Application of Gold nanoparticle in Phtothermal therapy of cancerDaba Gudeta
Gold nanoparticles are clusters of gold atoms up to 100nm in diameter that appear in various forms like spheres, rods, shells, cages, and stars. They are synthesized using chemical methods like the Turkevich, Brust, and Martin methods. Gold nanoparticles are analyzed using techniques like UV-Vis spectroscopy, TEM, and AFM. Due to their biocompatibility and stability, gold nanoparticles have medical applications in diagnosis, imaging, drug delivery, and photothermal therapy. In particular, gold nanoparticles can be used for photothermal therapy of cancer by converting light to heat to destroy tumor cells when irradiated with near infrared light.
Review paper on the applications and challenges of gold nanoparticles in medicine and dentistry.
Gold nanoparticles is a game-changer in delivering patient care. Its versatility can be put to use in diagnosis, imaging and treatment of various conditions. It relatively recent innovation although gold is a metal that has had a lot of meaning in human civilisation.With a lot of potential left unexplored one has to what and watch the miracles this breakthrough has in store for medical science.
The document discusses the use of gold nanoparticles for cancer detection and treatment. It describes how gold nanoparticles can be functionalized with antibodies to detect specific cancer types by binding to protein markers on cancer cells. Laser-activated gold nanoparticles may also be used to destroy cancer cells through localized heating. The document also mentions potential applications for targeted drug delivery and angiogenesis inhibition. Overall, the document outlines how the optical and structural properties of gold nanoparticles can be exploited for cancer diagnosis and therapy.
Gold nanoparticles, also called AuNPs, are nanoparticles of gold that appear red in solution. AuNPs are very stable and have unique optical and electronic properties that make them useful for a wide range of applications. Historically, medieval artists first created AuNPs unintentionally when mixing gold into glass to produce stained glass windows with various colors. Today, AuNPs are commonly synthesized using the Turkevich method and characterized using techniques like TEM, SEM, and UV-Vis spectroscopy. Current applications of AuNPs include uses in electronics, medicine for cancer detection and therapy, and as catalysts.
1. Gold nanoparticles show potential for use in cancer diagnosis and treatment due to their optical and photothermal properties.
2. Gold nanoparticles can be engineered to absorb near-infrared light and convert it to heat, killing nearby cancer cells through localized hyperthermia while sparing healthy cells.
3. Various synthesis methods like the Turkevich and Brust methods allow for production of monodisperse gold nanoparticles tuned to specific light absorption properties ideal for photothermal therapy applications.
This document discusses the use of gold nanoparticles for the treatment of cancer. It begins with an introduction to cancer and the side effects of traditional chemotherapy and radiation treatments. It then discusses how nanotechnology can be used to develop targeted drug delivery systems using gold nanoparticles. The document outlines the properties of gold nanoparticles that make them suitable for photothermal therapy applications for cancer treatment, including their ability to absorb light and generate heat. It also discusses the different types of gold nanoparticles, methods for synthesizing and characterizing them, and their potential applications and progress in cancer treatment.
1. Done by: Dr. Mohamad Ghazi Kassem
2. What is Nanotechnology An engineered DNA strandtiny motor pRNA Semiconducting metal junction formed by two carbon nanotubes Nanotechnology is the creation of functional materials, devices and systems, through the understanding and control of matter at dimensions in the nanometer scale length (1-100 nm), where new functionalities and properties of matter are observed and harnessed for a broad range of applications.
3. What is Nanoscale Fullerenes C60 22 cm 12,756 Km 1.27 × 107 m 0.22 m 10 millions times smaller 0.7 nm 0.7 × 10-9 m 1 billion times smaller
4. What Are Gold Nanoparticles? • Gold nanoparticles (‘nanogold’) occur as clusters of gold atoms up to 100nm in diameter. Gold nanoparticle • Nanogold has unusual visible properties because the particles are small enough to scatter visible light. - in contrast, mass gold reflects light. 5nm gold clusters
5. • Gold nanoparticles appear yellow to deep red to in solution. - colour depends on size of nanoparticles • The distance between particles also affects colour - surface plasmon resonance is the term used by nanotechnologists to describe this effect.
