The document provides an overview of dengue fever and HIV/AIDS. It discusses the causative agents, modes of transmission, clinical manifestations, pathogenesis, diagnosis and treatment of both diseases. Dengue is caused by the dengue virus and transmitted by mosquitoes. It can present as undifferentiated fever or dengue hemorrhagic fever. HIV is a retrovirus that causes AIDS by destroying CD4+ T cells. It is most commonly transmitted through unprotected sex or needle sharing and progresses to immunosuppression over many years.
Lec 1. introduction to infectious diseaseAyub Abdi
Introduction to the infectious disease, how they transmitt and the stratigies used for the management of infectious disease because it's more in tropical and subtropicals
The lecture gives concise review about the main four groups of viruses causing hemorrhagic fever i.e. Flavivirues, Filoviruses, Arenaviruses and Bunyaviruses.
Legionellosis is a respiratory disease caused by Legionella bacteria.
The term“legionellosis” may be used to refer to either Legionnaires’ disease or Pontiac fever.
https://www.cdc.gov/legionella/index.html
Escherichia coli species are components of the
Normal animal and human colonic flora;
Flora of a variety of environmental habitats, including long-term care facilities (LTCFs) and hospitals.
E.coli are the cause of most nosocomial infections.
At the end of the session, the students shall be able to
Describe the HIV AIDS introduction, epidemiology of HIV AIDS, diagnosis of HIV AIDS, treatment of HIV AIDS and prevention control of HIV AIDS.
Lec 1. introduction to infectious diseaseAyub Abdi
Introduction to the infectious disease, how they transmitt and the stratigies used for the management of infectious disease because it's more in tropical and subtropicals
The lecture gives concise review about the main four groups of viruses causing hemorrhagic fever i.e. Flavivirues, Filoviruses, Arenaviruses and Bunyaviruses.
Legionellosis is a respiratory disease caused by Legionella bacteria.
The term“legionellosis” may be used to refer to either Legionnaires’ disease or Pontiac fever.
https://www.cdc.gov/legionella/index.html
Escherichia coli species are components of the
Normal animal and human colonic flora;
Flora of a variety of environmental habitats, including long-term care facilities (LTCFs) and hospitals.
E.coli are the cause of most nosocomial infections.
At the end of the session, the students shall be able to
Describe the HIV AIDS introduction, epidemiology of HIV AIDS, diagnosis of HIV AIDS, treatment of HIV AIDS and prevention control of HIV AIDS.
A comprehensive description of leischmaniasis with its types, transmission, epidemiology, pathogenesis, prevention and control. It also includes details regarding lab diagnosis, disease agent, vector and host.
Internal Medicine Board Review - Infectious Disease Flashcards - by KnowmedgeKnowmedge
Internal Medicine Board Review Flashcards - This eBook contains 50 Infectious Disease Flashcards. The Flashcards are review questions and can be used to study for medical board exams including the USMLE Step Exams and the ABIM Internal Medicine Exam. More questions can be found at www.knowmedge.com
A mosquito-borne viral disease occurring in tropical and subtropical areas.
Those who become infected with the virus a second time are at a significantly greater risk of developing severe disease.
Symptoms include high fever, headache, rash and muscle and joint pain. In severe cases there is serious bleeding and shock, which can be life threatening.
Treatment includes fluids and pain relievers. Severe cases require hospital care.
a quick review of the articles issued by WHO, CDC and other medical experts...
>>>
on its epidemiology, etiology, clinical manifestations, diagnosis, management and prevention.
