The document discusses the toxicity and hazards of mercury exposure from dental amalgam fillings. It notes that amalgam fillings are 50% mercury and their removal can generate mercury vapors which are inhaled or ingested. It outlines the various ways mercury is released during dental procedures and the toxic effects it can have on the body. The document provides recommendations for dental offices to reduce mercury exposure through improved ventilation, equipment, hygiene practices and waste disposal. It also discusses alternatives to dental amalgam like mercury-free alloys and treatments for mercury toxicity like chelation therapy.
direct filling gold... material aspect, types, condensation, cavity design, modifications. detaied seminar for post gradutes.... any doubts or suggestions contact dr.mb@hotmail.com
direct filling gold... material aspect, types, condensation, cavity design, modifications. detaied seminar for post gradutes.... any doubts or suggestions contact dr.mb@hotmail.com
this contains the steps for the class 1 cavity preparation for amalgam in detail. also contains the difference between composite and amalgam cavity preparation.
This presentation specifically deals with the maxillary and mandibular Major connectors used in a cast partial denture. it also mentions the uses, advantages and disadvantages of each,
this contains the steps for the class 1 cavity preparation for amalgam in detail. also contains the difference between composite and amalgam cavity preparation.
This presentation specifically deals with the maxillary and mandibular Major connectors used in a cast partial denture. it also mentions the uses, advantages and disadvantages of each,
We can can minimize the risks of disease transmission to our self and to the patients in the dental office through carefully following the infection control and safety guidelines,
Dr. Hesham Dameer
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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2. INTRODUCTION
• Mercury is a known toxic , bio accumulative
substance and it often finds its way into body
through dental amalgams, which is used to
restore cavitated tooth.
• The mercury release in body and negatively
affect brain, nervous system, kidney etc.
3. The silver fillings used by dentists to restore teeth are composed of a
metal "amalgam" containing roughly 50% elemental mercury and 50%
other metals (mostly silver with some tin and copper).
The mercury found in amalgam fillings has raised some safety
concerns over the years. Amalgam can release small amounts of
mercury vapor over time, and patients can absorb these vapors by
inhaling or ingesting them.
Dentists all over the world remove millions of amalgam fillings every
day, with no regard for the possible mercury exposure that can result
from grinding them out.
Taking out fillings with a high speed dental bur generates a cloud of
particles, at least 65% of which are one micron or less in size. These
are fully respirable, get deep into the lungs, where the microscopic
particles are broken down and the mercury is systemically absorbed
within a few days.
4. MERCURY EXPOSURE IN DENTAL OFFICE
Mercury exposure in dental office can occur-
When Amalgam raw material being stored in use.
During trituration , insertion & intraoral hardening.
From amalgam scrap.
During finishing & polishing.
Removal of old restoration.
5. Amount of exposure.
Length of exposure.
Length of mercury accumulation in body.
Amount of accumulated mercury
Overall health of the patient ( for detoxification).
6. Amount of mercury released
During manipulationof amalgam
TRITURATION 1-2µg
CONDENSATION 6-8µg
DRY POLISHING 44µg
WET POLISHING 2-4µg
REMOVAL OF AMALGAM RESTORATION UNDER WATER SPRAY
AND HIGH VOLUME SUCTION 15-20µg
ADDITIONAL EVAUATION FOR 1 MIN TO REMOVE RESIDUAL
AMALGAM DUST 1.5-2µg
.
7.
8. Bleeding gums
Alveolar bone loss
Loosening of teeth
Excessive salivation
Foul breath
Metallic taste
Burning sensation, with tingling of lips, face
Tissue pigmentation (amalgam tattoo of gums)
Stomatitis (sores in the mouth)
Ulceration of gingiva, palate, tongue
9. OTHER TOXIC EFFECT OF MERCURY ON BODY
G.I.T PROBLEMS
Cramps
Inflamed colon
Diarrhea
C.V.S PROMBLEMS
Weak pulse
Increase B.P
Chest pain/feeling of pressure
In the chest area
RESPIRATORY PROMBLEMS
Weakness and problems with breathing
Emphysema
Persistent cough
NEUROLOGICAL PROBLEMS
Headaches
Vertigo
Tinnitus
Twitching in various areas of the body
(eyelid, feet etc.)