6. Why Gold Nanoparticles Cancer is a difficult disease to treat, contain, and identify. There are many different ways for treating cancer such as surgery, chemotherapy, radiation and many others. These methods are effective if the cancer tumor is caught soon enough. However, these treatments are not effective enough because they do not only target the affected cells, they also affect healthy cells. But • Gold Nanoparticles are non toxic • With Gold Nanoparticles we can detecting cancer cells and even destroy them without affect healthy cells.
7. Mostafa A. El-Sayed Julius Brown Chair and Regents Professor; Director, Laser Dynamics Laboratory “Gold nanoparticles are very good at scattering and absorbing light,” said Mostafa El-Sayed, director of the Laser Dyanamics Laboratory and chemistry professor at Georgia Tech. “We wanted to see if we could harness that scattering property in a living cell to make cancer detection easier. So far, the results are extremely promising.”
8. Gold Nanoparticle Tumor Detection The common strategy to detect the tumor is the functionalization of the nanoparticle with an antibody specific to the tumor antigens, and then detect the nanoparticle by some spectroscopic technique B. Tumor photograph Imaging with gold nanoparticles as contrast agent
9. Many cancer cells have a protein, known as Epidermal Growth Factor Receptor (EFGR), all over their surface, while healthy cells typically do not express the protein as strongly. By conjugating, or binding, the gold nanoparticles to an antibody for EFGR, suitably named antiEFGR, researchers were able to get the nanoparticles to attach themselves to the cancer cells. Electrostatically + + + + - - - + + + - + -+ - - + + + + Covalently S S S S S S S S
10. Gold Nanoparticles Nanoshells
Application of Gold nanoparticle in Phtothermal therapy of cancerDaba Gudeta
Gold nanoparticles are clusters of gold atoms up to 100nm in diameter that appear in various forms like spheres, rods, shells, cages, and stars. They are synthesized using chemical methods like the Turkevich, Brust, and Martin methods. Gold nanoparticles are analyzed using techniques like UV-Vis spectroscopy, TEM, and AFM. Due to their biocompatibility and stability, gold nanoparticles have medical applications in diagnosis, imaging, drug delivery, and photothermal therapy. In particular, gold nanoparticles can be used for photothermal therapy of cancer by converting light to heat to destroy tumor cells when irradiated with near infrared light.
Review paper on the applications and challenges of gold nanoparticles in medicine and dentistry.
Gold nanoparticles is a game-changer in delivering patient care. Its versatility can be put to use in diagnosis, imaging and treatment of various conditions. It relatively recent innovation although gold is a metal that has had a lot of meaning in human civilisation.With a lot of potential left unexplored one has to what and watch the miracles this breakthrough has in store for medical science.
The document discusses the use of gold nanoparticles for cancer detection and treatment. It describes how gold nanoparticles can be functionalized with antibodies to detect specific cancer types by binding to protein markers on cancer cells. Laser-activated gold nanoparticles may also be used to destroy cancer cells through localized heating. The document also mentions potential applications for targeted drug delivery and angiogenesis inhibition. Overall, the document outlines how the optical and structural properties of gold nanoparticles can be exploited for cancer diagnosis and therapy.
Gold nanoparticles, also called AuNPs, are nanoparticles of gold that appear red in solution. AuNPs are very stable and have unique optical and electronic properties that make them useful for a wide range of applications. Historically, medieval artists first created AuNPs unintentionally when mixing gold into glass to produce stained glass windows with various colors. Today, AuNPs are commonly synthesized using the Turkevich method and characterized using techniques like TEM, SEM, and UV-Vis spectroscopy. Current applications of AuNPs include uses in electronics, medicine for cancer detection and therapy, and as catalysts.
1. Gold nanoparticles show potential for use in cancer diagnosis and treatment due to their optical and photothermal properties.
2. Gold nanoparticles can be engineered to absorb near-infrared light and convert it to heat, killing nearby cancer cells through localized hyperthermia while sparing healthy cells.
3. Various synthesis methods like the Turkevich and Brust methods allow for production of monodisperse gold nanoparticles tuned to specific light absorption properties ideal for photothermal therapy applications.
