Pearson's Hard Soft Lewis Acid Base (HSAB) principle classifies Lewis acids and bases as hard, soft or borderline based on their ability to form ionic or covalent complexes. According to the principle, hard acids prefer hard bases and form ionic complexes, while soft acids prefer soft bases and form covalent complexes. However, the HSAB model oversimplifies reactions and introduces ambiguities, as no single physical parameter determines hardness. A more nuanced analysis is needed to understand complex Lewis acid-base interactions.
1.Weak forces of attraction
2.Concepts of Hydrogen bonding
3.Types of hydrogen bonding
4.Properties of hydrogen bond.
5.Methods of detection of hydrogen bond.
6.Importance of Hydrogen bonding.
7.Vander walls forces
a.Ion-dipole
b.Dipole-dipole
c.London forces.
8.Origin of hydrogen bonds.
9.Consequences of hydrogen bonding.
10.Ice has less density than water.
11.Intermolecular forces.
1.Weak forces of attraction
2.Concepts of Hydrogen bonding
3.Types of hydrogen bonding
4.Properties of hydrogen bond.
5.Methods of detection of hydrogen bond.
6.Importance of Hydrogen bonding.
7.Vander walls forces
a.Ion-dipole
b.Dipole-dipole
c.London forces.
8.Origin of hydrogen bonds.
9.Consequences of hydrogen bonding.
10.Ice has less density than water.
11.Intermolecular forces.
Inorganic chemistry Unit-19 Metal Cluster.pdfkoreanhitz70
It's the best notes on the metal cluster of the subject inorganic chemistry. It presents knowledge on borane, diborane, carboranes, their reactions, introduction and classes.
The following questions answers are as under:-
What is the valence bond theory?
What are the shortcomings of VBT?
What are the merits of the valence bond theory?
Inorganic chemistry Unit-19 Metal Cluster.pdfkoreanhitz70
It's the best notes on the metal cluster of the subject inorganic chemistry. It presents knowledge on borane, diborane, carboranes, their reactions, introduction and classes.
The following questions answers are as under:-
What is the valence bond theory?
What are the shortcomings of VBT?
What are the merits of the valence bond theory?
Oedogonium LifeCycle /vegetative cell/Asexual and sexual reproduction.Katta Vani
Oedogonium belongs to chlorophyta. Fresh water alga .We can easily identify with the help of cap cells. The plant body is haploid and the life cycle is also haplontic type.
HSAB concept is an initialism for "hard and soft (Lewis) acids and bases". Also known as the Pearson acid-base concept, HSAB is widely used in chemistry for explaining stability of compounds, reaction mechanisms and pathways.
A carbene is any neutral carbon species which contains a non-bonding valance pair of electrons.
Contributed by Alison Brown & Nathan Buehler, Undergraduates, University of Utah
Acid base Theories
Role of the solvents
Acid base dissociation constant,
Relative strength of acids and bases
Distribution of acid base species with pH
Buffer solution
Henderson Hasselbalch equation,
Indicators, Mixed indicators
Different type of titrations (Neutralization curves)
Polyprotic systems,
Phosphoric acid system,
Polyamine and amino acid systems.
Titration of sodium carbonate
Lavoisier definition
Liebig definition
Arrhenius Acids and Bases
Bronsted-Lowry Acid and Base
Lewis Acid and Base
Solvent-system Concept
Lux-Flood Concept
Pearson’s Concept
Historically, the first of the scientific concepts of acids and bases was provided by the French chemist Antoine Lavoisier, circa 1776.
Lavoisier's knowledge of strong acids was mainly restricted to oxyacids, which tend to contain central atoms in high oxidation states surrounded by oxygen, such as HNO3 and H2SO4, and he was not aware of the true composition of the hydrohalic acids, HCl, HBr, and HI. From his limited knowledge,
He defined acids in terms of their content of oxygen, and he named oxygen from Greek words meaning "acid-former"
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdfPaige Cruz
Monitoring and observability aren’t traditionally found in software curriculums and many of us cobble this knowledge together from whatever vendor or ecosystem we were first introduced to and whatever is a part of your current company’s observability stack.
