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International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 4995
An Efficient Approach for Multi-Modal Brain Tumor Classification using
Texture Features and Machine Learning
Ajay Samuel. A1, Dhiwakar. J2, Arkesh. J3, Dr. J. Arun Nehru4
1,2,3,4Computer Science and Engineering SRM Institute of Science and Technology, Chennai, India
------------------------------------------------------------------***-------------------------------------------------------------
Abstract— In this paper, we propose an efficient
approach for Multi-modal brain tumor classification
using Texture features and Machine learning concepts.
MICCAI BraTS 2016 datasets are utilized which are raw
and skull-stripped and performed with high intensity.
The project is divided into 3 primary modules such as
Pre- processing, Feature extraction and classification of
the brain tumor. We use techniques such as Fuzzy-c
means clustering technique and further use region of
interest properties for segmentation of the brain tumor.
After the segmentation process, we use feature extraction
techniques such as GLCM (Grey-level co-occurence
matrix) and LBP (Local binary pattern) to record the
outer shape and inner shape of the tumor by therefore
extracting the following features such as Area, Density,
Major axis, Minor axis length. The extracted features are
then provided to the SVM (Support vector machine)
classifier for classifying the tumor and categorizing it as
BENIGN or MALIGNANT.
Keywords—Brain tumor, Segmentation, Benign,
Malignant
1. INTRODUCTION
The detection and classification of Brain tumor is
essential to decrease the number of casualties that are
increasing each year. Brain tumor is a compound
phenomenon in terms of controlling as well as curing it
because of the complex structure of the brain. Tumor
segmentation and classification is proven to be a
challenging task and therefore less number of success
rate has been achieved so far. Multi-Modal brain images
has the ability to capture multiple images of the brain
for a better result. Many researches based on mono-
modality images had performed but the segmentation
were not accurate. Recently, a notion of multi-modality
images can segment brain tumor with high accuracy has
been proved. MRI outputs multi-modal images with
precise detection of the abnormality present in the brain.
Brain tumor feature extraction and classification has
received a huge amount of interest in the medical field
over the past few years. Recent findings have stated that
an individual with brain tumor should get immediate
attention within hours of detection as the medication
involved depends on each stage and type of the tumor.
MRI images have proven to be a greater source for the
classification of brain tumors.
The culmination of Texture Features and Machine
learning concepts that have been explored in the
segmentation technique with further implications such as
using clustering techniques and region properties can
bring forth a better segmentation. Tumor regions can be
distinguished from normal brain cells by comparing the
concentration of density in the tumor cells.
2. LITERATURE REVIEW
With the advancement of technology in the course of
recent years, many methodologies have been proposed
for brain tumor segmentation. Many research scholars
and individuals have utilized various rationales and
algorithms to execute their ideas in the field of medical
sciences to segment the tumor.
Brain tumor segmentation activities are widely
encouraged by the Medical Sciences department to
reduce the pathologist's workload and thereby benefit
the patients by reducing the expenses spent on biopsy
reports.
1. Title : Brain Tumor Detection using Image
Segmentation Techniques
Author : Dig vijay Reddy, Dheeraj, Kiran, Bhavana.V and
Krishnappa H.K.
Year : 2018
Description: The methodology presented in this work
uses a two-step procedure for brain tumor detection that
combines k-means clustering algorithm followed by level
set segmentation and morphological operations.
Experimental results have shown that, this methodology
is robust in detecting and bounding the abnormal cells in
MRI images despite the complicate shape of the tumor.
This paper proposed a k-means clustering image
processing algorithm for brain tumor detection only.
2. Title: Detection of human brain tumour using MRI
image segmentation and morphological operators.
Author: Anupurba Nandi Year: 2017
Description: In this paper the output image clearly shows
the tumour cells have been separated from the healthy
cells. The Threshold and Watershed segmentation is very
simple and popular but using morphological operators is
the new introduction to this problem which on applying
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 4996
to the output image of other two provided a better
detection of tumour. The factor used in thresholding is
very difficult to determine because the factor used for
one image may not work for other image. This factor
may be different for different images. The watershed
method has the disadvantage that it is highly sensitive
to local minima, since at each minima, a watershed is
created. This paper proposed a morphology based
image processing algorithm for brain tumor detection
only.