This document discusses the use of gold nanoparticles for the treatment of cancer. It begins with an introduction to cancer and the side effects of traditional chemotherapy and radiation treatments. It then discusses how nanotechnology can be used to develop targeted drug delivery systems using gold nanoparticles. The document outlines the properties of gold nanoparticles that make them suitable for photothermal therapy applications for cancer treatment, including their ability to absorb light and generate heat. It also discusses the different types of gold nanoparticles, methods for synthesizing and characterizing them, and their potential applications and progress in cancer treatment.
1. Done by: Dr. Mohamad Ghazi Kassem
2. What is Nanotechnology An engineered DNA strandtiny motor pRNA Semiconducting metal junction formed by two carbon nanotubes Nanotechnology is the creation of functional materials, devices and systems, through the understanding and control of matter at dimensions in the nanometer scale length (1-100 nm), where new functionalities and properties of matter are observed and harnessed for a broad range of applications.
3. What is Nanoscale Fullerenes C60 22 cm 12,756 Km 1.27 × 107 m 0.22 m 10 millions times smaller 0.7 nm 0.7 × 10-9 m 1 billion times smaller
4. What Are Gold Nanoparticles? • Gold nanoparticles (‘nanogold’) occur as clusters of gold atoms up to 100nm in diameter. Gold nanoparticle • Nanogold has unusual visible properties because the particles are small enough to scatter visible light. - in contrast, mass gold reflects light. 5nm gold clusters
5. • Gold nanoparticles appear yellow to deep red to in solution. - colour depends on size of nanoparticles • The distance between particles also affects colour - surface plasmon resonance is the term used by nanotechnologists to describe this effect.
6. Why Gold Nanoparticles Cancer is a difficult disease to treat, contain, and identify. There are many different ways for treating cancer such as surgery, chemotherapy, radiation and many others. These methods are effective if the cancer tumor is caught soon enough. However, these treatments are not effective enough because they do not only target the affected cells, they also affect healthy cells. But • Gold Nanoparticles are non toxic • With Gold Nanoparticles we can detecting cancer cells and even destroy them without affect healthy cells.
7. Mostafa A. El-Sayed Julius Brown Chair and Regents Professor; Director, Laser Dynamics Laboratory “Gold nanoparticles are very good at scattering and absorbing light,” said Mostafa El-Sayed, director of the Laser Dyanamics Laboratory and chemistry professor at Georgia Tech. “We wanted to see if we could harness that scattering property in a living cell to make cancer detection easier. So far, the results are extremely promising.”
8. Gold Nanoparticle Tumor Detection The common strategy to detect the tumor is the functionalization of the nanoparticle with an antibody specific to the tumor antigens, and then detect the nanoparticle by some spectroscopic technique B. Tumor photograph Imaging with gold nanoparticles as contrast agent
9. Many cancer cells have a protein, known as Epidermal Growth Factor Receptor (EFGR), all over their surface, while healthy cells typically do not express the protein as strongly. By conjugating, or binding, the gold nanoparticles to an antibody for EFGR, suitably named antiEFGR, researchers were able to get the nanoparticles to attach themselves to the cancer cells. Electrostatically + + + + - - - + + + - + -+ - - + + + + Covalently S S S S S S S S
10. Gold Nanoparticles Nanoshells
This document presents research on using gold nanoparticles for the detection of the biomolecule heparin. It describes synthesizing positively-charged gold nanoparticles by coating them with a lipoic acid derivative. The nanoparticles were shown through SEM, UV-VIS spectroscopy, and other analysis to coagulate and change color when exposed to the negatively-charged heparin molecule. This provides a simple, visual method to detect heparin concentration and has potential applications for controlling heparin dosage during surgeries in Qatar. The research was conducted by two Qatari students at Mosab bin Omair secondary independent school under the supervision of two doctors.
This document summarizes a conference on nanoparticles organized by Ashoka Institute of Technology and Management. It discusses nanoparticles and their properties, various synthesis methods for gold and silver nanoparticles including chemical, physical and biological methods, characterization techniques, and applications in drug delivery, biomedical uses, and challenges including instability, impurities, and toxicity.