While the dev and ops silo continues to crumble….many organizations still relegate monitoring & observability as the purview of ops, infra and SRE teams. This is a mistake - achieving a highly observable system requires collaboration up and down the stack.
I, a former op, would like to extend an invitation to all application developers to join the observability party will share these foundational concepts to build on:
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
SAP Sapphire 2024 - ASUG301 building better apps with SAP Fiori.pdfPeter Spielvogel
Building better applications for business users with SAP Fiori.
• What is SAP Fiori and why it matters to you
• How a better user experience drives measurable business benefits
• How to get started with SAP Fiori today
• How SAP Fiori elements accelerates application development
• How SAP Build Code includes SAP Fiori tools and other generative artificial intelligence capabilities
• How SAP Fiori paves the way for using AI in SAP apps
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
Today, after several years of existence, an extremely active community and an ultra-dynamic ecosystem, Kubernetes has established itself as the de facto standard in container orchestration. Thanks to a wide range of managed services, it has never been so easy to set up a ready-to-use Kubernetes cluster.
However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
PHP Frameworks: I want to break free (IPC Berlin 2024)Ralf Eggert
In this presentation, we examine the challenges and limitations of relying too heavily on PHP frameworks in web development. We discuss the history of PHP and its frameworks to understand how this dependence has evolved. The focus will be on providing concrete tips and strategies to reduce reliance on these frameworks, based on real-world examples and practical considerations. The goal is to equip developers with the skills and knowledge to create more flexible and future-proof web applications. We'll explore the importance of maintaining autonomy in a rapidly changing tech landscape and how to make informed decisions in PHP development.
This talk is aimed at encouraging a more independent approach to using PHP frameworks, moving towards a more flexible and future-proof approach to PHP development.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...
Hard soft acid_base
1. Pearson's Hard Soft [Lewis] Acid Base
The Hard Soft [Lewis] Acid Base Principle
In the nineteen sixties, Ralph Pearson attempted to explain the differential affinity of electron
pair donating Lewis bases towards electron pair accepting Lewis acids, ie. Lewis acid/base
complexation:
A + B –> A-B
by classifying Lewis acids and Lewis bases as hard, borderline or soft.
According to Pearson's hard soft [Lewis] acid base (HSAB) principle:
Hard [Lewis] acids prefer to bind to Hard [Lewis] bases
and
Soft [Lewis] acids prefer to bind to Soft [Lewis] bases
Pearson's HSAB Species
Pearson's Hard Lewis Acids:
Pearson's Borderline Lewis Acids:
http://www.meta-synthesis.com/webbook/43_hsab/HSAB.html (1 of 7)1/12/2004 11:51:35 AM
2. Pearson's Hard Soft [Lewis] Acid Base
Pearson's Soft Lewis Acids:
Pearson's Hard Lewis Bases:
Pearson's Borderline Lewis Bases:
Pearson's Soft Lewis Bases:
http://www.meta-synthesis.com/webbook/43_hsab/HSAB.html (2 of 7)1/12/2004 11:51:35 AM
3. Pearson's Hard Soft [Lewis] Acid Base
In 1968, G. Klopman quantified Pearson's HSAB principle using frontier molecular orbital
(FMO) theory. (The Klopman equation is discussed, here. ) Klopman proposed that:
Hard [Lewis] Acids bind to Hard [Lewis] Bases to give charge-controlled
ionic complexes
and
Soft [Lewis] Acids bind to Soft [Lewis] Bases to give FMO-controlled
covalent complexes
Combining Pearson's and Klopman's ideas:
• Hard Lewis acids:
Atomic centres of small ionic radius and with net positive charge.
