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Heart Failure 
Noha Khalil , MD
Definition 
 Heart failure is a clinical syndrome usually due 
to left ventricular dysfunction, resulting in acute 
or chronic symptoms of cardiac pump failure.
Aetiology 
 The most common causes of heart failure are 
coronary heart disease, hypertension, alcohol 
abuse, and idiopathic dilated cardiomyopathy 
 Other causes are valvular and pericardial 
disease; or non-cardiac diseases causing high-output 
cardiac failure, such as anaemia, 
thyrotoxicosis, septicaemia, Paget's disease of 
bone, and arteriovenous fistulae.
Symptoms 
 DYSPNEA 
 CHEST PAIN 
 SYNCOPE 
 PALPITATION 
 EDEMA 
 COUGH 
 HEMOPTYSIS 
 FATIGUE 
 CYANOSIS
DYSPNEA 
 Abnormally uncomfortable awareness of breathing 
 Dyspnea after strenous activity- Normal Individual 
 Dyspnea after moderate activity – Deconditioned 
Individual 
 Dyspnea becomes abnormal only if it occurs at rest 
or at a level of activity not expected to cause dyspnea
DIFFERENTIAL DIAGNOSIS OF 
DYSPNEA 
 PULMONARY 
- Reactive airways disease 
- COPD 
- Pulmoary edema 
- Pulmonary hypertension 
- Infection 
- Pulmonary embolism 
- Pleural diseases 
- Interstitial lung disease
DIFFERENTIAL DIAGNOSIS OF 
DYSPNEA 
 CARDIAC 
-Ischemic heart dsease 
- Right sided heart failure 
- Arrhythmias 
- Dilated cardiomyopathy 
- Hypertrophic cardiomyopathy 
- Valve stenosis and regurgitation
ACUTE DYSPNEA 
 Sudden development of dyspnea 
- Pulmonary embolism 
- Pneumonia 
- Airway obstruction
CHRONIC DYSPNEA 
 Symptom progress slowly or gradual 
- HEART FAILURE 
- COPD ( chronic obstructive pulmonary 
disease )
PAROXYSMAL NOCTURNAL 
DYSPNEA 
 Interstitial or interalveolar pulmonary edema 
 Secondary to ventricular failure 
 Symptom starts 2-4 hours after sleeping, patient 
arise from sleep feeling short of breath 
 Symptom ameliorated by sitting on the side of 
bed and take about 15-30 min
ORTHOPNEA 
 Inability to breath comfortably when lying 
 Severe pulmonary venous congestion is the cause 
of orthopnea 
 Usually seen in advanced heart failure were 
resting pulmonary venous pressure is elevated
CHEST PAIN 
 Cardinal manifestation of coronary heart disease 
 There are other structures that can casue chest 
pain- Intrathoracic structures like aorta, 
pulmonary airway, pleura and mediastinum; 
tissue of the neck; thoracic wall and 
subdiaphragmatic structures
DIFFERENTIAL DIAGNOSIS OF 
CHEST PAIN 
 PULMONARY 
- pulmonary embolism 
- pneumothorax 
- pneumonia
 NEUROMUSCULAR 
- Degenerative joint disease of cervical area 
- Costochondritis 
- Herpes zoster
 PSYCHOGENIC 
- Anxiety 
- Depression
 GASTROINTESTINAL 
- Cholecystitis 
- Esophageal spasm 
- GERD
QUALITY OF PAIN 
 Angina means tightening 
 Unpleasant sensation which is describe as either 
heaviness, pressing, squeezing or constricting
LOCATION 
 Anginal pain is substrenal in location 
 Pain at times radiates to the jaw, left arm, or neck
DURATION 
 The pain of angina pectoris is usually brief and 
last between 2-10 minutes 
 Chest pain lasting for more than 15 minutes 
would fall into either UNSTABLE ANGINA OR 
MYOCARDIAL INFARCTION
COUGH 
 Cough due to left ventricular failure is dry, 
irritating , spasmodic and nocturnal 
 It is due to pulmonary venous congention 
 Cough of pulmonary disease is usually productive 
 Cough follwed by dyspnea is usally pulmonary in 
nature while dyspnea follwed by cough is cardiac 
in nature
HEMOPTYSIS 
 Expectoration of blood in sputum 
 RBC escapes into aleveoli 
 Rupture of bronchial vessel 
 Necrosis and hemorrahge into the alveoli
FATIGUE 
 Patient with impaired cardiovascular function 
 Decrease peripheral perfusion 
Muscle weakness
Chronic Heart Failure 
 The most specific signs are: 
 Laterally displaced apex beat 
 Elevated jugular venous pressure 
 Third heart sound 
 Less specific signs include: 
 Tachycardia 
 Lung crepitations 
 Hepatic engorgement (tender hepatomegaly) 
 Peripheral oedema
Investigations 
 Electrocardiogram (ECG) may show acute ischaemia, arrhythmias, 
left ventricular hypertrophy, left bundle branch block, or prior MI. 