3 . Title: Segmentation of Brain Tumors in MRI Images
Using Three-Dimensional Active Contour Edge.
Author: Ali M. Hasan, Farid Meziane, Rob Aspin and
Hamid A. Jalab.
Year: 2015
Description: In this paper the proposed method can
recognize and segment MRI brain abnormality on T2-w,
T1-w, T1c-w, and FLAIR images. The 3DACWE
segmentation technique reduces manual input, offers a
rapid operation, and exhibits high accuracy compared
with manual segmentation as evaluated. We conclude
that the 3DACWE method is effective in brain tumor
segmentation because the approach does not only
consider local tumor properties, such as gradients, but
also relies on global properties, such as intensity,
contour length, and region length.
Although the achieved accuracy was high relative to
those of other segmentation techniques, the 3DACWE
was relatively slow for brain tumor segmentation. Such a
slow pace was ascribed to the processing of a massive
number of MRI slices of 512 512 pixel resolution with a
high number of iterations used to attain the required
accuracy. This paper proposed a texture based image
processing algorithm for detection of tumor only.
3. PROPOSED METHOD
The proposed algorithm uses MICCAI BraTS dataset
and the main flow of our proposed technique is
presented in Fig.1 with further details present in
following subsection.
A. Pre-processing
The pre-processing stage is the stage of rising
operations involving images at the lowest abstraction
level. The goal of the preprocessing stage is to process
the image. All images are visualized through Read
medical data 3D and segment the tumor using clustering
techniques and to extract and classify the clustered
image for better segmentation.
Fig. 1 Block diagram of proposed method
1. Resizing the input image
Input images are resized into an uniform size for
reducing the distortion present (i.e) noise. Images that
are processed without the default size can lead to
distortion of the output, that would in return makes the
segmentation to be less precise
2. Converting color format
Resized input images will be further checked for
clarification on whether the image is in RGB or Gray
scale. They will be translated to Gray scale format with
an appropriate value, unless the resized images are in
RGB scale. For improved tumor segmentation the Gray
Scale image is further transformed into the Black and
White image.
Fig. 2 Resized input image with gray scale conversion
Fuzzy-c means clustering algorithm is one of the most
commonly used clustering technique in the field of
medical imaging. Clustering techniques are used to
group the abnormal areas of the brain and these
clustered abnormal images are used to extract the tumor
by incorporating with region of interest properties such
as area and density to distinguish the tumor region and
detect the tumor.
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 4997
Fig. 3 Fuzzy-c means segmentation
B. Feature extraction
Feature extraction is the process of masking the
particular brain tumor part and extracting the tumor
region to enhance the textures of the image. In feature
extraction, texture features plays a major role in
extracting spatial arrangement of color or intensities in
the image or selected region in the image. For analyzing
the texture features, Gray level co-occurrence matrix
and Local binary pattern are used.
Gray level co-occurrence matrix has features such as
extraction of color, shape, skewness and so on. In gray
level co-occurrence matrix, Homogeneity measures the
closeness of the distribution of the elements in the inner
ridges. Local Binary pattern represents the
homogeneity involved in the distribution of elements in
outer edges of the tumor.
C. Classification
Supervised classification is a machine learning
approach in which training data are used to construct
the model on unseen data to measure the performance
of the algorithm. Support Vector Machine is the
classifier used in this work to classify the data and
categorizing it by Benign or Malignant. SVM is generally
a binary classifier and can be used for both linear and
non-linear operations. Linear operations is performed
in this work as it involves multiclass operations and
Support vector machine provides better classification in
terms of multiclass operations. Extracted tumor images
using texture features are produced to the SVM
classifier which measures the performance of the
algorithm with the unseen data.
Fig. 4 Malignant tumor classification
Fig. 5 Benign tumor classification
4. CONCLUSION
This paper presented an hierarchial way of
classifying the tumor into two types such as Benign or
Malignant. Segmentation techniques, region properties
and Texture features are extracted and utilized in the MRI
images with SVM classifier. The use of Fuzzy-c
segmentation with Region of interest properties has
increased the segmentation accuracy which then
contributed to better classification of the tumor.
