrodes.
Jan Eite Bullema 137
138. Jan Eite Bullema 138
Surface Micro Machined Capacitive Sensor
Proof mass typical 0.3 to 1 micro grams
Total capacitance 100 f F (f = femto = 10-15)
Measurement 100 aF (a = atto = 10-18)
100 aF equals circa 625 electrons
no parasitic currents are allowed all signal processing on the sensor
Measurement typical airbag 1 - 50 G
Price current below 3 USD per product (Bosch and Analog Devices)
Jan Eite Bullema 138
139. Jan Eite Bullema 139
Accelerometer
Photograph of a deep-reactive-ion-etched (DRIE) accelerometer using
60-mm-thick comb structures.
Jan Eite Bullema 139
140. Jan Eite Bullema 140
DRIE Capacitive Sensor
Proof mass typical 43 micro grams
Total capicitance 3 pF (p = pico = 10-12)
Thermal Noise: 10 G / Hz
Compared to surface micro machined sensor
Thermal Noise: 500 G / Hz
Jan Eite Bullema 140
141. Jan Eite Bullema 141
Accelerometers
Commercial accelerometers only cost a few Euros
Jan Eite Bullema 141
142. Jan Eite Bullema 142
Angular-rate sensor
A conventional mechanical gyroscope and the three rotational degrees of
freedom it can measure.
Jan Eite Bullema 142
143. Jan Eite Bullema 143
Angular-rate sensor
The Coriolis acceleration on an object moving with a velocity vector v on the
surface of Earth from either pole towards the equator. The Coriolis acceleration
deflects the object in a counterclockwise manner in the northern hemisphere
and a clockwise direction in the southern hemisphere. The vector represents
the rotation of the planet.
Jan Eite Bullema 143
144. Jan Eite Bullema 144
Angular-rate sensor
Tuning fork structure for angular-rate sensing. The Coriolis effect transfers
energy from a primary, flexural mode to a secondary, torsional mode.
Jan Eite Bullema 144
145. Jan Eite Bullema 145
Angular-rate sensor
The corresponding standing wave pattern
Jan Eite Bullema 145
146. Jan Eite Bullema 146
Angular-rate sensor
Angular-rate sensor. The basic structure consists of a ring shell suspended
from an anchor by support flexures. A total of 32 electrodes (only a few are
shown) distributed around the entire perimeter of the ring excite a primary mode
of resonance using electrostatic actuation. A second set of distributed
electrodes capacitively sense the vibration modes. The angular shift of the
standing wave pattern is a measure of the angular velocity.
Jan Eite Bullema 146
147. Jan Eite Bullema 147
Angular-rate sensor
VSG angular-rate sensor from British Aerospace Systems and Equipment, and
corresponding fabrication process. The device uses a vibratory ring shell design,
similar to the Delco sensor. Eight current loops in a magnetic field, B, provide the
excitation and sense functions. For simplicity, only one of the current loops is
shown.
Jan Eite Bullema 147
148. Jan Eite Bullema 148
Angular-rate sensor
Angular-rate sensor from Daimler Benz. The structure is a strict implementation
of a tuning fork in silicon. A piezoelectric actuator excites the fork into resonance.
The Coriolis force results in torsional shear stress in the stem which is measured
by a piezoresistive sense element.
Jan Eite Bullema 148
149. Jan Eite Bullema 149
Angular-rate sensor
The main fabrication steps for the Daimler Benz micromachined angular-rate
sensor.
Jan Eite Bullema 149
150. Jan Eite Bullema 153
Carbon monoxide sensor
Carbon monoxide sensor, its equivalent circuit model, and the final packaged
part. The surface resistance of tin-oxide changes in response to carbon
monoxide. A polysilicon heater maintains the sensor at a temperature between
100 and 450º C in order to reduce the adverse effects of humidity.