Synthesis & Heating Mechanisms of Magnetic Nanoparticles in Hyperthermia Trea...Nikita Gupta
This document summarizes research on synthesizing magnetic nanoparticles for use in hyperthermia cancer treatment. It discusses two samples of magnesium ferrite nanoparticles synthesized via co-precipitation at different temperatures and concentrations. Characterization with XRD and VSM showed the samples had hexagonal structure and increasing magnetization with higher sintering temperature. In hyperthermia experiments, both samples saw increased temperature over time with applied alternating magnetic fields, with better results at higher frequencies above 500 kHz needed to effectively treat cancer.
Gold nanoparticles: strange properties and applicationsExpedeon
View our gold nanoparticle range: http://www.innovabiosciences.com/gold-conjugation-kits.html
Gold nanoparticles exhibit extraordinary properties quite unlike those of the bulk metal. These properties can be exploited in a variety of assay applications, including lateral flow tests, microscopy, flow cytometry and FRET assays. There are also a number of therapeutic applications, especially in the field of cancer. This free and exciting webinar focuses on the following points:
1. Introduction to Gold
2. Unique properties of nanoparticles
3. Why does "40nm gold" never look the same from different suppliers?
4. Methods of attaching proteins and analytes to gold
5. Uses of nanoparticles in diagnostics
6. Uses of nanoparticles in therapeutics
Synthesis and Characterization of nanoparticleMohammad Azam
This document summarizes the history and applications of nanoparticles. It discusses early examples of nanomaterials like the Lycurgus Cup from the 4th century. It classifies nanostructured materials and describes how properties change at the nanoscale. Applications discussed include electronics, medicine, energy, and environmental remediation. Common synthesis methods are outlined as well as characterization techniques like UV-Vis spectroscopy, FTIR, XRD, SEM, TEM, and AFM. Scanning probe microscopes like SEM, STM, and AFM are also briefly described.
Nanoparticle Gold in therapy and cosmetologyguest49edce
The document discusses the history and development of nanotechnology. It notes that while nanotechnology concepts have been around for some time, it was in the 1980s that major developments occurred with the invention of the scanning tunneling microscope and atomic force microscope. These microscopes allowed visualization and manipulation of materials at the nanoscale. The document also discusses various applications of gold nanoparticles in medicine, such as using them for drug delivery for cancer treatment, and in catalysis. However, it notes that while cosmetics containing gold nanoparticles are being widely sold, medical uses of gold nanoparticles still require extensive testing and FDA approval before being used to treat diseases.
Nanotechnology involves engineering at the nanoscale (1-100 nanometers) and can be used in various fields including medicine. It has several applications for cancer treatment such as using nanoparticles, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, silica nanoparticles, and nanorobots to more precisely deliver drugs to cancer cells, detect genetic mutations associated with cancer, and potentially diagnose and treat cancer. Nanoparticles in particular show promise for overcoming limitations of conventional cancer treatments like poor solubility, lack of targeting, and side effects by selectively targeting cancer cells and increasing drug localization.
This document discusses the potential applications of nanotechnology in cancer diagnosis and treatment. It begins with an overview of nanotechnology and nanomedicine. It then discusses how cancer forms and the various factors that can cause cancer like chemicals, radiation, viruses and lifestyle. The document outlines how nanotechnology can be used to more effectively deliver drugs, detect cancer at an early stage, and treat cancer through approaches like photothermal ablation using gold nanoparticles. It acknowledges challenges like ensuring nanoparticles are biocompatible and non-toxic, but envisions that human clinical trials within the next few years could demonstrate how nanotechnology allows for safer and more targeted cancer treatment.
Green syntheses are more environmentally friendly alternatives to conventional synthesis techniques as they aim to reduce toxic elements and costs while benefiting from sustainable sources. There are two main categories of green synthesis: microbial, which uses bacteria and other microbes to produce nanoparticles either intracellularly or extracellularly, and phyto-synthesis, which uses plants to produce nanoparticles on a large scale. Green synthesis methods provide single step, non-toxic and cost effective production of nanoparticles for applications in medicine, environmental remediation, and more.
