This document discusses megaloblastic anemia, its causes, symptoms, and treatments. It is characterized by abnormally large red blood cells due to a deficiency in vitamin B12 or folic acid, which is needed for DNA synthesis. The deficiencies can result from inadequate intake, malabsorption, or increased demand. Treatments include injections or supplements of vitamin B12, folic acid, or erythropoietin to stimulate red blood cell production. Adverse reactions are also discussed.
Megaloblastic anaemia is a red blood cell disorder due to the inhibition of DNA synthesis during erythropioesis.
Mitotically, the inhibition of the DNA synthesis impaires the progression of the cell cycle development from G2 to (M) stage.
Megaloblastic anaemia is a type of anaemia characterized by the formation of unusually large, abnormal and immature red blood cells called as megaloblasts by the bone marrow, which are released into the blood. To know more visit here: www.lazoi.com
Aplastic anemia is one of the stem cell disorder which leads to pancytopenia in the peripheral blood and decrease production of all cell line in bone marrow. it require bone marrow transplantation to cure the patient.
A decrease in red blood cells when the body can't absorb enough red blood cells.It is an organ specific autoimmune diseases in which the body’s immune system attacks the lining of the stomach.
It was considered as a deadly disease due to the lack of available treatment.
Pernicious anemia is most common in caucasian persons of north European ancestry than in other racial groups.
Megaloblastic anaemia is a red blood cell disorder due to the inhibition of DNA synthesis during erythropioesis.
Mitotically, the inhibition of the DNA synthesis impaires the progression of the cell cycle development from G2 to (M) stage.
Megaloblastic anaemia is a type of anaemia characterized by the formation of unusually large, abnormal and immature red blood cells called as megaloblasts by the bone marrow, which are released into the blood. To know more visit here: www.lazoi.com
Aplastic anemia is one of the stem cell disorder which leads to pancytopenia in the peripheral blood and decrease production of all cell line in bone marrow. it require bone marrow transplantation to cure the patient.
A decrease in red blood cells when the body can't absorb enough red blood cells.It is an organ specific autoimmune diseases in which the body’s immune system attacks the lining of the stomach.
It was considered as a deadly disease due to the lack of available treatment.
Pernicious anemia is most common in caucasian persons of north European ancestry than in other racial groups.
causes of macrocytic anemia pathopysiology, sign and symptoms and the difference between macrocytic anemia megaloblastIc anemia. causes of hypersegmented neutrophils and its association between them. investigation and medical management plus pictures illustration.
Anemia Causes, Types, Symptoms, Diet, and Treatment Dr Medical
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Anemia is a condition that develops when your blood lacks enough healthy red blood cells or hemoglobin. Hemoglobin is a main part of red blood cells and binds oxygen. If you have too few or abnormal red blood cells, or your hemoglobin is abnormal or low, the cells in your body will not get enough oxygen.
causes of macrocytic anemia pathopysiology, sign and symptoms and the difference between macrocytic anemia megaloblastIc anemia. causes of hypersegmented neutrophils and its association between them. investigation and medical management plus pictures illustration.
Anemia Causes, Types, Symptoms, Diet, and Treatment Dr Medical
https://userupload.net/0gv9ijneu7hf
Anemia is a condition that develops when your blood lacks enough healthy red blood cells or hemoglobin. Hemoglobin is a main part of red blood cells and binds oxygen. If you have too few or abnormal red blood cells, or your hemoglobin is abnormal or low, the cells in your body will not get enough oxygen.
Immunosupressants and Immunostimulants their pharmacology, uses etc. Basics of immunology, innate immune response, acquired immune response, role of complement in innate immune response. Major histocompatibility complex, antibody structure. classification of immunosupressants, their mechanism of action, uses and adverse effects.
Pharmacology of antimalarial drugs with treatment of malaria. mechanism of action, uses, adverse effects of antimalarial drugs like chloroquine, quinine, artemisinin compounds.
Antileprosy drugs have been described with their pharmacology also this topic covers Multidrug treatment for leprosy including paucibacillary and multibacillary leprosy and lepra reactions
Pharmacology of cephalosporins, monobactums and carbapenums including their mechanism of action, indications, adverse effects.
The various generations of cephalosporins and their spectrum of action
Pharmacology of Penicllins (Beta lactam antibiotics), description of their mechanism of action, mechanism of resistance, classification, indications and adverse effects
Drugs for treatment of Diabetes MellitusNaser Tadvi
These slides contain the brief description of Insulin and the other oral drugs indicated in the treatment of Diabetes Mellitus. Their mechanism of action, effects, uses, Adverse effects etc.
Introduction to Autonomic Nervous systemNaser Tadvi
Lecture intends to give a brief overview of autonomic nervous system.
it includes the anatomical distribution of ANS, Neurohumoral transmission, co-transmission, receptors for ANS and synthesis of the neurotransmitters, Acetylcholine and Catecholamines
Lecture covers the pharmacology of anticholinergic drugs. Includes classification, therapeutic uses, adverse effects of anticholinergics. Atropine has been described as prototype drug.
Lecture includes definition of bioassay, Types of Assay and Bioassay , Indications, principles, advantages of bioassay. Example of a Bioassay with calculations. This lecture will be of help for postgraduate pharmacology students as well as undergraduates
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. Megaloblastic anemia:
Characterized by abnormally large nucleated
red cell precursors called megaloblasts in bone
marrow
Megaloblast eg of unbalance between cytoplasm
and nucleus due to improper and defective
synthesis of nucleoproteins
95 % cases due to vit B12 or folic acid deficiency
leading to defective DNA synthesis
4. DNA present in every basic cell so abnormality
effects rapidly proliferating cells.
Peripheral blood picture: Hemoglobinized large
RBC (Macrocytes), PMN leucocytes &
hypersegmented giant platelets.