5. ACKNOWLEDGEMENT
We would like to express our gratitude to our guide,
Dr. Arun Nehru, who guided us throughout the project
and offered a deep insight into the study. We wish to
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 4998
acknowledge the help provided by the technical and
support staff in computer science department of SRM
institute of science and technology.
7. REFERENCES
[1] C. Gonzalez and R. E. Woods, “Digital image
processing”, 2nd edition, Addison-Wesely, (2004).
[2] Isaac N. Bankman, “Handbook of image processing
and analysis”, 2nd edition, Elsevier, 2009.
[3] Mallat S, Hwang W L. Singularity detection and
processing with Wavelets [J]. IEEE Transactions on
Information Theory, 38(2) : 617-643 (1992).
[4] Chaplot, S.; Patnaik, L.M.; Jagannathan, N.R. (2006).
Classification of magnetic resonance brain images using
wavelets as input to support vector machine and neural
network, Biomed. Signal Process Control, 1, 86–92.
[5] Rafiee J, Rafiee MA, Prause N and Schoen , “
Wavelet basis functions in biomedical signal
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[6] Sugandha Agarwal1*, O.P. Singh1 and Deepak
Nagaria, “Analysis and Comparison of Wavelet
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Pharmacology Journal, Vol. 10(2), 831-836 (2017).
[7] Rajesh C. Patil, Dr. A. S. Bhalchandra, “Brain Tumour
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International Journal of Electronics, Communication &
Soft Computing Science and Engineering ISSN: 2277-
9477, Volume 2, Issue 1.
[8] Xu Y, Weaver B, Healy D M, et al. Wavelet transform
domain filters: A spatially selective noise filtration
technique [J]. IEEE Transactions on Image Processing,
3(6) : 217-237 (1994).
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MR Image Segmentation for Tumour Detection using
Artificial Neural Networks” ISSN : 0975-4024 Vol 5 No 2
Apr-May 2013.
[10] S.Grace Chang, Bin Yu, Martin Vetterli , “Adaptive
Wavelet Thresholding for image denoising and
compression,” IEEE Transaction On Image Processing,
9(9), 2000.
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Gray-Level Histograms," IEEE Transactions on Systems,
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[13] Durgesh K. Srivatsa, LekhaBhambhu, “Data
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[14] Zhang, Yudong, and Lenan Wu. "An MR brain
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[15] Hastie, T., R. Tibshirani, and J. Friedman. The
Elements of Statistical Learning, second edition. New
York: Springer, 2008.
[16] Christianini, N., and J. Shawe-Taylor. An
Introduction to Support Vector Machines and Other
Kernel-Based Learning Methods. Cambridge, UK:
Cambridge University Press, 2000.
[17] S. Karthik V.K and K. P. Soman, “Level Set
Methodology for Tamil Document Image Binarization
and Segmentation”, Int. Journal of Computer
Applications (IJCA), vol. 39, no. 9, 2012.