This document discusses various methods for synthesizing silver nanoparticles (Ag NPs). It covers physical approaches like evaporation-condensation and laser ablation. It then discusses several chemical approaches for reduction of silver ions to produce Ag NPs, including reduction by tri-sodium citrate, sodium borohydride, UV irradiation, gamma irradiation, laser irradiation, microwave irradiation, sonochemical reduction, and electrochemical methods. It notes the advantages of these chemical synthesis techniques and how stabilizing agents prevent agglomeration of the nanoparticles.
Process design.cancer treatment using nanoparticles. pptHoang Tien
Nanoparticles show promise for improving cancer detection and treatment. They are small enough to enter cells and interact with DNA and proteins. Quantum dots and nanoshells can be used to detect cancer signatures. Nanoshells coated with cancer-targeting molecules can selectively heat and destroy cancer cells when exposed to near-infrared light, protecting healthy cells. While challenges remain around toxicity and delivery, nanoparticles may enable cheaper, less toxic cancer therapies compared to chemotherapy and improve outcomes.
Green Synthesis Of Silver NanoparticlesAnal Mondal
This document discusses the green synthesis of silver nanoparticles. It begins by defining nanoparticles and describing their properties. It then discusses silver nanoparticles specifically, including their size range and color properties. The rest of the document discusses the green synthesis technique for producing silver nanoparticles using plant extracts, the advantages of this method over chemical synthesis, and various characterization techniques and applications of the synthesized silver nanoparticles.
Synthesis of nanoparticles physical, chemical and biological meansPRIYABHATT26
The document discusses various physical, chemical, and biological methods for synthesizing nanoparticles. It provides case studies on the synthesis of nanoparticles including silver, gold, platinum, zinc oxide and more using methods such as polyol, microemulsion, thermal decomposition, electrochemical synthesis, plasma, microwave irradiation, pulsed laser, sonochemical reduction, gamma radiation, bacteria, fungi, and plants. The document compares top-down and bottom-up synthesis approaches and provides details on specific synthesis techniques for producing metallic nanoparticles using different organisms, reactions conditions, and applications.
This will enhance the knowledge about the methods of nano particle synthesis. The application of Green method is also described. Gold nano particles are also explained with its toxicity and application.
Review on green synthesis of silver nanoparticles using plant extract. Various green materials are used for the synthesis of Ag. Several synthesis method main emphasis on green method.
The main methods of producing nanoparticles are often cost effective and harmful to the environment. The green synthesis of nanoparticles has been proposed as a cost-effective and eco-friendly alternative of the previous methods. At present the metal nanoparticle synthesis using plant extracts has become a major focus of researchers.
This document summarizes the green synthesis of silver nanorods and wires using plant extracts from Zoysia japonica lawn grass, Azadarichta indica neem leaves, and Prunus dulcis almond. The aim was to produce silver nanoparticles using these plant extracts as reducing agents. Silver nanoparticles were synthesized by adding plant extracts to a silver nitrate solution and incubating for 24 hours, resulting in color changes. The synthesized nanoparticles were characterized using UV-visible spectroscopy, which showed absorption peaks varying between 300-500 nm depending on the plant extract used. Further analysis using techniques like iodometric titration, TEM, and FTIR were proposed to understand stabilization and structure of the synthesized silver nanoparticles.
Novel effects can occur in materials when structures are formed with sizes comparable to any one of many possible length scales, such as the de Broglie wavelength of electrons, or the optical wavelengths of high energy photons. In these cases quantum mechanical effects can dominate material properties. One example is quantum confinement where the electronic properties of solids are altered with great reductions in particle size. The optical properties of nanoparticles, e.g. fluorescence, also become a function of the particle diameter. This effect does not come into play by going from macrosocopic to micrometer dimensions, but becomes pronounced when the nanometer scale is reached.
Nanoparticles for magnetic resonance imagingAlex Chris
This document discusses the use of various types of nanoparticles for molecular imaging applications such as magnetic resonance imaging (MRI) and computer tomography (CT). It describes how gold nanoparticles, quantum dots, iron oxide nanoparticles, carbon nanotubes, dendrimers, and other nanoparticles are being investigated and developed as contrast agents for molecular imaging due to their tunable properties and potential for functionalization and targeted delivery. For example, one study demonstrated how antibody-conjugated gold nanorods could selectively target and image squamous cell carcinoma tumors using CT. Overall, the controlled properties of engineered nanoparticles show promise for improving molecular imaging techniques.
