This document summarizes essential and non-essential elements in biological systems. It defines essential elements as those required for life that cause death or malfunction if absent. Examples include oxygen, hydrogen, nitrogen, calcium and phosphorus. Non-essential elements do not play a positive role if absent. The document further describes essential elements as either bulk elements, which are found at higher concentrations, or trace elements, which are needed at very low concentrations. It provides sodium, potassium, calcium, magnesium, iron, copper, cobalt, iodine, fluoride and zinc as examples of essential bulk and trace elements and describes their roles in biological processes. The document also discusses porphyrins, metalloporphyrins like heme and chlor
Bioinorganic Chemistry-Introduction,
Essential Elements,Functions of metal ions in biochemical process.Biochemistry Of Iron,Haemoglobin And Myoglobin,Biological Functions And Toxicity Of Some Elements
A brief introduction to lanthanide elements is given.
Order .ppts like this at <https://www.fiverr.com/anikmal/teamup-with-you-to-prepare-the-best-presentation>
Along with their physical and chemical properties are also shown. Helpful for quick understanding on lanthanide series.
Non-heme oxygen carrier proteins, Hemocyanin, Copper containing metalloprotein, Active site of deoxyhemocyanin and oxyhemocyanin, Oxidative addition of dioxygen, peroxide bridging, antiferromagnetic, Hemerythrin, Active site structure of deoxyhemerythrin and oxyhemerythrin, Comparison between hemoglobin, hemerythrin and hemocyanin
Bioinorganic Chemistry-Introduction,
Essential Elements,Functions of metal ions in biochemical process.Biochemistry Of Iron,Haemoglobin And Myoglobin,Biological Functions And Toxicity Of Some Elements
A brief introduction to lanthanide elements is given.
Order .ppts like this at <https://www.fiverr.com/anikmal/teamup-with-you-to-prepare-the-best-presentation>
Along with their physical and chemical properties are also shown. Helpful for quick understanding on lanthanide series.
Non-heme oxygen carrier proteins, Hemocyanin, Copper containing metalloprotein, Active site of deoxyhemocyanin and oxyhemocyanin, Oxidative addition of dioxygen, peroxide bridging, antiferromagnetic, Hemerythrin, Active site structure of deoxyhemerythrin and oxyhemerythrin, Comparison between hemoglobin, hemerythrin and hemocyanin
Metalloporphyrins with special reference to Iron porphyrins ( Haemoglobin and...ADITYA ARYA
Metalloporphyrins with special reference to Iron
porphyrins ( Haemoglobin and Myoglobin )
Porphyrins are one of the most important groups of
bioinorganic compounds in which a metal ion is
surrounded by the four nitrogens of porphin ring.
❑ Porphines are made of four pyrrole rings linked
together through methene bridges.
❑ Therefore, porphines have macrocylic pyrrole system
with conjugated double bonds as shown here:
❑ These porphines act as tetradentate ligands with four
nitrogen donor sites.
Two of these are tertiary nitrogen donor positions which can form
coordinate bonds by donating a pair of electrons each to the metal
ion.
❑ The other two are secondary nitrogen donor positions. each of
which lose a proton in forming a coordinate bond with a metal
ion.
❑ Thus, a porphin ring acts as a tetradentate dinegative ligand (or
dianion).
❑ Dipositive cations such as Mg2+ Fe2+ or Ni2+ are capable of
forming neutral complexes with porphine as shown here:
❑ Four pyrrole rings of porphin carrying substituents other than hydrogen
are called porphyrins. The complexes in which a metal ion is held in
the porphyrin ring system are called metalloporphyrins.
❑ Such complexes play a vital role in biological systems.
Comaparative study of lanthanides and actinidesRamyaR162
Comparison of Lanthanides and Actinides. Points of Similarities and difference. Both show close resemblance because these involve filling of f-subshells. Both have coloured ions, low electronegativity, high reactivity and show magnetic properties.
Quantum yield, experimental arrangement, reasons for high and low Quantum yield, problems, photochemical reactions, kinetics of photochemical decomposition of HI, photosensitized reaction, mechanism of photosensitization,
Introductory PPT on Metal Carbonyls having its' classification,structure and applications.This is a basic level PPT specially prepared for UG/PG Chemistry students.
Contains information about various crystal types in solid state chemistry like Rock Salt, Wurtzite, Nickel Arsenide, Zinc Blende etc. It also gives a brief description of lattice energy and Born Haber cycle.