[18] M.T. El-Melegy and H. M. Mokhtar, “Tumor
segmentation in brain MRI using a fuzzy approach with
class center priors,” EURASIP Journal on Image and
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[19] Jason J. Corso, Eitan Sharon, and Alan Yuille,
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Classification with an Application to Brain Tumor
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[20] Dimitris N Metaxas, Zhen Qian, Xiaolei Huang and
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IRJET - An Efficient Approach for Multi-Modal Brain Tumor Classification using Texture Features and Machine Learning

  • 1. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 4995 An Efficient Approach for Multi-Modal Brain Tumor Classification using Texture Features and Machine Learning Ajay Samuel. A1, Dhiwakar. J2, Arkesh. J3, Dr. J. Arun Nehru4 1,2,3,4Computer Science and Engineering SRM Institute of Science and Technology, Chennai, India ------------------------------------------------------------------***------------------------------------------------------------- Abstract— In this paper, we propose an efficient approach for Multi-modal brain tumor classification using Texture features and Machine learning concepts. MICCAI BraTS 2016 datasets are utilized which are raw and skull-stripped and performed with high intensity. The project is divided into 3 primary modules such as Pre- processing, Feature extraction and classification of the brain tumor. We use techniques such as Fuzzy-c means clustering technique and further use region of interest properties for segmentation of the brain tumor. After the segmentation process, we use feature extraction techniques such as GLCM (Grey-level co-occurence matrix) and LBP (Local binary pattern) to record the outer shape and inner shape of the tumor by therefore extracting the following features such as Area, Density, Major axis, Minor axis length. The extracted features are then provided to the SVM (Support vector machine) classifier for classifying the tumor and categorizing it as BENIGN or MALIGNANT. Keywords—Brain tumor, Segmentation, Benign, Malignant 1. INTRODUCTION The detection and classification of Brain tumor is essential to decrease the number of casualties that are increasing each year. Brain tumor is a compound phenomenon in terms of controlling as well as curing it because of the complex structure of the brain. Tumor segmentation and classification is proven to be a challenging task and therefore less number of success rate has been achieved so far. Multi-Modal brain images has the ability to capture multiple images of the brain for a better result. Many researches based on mono- modality images had performed but the segmentation were not accurate. Recently, a notion of multi-modality images can segment brain tumor with high accuracy has been proved. MRI outputs multi-modal images with precise detection of the abnormality present in the brain. Brain tumor feature extraction and classification has received a huge amount of interest in the medical field over the past few years. Recent findings have stated that an individual with brain tumor should get immediate attention within hours of detection as the medication involved depends on each stage and type of the tumor. MRI images have proven to be a greater source for the classification of brain tumors. The culmination of Texture Features and Machine learning concepts that have been explored in the segmentation technique with further implications such as using clustering techniques and region properties can bring forth a better segmentation. Tumor regions can be distinguished from normal brain cells by comparing the concentration of density in the tumor cells. 2. LITERATURE REVIEW With the advancement of technology in the course of recent years, many methodologies have been proposed for brain tumor segmentation. Many research scholars and individuals have utilized various rationales and algorithms to execute their ideas in the field of medical sciences to segment the tumor. Brain tumor segmentation activities are widely encouraged by the Medical Sciences department to reduce the pathologist's workload and thereby benefit the patients by reducing the expenses spent on biopsy reports. 1. Title : Brain Tumor Detection using Image Segmentation Techniques Author : Dig vijay Reddy, Dheeraj, Kiran, Bhavana.V and Krishnappa H.K. Year : 2018 Description: The methodology presented in this work uses a two-step procedure for brain tumor detection that combines k-means clustering algorithm followed by level set segmentation and morphological operations. Experimental results have shown that, this methodology is robust in detecting and bounding the abnormal cells in MRI images despite the complicate shape of the tumor. This paper proposed a k-means clustering image processing algorithm for brain tumor detection only. 2. Title: Detection of human brain tumour using MRI image segmentation and morphological operators. Author: Anupurba Nandi Year: 2017 Description: In this paper the output image clearly shows the tumour cells have been separated from the healthy cells. The Threshold and Watershed segmentation is very simple and popular but using morphological operators is the new introduction to this problem which on applying
