This document summarizes a webinar about applications for identifying research study participants from medical record data. It describes TriNetX, SHRINE, and i2b2 which allow searching for de-identified patient counts across various healthcare organizations. TriNetX provides counts to attract clinical trials while SHRINE and i2b2 allow searching within local hospitals. Users must complete regulatory training to access these tools for cohort discovery and study planning. The webinar covered how each system works and potential weaknesses in using medical record data for research recruitment.

1. Digital Scholar
Webinar
May 2, 2018
Hosted by the Southern California Clinical and Translational Science Institute (SC CTSI)
University of Southern California (USC) and Children’s Hospital Los Angeles (CHLA)

2. Katja Reuter, PhD,
Director of the Digital
Scholar Program
About Today’s Session

3. Leveraging Medical Health Record Data
for Identifying Research Study Participants
+

4. Applications for Cohort Discovery
TriNetX: Providing health care providers and pharma
companies with de-identified USC patient counts to attract
clinical trials and enhance local research.
SHRINE: Finding sets of aggregated patient information across
major Los Angeles health care provider organizations while
preserving patient privacy.
i2b2: Searching health system data for de-identified counts of
patients who meet certain study criteria.

5. Today’s Learning Objectives
v Describe the characteristics and strengths of the three
applications: TriNetX, Shrine, and i2b2
v Understand required steps for accessing and using the
data provided by the applications, including the
regulatory process
v Describe potential weaknesses of these three
applications and how to address them

6. Juan Espinoza
Today’s Speakers
Juan Espinoza, MD, FAAP, Assistant Professor of
Clinical Pediatrics, Keck School of Medicine of USC,
Physician and Director of Clinical Research
Informatics, Children’s Hospital Los Angeles
AND
Mark Abajian, Applications Lead, Clinical Research
Informatics, SC CTSI
Mark Abajian

7. Questions: Please use the Q&A
Feature
1. Click on the tab here to
access Q&A
2. Ask and post question here
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8. Thinking About Data
o Back to Basics
o What is your question?
o Who is your study population?
– The more specific, the better
o What is the answer you expect?
– The more specific, the better

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37. TriNetX - Summary
o Get access by emailing cri@usc.edu and include the subject line,
“Trinetx account request”
o Cohort discovery tool
– USC patients
– Patients at other Trinetx research institutions (10 and growing)
o Great for grants and proposals when you need counts
o At this time, CANNOT be used to request patient data (but soon!)

38. LADR/SHRINE

39. LADR / SHRINE
LADR Los Angeles Data Resource
CHLA Children's Hospital Los Angeles
COH City of Hope
CSMC Cedars-Sinai Medical Center
UCLA UCLA (hub)
USC Keck Hospital
SHRINE Shared Health Research
Information NEtwork

40. LADR / SHRINE
v SHRINE = Federated query (EMR, EHR)
v LADR = Five local hospitals (CHLA, COH, CSMC,
UCLA, USC)
v SHRINE utilizes i2b2 technology (cohort discovery)
v Delivers number of patients at each hospital
v Unlike i2b2, Patient data unavailable

41. LADR / SHRINE
https://shrine-keck.med.usc.edu

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55. LADR / SHRINE
v Keck SHRINE: https://shrine-keck.med.usc.edu
v CHLA SHRINE: https://shrine-chla.med.usc.edu
v Other SHRINE resources:
§ Wiki: https://open.med.harvard.edu/wiki/pages/viewpage.
action?pageId=18677899
§ ACT (Accruals to Clinical Trials) (planned)
§ Other University hospitals, such as Harvard

56. i2b2

57. i2b2
o Same interface as LADR/SHRINE
o Once you build your search, can export query to include
in your IRB
o Once IRB approves your study, CRI can provide you
your dataset based on your iStar application

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66. Summary

67. Applications for Cohort Discovery
i2b2:
- Search USC data for de-identified counts of patients who
meet certain study criteria
- Data requests and automated iStar process
SHRINE:
- Cohort discovery across 5 Los Angeles HCOs
TriNetX:
- User friendly interface
- Patient counts at USC, and certain other HCOs
- provide industry and other HCOs with de-identified USC
patient counts to attract clinical trials ad enhance local
research.
- Find potential study participants at other HCOs

68. Applications for Cohort Discovery
Access
v Request through https://sc-ctsi.org/resources
v Or email cri@usc.edu specifying the service(s) you would like
to access.
§ TriNetX
§ Keck i2b2
§ CHLA i2b2
§ Keck LADR
§ CHLA LADR
All accounts require current HIPAA Certification and Human
Subjects Certification in iSTAR

69. Applications for Cohort Discovery
Sites
vTriNetX: https://live.trinetx.com
vKeck i2b2: https://i2b2-keck.med.usc.edu
vKeck LADR: https://shrine-keck.med.usc.edu
vCHLA i2b2: https://i2b2-chla.med.usc.edu
vCHLA LADR: https://shrine-chla.med.usc.edu

70. Questions
Program director: Katja Reuter, PhD
Email: katja.reuter@usc.edu
Twitter: @dmsci
Next Digital Scholar Webinar
Information about
the program
http://sc-ctsi.org/digital-scholar/
June 6, 2018/12-1PM PST
Topic: Webinar: Introducing Figshare, a Free Repository where
Researchers Can Make all of Their Research Outputs Available in a
Citable, Shareable and Discoverable Manner
Speaker: Mark Hahnel, PhD, CEO and founder of Figshare
Register at: https://bit.ly/2IFpXzG