this is a series of lectures on microbiology useful for undergraduate and postgraduate, medical and paramedical students

1. Meningitis
Dr. Ashish V. Jawarkar

2. The Central nervous system
Consists of:
Brain
Spinal
cord
ventricles
CSF
Peripheral
nerves
Dr. Ashish V. Jawarkar

3. Meningitis
Inflammation of the membranes surrounding the
brain and spinal cord
Most common organisms



Haemophilus influenzae
Streptococcus pneumoniae
Neisseria meningitidis
Dr. Ashish V. Jawarkar

4. H. Influenzae
Morphology


Gram negative
Cocco-bacillary
Dr. Ashish V. Jawarkar

5. Growth requirements on culture
Factor X – haemin
Factor V – NAD – nicotineamide adenine
dinucleotide
Dr. Ashish V. Jawarkar

6. Sattelitism
Dr. Ashish V. Jawarkar

7. Types
Capsulated (type B) – cause meningitis,
conjunctivitis, bacteriemia, pneumonia, arthritis,
endocarditis

children
Non capsulated – infections of respiratory tract

adults
Dr. Ashish V. Jawarkar

8. Meningitis
Dr. Ashish V. Jawarkar

9. Lab diagnosis
Sample – CSF
Lumbar puncture
Gram stain – gram negative cocco bacilli
Latex particle agglutination test
Culture – blood agar or chocolate agar with added
factor X and V
Dr. Ashish V. Jawarkar

10. Treatment
Cefotaxime
Augmentin
Cotrimoxazole
Dr. Ashish V. Jawarkar

11. Neisseria
Two types


N. meningitidis (meningococci) - meningitis
N. gonorrhoe – Uro genital infections
Dr. Ashish V. Jawarkar

12. Meningococci
Morphology


Gram negative
diplococci
Dr. Ashish V. Jawarkar

13. Pathogenicity
Cerebrospinal meningitis


Acute fever with chills
Rash
Meningococcal septicemia


Shock
Multisystem failure
Dr. Ashish V. Jawarkar

14. Dr. Ashish V. Jawarkar

15. Lab diagnosis
Sample – CSF
Gram stain
Latex agglutination test
Culture
Nasal swab for detection of carriers
Dr. Ashish V. Jawarkar

16. Treatment
IV penicillin G
Third generation cephalosporin
Dr. Ashish V. Jawarkar

17. Dr. Ashish V. Jawarkar