This document discusses renal trauma, providing information on evaluation and management. It notes that the kidney is the most commonly injured abdominal organ in trauma cases. Evaluation involves clinical examination looking for hematuria, hypotension, and flank tenderness, as well as imaging like CT or IVU to grade injuries. Most grade I-III injuries can be managed conservatively with bed rest, but higher grade injuries involving the renal parenchyma or vessels often require surgical exploration or angiography. Surgical management principles include debridement, hemostasis and repair of lacerations. Complications of renal trauma include urinoma, abscess, impaired renal function and death in severe cases.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
1. RENAL TRAUMA
Dept of Urology
Govt Royapettah Hospital and Kilpauk Medical College
Chennai
1
2. Moderators:
Professors:
Prof. Dr. G. Sivasankar, M.S., M.Ch.,
Prof. Dr. A. Senthilvel, M.S., M.Ch.,
Asst Professors:
Dr. J. Sivabalan, M.S., M.Ch.,
Dr. R. Bhargavi, M.S., M.Ch.,
Dr. S. Raju, M.S., M.Ch.,
Dr. K. Muthurathinam, M.S., M.Ch.,
Dr. D. Tamilselvan, M.S., M.Ch.,
Dr. K. Senthilkumar, M.S., M.Ch.
Dept Of Urology, KMC and GRH, Chennai
2
3. Introduction
Most commonly injured organ
10 % of abdominal trauma cases
Children more susceptible
Pre existing congenital renal abnormalities
increases the risk
Dept Of Urology, KMC and GRH, Chennai
3
7. Evaluation
Degree of deceleration
Rapid deceleration can cause vascular damage to
the renal vessels,
o renal artery thrombosis,
o renal vein disruption,
o renal pedicle avulsion.
Dept Of Urology, KMC and GRH, Chennai
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8. Movement of the kidney
from blunt trauma
(deceleration injury)
causes stretch on the
renal artery, resulting in
rupture of the arterial
intima and formation of
a thrombus.
Dept Of Urology, KMC and GRH,
Chennai
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9. Clinical evaluation
Haematuria
Hypotension
Flank haematoma
Abdominal / flank tenderness
Fractures of the lower ribs
Penetrating injuries to the lower thorax or flank
Dept Of Urology, KMC and GRH, Chennai
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10. Haematuria
Adults
>5 RBCs/HPF
Dipstick evaluation
Gross haematuria
Paediatric
Penetrating > 5 RBCs/HPF
Blunt >50 RBCs/HPF
Dept Of Urology, KMC and GRH, Chennai
10
11. Haematuria
Low correlation between the degree of
haematuria and the severity of the renal injury
Haematuria is absent
36% of renal pedicle injuries
24 % of renal Artery occlusions
Dept Of Urology, KMC and GRH, Chennai
11
12. Hypotension
Systolic blood pressure <90 mm Hg at any time before
resuscitation . Signifies significant haemorrhage (renal
parenchyma/pedicle)
Dept Of Urology, KMC and GRH, Chennai
12
13. Renal Imaging
USG
CECT
Single shot IVU
Angiography
Dept Of Urology, KMC and GRH, Chennai
13
14. Contrast-enhanced CT
Gold standard
Rapid
Widely available
Three dimensional data
Anatomic / functional data
Concomitant abdominal injuries
Dept Of Urology, KMC and GRH, Chennai
14
15. CT KUB
Medial haematoma- vascular injury
Medial urinary extravasation- pelvis or
ureteropelvic junction avulsion injury
Lack of contrast enhancement of the parenchyma -
arterial injury.
Dept Of Urology, KMC and GRH, Chennai
15
16. American association for the surgery of trauma
organ injury severity scale for the kidney
Grade I
Hematoma : Non
expanding sub
capsular hematoma.
Contusion: Micro or
Gross hematuria with
normal imaging
studies.
Dept Of Urology, KMC and GRH, Chennai
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18. Grade II
Hematoma: Non
expanding Perirenal
Hematoma confined to
Renal retroperitoneum.
Laceration:
Parenchymal
(cortical) laceration <
1cm without urinary
extravasation.