Jan Eite Bullema 153
151. Jan Eite Bullema 154
DMD™
Single DMD™ pixel in its resting and actuated states. The basic structure
consists of a bottom aluminum layer containing electrodes, a middle aluminum
layer containing a yoke suspended by two torsional hinges, and a top reflective
aluminum mirror. An applied electrostatic voltage on a bias-electrode deflects
the yoke and the mirror towards that electrode. A pixel is 17 m on a side.
Jan Eite Bullema 154
152. Jan Eite Bullema 155
DMD™
Optical beam-steering using the switching of micromirrors. Off-axis illumination
reflects into the pupil of the projection lens only when the micromirror is tilted in
its +10º-state, giving the pixel a bright appearance. In the other two states, the
pixel appears dark
Jan Eite Bullema 155
156. Jan Eite Bullema 159
Grating Light Valve
Operating principle of a single pixel in the grating light valve. Electrostatic pull-
down of alternate ribbons changes the optical properties of the surface from
reflective to diffractive.
Jan Eite Bullema 159
157. Jan Eite Bullema 160
Passive structures
Nozzles are the most simple passive structure
Patents for IBM In the 1970s for silicon nozzles for ink jet application
Patents for Ford in the 1980s for motor fuel injection applications
Nowadays these patents are expired. Many new research in the field of
medical inhalers, atomizers, fluid spray systems
Jan Eite Bullema 160
166. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
173Jan Eite Bullema
169. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
176Jan Eite Bullema
170. Medical Applications of Micro and Nano
Technology
Jan Eite Bullema
‘It would be interesting in surgery
if you could swallow the surgeon’
Richard P. Feynman
177
171. Jan Eite Bullema 178
Pacemaker
The pacemaker is one of the oldest examples of a MST product
Jan Eite Bullema 178
172. Jan Eite Bullema 179
Pacemaker Historic Developments (1950)
Jan Eite Bullema 179
173. Jan Eite Bullema 180
Pacemaker Historic Developments (2000s)
Jan Eite Bullema 180
174. Jan Eite Bullema 181
Pacemaker ( Integration of Functions)
Integration of Functions
In the pacemaker by:
- MEMS Accelerometer
- Digital control
- Remote diagnostics
- use of MEMS switches
Jan Eite Bullema 181
175. jan_eite.bullema@tno.nl
Medical Applications of Micro and
Nano Technology
Pacemaker Decreasing Dimensions
MEDTRONIC, is using micro electronics
and chip manufacturing to shrink pacemakers
– implanted devices that regulate the hearts
rhythm. Whereas current pacemakers are
the size of a silver dollar. Medtronics new
device would be smaller than a tic-tac.
At that size the pacemaker could be inserted
through a catheter rather than invasive surgery
http://www.technologyreview.com/biomedicine/32436
176. Jan Eite Bullema 183
Implantable wireless pressure sensor
CardioMEMs’ device measures blood pressure in people who have an
abdominal aortic aneurysm. Doctors can treat the bulging artery with a
stent graft, stents can fail, aneurysm patients require lifetime monitoring
Jan Eite Bullema 183
179. Jan Eite Bullema 186
Hearing Aid
Trend is that products become
smaller
and
smarter
This is enabled by developments
In micro electronics and in micro
systems technology
Jan Eite Bullema 186
180. Jan Eite Bullema 187
Type Typical cost
Euro per unit
Behind the ear 200 - 300
In the ear 500 - 700
In the canal 700 - 1000
Completely
in the canal 1400 - 2000
Cochlear Implants 35000 - 50000
Hearing Aids & Cochlear implants
Jan Eite Bullema 187
181. Jan Eite Bullema 188
Hearing Aids
Source: Phonak
Jan Eite Bullema 188
182. Jan Eite Bullema 189
Cochlear Implants
1985 1991 1997 1999 2000 2004
Jan Eite Bullema 189
183. jan_eite.bullema@tno.nl
Medical Applications of Micro and
Nano Technology
Flexible Solar Retinal Implants
Age related Macular
Degeneration (AMD)
Affects about 1,5 Million
people per year in the US
and is the most prevalent
cause for blindness in the US
187. jan_eite.bullema@tno.nl
Medical Applications of Micro and
Nano Technology
Eye pressure measurement
in glaucoma patients
In the eye pressure sensor
- a pressure sensor
- a low-power microprocessor
- a solar cell
- a wireless radio
- memory
- and a thin film battery.