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Metalloporphyrins with special reference to Iron porphyrins ( Haemoglobin and...ADITYA ARYA
Metalloporphyrins with special reference to Iron
porphyrins ( Haemoglobin and Myoglobin )
Porphyrins are one of the most important groups of
bioinorganic compounds in which a metal ion is
surrounded by the four nitrogens of porphin ring.
❑ Porphines are made of four pyrrole rings linked
together through methene bridges.
❑ Therefore, porphines have macrocylic pyrrole system
with conjugated double bonds as shown here:
❑ These porphines act as tetradentate ligands with four
nitrogen donor sites.
Two of these are tertiary nitrogen donor positions which can form
coordinate bonds by donating a pair of electrons each to the metal
ion.
❑ The other two are secondary nitrogen donor positions. each of
which lose a proton in forming a coordinate bond with a metal
ion.
❑ Thus, a porphin ring acts as a tetradentate dinegative ligand (or
dianion).
❑ Dipositive cations such as Mg2+ Fe2+ or Ni2+ are capable of
forming neutral complexes with porphine as shown here:
❑ Four pyrrole rings of porphin carrying substituents other than hydrogen
are called porphyrins. The complexes in which a metal ion is held in
the porphyrin ring system are called metalloporphyrins.
❑ Such complexes play a vital role in biological systems.
Comaparative study of lanthanides and actinidesRamyaR162
Comparison of Lanthanides and Actinides. Points of Similarities and difference. Both show close resemblance because these involve filling of f-subshells. Both have coloured ions, low electronegativity, high reactivity and show magnetic properties.
Quantum yield, experimental arrangement, reasons for high and low Quantum yield, problems, photochemical reactions, kinetics of photochemical decomposition of HI, photosensitized reaction, mechanism of photosensitization,
Introductory PPT on Metal Carbonyls having its' classification,structure and applications.This is a basic level PPT specially prepared for UG/PG Chemistry students.
Contains information about various crystal types in solid state chemistry like Rock Salt, Wurtzite, Nickel Arsenide, Zinc Blende etc. It also gives a brief description of lattice energy and Born Haber cycle.
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
We present an ab-initio real-time based computational approach to nonlinear optical properties in Condensed Matter systems. The equation of mot ions, and in particular the coupling of the electrons with the external electric field, are derived from the Berry phase formulation of the dynamical polarization. The zero-field Hamiltonian includes crystal local field effects, the renormalization of the independent particle energy levels by correlation and excitonic effects within the screened Hartree- Fock self-energy operator. The approach is validated by calculating the second-harmonic generation of SiC and AlAs bulk semiconductors : an excellent agreement is obtained with existing ab-initio calculations from response theory in frequency domain . We finally show applications to the second-harmonic generation of CdTe the third-harmonic generation of Si.
Reference :
Real-time approach to the optical properties of solids and nanostructures : Time-dependent Bethe-alpeter equation Phys. Rev. B 84, 245110 (2011)
Nonlinear optics from ab-initio by means of the dynamical Berry-phase
C. Attaccalite and M. Gruning Phys. Rev. B 88 (23), 235113 (2013)
The Role Of Transition Metals & Reactive Oxygen Species (ROS) In Alzheimer's ...Pırıl Erel
This powerpoint discusses the role of transition metals and amyloid plaque formation in Alzheimer’s disease (AD) and how metal ion chelators may be employed as therapeutic agents for AD. It describes the disorder, how it progresses and what happens to the brain tissue.
Furthermore, within the presentation I describe a drug which chelates metals including a description about the chemical formulation of these drugs and how the drug can be preventative of AD.
Essential and non-essential elements/types of essential elements-Bulk and trace elements/ Some important essential elements/their uses / role in biological processes.
Prepared for my college-Kanya Maha Vidyalaya,Jalandhar.
this matter useful for B.V.Sc student . Minerals ,their deficiency and their roles also available in this matter it is also useful for Animal nutritionist .
The minerals form only a small portion of the total body weight. They form only 7% of the composition of human body.
Many of these minerals are widely distributed in foods so that a well-balanced diet will supply them in sufficient quantities.
