Retinal vein occlusion (RVO) is an obstruction of the retinal venous system by thrombus formation and may involve the central, hemi-central or branch retinal vein.
The most common aetiological factor is compression by adjacent atherosclerotic retinal arteries.
Other possible causes are external compression or disease of the vein wall e.g. vasculitis.
The presentation I have made and uploaded provides you with an in-depth insight into the patterns the strabismus may take following anomalies of extraocular muscles, deformities of the orbital structures,innnervational disturbances.
The author does not assume responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work.
No copyright infringement, or plagiarism intended.
Amrit Pokharel
Retinal vein occlusion (RVO) is an obstruction of the retinal venous system by thrombus formation and may involve the central, hemi-central or branch retinal vein.
The most common aetiological factor is compression by adjacent atherosclerotic retinal arteries.
Other possible causes are external compression or disease of the vein wall e.g. vasculitis.
The presentation I have made and uploaded provides you with an in-depth insight into the patterns the strabismus may take following anomalies of extraocular muscles, deformities of the orbital structures,innnervational disturbances.
The author does not assume responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work.
No copyright infringement, or plagiarism intended.
Amrit Pokharel
Aphakia and its causes. Correction of Aphakia. Advantages and disadvantages of different corrections. Surgeries and related signs and symptoms of aphakia. Complications related to Aphakia.
It describes about the procedure of Hess charting. it serves as a great tool to understand the concepts involved. Suitable for optometry course. This is not a routine procedure but an important procedure which is used in diagnosis.
Aphakia and its causes. Correction of Aphakia. Advantages and disadvantages of different corrections. Surgeries and related signs and symptoms of aphakia. Complications related to Aphakia.
It describes about the procedure of Hess charting. it serves as a great tool to understand the concepts involved. Suitable for optometry course. This is not a routine procedure but an important procedure which is used in diagnosis.
Surgical excision of congenital Dermoid cysts in the orbitiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
presentation on intraolcular tumors including detailed explaination on their pathology diagnosis and treatment including details of retinoblastoma. enucleation
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. THE HAIRY EYEBALL-
LIMBAL DERMOID
DR.PAWAN N. JARWAL,
DR.KINJAL H. DESAI,
THIRD YEAR RESIDENTS
DEPARTMENT OF OPHTHALMOLOGY
S. S. G. HOSPITAL,VADODARA
2. INTRODUCTION:
• The estimated worldwide incidence of limbal dermoid is 1 per 10,000 to 3
per 10,000.
• Limbal dermoid are benign congenital tumours that contain choristomatous
tissue (tissue not found normally at that site).
• They appear most frequently at the inferior temporal quadrant of corneal
limbus and remain localised mostly to the superficial layer of the cornea and
sclera.
• They may contain a varity of histologically aberrant tissues, including
epidermal appendages, connective tissue,skin,fat,sweat gland,lacrimal gland
,muscle ,teeth,cartilage,bone,vascular structure and neurologic tissue
including the brain. Malignant degeneration is extremely rare.
3. • Limbal dermoid are thought to arise from an early embryological
anomaly (occurring at 5-10 weeks gestation)resulting in metaplastic
transformation of mesoblast between the rim of optic nerve and
surface ectoderm .
• Limbal dermoid are present at birth but may not be recognized until
the first or second decade of life . They may appear to enlarge as the
body mature.
4. MATERIALS AND METHODS:
• A 30 year old man presented with a mass in his left
eye that was present since birth and gradually
increased in size . He did not have pain, but the mass
caused vision defect, sensation of presence of a
foreign body, discomfort on blinking and cosmetic
disfigurement. There was no family history of
similar lesion.
5. • Examination revealed a solid reddish-
yellow, round, mass measuring 5x5x3
mm having rough surface with partly
keratinized epithelium and hair
involving the infero-temporal limbus
and cornea .No associated regional or
systemic abnormalities were found
.Visual acuity was 6/6 in right eye and
6/60 in left eye. The finding on slit-lamp
examination,fundoscopy and ocular
USG were within normal limit and IOP
was normal .
6. • After obtaining consent from patient the lesion
was dissected off the cornea and limbus under
local anaesthesia with meticulous attention for
preservation of normal tissue. A cleavage plane
was fashioned, and the dermoid was removed
from the cornea first, with movement towards
the limbus. Removed section was sent for
histopathologic examination where section
showed histology of flattened epidermis. Dermis
contained occasional sebaceous gland lobule
with hair follicle and adnexal glands in a loose
collagenised tissue.
7. • The surgical result was very reasonable from a cosmetic result, and
the patient recovered well from his symptoms .As expected there was
little improvement in visual acuity after surgery because of the
amblyopia and induced astigmatism.
8. DISCUSSION:
• Anatomically limbal dermoids have been classified into three grades.
This form of grading allows clinicians to take a more stepwise
approach to the clinical and surgical management of such lesion.
*Grade 1 limbal dermoid are superficial lesion measuring less than 5
mm and are localized to limbus. Such lesion may lead to development
of anisometropic amblyopia ,with slow growth resulting in oblique
astigmatism and flattening of cornea adjacent to the lesion.
*Grade 2 limbal dermoids are larger lesion covering most of the cornea
and extending deep to the stroma down to Descemet's membrane
without involving it.
*Grade 3 limbal dermoids ,the least common of all the presenting
dermoids ,are larger lesion covering the whole cornea and extending
through the histological structures between the anterior surface of the
eye ball and the pigmented epithelium of iris .
9. • Visual morbidity in limbal dermoid mainly results from
encroachment of the lesion into the visual axis, development of
astigmatism or formation of lipid infiltration of the cornea, which
obstructs the visual axis . Large Limbal dermoid can be cosmetically
disfiguring. In some cases staphyloma formation adjacent to dermoid
has been reported and may be associated with spontaneous
perforation of cornea or sclera.
• A varity of surgical techniques has been described in the literature ,
ranging from simple excision to lamellar and/or penetrating keratoplasty
with relaxing corneal incision, depending on the grade of lesion.
Depth,size,and site of such lesion are critical factor .Other techniques
include corneal-limbal scleral donor graft transplantation and surgical
resection followed by reconstructive multi-layered amniotic membrane
transplantation.
10. Conclusion:
• Treatment of limbal dermoid may consist of periodic removal of
irritating cilia, topical lubrication to prevent foreign body sensation, or
excision of the lesion if it causing significant cosmetic disfigurement
or interfering with vision.
• Attempts at complete removal are unnecessary because lesion may
extend into the deeper structure of the eye and risk of perforation
increase if attempts are made to remove lesion completely. If a deep
excision is necessary, then a lamellar keratoplasty can be performed to
reinforce the site of excision.