 Heart failure is unlikely if the ECG is normal, and the diagnosis 
should be reconsidered in this situation. 
 Chest X-ray (CXR) 
 pulmonary vascular congestion (upper lobe diversion), 
 pulmonary oedema 
 effusions 
 cardiomegaly
Chronic Heart Failure 
 B-type natriuretic peptide (BNP) and its N-terminal 
fragment (NTproBNP) 
 New diagnostic test 
 A raised concentration of either has been shown to have a 
sensitivity of greater than 90% and a specificity of 80- 
90% for the diagnosis of heart failure. 
 Heart failure is unlikely if the level of BNP or NTproBNP 
is normal, especially if the ECG is also normal, and the 
diagnosis should be reconsidered in this situation.
Medication 
 Drug treatments should be initiated in the 
following order: 
 ACE inhibitor - with diuretic if needed - for 
NYHA Grades I-IV. 
 Angiotensin-II receptor antagonist - if intolerant 
of ACE inhibitor. 
 Beta-blocker - for NYHA Grades I-IV. 
 Spironolactone - for NYHA Grades III-IV. 
 Digoxin - for NYHA Grades II-IV.
Thank you

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Heart failure

  • 1. Heart Failure Noha Khalil , MD
  • 2. Definition  Heart failure is a clinical syndrome usually due to left ventricular dysfunction, resulting in acute or chronic symptoms of cardiac pump failure.
  • 3. Aetiology  The most common causes of heart failure are coronary heart disease, hypertension, alcohol abuse, and idiopathic dilated cardiomyopathy  Other causes are valvular and pericardial disease; or non-cardiac diseases causing high-output cardiac failure, such as anaemia, thyrotoxicosis, septicaemia, Paget's disease of bone, and arteriovenous fistulae.
