Bovine herpes virus causes a highly infectious disease in cattle and buffaloes known as rhinotracheitis. Clinical signs include fever, respiratory issues like coughing and nasal discharge, eye discharge and inflammation, oral lesions, diarrhea, abortion, and neurological issues in young calves. Treatment involves antibiotics and symptom relief while vaccination uses modified live vaccines in young calves to prevent disease spread.
Bovine herpesvirus 1 (BHV-1) is associated with several diseases in cattle: infectious bovine rhinotracheitis (IBR), infectious pustular vulvovaginitis (IPV), balanoposthitis, conjunctivitis, abortion, encephalomyelitis, and mastitis.
Bovine herpesvirus 1 (BHV-1) is associated with several diseases in cattle: infectious bovine rhinotracheitis (IBR), infectious pustular vulvovaginitis (IPV), balanoposthitis, conjunctivitis, abortion, encephalomyelitis, and mastitis.
Lumpy skin disease is an infectious, eruptive, occasionally fatal disease of cattle characterized by nodules on the skin and other parts of the body. Secondary bacterial infection often aggravates the condition. Traditionally, lumpy skin disease is found in southern and eastern Africa, but in the 1970s it extended northwest through the continent into subSaharan west Africa. Since 2000, it has spread to several countries of the Middle East and in 2013 extended west into Turkey and several countries in the Balkans. More recently, outbreaks of lumpy skin disease were reported for the first time in Georgia, Russia, Bangladesh, and the People's Republic of China. The recent geographic spread of lumpy skin disease has caused international concern. The disease has not been recorded in the Western hemisphere or in Australia or New Zealand.
Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants.
It is caused by the bacterium Mycobacterium avium subspecies paratuberculosis.
Infections normally affect ruminants (mammals that have four compartments of their stomachs, of which the rumen is one),
but have also been seen in a variety of non ruminant species, including rabbits, foxes, and birds. Horses, dogs, and nonhuman primates have been infected experimentally.
Paratuberculosis is found worldwide
Blue tongue is a non-contagious, infectious, arthropod-borne viral disease of sheep, goat, cattle and deer, with a worldwide distribution. Initially, the disease was reported in sheep in South Africa in 1881 and it was ascribed as “epizootic catarrh”. In 1905, the disease was renamed as “blue tongue”. In India, the first outbreak of blue tongue disease in sheep and goat was reported by Sapre (1964) from Maharashtra. It is listed under category ‘A’ of disease by OIE. The presence of this disease disrupts international commerce by putting a trade barrier on the movement of animals, their germplasm as well as animal products (OIE Bulletin, 1998).
Bluetongue is an infectious arthropod-borne viral disease primarily of domestic and wild ruminants. Infection with bluetongue virus (BTV) is common in a broad band across the world, which until recently stretched from ~35°S to 40°–50°N. Bluetongue virus is the type-species of the genus Orbivirus in the family Reoviridae. The geographic restriction is in part related to the climatic and environmental conditions necessary to support the Culicoides vectors.
Canine parvovirus (CPV) is a highly contagious and relatively common cause of acute, infectious GI illness in young dogs. Although its exact origin is unknown, it is believed to have arisen from feline panleukopenia virus or a related parvovirus of nondomestic animals
Fowl typhoid is a septicemic acute or chronic disease of domesticated birds.
The disease is worldwide distributed and natural outbreaks occur in chickens, turkeys, guinea fowl, peafowl, duckling and game birds such as quail, grouse and pheasant.
This can cause mortality in birds of any age.
Broiler parents and brown-shell egg layers are especially susceptible.
Pseudorabies is an acute, frequently fatal disease with a worldwide distribution that affects swine primarily and other domestic and wild animals incidentally. The pseudorabies virus has emerged as a significant pathogen in the USA since the 1960s, probably because of the increase in confinement swine housing or perhaps because of the emergence of more virulent strains. Clinical signs in nonporcine animals are similar to those of rabies, hence the name “mad itch” (pigs do not display this sign). Pseudorabies is a reportable disease and has been successfully eradicated from the vast majority of the USA.
Lumpy skin disease is an infectious, eruptive, occasionally fatal disease of cattle characterized by nodules on the skin and other parts of the body. Secondary bacterial infection often aggravates the condition. Traditionally, lumpy skin disease is found in southern and eastern Africa, but in the 1970s it extended northwest through the continent into subSaharan west Africa. Since 2000, it has spread to several countries of the Middle East and in 2013 extended west into Turkey and several countries in the Balkans. More recently, outbreaks of lumpy skin disease were reported for the first time in Georgia, Russia, Bangladesh, and the People's Republic of China. The recent geographic spread of lumpy skin disease has caused international concern. The disease has not been recorded in the Western hemisphere or in Australia or New Zealand.
Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants.
It is caused by the bacterium Mycobacterium avium subspecies paratuberculosis.
Infections normally affect ruminants (mammals that have four compartments of their stomachs, of which the rumen is one),
but have also been seen in a variety of non ruminant species, including rabbits, foxes, and birds. Horses, dogs, and nonhuman primates have been infected experimentally.
Paratuberculosis is found worldwide
Blue tongue is a non-contagious, infectious, arthropod-borne viral disease of sheep, goat, cattle and deer, with a worldwide distribution. Initially, the disease was reported in sheep in South Africa in 1881 and it was ascribed as “epizootic catarrh”. In 1905, the disease was renamed as “blue tongue”. In India, the first outbreak of blue tongue disease in sheep and goat was reported by Sapre (1964) from Maharashtra. It is listed under category ‘A’ of disease by OIE. The presence of this disease disrupts international commerce by putting a trade barrier on the movement of animals, their germplasm as well as animal products (OIE Bulletin, 1998).
Bluetongue is an infectious arthropod-borne viral disease primarily of domestic and wild ruminants. Infection with bluetongue virus (BTV) is common in a broad band across the world, which until recently stretched from ~35°S to 40°–50°N. Bluetongue virus is the type-species of the genus Orbivirus in the family Reoviridae. The geographic restriction is in part related to the climatic and environmental conditions necessary to support the Culicoides vectors.
Canine parvovirus (CPV) is a highly contagious and relatively common cause of acute, infectious GI illness in young dogs. Although its exact origin is unknown, it is believed to have arisen from feline panleukopenia virus or a related parvovirus of nondomestic animals
Fowl typhoid is a septicemic acute or chronic disease of domesticated birds.
The disease is worldwide distributed and natural outbreaks occur in chickens, turkeys, guinea fowl, peafowl, duckling and game birds such as quail, grouse and pheasant.
This can cause mortality in birds of any age.
Broiler parents and brown-shell egg layers are especially susceptible.
Pseudorabies is an acute, frequently fatal disease with a worldwide distribution that affects swine primarily and other domestic and wild animals incidentally. The pseudorabies virus has emerged as a significant pathogen in the USA since the 1960s, probably because of the increase in confinement swine housing or perhaps because of the emergence of more virulent strains. Clinical signs in nonporcine animals are similar to those of rabies, hence the name “mad itch” (pigs do not display this sign). Pseudorabies is a reportable disease and has been successfully eradicated from the vast majority of the USA.
Ranikhet disease, also known as Newcastle disease, is a viral disease that affects birds, especially poultry. It can cause respiratory, nervous, and digestive symptoms, leading to high mortality rates in infected flocks.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
10. Cause
*bovine herps virus
-it is highly infectious disease of cattle & buffaloes
*ch` clinically by:
-rhinotracheitis -conjunctivitis
-fever -encephalitis -abortion
***highly fatal in calves less than 2 weeks of age
Clinical signs:
1-respiratory form:
●fever (40-42 c) , shallow rapid respiration
●persistant cough & dyspnoea
●serous to mucopurulent nasal discharge
●hyperemia & hemorrhagic focal necrosis of nasal mucosa
(red nose)ْ
11. 2-occular form:
●bilateral conjunctivitis ( congestion & swelling)
●keratoconjunctivitis – corneal opacity (at corneo-
sclearal junction)
●serous to mucopurulent occular discharge
3-enteric form (in newly born calves)
●fever , anorexia , dullness...............etc
●erosion & ulceration of oral cavity
●diarrhea
4-abortion in 5-9 month of pregnancy
5-encephalitis ( in calves less than 6 month of age) → in
co-ordination , excitment , bellowing , convulsion &
blindness
6-infectious valvo-vaginitis (IPV(
7-infectious pustular balanopothitis(IPB(
12. Treatment
Broad spectrum antibiotic & symptomatic treatment for the
respiratory signs
Vaccination
a-modified live attinuated vaccine:
-contraindicated in pregnant animal ( cause abortion)
-given by I/M injection
-given to calves at 6 m` of age
b-killed vaccine:
-avilable in combination with PI3 , B.V.D & resp.synctial virus
-given to calves → I/M → 2 dose ( 5 ml in each dose)
→ 2 weeks interval