Advances in Diagnosis & Imaging Impacting Cancer Treatment Dr.Harsha Doddihal
This document discusses advances in cancer diagnosis and treatment. It covers new diagnostic techniques like advanced pathology using techniques like IHC, FISH, and genomic assays that provide more molecular information about tumors. Imaging techniques like PET scans are now able to more precisely define tumors and monitor treatment response. The document also discusses the shifting treatment paradigm towards personalized and targeted therapies that act on specific molecular pathways identified as disrupted in a patient's cancer. Several new targeted drugs approved in recent years are mentioned along with the biomarkers they target like HER2, BCR-ABL, MEK, PI3K, VEGF receptors.
This document presents research on using gold nanoparticles for the detection of the biomolecule heparin. It describes synthesizing positively-charged gold nanoparticles by coating them with a lipoic acid derivative. The nanoparticles were shown through SEM, UV-VIS spectroscopy, and other analysis to coagulate and change color when exposed to the negatively-charged heparin molecule. This provides a simple, visual method to detect heparin concentration and has potential applications for controlling heparin dosage during surgeries in Qatar. The research was conducted by two Qatari students at Mosab bin Omair secondary independent school under the supervision of two doctors.
This document summarizes a conference on nanoparticles organized by Ashoka Institute of Technology and Management. It discusses nanoparticles and their properties, various synthesis methods for gold and silver nanoparticles including chemical, physical and biological methods, characterization techniques, and applications in drug delivery, biomedical uses, and challenges including instability, impurities, and toxicity.
Synthesis & Heating Mechanisms of Magnetic Nanoparticles in Hyperthermia Trea...Nikita Gupta
This document summarizes research on synthesizing magnetic nanoparticles for use in hyperthermia cancer treatment. It discusses two samples of magnesium ferrite nanoparticles synthesized via co-precipitation at different temperatures and concentrations. Characterization with XRD and VSM showed the samples had hexagonal structure and increasing magnetization with higher sintering temperature. In hyperthermia experiments, both samples saw increased temperature over time with applied alternating magnetic fields, with better results at higher frequencies above 500 kHz needed to effectively treat cancer.
Gold nanoparticles: strange properties and applicationsExpedeon
View our gold nanoparticle range: http://www.innovabiosciences.com/gold-conjugation-kits.html
Gold nanoparticles exhibit extraordinary properties quite unlike those of the bulk metal. These properties can be exploited in a variety of assay applications, including lateral flow tests, microscopy, flow cytometry and FRET assays. There are also a number of therapeutic applications, especially in the field of cancer. This free and exciting webinar focuses on the following points:
1. Introduction to Gold
2. Unique properties of nanoparticles
3. Why does "40nm gold" never look the same from different suppliers?
4. Methods of attaching proteins and analytes to gold
5. Uses of nanoparticles in diagnostics
6. Uses of nanoparticles in therapeutics
Synthesis and Characterization of nanoparticleMohammad Azam
This document summarizes the history and applications of nanoparticles. It discusses early examples of nanomaterials like the Lycurgus Cup from the 4th century. It classifies nanostructured materials and describes how properties change at the nanoscale. Applications discussed include electronics, medicine, energy, and environmental remediation. Common synthesis methods are outlined as well as characterization techniques like UV-Vis spectroscopy, FTIR, XRD, SEM, TEM, and AFM. Scanning probe microscopes like SEM, STM, and AFM are also briefly described.
Nanoparticle Gold in therapy and cosmetologyguest49edce
The document discusses the history and development of nanotechnology. It notes that while nanotechnology concepts have been around for some time, it was in the 1980s that major developments occurred with the invention of the scanning tunneling microscope and atomic force microscope. These microscopes allowed visualization and manipulation of materials at the nanoscale. The document also discusses various applications of gold nanoparticles in medicine, such as using them for drug delivery for cancer treatment, and in catalysis. However, it notes that while cosmetics containing gold nanoparticles are being widely sold, medical uses of gold nanoparticles still require extensive testing and FDA approval before being used to treat diseases.