http://techknowbits.com
188. Jan Eite Bullema 195
Endoscope
Source: PENTAX FG-32UA
Jan Eite Bullema 195
189. Jan Eite Bullema 196
Smart pill
This smart-pill (M2A capsule) contains
a number of the functions that a
microsystem can have:
- The pill can observe with a camera
- The pill has a processor to process
signals to information
-The pill has coil to transmit information
- The pill has a battery for energy
supply purposes
Jan Eite Bullema 196
190. Jan Eite Bullema 197
Properties of the smart pill
The capsule is 11mm x 26mm (<4 grams)
Field of view is 140 degrees.
Detection of objects at a minimum size
less than 0.1 mm
In a normal (8 hr) procedure the
generates approximately 57,000 images,
at a rate of two frames / second.
Jan Eite Bullema 197
191. Jan Eite Bullema 198
Capsule Endoscopy Image
Eosinophilic Enteritis
visualizing folds
of the cecum
Cecum Nematodes
Pinworm in
healthy volunteer
Note thickened...
Kaposi’s Sarcoma
cutaneous Kaposi’s
Normal ColonHemorrhagic
60 year old woman Normal vessels
Jan Eite Bullema 198
192. Jan Eite Bullema 199
Billicheck improves comfort
Not a heel puncture but an optical measurement
The analysis is done with a plastic grating
The grating is made with LIGA technology
Jan Eite Bullema 199
193. Jan Eite Bullema 200
Optical Diagnosis with MST components
Source: Micro Parts
Color Check of Teeth Bili Check for Jaundice
Jan Eite Bullema 200
194. Jan Eite Bullema 201
Drug Delivery Pill: iPill by Philips
Philips has developed
a drug delivery pill
(2.6 x 1.1 Ø cm)
30% is drug container
It measures pH and
temperature and can
deliver drugs on site
IMAPS iPill for controlled drug delivery – Frits Dijksman, November 20-th 3-rd, 2008
195. Jan Eite Bullema
Drug Delivery Pill: iPill by Philips
Length small intestines 4-6 m
Drift velocity (due to peristalsis) in small
intestines 1 m/h
Residence time in small intestines 4-5
hrs
Length large intestines 1-1.5 m
Throughput time1-5 days
202
197. Jan Eite Bullema
Drug Delivery Pill: iPill by Philips
• Crohn’s Disease and Ulcerative
Colitis
• Chronic autoimmune disease of
• unknown etiology
• Prevalence: ~1.4M in U.S., similar in
Europe
• High patient burden and cost to
society
• Significant unmet needs in diagnosis,
treatments, and disease management
204
198. Jan Eite Bullema
Drug Delivery Pill: iPill by Philips
• Dimensions length 26 mm, diameter 11 mm
• Weight 3.2 gr (specific mass 1450 kg/m3)
• Medication content 300 micro liter
• Minimum dispensed volume 1 micro liter
• Once per 20 seconds the status on temperature, pH, medication
content, battery will be transmitted to the outside of the body
• Reach RF link 0.3 m in the body
205
199. Jan Eite Bullema
Drug Delivery Pill
Diagnostic Therapeutic
Non-invasive Non Invasive
Miniaturized Miniaturized
Patient Comfort Intelligent Device
Ease of Use Individual Therapy
High Data Content Disease Management
Faster Health Monitoring
Cheaper Compliance Monitoring
206
201. Jan Eite Bullema208
Insulin Dispenser
Debiotech’s Insulin Nanopump
Each pump actuation injects only 200
nanoliters of drug,and reproducibility is
better than 2%, bringing it very close
to physiological delivery of insulin.