Dept Of Urology, KMC and GRH, Chennai
18
20. Grade III
Laceration:
> 1cm parenchymal
cortical laceration,
without collecting
system rupture,
urinary extravasation
Dept Of Urology, KMC and GRH, Chennai
20
22. Grade IV
Laceration: laceration
involving cortex,
medulla and
collecting system,
urinary extravasation
Vascular Injury: Main
Renal Artery, Renal
Vein Injury with
contained Hge.
Dept Of Urology, KMC and GRH, Chennai
22
25. Computed tomography of a left kidney with renal artery
thrombosis, demonstrating lack of contrast perfusion to the
kidney.
Dept Of Urology, KMC and GRH, Chennai
25
28. IVU
Single shot ivu
Unexpected retroperitoneal or perinephric haematoma
2ml/kg
10 min film
Functional status of normal side
Staging of injured side
Dept Of Urology, KMC and GRH, Chennai
28
29. Single shot IVU
Kidney trauma. One-shot
intravenous pyelogram,
normal. Ten-minute
radiograph taken after
intravenous contrast
administration on a patient
with a stab wound to the
back shows normal
kidneys and ureters
bilaterally.
Dept Of Urology, KMC and GRH,
Chennai
29
30. IVU
Focal nephrogram loss
Extravasation of
opacified urine
Dept Of Urology, KMC and GRH,
Chennai
30
32. Indication of angiography
Renal segmental artery
Unstable grade 3 or 4 injury
AV fistula
Pseudoaneurysm
Blood loss more than 2 units in 24 hrs.
Renal artery thrombosis with intimal flaps.
Dept Of Urology, KMC and GRH, Chennai
32
33. Arteriography demonstrating complete occlusion of
the left renal artery secondary to thrombus formation.
Dept Of Urology, KMC and GRH, Chennai
33
34. USG
Efficacy in trauma lacking
Inferior to CT (78% false negative)
Dept Of Urology, KMC and GRH, Chennai
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35. Surgical evaluation
Pts too unstable to undergo complete clinical or
radiological evaluation
Single shot IVU
Dept Of Urology, KMC and GRH, Chennai
35
36. Conservative Management
Indications :
Grade I , II & III.
contusion,
intrarenal haematoma,
small subcapsular haematoma,
a laceration that does not communicate with
the collecting system,
small segmental infarcts
Dept Of Urology, KMC and GRH, Chennai
36
37. Conservative Management
Absolute bed rest – till gross haematuria resolves.
Fluid management.
Antibiotics.
Careful clinical follow-up.
Repeat imaging if – fever, flank pain, dropping
haematocrit.
Dept Of Urology, KMC and GRH, Chennai
37
39. Renal Exploration-Indications
Relative
Urinary extravasation with laceration,
Nonviable tissue > 20%,
Delayed diagnosis of arterial injury,
Incomplete staging – complete it surgically
Other organ injuries – pancreatic/colon
Dept Of Urology, KMC and GRH, Chennai
39
40. Principles of reconstruction
Broad exposure
Temporary vascular control
Non viable parenchyma debridement
Haemostasis
Water tight closure
Reapproximate edges
Omental interposition
Retroperitoneal drain
Dept Of Urology, KMC and GRH, Chennai
40
50. Renovasular injuries
Uncommon
Salvage rate only 33% in renal artery repair
Endovascular stenting
Delay in diagnosis >8 hrs kidney cannot be
salvaged
Dept Of Urology, KMC and GRH, Chennai
50
52. Damage control surgery
Laparotomy pads around kidney
To control bleeding
Rexplore after 24 hrs.
Evaluate the extent of injury
Dept Of Urology, KMC and GRH, Chennai
52
53. Indications of nephrectomy
Haemodynamically Unstable
Hypoxia
Hypothermia
Acidosis
coagulopathy
Dept Of Urology, KMC and GRH, Chennai
53
54. complications
Extravasation of urine
Urinoma
Perinephric abscess
Co incident organ injury
Impaired renal function
Hypertension
Dept Of Urology, KMC and GRH, Chennai
54
55. Complications
Page kidney
Renal vascular injury
Secondary haemorrhage
AV fistulas
Pseudo aneurysms
Death
Dept Of Urology, KMC and GRH, Chennai
55
56. complications
Miscellaneous
Post injury hydronephrosis
Flank pain
Fistula
Pulmonary complication
Dept Of Urology, KMC and GRH, Chennai
56