  • 4. Symptoms  DYSPNEA  CHEST PAIN  SYNCOPE  PALPITATION  EDEMA  COUGH  HEMOPTYSIS  FATIGUE  CYANOSIS
  • 5. DYSPNEA  Abnormally uncomfortable awareness of breathing  Dyspnea after strenous activity- Normal Individual  Dyspnea after moderate activity – Deconditioned Individual  Dyspnea becomes abnormal only if it occurs at rest or at a level of activity not expected to cause dyspnea
  • 6. DIFFERENTIAL DIAGNOSIS OF DYSPNEA  PULMONARY - Reactive airways disease - COPD - Pulmoary edema - Pulmonary hypertension - Infection - Pulmonary embolism - Pleural diseases - Interstitial lung disease
  • 7. DIFFERENTIAL DIAGNOSIS OF DYSPNEA  CARDIAC -Ischemic heart dsease - Right sided heart failure - Arrhythmias - Dilated cardiomyopathy - Hypertrophic cardiomyopathy - Valve stenosis and regurgitation
  • 8. ACUTE DYSPNEA  Sudden development of dyspnea - Pulmonary embolism - Pneumonia - Airway obstruction
  • 9. CHRONIC DYSPNEA  Symptom progress slowly or gradual - HEART FAILURE - COPD ( chronic obstructive pulmonary disease )
  • 10. PAROXYSMAL NOCTURNAL DYSPNEA  Interstitial or interalveolar pulmonary edema  Secondary to ventricular failure  Symptom starts 2-4 hours after sleeping, patient arise from sleep feeling short of breath  Symptom ameliorated by sitting on the side of bed and take about 15-30 min
  • 11. ORTHOPNEA  Inability to breath comfortably when lying  Severe pulmonary venous congestion is the cause of orthopnea  Usually seen in advanced heart failure were resting pulmonary venous pressure is elevated
  • 12. CHEST PAIN  Cardinal manifestation of coronary heart disease  There are other structures that can casue chest pain- Intrathoracic structures like aorta, pulmonary airway, pleura and mediastinum; tissue of the neck; thoracic wall and subdiaphragmatic structures
  • 13. DIFFERENTIAL DIAGNOSIS OF CHEST PAIN  PULMONARY - pulmonary embolism - pneumothorax - pneumonia
  • 14.  NEUROMUSCULAR - Degenerative joint disease of cervical area - Costochondritis - Herpes zoster
  • 15.  PSYCHOGENIC - Anxiety - Depression
  • 16.  GASTROINTESTINAL - Cholecystitis - Esophageal spasm - GERD
  • 17. QUALITY OF PAIN  Angina means tightening  Unpleasant sensation which is describe as either heaviness, pressing, squeezing or constricting
  • 18. LOCATION  Anginal pain is substrenal in location  Pain at times radiates to the jaw, left arm, or neck
  • 19. DURATION  The pain of angina pectoris is usually brief and last between 2-10 minutes  Chest pain lasting for more than 15 minutes would fall into either UNSTABLE ANGINA OR MYOCARDIAL INFARCTION
  • 20. COUGH  Cough due to left ventricular failure is dry, irritating , spasmodic and nocturnal  It is due to pulmonary venous congention  Cough of pulmonary disease is usually productive  Cough follwed by dyspnea is usally pulmonary in nature while dyspnea follwed by cough is cardiac in nature
  • 21. HEMOPTYSIS  Expectoration of blood in sputum  RBC escapes into aleveoli  Rupture of bronchial vessel  Necrosis and hemorrahge into the alveoli
  • 22. FATIGUE  Patient with impaired cardiovascular function  Decrease peripheral perfusion Muscle weakness
  • 23. Chronic Heart Failure  The most specific signs are:  Laterally displaced apex beat  Elevated jugular venous pressure  Third heart sound  Less specific signs include:  Tachycardia  Lung crepitations  Hepatic engorgement (tender hepatomegaly)  Peripheral oedema
  • 24. Investigations  Electrocardiogram (ECG) may show acute ischaemia, arrhythmias, left ventricular hypertrophy, left bundle branch block, or prior MI.  Heart failure is unlikely if the ECG is normal, and the diagnosis should be reconsidered in this situation.  Chest X-ray (CXR)  pulmonary vascular congestion (upper lobe diversion),  pulmonary oedema  effusions  cardiomegaly
  • 25. Chronic Heart Failure  B-type natriuretic peptide (BNP) and its N-terminal fragment (NTproBNP)  New diagnostic test  A raised concentration of either has been shown to have a sensitivity of greater than 90% and a specificity of 80- 90% for the diagnosis of heart failure.  Heart failure is unlikely if the level of BNP or NTproBNP is normal, especially if the ECG is also normal, and the diagnosis should be reconsidered in this situation.
  • 26. Medication  Drug treatments should be initiated in the following order:  ACE inhibitor - with diuretic if needed - for NYHA Grades I-IV.  Angiotensin-II receptor antagonist - if intolerant of ACE inhibitor.  Beta-blocker - for NYHA Grades I-IV.  Spironolactone - for NYHA Grades III-IV.  Digoxin - for NYHA Grades II-IV.