Species do not contain electron pairs in their valence shells, they
have a low electron affinity and are likely to be strongly solvated.
High energy LUMO.
• Soft Lewis acids:
Large radius, low or partial (delta+) positive charge.
Electron pairs in their valence shells. Easy to polarise and oxidise.
http://www.meta-synthesis.com/webbook/43_hsab/HSAB.html (3 of 7)1/12/2004 11:51:35 AM
4. Pearson's Hard Soft [Lewis] Acid Base
Low energy LUMOs but large magnitude LUMO coefficients.
• Hard Lewis bases:
Small, highly solvated, electronegative atoms: 3.0-4.0.
Species are weakly polarisable and are difficult to oxidise. Low
Low energy HOMO.
• Soft Lewis bases:
Large atoms of intermediate electronegativity: 2.5-3.0.
Easy to polarise and oxidise.
High energy HOMOs but large magnitude HOMO coefficients.
• Borderline species have intermediate properties.
• It is not necessary for species to possess all properties.
The Pearson approach is very successful when comparing pairs of species:
Sodium ion Na+ is harder than the silver ion Ag+
Alkoxide ions, RO–, are harder than thioanions, RS–
Copper(II) ion, Cu2+, is harder than copper(I) ion, Cu+
The nitrogen anion end of the ambidentate cyanide ion, CN–, is harder than the
carbon anion end, NC–
This type of analysis can be very useful. For example, beta-propiolactone is ring opened by
nucleophilic Lewis bases, however, attack can occur at two positions:
• Harder nucleophiles like alkoxide ion, R-O–, attack the acyl (carbonyl) carbon.
• Softer nucleophiles like thioanion, R-S–, attack the 3-position carbon.
http://www.meta-synthesis.com/webbook/43_hsab/HSAB.html (4 of 7)1/12/2004 11:51:35 AM
5. Pearson's Hard Soft [Lewis] Acid Base
This graphic is captured from The Chemical Thesaurus, here. There are a
number of examples of this type in this reaction chemistry database.
Problems...
However, there is a problem.
While the Pearson-Klopman HSAB model is not "wrong"... it does grossly oversimplify the
reaction chemistry. The reason is that no physical parameter correlates with hardness over
Pearson's chosen set of species.
And as a result, the model introduces ambiguities. How similar are:
Pearson's hard Lewis acids: [NH4]+ H+ CO2 Cs+ Cu2+
http://www.meta-synthesis.com/webbook/43_hsab/HSAB.html (5 of 7)1/12/2004 11:51:35 AM
6. Pearson's Hard Soft [Lewis] Acid Base
Pearson's soft Lewis bases: H– R2S: R– benzene
Even more importantly, the interesting hard-soft interactions and complexations are simply not
discussed by Pearson's model. What about:
Sodium hydride
Lithium aluminium hydride
Lead(IV) acetate
Methyl lithium
Borane-THF
Triethyloxonium tetrafluoroborate
Ferrocene
The one-dimensional hard-borderline-soft continuum or Pearson's analysis actually has
the effect of blurring much of the rich, linear (predictable) behaviour which can be
found in Lewis acid/base reaction chemistry space.
The chemogenesis analysis, here, avoids and explains the pitfalls of the
Pearson approach.
The HSAB Papers
R.G.Pearson, J.Am.Chem.Soc., 85, 3533-3543, 1963
R.G.Pearson, Science, 151, 172-177, 1966
R.G.Pearson, Chem. Br., 3, 103-107, 1967
R.G.Pearson, J.Chem.Ed., 45, 581-587, 1968
G.Klopman and R.F.Hudson, Theoret. Chim. Acta, 8, 165, 1967
G.Klopman, J.Am.Chem.Soc., 90, 223-234, 1968
http://www.meta-synthesis.com/webbook/43_hsab/HSAB.html (6 of 7)1/12/2004 11:51:35 AM