202. Jan Eite
Bullema209
Aerosol dispenser
By the micro holes an aerosol can be dispensed with
droplets of a very well defined droplet diameter
(droplets of circa 1 micron diameter)
204. Jan Eite Bullema 211
Catheters for key-hole surgery
A surgical doctor inspects a pressure sensor before he
Starts measuring the pressure in the heart of the patient
Jan Eite Bullema 211
205. Jan Eite Bullema 212
Catheters for brain measurements
Length: 340 mm
Diameter: 0,6 mm
Electrodes: 31 + 1
Array length: ca. 6 mm
Jan Eite Bullema 212
206. Jan Eite Bullema 213
Neuroprobes for brain probing
2mm shank length: 112 electrodes
8 mm shank length: 512 electrodes
Jan Eite Bullema 213
207. Jan Eite Bullema 214
Full 3D array for brain probing
Jan Eite Bullema 214
208. Jan Eite Bullema 215
Microfluidics: Market
World Market Microfluidics (MST News Feb 2008)
2004 2009 (prognosis)
Volume 630 M USD 1500 M USD
Microfluidic Chips 65% 67%
Pressure Sensors 23% 13%
Drug Delivery 1% 13%
IR Sensors 5% 3%
Micro Spectrometers 3% 2%
Other 2% 3%
Jan Eite Bullema 215
209. Jan Eite Bullema 216
Lab-on-a-chip (micro array)
By capillary action the sample is pulled to the reactive spots
Small sample volume + large number of analysis simultaneously
Jan Eite Bullema 216
210. Jan Eite Bullema 217
Microfluidics: Overview
One important manner in which microfluidics differs from micro
electronics. Is that the fundamental physics changes more rapidly as
the size scale is decreased
Micro fluidics quickly reach length scales were fundamental fluid
physics change dramatically.
E.g.
Reynolds (Re) = inertial / viscous = . U0 .L0 /
Péclet (Pe) = convection / diffusion = U0 . L0 / D
Capillary (Ca) = viscous / interfacial = . U0 /
Jan Eite Bullema 217
211. Jan Eite Bullema 218
Micro fluidics: Reynolds (viscous / interfacial)
Reynolds (Re) = inertial / viscous = . U0 .L0 /
Flow in micro channels has typically Re 10 -6 to 10
{ water (1 mPa.s, diameter (L0) 1 – 100 mm, flow (U0) 1m/s to 1cm/s }
Flow in micro channels is always laminair as
viscous forces >> inertial forces
Spermatozoa ~ 1×10 −2
Blood flow in brain ~ 1×102
Blood flow in aorta ~ 1×103
Onset of turbulent flow ~ 2.3×103
Person swimming ~ 4×106
Aircraft ~ 1×107
Blue whale ~ 3×108
A large ship (RMS Queen Elizabeth 2) ~ 5×109
Jan Eite Bullema 218
212. Jan Eite Bullema 219
Microchannels in Plastics
Micro channels are used more and more in ‘Lab on a Chip’ products
The example is a capillary with a width of 100 micron
Jan Eite Bullema 219
213. Jan Eite Bullema 220
Lab-on-a-Disk
The Gyros device uses a passive valve principle. Some parts of the
micro-channels have hydrophobic properties. These will act as a closed
valve, fluid can not pass due to the hydrophobic surface. As the device
is rotated, centrifugal forces will overcome the hydrophobic forces and
pass the hydrophobic valve region.