  • 2. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 4996 to the output image of other two provided a better detection of tumour. The factor used in thresholding is very difficult to determine because the factor used for one image may not work for other image. This factor may be different for different images. The watershed method has the disadvantage that it is highly sensitive to local minima, since at each minima, a watershed is created. This paper proposed a morphology based image processing algorithm for brain tumor detection only. 3 . Title: Segmentation of Brain Tumors in MRI Images Using Three-Dimensional Active Contour Edge. Author: Ali M. Hasan, Farid Meziane, Rob Aspin and Hamid A. Jalab. Year: 2015 Description: In this paper the proposed method can recognize and segment MRI brain abnormality on T2-w, T1-w, T1c-w, and FLAIR images. The 3DACWE segmentation technique reduces manual input, offers a rapid operation, and exhibits high accuracy compared with manual segmentation as evaluated. We conclude that the 3DACWE method is effective in brain tumor segmentation because the approach does not only consider local tumor properties, such as gradients, but also relies on global properties, such as intensity, contour length, and region length. Although the achieved accuracy was high relative to those of other segmentation techniques, the 3DACWE was relatively slow for brain tumor segmentation. Such a slow pace was ascribed to the processing of a massive number of MRI slices of 512 512 pixel resolution with a high number of iterations used to attain the required accuracy. This paper proposed a texture based image processing algorithm for detection of tumor only. 3. PROPOSED METHOD The proposed algorithm uses MICCAI BraTS dataset and the main flow of our proposed technique is presented in Fig.1 with further details present in following subsection. A. Pre-processing The pre-processing stage is the stage of rising operations involving images at the lowest abstraction level. The goal of the preprocessing stage is to process the image. All images are visualized through Read medical data 3D and segment the tumor using clustering techniques and to extract and classify the clustered image for better segmentation. Fig. 1 Block diagram of proposed method 1. Resizing the input image Input images are resized into an uniform size for reducing the distortion present (i.e) noise. Images that are processed without the default size can lead to distortion of the output, that would in return makes the segmentation to be less precise 2. Converting color format Resized input images will be further checked for clarification on whether the image is in RGB or Gray scale. They will be translated to Gray scale format with an appropriate value, unless the resized images are in RGB scale. For improved tumor segmentation the Gray Scale image is further transformed into the Black and White image. Fig. 2 Resized input image with gray scale conversion Fuzzy-c means clustering algorithm is one of the most commonly used clustering technique in the field of medical imaging. Clustering techniques are used to group the abnormal areas of the brain and these clustered abnormal images are used to extract the tumor by incorporating with region of interest properties such as area and density to distinguish the tumor region and detect the tumor.
  • 3. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 4997 Fig. 3 Fuzzy-c means segmentation B. Feature extraction Feature extraction is the process of masking the particular brain tumor part and extracting the tumor region to enhance the textures of the image. In feature extraction, texture features plays a major role in extracting spatial arrangement of color or intensities in the image or selected region in the image. For analyzing the texture features, Gray level co-occurrence matrix and Local binary pattern are used. Gray level co-occurrence matrix has features such as extraction of color, shape, skewness and so on. In gray level co-occurrence matrix, Homogeneity measures the closeness of the distribution of the elements in the inner ridges. Local Binary pattern represents the homogeneity involved in the distribution of elements in outer edges of the tumor. C. Classification Supervised classification is a machine learning approach in which training data are used to construct the model on unseen data to measure the performance of the algorithm. Support Vector Machine is the classifier used in this work to classify the data and categorizing it by Benign or Malignant. SVM is generally a binary classifier and can be used for both linear and non-linear operations. Linear operations is performed in this work as it involves multiclass operations and Support vector machine provides better classification in terms of multiclass operations. Extracted tumor images using texture features are produced to the SVM classifier which measures the performance of the algorithm with the unseen data. Fig. 4 Malignant tumor classification Fig. 5 Benign tumor classification 4. CONCLUSION This paper presented an hierarchial way of classifying the tumor into two types such as Benign or Malignant. Segmentation techniques, region properties and Texture features are extracted and utilized in the MRI images with SVM classifier. The use of Fuzzy-c segmentation with Region of interest properties has increased the segmentation accuracy which then contributed to better classification of the tumor. 5. ACKNOWLEDGEMENT We would like to express our gratitude to our guide, Dr. Arun Nehru, who guided us throughout the project and offered a deep insight into the study. We wish to
