The document summarizes the origins and cultures of indigenous peoples in the Americas, including the Maya, Aztec, and Inca civilizations. It describes how Native Americans migrated to the Americas over a land bridge connecting Asia to Alaska around 13,000 years ago. It provides details about the complex societies and achievements of these civilizations, such as their advanced agricultural practices, construction of major cities and temples, and calendars. It also outlines their religious practices and how European diseases and conquest by the Spanish led to the collapse of the Aztec and Inca Empires in the 16th century.
Ancient China was one of the oldest and longest lasting civilizations in the history of the world. The history of Ancient China can be traced back over 4,000 years. Located on the eastern part of the continent of Asia, today China is the most populous country in the world.
A brief history of the Chinese Dynasties. It was done on a short notice. I hope you enjoy and please feel free to correct any mistakes I made or comment. if you wish.
This presentation talk about the Mayan Civilization.
The Mayan civilization was developed in the region of Mesoamerica, including the southwest of Mexico, Guatemala and Belize, and the west of El Salvador and Honduras.
Ancient China was one of the oldest and longest lasting civilizations in the history of the world. The history of Ancient China can be traced back over 4,000 years. Located on the eastern part of the continent of Asia, today China is the most populous country in the world.
A brief history of the Chinese Dynasties. It was done on a short notice. I hope you enjoy and please feel free to correct any mistakes I made or comment. if you wish.
This presentation talk about the Mayan Civilization.
The Mayan civilization was developed in the region of Mesoamerica, including the southwest of Mexico, Guatemala and Belize, and the west of El Salvador and Honduras.
erican cultures. Between A.D. 1345 and 1521, the Aztecs forged an empire over much of the central Mexican highlands. ... The Nahuatl speaking peoples began as poor hunter-gatherers in northern Mexico, in a place known to them as Aztlan.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
1. The First Americans
• How did they get here?
• Land Bridge connected Asia to
Alaska
• Migrated down through Canada,
North America, Mexico, Central
America, and South America
3. The First Americans
• Native Americans learned to grow corn
(maize) and other crops.
• Several complex civilizations emerged in
Mesoamerican (present-day Mexico and
Central America).
• Historians refer to these civilizations as
Pre-Columbian because they existed
before the arrival of Columbus.
• Native Americans did not emerge in river
5. The Maya
• The Maya focused on
• War
• Human Sacrifice
• Chichen Itza- important city
• Around the 9th Century, the Maya
disappeared into the jungle and no
one knows why
7. Maya Achievements
• Builders
• huge cities in the jungles
• pyramids
• temples
• Writing System
• Math and Science
• complex numbering system, use of zero.
• calendar with 365 days
• Artistry
• colorful murals
8. The Inca Empire ( 1200-1535)
Lived in the Andes Mountains in
present day Peru
Farming
terraced mountains
grew potatoes
kept llamas for their meat, wool and to
carry goods
9. The Inca Empire
• Built stone roads over 10,000 miles.
• No writing system
– used quipu—bundles of knotted and colored ropes
to count, keep records, and send messages.
10. The Inca Empire
• Machu Picchu
• Built stone buildings with no cement, but
fit stones together perfectly.
15. Aztec civilization
• Locatedin aridvalley in centralMexico
• RepresentedbyTenochtitlan
• Ruledbyanemperor
• Economybasedon agricultureandtributefrom
conqueredpeoples
• Polytheisticreligion with pyramids/rituals
TheAztec began c. 12th centuryA.D.
Began a long migration that brought them into the Valley of Mexico.
Theyestablished their capital city at Tenochtitlán.
Tenochtitlán
An Aztec legend said that when the people found their newhome they would seean
eagle perched ona cactus holding a snake. They saw this in lake Texcoco.
Their city was built up on rafts made from reeds and coveredwith dirt. They werecalled
chinampas. Present-Day Mexico-City is built on top of this city. Theoriginal was
destroyed by the Spanish.
Lake Texcoco-Swampy lake that was the home of the capital city. Tenochtitlán means
the Place of the Prickly PearCactus.
17. Political and Social Structure
By 1500 there wereabout 4 million people in the Aztec Empire.
Aztec Emperor
Ruled over the Aztec Empire.
Was the supreme leaderofthe people.
Heclaimed that hewas divine.
People
Madeupofcommoners, indentured workers, andslaves.
Most people were farmers, butthey also traded with people in the surrounding areas.
Men weretobe the warriors, while a woman’s role was to bein the home. Women were
allowed toown and inherit property and enter contracts. Womenwovetextiles and raised
children. They could also be priestesses.
18. Religion
Had a polytheistic religion based on warfare.
Huitzilopochtli
Their chief god. He was the godof the sun. The Aztec
offered him human sacrifice to givehim strength to battle the forces of darkness each
night so that hecould rise each morning.
Quetzalcoatl
Thefeathered Serpent
Hebelieved he had left the valley of
Mexico and promised to return in triumph.
Human Sacrifice
Each Aztec city contained a pyramid where they
practiced human sacrifice as a way to postpone
the end of the world.
19. Destruction oftheAztec
Thesubjugation of the people of the Aztec
Empire bredhatred and discontent among the
people. When the Spanish arrived they did
not have a difficult time finding allies to fight
the Aztec.
HernánCortés1519
Spanish Conquistador who cameto the valley of Mexico in 1519 with 550 soldiers and 16
horses. He was at first greetedby the Aztec EmperorMontezuma (Moctezuma). The
Spanish later kidnapped the Emperorand madehim a puppet. Thepeople rebelled and
the Emperorwas killed. TheSpanish barelyescaped.
TheSpanish returned several months later. Many ofthe natives had fallen ill with
Smallpox. Cortés and his allies destroyed the Aztec capital and subjugated the Aztec
people.
20.
21. Incancivilization
•Located in the Andes Mountains of South America
•Represented by Machu Picchu
•Ruled by anemperor
•Economy based on high-altitude agriculture
•Polytheistic religion
•Road system
Late 1300's Inca
TheInca started as a small group that werelocated in Cuzco. They did not begin to
becomepowerful until after the fall of the Mocheof Peru.
Pachacuti
Unified the Inca and established the Inca Empire.
22. Organization ofthe Empire
Incan state was built on war.
Theconquered peoples were all taught the same language.
Each region was appointed a governorwhoanswered to the
Emperor.
Road System: 24, 800 miles of Road
TheInca built roads to unify their people. Roads made travel
and communication throughout the empire more efficient.
There were rest houses and storage depots along with bridges
to span ravines and waterways.
23. Culture
Were required to marryfrom within their own social group.
Women wereexpected to live at home,the only alternative was to be a priestess.
Most people were farmers, they also herdedllamas and alpacas.
Quipu-Asystem of knotted strings used by the Inca to keeprecords.
24. Great Builders
Theyhad great buildings made ofstone held
without mortar. Theirroads also show their
ability as great builders.
MachuPicchu
City built at 8,000 ft above sea level.
UrubambaRiver
Riverbelow Machu Picchu
30. Defeat
TheSpanish arrived in 1531
1531: Francisco Pizarro
Spanish Conquistador led a band of 180 men with
superior weapons.
TheInca, like the Aztec, weredevastated by disease.
Smallpox
Devastated the Population
Civil War
After the death ofthe Inca Emperora civil war brokeout, Pizarro took advantage and defeated
the people.
Defeat
Pizarro andhis men established Lima as the newcapital ofthe Spanish Colony in 1535.