Upper tract urothelial carcinoma arising in a horseshoe kidney presents unique treatment challenges. The patient underwent right heminephrectomy for a T1 low-grade tumor, with subsequent recurrences in the bladder and ureter. Close follow-up is important given the high risk of recurrence in UTUC, particularly in the bladder due to field cancerization effects. While adjuvant therapies have unclear benefits, intravesical BCG may help prevent recurrence in selected cases. Complete surgical resection remains the mainstay of treatment for UTUC in horseshoe kidneys.