Anemia described is hyperchromic macrocytic
5.
6.
7.
8. Vit B12 deficiency causes damage to myelin in the
peripheral nerves , spinal cord & brain
Folate deficiency: weight loss, nervous instability
but damage to myelin is doubtful
Other causes of macrocytic anemias: Liver disease
, myxedema, Leukemia & certain hemolytic states
9. Cobalamins:
Vit B12 belongs to cobalamin family i.e cobalt
containing compounds
Cyanocobalamin: CN group attached to cobalt
Hydroxycobalamin: OH group attached to
cobalt
Light
Cyanocobalamin Hydroxycobalamin
Cyanide
Other cobalamins: aquocobalamin,
nitrocobalamin & methyl cobalamin
10. Sources of Vit B12:
Micro-organisms (Soil, water animal intestine)
Man and animals intestinal lumen but not
absorbed 3-5 µg excreted daily in faeces
Non veg foods:
Muscle, liver, kidney, oysters,fish, egg yolk
The only vegetable source is pulses(legumes)
Dairy milk in smaller amounts
Daily requirement: 1-3 µg,
pregnancy & lactation 3-5 µg
Commercial source: Streptomyces Griseus
11. Pharmacokinetics:
Absorption: Cobalamins in food are in bound form
inactive , released by cooking (heat) and by
proteolysis in stomach & intestine .
Vit B12 is not soluble so absorption depends on
various transfer factors
R- Factor, Intrinsic factor & Transcobolamin II
16. Preparations & doses:
Cyanocobalamin: Pink color injection 100
µg/mL DOC in pernicious anemia 1000 µg once
a week IM for 8 weeks then 1000 µg once a
month life long
Hydroxy cobalamin 100, 500, 1000 µg/mL,
better retention but can induce antibody
formation not used in US. 1 mg every 2 – 3 days
5 doses , then 1 mg 3 monthly
Methyl cobalamin 0.5 mg tab, Dose 1.5 mg
promoted for neurological defects in diabetics
and other peripheral neuropathies
17. Uses :
1. Treatment of vit B12 Deficiency: wise to add
folic acid and iron, symptoms improvement in
2 days ( appetite increased, feels good.
Mucosal lesions heal in 1-2 weeks. Platelet
count normal in 10 days. WBC`S = 2-3 weeks .
Neurological parameters take several month.
2. Prophylaxis : 3-10 µg/ day
3. Mega dose of B12 used in neuropathic
psychiatric disorders and as general tonic to
allay fatigue , improve growth.
4. Tobacco amblyopia: OH Cobalamine
Adverse events
19. Called as folic acid as it is found in green leafy
vegetables
Source: Green leafy vegetable , liver , yeast, kidney,
egg, meat, fish and dairy foods
Much of it is destroyed in cooking (heat)
Micro-organisms
Daily requirement: adult 50-100 µg pregnancy and
lactation 500- 800 µg
20. Absorption:
Folic acid conjugates hydrolysed to pteroyl
monoglutamic acid by conjugases
Conjugases are enzymes present in vegetables
and mammalian tissue, GIT mucosa & pancreas
Pteroyl monoglutamic acid is completely
absorbed in small intestine jejunum
21. Transport storage and fate:
Orally given folic acid appears in 30 min as
circulation it circulates as N5 Methyl THF
Majority is loosely bound to albumin from
where it is easily taken up by cells
Inside the cells converted to THF by
cobalamine dependent enzyme methionne
synthetase
Vit C protects THF from destruction
Total folate in body = 5 to 10 mg (1/3 in liver
as methyl folate)
22. Metabolic functions
Folic acid DHFA THFA (Active form)
folate DHF
reductase reductase
THFA mediates number of one Carbon tranfer
reactions
Conversion of homocysteine to methionine
Generation of thymidylate
Conversion of serine to glycine
Purine synthesis
Histidine metabolism
25. Preparations and dose:
Folic acid tab 5 mg ; dose = 5 to 20 mg
Prophylaxis 0.5 mg/day
Parenteral form available in combination only
Folinic acid: N5 Formyl THFolinic acid
(Citrovorum factor) 3 mg/mL Inj
26. Uses:
1. Megaloblastic anemia
2. Prophylaxis
3. Methotrexate toxicity: Folinic acid used as it is an
active no need to reduced by DHFR before it can
act, Methotrexate is DHFR inhibitor, its toxicity
not reversed by folic acid
4. Citrovorum factor rescue: Methotrexate high
dose IV then half to 2 hr later 1-3 mg folinic acid
IV to rescue normal cells
Adverse events:
27. Short gun antianemia therapy
Erythropoietin:
Uses
1. Primary : Anemia of CRF due to low EPO 25-100 µg/Kg
S.C /IV Three times a week max 600 µg/Kg/week
2. Anemia in AIDS patients on T/t with zidovudine
3. Cancer chemotherapy induced anemia
4. Autologus blood transfusion
Adverse events : ↑ clot formation in AV shunts ,
Hypertension, occasional seizures, flu like symptoms
28. Drugs used in neutropenia:
G- CSF , GM- CSF
Recombinant drugs
Filgrastim, molgrastim
Uses:
1. To decrease severity and duration of neutropenia
2. Shorten duration of neutropenia in BMT, after
high dose intense chemotherapy
3. Stimulate release of harvested progenitor cells
4. Expand the number of progenitor before
harvesting
5. Persistant neutropenia in advanced HIV
6. Aplastic anemia
29. Adverse events:
Bone pain, fever, myalgia, lethargy, pain and
reddening at site of injection
Hypersensitivity: Skin rashes, hypotension,
nausea, vomiting and dyspnoea
Filgrastim: dysuria, derange liver function , mild
to moderate spleenomegaly