The mineral elements present in the animal body may be classified into 2 groups:
1.Principal elements(macro nutrients)
2.Trace elements(micro nutrients)
Protein is a macronutrient that is essential to building muscle mass. It is commonly found in animal products, though is also present in other sources, such as nuts and legumes. There are three macronutrients: protein, fats and carbohydrates. Macronutrients provide calories, or energy.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
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Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
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2. Essential & Non-Essential Elements
Essential elements are those elements
which are required for the
maintainance of life of plants
&animals.
Absence of these elements results in
death or a severe malfunction of the
organism.
ExampleOxygen,hydrogen,nitrogen,calcium,p
hosphorus etc.
Non essential elements are those
elements which don”t play any
positive role in biological systems.
Absence of these elements does not
affect the body of an organism.
4. Essential Bulk elements
SODIUM
Major cation of extra cellular fluid in
animals.
Important in nerve functioning in
animals.
Major component of vertebrate
blood.
NaCl helps in osmotic regulation of
body & tissue fluids.
Na+ ions also serves as essential
activating ions for specific enzyme
activity.
5. Potassium
Maintains the electrolyte balance in
your body's cells.
Manages your blood pressure
and keeps your heart functioning
properly.
Assists nervous system by aiding in
the correct function of tissues
needed for sending nerve impulses.
Aids in the waste removal process.
Enhances muscle control, the growth
and health of your cells.
6. Calcium & Magnesium
Present as carbonates &phosphates in
the skeletal structure of mammals as
about 99% of Ca2+ &70% Mg2+ .
Calcium essential for blood clotting.
Calcium stabilizes blood pressure.
Calcium contributes to normal brain
function.
Magnesium is required for all living cells It
is catalyst for numerous biological
reaction involving the release of energy.
Mg is a constituent of bone.
Magnesium presence in extracellular
regulates the transmission of nerve
impulses.
Also present in chlorophyll.
7. Essential Trace Elements
Iron
Iron is one of the metals found in greatest abundance in biological systems
in the form of porphyrin complexes such as haemoglobin & myoglobin.
Of total iron in the human body,70% is present in haemoglobin & about
3%in myoglobin.
Most of the remaining iron is stored as ferritin.
Ferritin is major iron storage protein in mammals but is also found in plant
chloroplasts.
Distributed mainly in spleen,liver &bone marrow.
8. Pathway of Fe2+ from food stuffs to haemoglobin and to
ferritin involves the following mechanism:-
I.
FE3+ OF DIETERY MATERIAL IS REDUCED TO FE2+ IN THE GASTROINTESTINAL TRACT.
II.
AFTER ABSORPTION INTO THE CELLS OF THE INTESTINAL MUCOSA,FE2+ IS INCORPORATED INTO FERRITIN AS
FE3+ .
III.
THE FE2+ IN MUCOSA IS ALSO CONVERTED TO FE3+ PLASMA.
IV.
PLASMA FE3+ IS IN EQUILIBRIUM WITH IRON IN THE LIVER,SPLEEN & BONE MARROW.
9. Copper
Cu Is a constituent of redox enzymes &hemocyanin.
The Cu in hemocyanin protein is oxygen carrier & supplies oxygen to
certain aquatic creatures &redox enzymes.
Cu containing enzymes plays an important role in the pigmentation of
skin,functioning of brain &in iron,metabolism in body in hemoglobin
formation.
Deficiency of cu in human system develops an Anemia.
Because of excess of copper,a person suffers from Wilson’s disease.
Wilson”s disease:-
Autosomal recessive genetic disorder with onset in the 2ndor 3rd decade.
Onset in children aged 4-5yrs is also reported but rarely.
Excess Cu is deposited in excess in the liver,kidney or brain.
10. Cobalt-: Cobalt is also essential trace element which is essential
for many organisms including mammals.
A.)Activates number of enzymes.
B.) Highly toxic to plants.
Iodine
A. Iodine is critical for formation of thyroid hormones T3, or
triiodothyronine, and T4, or thyroxine.
B. Inadequate production of thyroid hormones can cause
enlargement of the thyroid gland, also known as goiter, while its
deficiency during pregnancy can cause irreversible brain
damage in newborns.
Fluoride
A. Well recognized for its role in forming bones and teeth, fluoride
is present in the body as calcium fluoride.
B. Fluoride hardens tooth enamel, reduces incidence of tooth
decay and may prevent bone loss.
11. Zinc
In addition to its role in formation of
enzymes, zinc improves immune function, helps
clot blood, maintains sense of taste and smell.
keepYou can obtain sufficient amounts of zinc
by regularly eating eggs, seafood, red
meats, fortified cereals and whole grains.