Gyros: Lab-on-a-Disk
Jan Eite Bullema 220
215. Jan Eite Bullema 222
Smart Diagnostics for Healthcare
Sample
Biopsy
Filtering /
Concentrating
Lysis /
Extract DNA
Seperating
DNA / Rest
PCR
Washing /
Filtering
DNA
detection
Sample preparation and analysis on a 1’ x 3’ (25 x 75 mm) lab-on-a-chip
Washing
1 2 3 4
4 65 7
Jan Eite Bullema 222
216. Jan Eite Bullema 223
Genome Size
FERN 160,000,000,000
LUNGFISH 139,000,000,000
SALAMANDER 81,300,000,000
NEWT 20,600,000,000
ONION 18,000,000,000
GORILLA 3,523,200,000
MOUSE 3,454,200,000
HUMAN 3,400,000,000 31,000
Drosophila 137,000,000 13,500
C. Elegans 96,000,000 19,000
Yeast 12,000,000 6,315
E. Coli 5,000,000 5,361
smallest Genome ??????
genes
Jan Eite Bullema 223
217. Jan Eite Bullema 224
Cells
Humans
60 trillion (1012) cells
320 cell types
Jan Eite Bullema 224
218. Jan Eite Bullema 225
Jan Eite Bullema 225
The original Watson and Crick’s paper
219. Jan Eite Bullema 226
The central dogma of molecular biology
DNA RNA proteintranscription translation
Jan Eite Bullema 226
220. Jan Eite Bullema 227
PCR = Polymerase Chain Reaction
Jan Eite Bullema 227
225. Jan Eite Bullema 232
Capillary Electrophoresis
Jan Eite Bullema 232
226. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
233Jan Eite Bullema
227. Jan Eite Bullema 234
Packaging of MEMS
Packaging of MEMS converts a machined structure into a useful
assembly that can safely and reliable interact with its environment
Definition of MEMS packaging is broad because each application is
unique in its packaging requirements
Function =
Protect the micro machined structure to a broadening range of
environments. It must also provide interconnections toelectrical signals,
electrical interconnect, access to environment and interaction with
environment
Jan Eite Bullema 234
228. Jan Eite Bullema 235
Packaging Hierarchy
(level of packaging)
Jan Eite Bullema 235
229. Jan Eite Bullema 236
Package Functions
- Power distribution
- Signal distribution
- Heat dissipation
- Protection
- Manufacturability /
Processing of
Components
Jan Eite Bullema 236
230. Jan Eite Bullema 237
Typical MEMS packaging process flow
Jan Eite Bullema 237
231. Jan Eite Bullema 238
Saw and Dice wafer
In a FAB thousands of micro structures are made simultaneously.
Dicing separates the structures into individual components
Most common is a diamond saw with 75 - 250 micron thick
blades, The wafer is held by a blue colored sticky tape and
the wafer is cooled continuously
Potential damaging of the structure during the process
Sometimes the last sacrificial etching is done after dicing
Jan Eite Bullema 238
232. Jan Eite Bullema 239
Process Flow Wire Bonding
Jan Eite Bullema 239
233. Jan Eite Bullema 240
Characteristics Flip Chip Bonding
Flip Chip implies bonding the die face down. Electrical contacts are
made by means of plated bumps between bond pads on the die and
metal pads on the package substrate. The attachment is intimate with
small spaces (50 - 200 micron) between the die and the package. The
pads can be all over the surface of the die (area arrays) resulting in an
increase in density of (I/Os)
Inductance of a solder bump
is less than 0.05 nH compared
to 1 nH for a 125 micron long
and 25 micro thick wire bond
Jan Eite Bullema 240
234. Jan Eite Bullema 242
Thermal Condsiderations
More complex chips make more demands on efficient heat removal
from the chips.
Silicon chips limited to approximately 100ºC for normal operation
which limits power densities on chip to a maximum of 10watts/cm2
in current IC packages.
Imposes a limit average on power dissipation per individual circuit
on chip of approximately 1µW/circuit for a 10 million transistor chip
of area 1cm × 1 cm.
Jan Eite Bullema 242
235. Jan Eite Bullema 243
Thermomechanical Considerations
Important to reduce power dissipation/circuit and improve package
thermal design in order to produce larger, more complex ICs in the
future.
Differential thermal expansion of package parts gives rise to
mechanical stresses and reliability risks.
E.g. Coffin Manson behaviour
# cycles before failure = Function ( thickness / T * CTE)
Jan Eite Bullema 243
236. Jan Eite Bullema 244
Package Sealing and Encapsulation
Intended to protect the chip and package metallisation from corroding
environments and from mechanical damage due to handling.
