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Hormonal Control of
Gastrointestinal
Motility
Prepared by Fatima sundus
Gastrin is secreted by the “G” cells of the antrum of the
stomach
Gastrin is secreted in response to stimuli
associated with
1. Ingestion of a meal
2. distention of the stomach
3. the products of proteins,
4. gastrin releasing peptide(GIP), which is
released by the nerves of the gastric
mucosa during vagal stimulation.
The primary actions of gastrin are
(1) stimulation of gastric acid (HCL) secretion
(2) stimulation of growth of the gastric mucosa
Cholecystokinin (CCK) is secreted by “I” cells in the mucosa of the duodenum
and jejunum
CCK secreted mainly in response to digestive products of fat, fatty acids, and
monoglycerides in the intestinal contents.
1.This hormone strongly contracts the
gallbladder, expelling bile into the small
intestine, where the bile in turn plays important
roles in emulsifying fatty substances
2.CCK also inhibits stomach contraction
moderately.
3.CCK also inhibits appetite to prevent overeating
during meals by stimulating
4.sensory afferent nerve fibers in the duodenum;
these fibers, in turn, send signals by way of the
vagus nerve to inhibit feeding centers in the
brain
Secretin was the first gastrointestinal hormone discovered
secretin is secreted by the “S” cells in the mucosa of
the duodenum
Secretin is secreted in response to acidic gastric juice emptying
into the duodenum from the pylorus of the stomach.
Secretin has a mild effect on motility of the gastrointestinal tract and acts to
promote pancreatic secretion of bicarbonate, which in turn helps to neutralize the
acid in the small intestine
Gastric inhibitory peptide (GIP) is secreted by the mucosa of the upper small
intestine
• mainly in response to fatty acids and amino acids but to a lesser extent in
response to carbohydrate.
• It has a mild effect in decreasing motor activity of the stomach and
therefore slows emptying of gastric contents into the duodenum when the
upper small intestine is already overloaded with food products.
• GIP, at blood levels even lower than those needed to inhibit gastric motility,
also stimulates insulin secretion and for this reason is also known as glucose
dependent insulinotropic peptide
Motilin is secreted by the stomach and upper duodenum during fasting
The only known function of this hormone is to increase gastrointestinal
motility.
Motilin is released cyclically and stimulates waves of gastrointestinal motility
called interdigestive myoelectric complexes that move through the stomach
and small intestine every 90 minutes in a fasted person
Motilin secretion is inhibited after ingestion
Hormonal Control of Gastrointestinal Motility (1).pptx
Hormonal Control of Gastrointestinal Motility (1).pptx

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Hormonal Control of Gastrointestinal Motility (1).pptx

  • 2.
  • 3.
  • 4. Gastrin is secreted by the “G” cells of the antrum of the stomach
  • 5. Gastrin is secreted in response to stimuli associated with 1. Ingestion of a meal 2. distention of the stomach 3. the products of proteins, 4. gastrin releasing peptide(GIP), which is released by the nerves of the gastric mucosa during vagal stimulation.
  • 6.
  • 7. The primary actions of gastrin are (1) stimulation of gastric acid (HCL) secretion (2) stimulation of growth of the gastric mucosa
  • 8.
  • 9. Cholecystokinin (CCK) is secreted by “I” cells in the mucosa of the duodenum and jejunum
  • 10. CCK secreted mainly in response to digestive products of fat, fatty acids, and monoglycerides in the intestinal contents.
  • 11. 1.This hormone strongly contracts the gallbladder, expelling bile into the small intestine, where the bile in turn plays important roles in emulsifying fatty substances 2.CCK also inhibits stomach contraction moderately. 3.CCK also inhibits appetite to prevent overeating during meals by stimulating 4.sensory afferent nerve fibers in the duodenum; these fibers, in turn, send signals by way of the vagus nerve to inhibit feeding centers in the brain
  • 12.
  • 13.
  • 14.
  • 15. Secretin was the first gastrointestinal hormone discovered secretin is secreted by the “S” cells in the mucosa of the duodenum
  • 16. Secretin is secreted in response to acidic gastric juice emptying into the duodenum from the pylorus of the stomach.
  • 17. Secretin has a mild effect on motility of the gastrointestinal tract and acts to promote pancreatic secretion of bicarbonate, which in turn helps to neutralize the acid in the small intestine
  • 18.
  • 19.
  • 20. Gastric inhibitory peptide (GIP) is secreted by the mucosa of the upper small intestine • mainly in response to fatty acids and amino acids but to a lesser extent in response to carbohydrate. • It has a mild effect in decreasing motor activity of the stomach and therefore slows emptying of gastric contents into the duodenum when the upper small intestine is already overloaded with food products. • GIP, at blood levels even lower than those needed to inhibit gastric motility, also stimulates insulin secretion and for this reason is also known as glucose dependent insulinotropic peptide
  • 21.
  • 22.
  • 23. Motilin is secreted by the stomach and upper duodenum during fasting The only known function of this hormone is to increase gastrointestinal motility. Motilin is released cyclically and stimulates waves of gastrointestinal motility called interdigestive myoelectric complexes that move through the stomach and small intestine every 90 minutes in a fasted person Motilin secretion is inhibited after ingestion