Skin healthy and enables normal growth and
development.
Chromium and Selenium
Chromium is an important trace mineral that is
necessary for normal functioning of insulin, a
hormone that maintains blood sugar levels.
It is also essential for metabolism of
carbohydrates, proteins and fats.
Some important sources of chromium include
liver, processed meats, brewer’s yeast, whole
grains, cheese and nuts.
Selenium, along with vitamin E works as an
antioxidant that prevents damage of cells, may
prevent some cancers and is essential for the
normal functioning of the thyroid gland.
Meat, seafood, nuts and cereals are good
sources of selenium.
12.
NICKEL
•
ESSENTIAL TRACE ELEMENT FOR PLANT UREASES.
•
DEFICIENCY IN FOOD SLOWS DOWN THE FUNCTIONING OF LIVER IN CHICKS &RATS RAISED ON DEFICIENT
DIET.
•
HIGHLY TOXIC TO MOST PLANTS & MODERATELY TOXIC TO MAMMALS.
•
CARCINOGENIC IF PRESENT IN LARGE CONC. IN BIOLOGICAL SYSTEMS.
ARSENIC:-
•
ULTRATRACE ELEMENT IN RED ALGAE,CHICK,RAT,PIG,GOAT &SOME MAMMALS INCLUDING HUMANS.
•
DEFICIENCY IN CHICKS RESULTS IN DEPRESSED GROWTH.
•
MODERATELY TOXIC TO PLANTS &HIGHLY TOXIC TO MAMMALS WHEN PRESENT IN MORE THAN ULTRA
TRACE ELEMENTS.
13. Porphyrins &Metalloporphyrins
Porphines are macrocyclic rings made of four pyrolle rings linked
together through methane bridges.these porphines have pyrolle
system with double bonds.therefore act as tetradentate ligands with
nitrogen donor sites.
Two of these are tertiary nitrogen donor positions which can form
coordinating bonds by donating a pair of electrons each to the metal
ion.
The other two are secondary nitrogen donor positions,each of which
can lose a proton in forming a coordinate bond with a metal ion.
Porphin Ligand(porphine)
Thus,a porphin ring can act a a tetradentate dinegative ligand.
When the four pyrolle rings of porphin carry substituents other than
hydrogens,these are called porphyrins.
These substituents are usually organic groups with electron
withdrawing or electron donating characteristics.
The complexes in which a metal ion is held in the porphyrin ring
system are called Metalloporphyrins.
The porphyrin ring system is rigid because of the delocalization of
electrons in the pyrolle rings.
Metal complex with
The nature of metalloporphyrins vary with the nature of the metal ion porphin ligand
&the type of organic substituents on the porphyrin structure.
14. Heme is an iron porphyrin which is present in hemoglobin and myoglobin.
Chlorophyll is magnesium complex of porphyrin which plays important role in
the process of photosynthesis.
Photosynthesis is an important redox reaction occurring in nature to convert
water & Carbon dioxide into carbohydrates &oxygen in the presence of solar
energy.
PHOTOSYNTHESIS PROCESS
In this metalloporphyrin,in addition to substituents,a double bond in one of the
pyrolle rings is reduced to form magnesium dyhydrido porphyrin complex as
16. Hemoglobin is a large protein with a
molecular weight of about 64500.
Consists of four subunits each of
which contains one heme group
associated with protein globin.
Therefore,there are 4 heme groups
bonded to four protein chains.one
heme group with its protein is called
subunit.
Froms alpha chains of 141 amino
acids&two forms beta chains of 146
amino acids.
An outline structure of
17.
Myoglobin is relatively a small protein of
molecular weight of about 17000.
Consists of one polypeptide chain (globin)
with one heme group (iron porphyrin
complex) embedded their in.
The peptide chain consists of 150-160 amino
acid residues folded about the single heme
group as shown in figure.
Heterocyclic ring system of heme is porphyrin
derivative containing 4 pyrolle rings labelled
as A,B,C,D joined by methane bridges.
The Fe atom present at the centre of the heme
is bonded by four porphyrin nitrogen atoms
&one nitrogen atom from imidazole side chain
of histidine residue.
Polypeptide chain plays an important role in
biological fixation of Oxygen.
18. ROLE OF HEMOGLOBIN & MYOGLOBIN
Hemoglobin &myoglobin plays very important role in transporting oxygen from lungs to
tissues & Carbon dioxide.