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
3. S. pneumoniae , H. influenzae , N. meningitidis Purpura fulminans Rickettsia rickettsii Rocky Mountain spotted fever N. meningitidis Meningococcemia Petechiae: Sepsis with skin findings Erythroderma: toxic shock syndrome Group A Streptococcus , Staphylococcus aureus
19. Unusual Presentations of Severe Dengue Fever ~Encephalopathy ~Hepatic damage ~Cardiomyopathy ~Severe gastrointestinal hemorrhage
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21. Tourniquet Test ~Inflate blood pressure cuff to a point midway between systolic and diastolic pressure for 5 minutes ~Positive test: 20 or more petechiae per 1 inch² (6.25 cm²)
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23. TREATMENT: Outpatient Triage ~No hemorrhagic manifestations and patient is well-hydrated: home treatment ~Hemorrhagic manifestations or hydration borderline: outpatient observation center or hospitalization ~Warning signs (even without profound shock) or DSS: hospitalize
24. Treatment of Dengue Fever ~Fluids ~Rest ~Antipyretics (avoid aspirin and non-steroidal anti- inflammatory drugs) ~Monitor blood pressure, hematocrit, platelet count, level of consciousness ~Continue monitoring after defervescence ~If any doubt, provide intravenous fluids, guided by serial hematocrits, blood pressure, and urine output ~The volume of fluid needed is similar to the treatment of diarrhea with mild to moderate isotonic dehydration (5%-8% deficit)
26. Acquired Immune Deficiency Syndrome (AIDS) ~1st recognized in the U.S. in 1981 when Center for Disease Control (CDC) reported the unexplained occurrence of Pneumocystis carinii pneumonia in 5 previously healthy homosexual men in Los Angeles ~Kaposi’s sarcoma (KS) was also noted in 26 previously healthy homosexual men in New York and L.A. ~1983 – HIV was isolated from pxs with lymphadenopathy ~1984 – clearly demonstrated as causative agent of AIDS ~1985 – ELISA was developed leading to appreciation of the scope and evolution of HIV epidemic in the U.S. and other nations
27. Definition ~currently, CDC classification system for HIV-infected adolescents and adults categorizes persons on the basis of clinical conditions associated with HIV infections and CD4+ T lymphocyte count ~the system is based on 3 ranges of CD4+ T lymphocyte counts and 3 clinical categories and is represented by a matrix of nine mutually exclusive categories
28. 1993 Revised classification System for HIV Infection and Expanded AIDS Surveillance Case Definition for Adolescents and Adults Clinical Categories CD4+ T Cell categories A Asymptomatic, Acute(Primary) HIV or PGL B Symptomatic, Not A or C Conditions C AIDS-Indicator Conditions >500/µL A1 B1 C1 200-499/µL A2 B2 C2 <200/µL A3 B3 C3
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41. Pathophysiology and Pathogenesis - hallmark is profound immunodeficiency resulting from progressive qualitative and quantitative -deficiency of the subset of t helper cells or inducer cells with CD4 molecule on its surface w/c serves as primary cellular receptor for HIV
42. Clinical Manifestations a.Acute HIV syndrome - in 50%-70% of indiv. with primary infection - high levels of viremia measured in million of copies of HIV RNA/ml that last for several wks. - 3-6 weeks after primary infection - fever, pharyngitis, lmphadenopathy, meningitis, encephalitis, mucocutaneous ulceration - Most will recover spontaneously w/ mildly depressed CD4+ T cells
43. b.Asymptomatic stage - Median time for untreated pats. - 10 yrs. - Rate of progression is directly correlated w/ HIV RNA levels c.Symptomatic dse - More severe & life threratening complic. of HIV infec. occurs with CD4+ T cell counts <200/µL - 60% of deaths among - due to P. carinii & viral hepatitis
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45. - Oropharynx and GIT * Thrush - candida * Hairy leukoplakia - EBV * Aphthous ulcers * Esophagitis * Diarrhea cauased by Shigella,Salmonella, * Shigella, Campylobacter -Kidney and GUT * HIV-assoc. nephropathy * dysuria, heamturia or pyuria * Condyloma lata – most common presentation of syphilis in HIV pats.
46. Advanced HIV dis. - CD4+ T cells count falls below a critical level <200/µL & pat. becomes susceptible to opportunistic dse Long term nonprogressors Those who had been infected with HIV for long periods (>10yrs) whose CD4 + T cell counts move w/in normal range & remained stable over the years who had not received antiretroviral tx
47. Diagnosis and Lab Monitoring depends on demonstrations of Ab to HIV & or direct detection of HIV or one of its components ELISA - enzyme immunoassay (EIA) - standard screening test - Sensitivity 99.5%, - nonspecific - 10% of EIA (+) pat . developed HIV infec.
48. Western blot - Confirmatory test If western blot patterns of reactivity do not fall into the (+) or (-) categories - considered “indeterminate” - can be repeated in one month HIV RNA levels – determine the prognosis and assess the response to antiviral tx P24 antigen capture assay – detects viral protein p24 in blood PCR, Nucleic acid sequenced based assay
53. Types: * Influenza A - isolated in 1933 - most severe type causing pandemics - hosts are humans, swine, horses * Influenza B - isolated in 1939 - usually mild illness * Influneza C - isolated in 1950 usually no s/s
54. INFLUENZA A ~ classified by Hemagglutinin (H) & Neuraminidase (N) sub-types ~ Current circulating strains: H1N1 & H3N2 ~ Human subtypes include H1N1, H3N2, H1N2, & H2N2 ~ Avian subtypes: H1 to H15 & N1 to N9 ~ Bird human H5N1, H9N2, H7N7, H7N2, H7N3
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57. AVIAN INFLUENZA IN BIRDS ~ carry the viruses in their intestines ~ shed the virus in their saliva, nasal secretions, & feces ~ contact with contaminated secretions or excretions or w/ surfaces that are contaminated w/ secretions ~ Domestic birds infected w/ direct contact w/ infected waterfowl or poultry ~ contact w/ surfaces (dirt/cages) or materials contaminated w/ virus
58. AVIAN INFLUENZA IN HUMANS ~ Risk is low; usually do not infect humans ~ From contact with infected poultry or surfaces contaminated with secretions/excretions from birds ~ Spread of avian virus from one person to another has been very rare