10. DENTALMERCURY Hygiene RECOMMENDATIONS
Ventilation: Provide proper ventilation in the place
by having fresh air exchanges and periodic
replacement of filters, which may act as traps for
mercury .
Monitor office: Monitor the hg vapor level in the
office periodically. This may be done by using
dosimeter badges & vapor analyzer(limit –
50µg/m³ 8 hr shift over 40 hr work week).
Monitor personnel: monitor office by
periodic analysis.
Office design: Use proper work area design to
facilitate spill containment and cleanup .
11. DENTALMERCURYHygiene RECOMMENDATIONS
Pre-capsulated alloys: Use pre-capsulated
Alloy. Eliminate the possibility of
a bulk hg Spill, otherwise store bulk
hg properly in unbreakable containers
on stable surface.
Amalgamator cover: use an amalgamator fitted with a
cover.
Handling care: use care in handling amalgam avoid skin
contact with mercury or freshly mixed amalgam avoid
dry polishing.
Evacuation systems: Use high volume evacuation when
finishing or removing amalgam .Evacuation system have
traps or filter. Check, clean / replace traps and filter
periodically.
12. DENTALMERCURYHygiene RECOMMENDATIONS
Masks: Change mask as necessary when removing
amalgam restoration.
Contaminated items: Dispose of Hg contaminated
items in sealed bags according to applicable
regulation .
Spills: clean up Hg properly by using bottle tapes/
fresh mixes of amalgam to pick- up droplets/ use
commercial clean up kits. Do not use household
vacuum cleaner.
Select an appropriate alloy: Proper Hg: alloy ratio to
avoid the need to remove excess Hg before packing.
13. DENTALMERCURYHygiene RECOMMENDATIONS
Recycling: store amalgam scrap under radiographic
fixer solution in covered container. Recycle
amalgam scraps through refiners .
Clothing: Wear professional clothing only in dental
operatory.
Avoid carpet/floor coverings in dental office ; floor
coverings should be easy to clean, nonabsorbent
and seamless.
Use rubber dam during insertion, condensation,
and polishing of amalgam.
15. Gallium based alloy:
- Gallium was discovered in 1875 .it is metal
With similar atomic structure and characteristics
To mercury and has a melting temp of 29˚c. Hence , by 1928
Puttkammer suggested Gallium as a substitute for mercury
It is available as :
1. Gallium Alloy
2. Galloy
DISADVATAGES
. Handling characteristics of alloy not favorable
. High level of corrosion is seen which causes loss of strength
marginal disintegration and marginal fracture in chunks.
. Dimensional change of 21.5%
. Poor biocompatibility
. Costly.
OTHER OPTION TO REDUCE MERCURY HAZARDS:
MERCURY FREE ALLOYS
16. TREATMENT OF MERCURY TOXICITY
• Chelation therapy is the administration of
chelating agents to remove heavy metals from the
body.
Chelation agent are chemical substances that
contain molecules capable of bonding securely to
minute particles of metal called ions. In addition
to directly supporting vital body functions, this
bonding process---called Chelation---provides a
means of trapping harmful metals in your
bloodstream and making them susceptible to safe
excretion in urine. The process of Chelation, called
Chelation therapy, is commonly used in the
treatment of heavy metal poisoning
17. A chelating agent could be given orally, intramuscularly, or
intravenously.
Chelation therapy for acute inorganic mercury poisoning can
be done with DMSA, 2,3-dimercapto-1-propanesulfonic acid
(DMPS), D-penicillamine (DPCN), or dimercaprol (BAL).[1]
Only DMSA is FDA-approved for use in children for treating
mercury poisoning.
correct dosage is required, as inappropriate dosages
increase toxicity.