I.
II.
III.
IV.
V.
VI.
Oxygen is inhaled into the lungs at very high pressure where
it binds Hb in the blood forming HbO2.
The oxygen is then transported to respiring tissues whre the
partial pressure of O2 is low.
The O2 then dissociates from Hb & diffuses to the tissues
where myoglobin picks it up &stores until it is needed.
Myoglobin has a great affinity for O2 then Hb.
This increases the rate od diffusion of O2 from the capillaries
to the tissues by increasing its solubility.
The Hb & CO2 (as HCO3- ) are then returned to the lungs
where CO2 is exhaled.
19.
20. • The main function of hemoglobin is to bind O2 at high partial
O2 at high partial
pressure of O2 found in the lungs &then carry it without any loss
O2 found in the lungs &then carry it without any loss
through the blood to the tissues where myoglobin picks up O2
O2
from Hb.
• In the lungs,where the pressure of O2 is high &much O2 isis
O2 is high &much O2
bound,the affinity of heme fro O2becomes very high . .
O2 becomes very high
• But when Hb reaches the cells where the pressure of O2 is low &
O2 is low &
O2begins to dissociate from the complex.
O2 begins to dissociate from the complex.
• This information is passed on so that the remaining heme groups
also unload their O2 groups.
O2 groups.
• The myoglobin picks up all the O2.
O 2.
• Since myoglobin has only one heme group .it does not have any
cooperative binding so it does not lose its affinity fro O2.this shows
O2.this
shows that myoglobin has higher affinity then Hb at low partial
that myoglobin has higher affinity for O2 for O2 then Hb at low
partial pressure of O2 in the muscle.
pressure of O2 in the muscle.
21. • Myoglobin has only one heme group per molecule &the binding
between the iron &the oxygen molecule is similar to that in Hb but
the equilibrium is simpler because only one oxygen molecule is
bound.
Its very interesting to study the oxygenation behavior vs oxygen
pressure Po under physiological conditions for myoglobin & Hb.
2
22. The reversible binding of O2 to Mb may be represented by the simple equilibrium
reaction:-
Mb + O
MbO ……..(1)
2
2
The equilibrium constant K may be expressed as:-
K = [MbO ]
[Mb] [O ]
2
2
or
K= [MbO ] ……………………(2)
[Mb]P
(P = Equilibrium partial pressure of oxygen)
2
23. Let us define a term fractional oxygen saturation ,θ which represents the Ratio of the
concentration of the Mb present as MbO2 to the total concentration of Mb. i.e.
θ = [MbO ]
…………….(3)
[Mb]+[MbO ]
2
2
From eq. (2) & (3),we get,
θ
K= θ
(1-θ)P
=
KP
1+KP
24. This is the equation for the hyperbolic curve .This curve shows that as partial pressure of O
increases,more of O2 binds to Mb.At very high partial pressure of O2,almost all the O2
binding sites are occupied &Mb is said to be saturated with O2.At a partial pressure of
2.88 torr,Mb is half saturated with O2. When Mb is half saturated θ is 0.5 so that partial
pressure of oxygen, P1/2 is
K = θ
(1-θ)P1/2
K = 0
(1-0.5)P1/2
K =1
P1/2
25. P1/2 (O ) = 1
K
2
Thus,at 0.5 or 50% saturation ,K is defined as inverse of partial
pressure of O2 at 50% saturation (θ =0.5)
Hb having four subunits has more complex behavior.Fractional
oxygen saturation in case of Hb is given by the expression :
θ =
kPn
1+kPn
The exact value of n depends upon the pH.The
shape of the Hb binding curve is not like the hyperbolic
curve of Mb.The HbO2 binding curve is described by
26.
27. Bohr”s Effect
The variation of oxygen affinity with the pH of
the medium is called Bohr”s effect.
It is also called pH sensitivity effect.
According to this effect,the affinity of Hb for
O2 decreases with decreasing pH.
However,blood is buffer so that the decrease
in pH is very small with accumulation of CO2
in muscules.
The decreasing affinity of Hb for O2 with
decreaing pH is shown in graph.
Bohr “s effect has important physiological
effect in transporting O2 from the lungs to the
respiring tissues &in transporting CO2
produced there back to lungs.
The CO2 produced diffuses from the muscles
tissues to the capillaries & dissolved CO2 forms
bicarbonate only very slowly.