  • 4. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 4998 acknowledge the help provided by the technical and support staff in computer science department of SRM institute of science and technology. 7. REFERENCES [1] C. Gonzalez and R. E. Woods, “Digital image processing”, 2nd edition, Addison-Wesely, (2004). [2] Isaac N. Bankman, “Handbook of image processing and analysis”, 2nd edition, Elsevier, 2009. [3] Mallat S, Hwang W L. Singularity detection and processing with Wavelets [J]. IEEE Transactions on Information Theory, 38(2) : 617-643 (1992). [4] Chaplot, S.; Patnaik, L.M.; Jagannathan, N.R. (2006). Classification of magnetic resonance brain images using wavelets as input to support vector machine and neural network, Biomed. Signal Process Control, 1, 86–92. [5] Rafiee J, Rafiee MA, Prause N and Schoen , “ Wavelet basis functions in biomedical signal processing,” Expert System Appl 38,2011, Pages.6190– 6201. [6] Sugandha Agarwal1*, O.P. Singh1 and Deepak Nagaria, “Analysis and Comparison of Wavelet Transforms For Denoising MRI Image” in Biomedical & Pharmacology Journal, Vol. 10(2), 831-836 (2017). [7] Rajesh C. Patil, Dr. A. S. Bhalchandra, “Brain Tumour Extraction from MRI Images Using MATLAB” International Journal of Electronics, Communication & Soft Computing Science and Engineering ISSN: 2277- 9477, Volume 2, Issue 1. [8] Xu Y, Weaver B, Healy D M, et al. Wavelet transform domain filters: A spatially selective noise filtration technique [J]. IEEE Transactions on Image Processing, 3(6) : 217-237 (1994). [9] Monica Subashini.M , Sarat Kumar Sahoo , “Brain MR Image Segmentation for Tumour Detection using Artificial Neural Networks” ISSN : 0975-4024 Vol 5 No 2 Apr-May 2013. [10] S.Grace Chang, Bin Yu, Martin Vetterli , “Adaptive Wavelet Thresholding for image denoising and compression,” IEEE Transaction On Image Processing, 9(9), 2000. [11] Otsu, N., "A Threshold Selection Method from Gray-Level Histograms," IEEE Transactions on Systems, Man, and Cybernetics, Vol. 9, No. 1, 1979, pp. 62-66. [12] Miss Hetal J. Vala, Prof. AsthaBaxi, A Review on Otsu Image Segmentation Algorithm, International Journal of Advanced Research in Computer Engineering & Technology (IJARCET), ISSN: 2278 – 1323, Volume 2, Issue 2, February 2013. [13] Durgesh K. Srivatsa, LekhaBhambhu, “Data Classification Using Support Vector Machine”, Journal of Theoretical and Applied Information Technology, 2005- 2009. [14] Zhang, Yudong, and Lenan Wu. "An MR brain images classifier via principal component analysis and kernel support vector machine." Progress In Electromagnetics Research 130 (2012): 369-388. [15] Hastie, T., R. Tibshirani, and J. Friedman. The Elements of Statistical Learning, second edition. New York: Springer, 2008. [16] Christianini, N., and J. Shawe-Taylor. An Introduction to Support Vector Machines and Other Kernel-Based Learning Methods. Cambridge, UK: Cambridge University Press, 2000. [17] S. Karthik V.K and K. P. Soman, “Level Set Methodology for Tamil Document Image Binarization and Segmentation”, Int. Journal of Computer Applications (IJCA), vol. 39, no. 9, 2012. [18] M.T. El-Melegy and H. M. Mokhtar, “Tumor segmentation in brain MRI using a fuzzy approach with class center priors,” EURASIP Journal on Image and Video Processing, vol. 2014, article no. 21, 2014. [19] Jason J. Corso, Eitan Sharon, and Alan Yuille, “Multilevel Segmentation and Integrated Bayesian Model Classification with an Application to Brain Tumor Segmentation,” MICCAI 2006. [20] Dimitris N Metaxas, Zhen Qian, Xiaolei Huang and Rui Huang Ting Chen, Leon Axel, “Hybrid Deformable Models for Medical Segmentation and Registration,” Ninth International Conference on Control, Automation, Robotics and Vision, ICARCV 2006, Singapore, 2006. [21] AnishaRadhakrishna and Divya, M., “Survey of data fusion and tumor segmentation techniques using brain images”, International Journal of Applied Engineering Research, vol.10, 2015. [22] R. Hiralal and Menon, H. P., “A survey of brain MRI image segmentation methods and the issues involved”, Advances in Intelligent Systems and Computing, vol. 530, pp. 245-259, 2016. [23] Bhavana. V, Krishnappa H.K, “Multi-Modality Medical Image Fusion using Discrete Wavelet Transform”, 4th International Conference on Eco- friendly Computing and Communication Systems, ICECCS 2015, ELSEVIER Procedia Computer Science, pp.625- 631.