Moisture is one of the major sources of corrosion.
Plastic materials, such as silicones and epoxies, developed with low water
diffusion properties are used extensively for IC encapsulation.
For high reliability devices hermetic sealing used based on welding or brazing
of ceramic/metal packages. More expensive and time-consuming than plastic
encapsulation
Jan Eite Bullema 244
237. Jan Eite Bullema 245
Protective coating and media isolation
Coatings are often used in flow sensors and pressure sensors.
- in cars salt water sprays, acid rain polutants can attack the sensor
- home applyances oftengive alkaline environments
An often used coating is parylene ( p-xylylene) which can
be deposited at room temperature and gives a conformal
coating resistant to: exhaust gasses, fuel, salt spray,
water, alcohol, organic solvents.
Strong acids and bases dissolve parylene
Jan Eite Bullema 245
238. 246Jan Eite Bullema
Thermal Shock
Thermal
Humidity
Corrosive
Dust
Vibration
Power Cycling
Voltage Margining
Frequency Margining
Relative Causes for Failure in Electronics
239. Jan Eite Bullema 247
Characteristics of Ceramic Packaging
Ceramics are hard and brittle materials made by shaping a nonmetalic
mineral, then firing at high temperatures for densification. Most
ceramics are electrical insulators and good thermal conductors
Jan Eite Bullema 247
240. Jan Eite Bullema 248
Process Flow Ceramic Package
Jan Eite Bullema 248
241. Jan Eite Bullema 249
Ceramic Packaging of DMD
The DMD package is a ceramic package.
A DMD sells for several hundred dollars.
An accelerometer packaged in ceramic would cost 35 USD, a plastic
packaged accelerometer only 2-4USD
Jan Eite Bullema 249
244. Jan Eite Bullema 252
Metal Package
Metal packages are attractive for MEMS because they can be
prototyped in small series and are hermetic. Disadvantage is the
high costs relative to plastic
Jan Eite Bullema 252
248. Jan Eite Bullema 256
Molded plastic packaging
Post molded: plastic is molded after the die is attached to a lead
frame (process subject die and interconnect to harsh molding
conditions)
A major disadvantage of plastic
packages is hat they are not
hermetic
Yet in traditional electronics plastic
packages are prefered:
low cost few pennies per pin
high reliability: one failure
per billion hours operating time
Jan Eite Bullema 256
249. Jan Eite Bulema 257
Plastic Cap for MEMS
Feasibility of polymers for wafer scale packaging of RF MEMS
P.J. Bolt, J.E. Bullema, R. Korbee, 4M, Cardiff 2008
Jan Eite Bullema 257
250. Jan Eite Bullema 258
3D - Packaging
3D Technology according to Suss
Jan Eite Bullema 258
251. Jan Eite Bullema 259
3D - Packaging
(e.g. MEMS Scale Package)
J.E. Bullema, M.H.M. Meuwissen, E.P. Veninga, " Design Study for Stacked MEMS",
Proceedings Eurosime 2003, Key note Paper, 30 March - 2 April 2003, p279..283,
Jan Eite Bullema 259
252. Jan Eite Bullema 260
3D - Packaging
Typical System in Package in 2010 [Wolf,2007]
Jan Eite Bullema 260
258. Build Up of the Micro- and
Nanotechnology course
Introduction
History, markets, expectations
Materials for micro and nano
Processes and technologies
Micro and nano products
Converging technologies: MNBT
Medical applications
Packaging
Wrap-up / multiple choice test
266Jan Eite Bullema
259. Jan Eite Bullema 267
Wrap - Up
Some Collective Multiple Choise
A typical proof mass of an accelerometer is in the range of:
A 10 micro gram to 100 micro gram
B 100 micro gram to 1 milligram
C 1 micro gram to 100 micro gram
D 0,1 micro gram to 100 micro gram
Jan Eite Bullema 267