Nanotechnology involves engineering at the nanoscale (1-100 nanometers) and can be used in various fields including medicine. It has several applications for cancer treatment such as using nanoparticles, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, silica nanoparticles, and nanorobots to more precisely deliver drugs to cancer cells, detect genetic mutations associated with cancer, and potentially diagnose and treat cancer. Nanoparticles in particular show promise for overcoming limitations of conventional cancer treatments like poor solubility, lack of targeting, and side effects by selectively targeting cancer cells and increasing drug localization.
This document discusses the potential applications of nanotechnology in cancer diagnosis and treatment. It begins with an overview of nanotechnology and nanomedicine. It then discusses how cancer forms and the various factors that can cause cancer like chemicals, radiation, viruses and lifestyle. The document outlines how nanotechnology can be used to more effectively deliver drugs, detect cancer at an early stage, and treat cancer through approaches like photothermal ablation using gold nanoparticles. It acknowledges challenges like ensuring nanoparticles are biocompatible and non-toxic, but envisions that human clinical trials within the next few years could demonstrate how nanotechnology allows for safer and more targeted cancer treatment.
Green syntheses are more environmentally friendly alternatives to conventional synthesis techniques as they aim to reduce toxic elements and costs while benefiting from sustainable sources. There are two main categories of green synthesis: microbial, which uses bacteria and other microbes to produce nanoparticles either intracellularly or extracellularly, and phyto-synthesis, which uses plants to produce nanoparticles on a large scale. Green synthesis methods provide single step, non-toxic and cost effective production of nanoparticles for applications in medicine, environmental remediation, and more.
This document discusses various methods for synthesizing silver nanoparticles (Ag NPs). It covers physical approaches like evaporation-condensation and laser ablation. It then discusses several chemical approaches for reduction of silver ions to produce Ag NPs, including reduction by tri-sodium citrate, sodium borohydride, UV irradiation, gamma irradiation, laser irradiation, microwave irradiation, sonochemical reduction, and electrochemical methods. It notes the advantages of these chemical synthesis techniques and how stabilizing agents prevent agglomeration of the nanoparticles.
Process design.cancer treatment using nanoparticles. pptHoang Tien
Nanoparticles show promise for improving cancer detection and treatment. They are small enough to enter cells and interact with DNA and proteins. Quantum dots and nanoshells can be used to detect cancer signatures. Nanoshells coated with cancer-targeting molecules can selectively heat and destroy cancer cells when exposed to near-infrared light, protecting healthy cells. While challenges remain around toxicity and delivery, nanoparticles may enable cheaper, less toxic cancer therapies compared to chemotherapy and improve outcomes.
Green Synthesis Of Silver NanoparticlesAnal Mondal
This document discusses the green synthesis of silver nanoparticles. It begins by defining nanoparticles and describing their properties. It then discusses silver nanoparticles specifically, including their size range and color properties. The rest of the document discusses the green synthesis technique for producing silver nanoparticles using plant extracts, the advantages of this method over chemical synthesis, and various characterization techniques and applications of the synthesized silver nanoparticles.
Synthesis of nanoparticles physical, chemical and biological meansPRIYABHATT26
The document discusses various physical, chemical, and biological methods for synthesizing nanoparticles. It provides case studies on the synthesis of nanoparticles including silver, gold, platinum, zinc oxide and more using methods such as polyol, microemulsion, thermal decomposition, electrochemical synthesis, plasma, microwave irradiation, pulsed laser, sonochemical reduction, gamma radiation, bacteria, fungi, and plants. The document compares top-down and bottom-up synthesis approaches and provides details on specific synthesis techniques for producing metallic nanoparticles using different organisms, reactions conditions, and applications.
This will enhance the knowledge about the methods of nano particle synthesis. The application of Green method is also described. Gold nano particles are also explained with its toxicity and application.
Review on green synthesis of silver nanoparticles using plant extract. Various green materials are used for the synthesis of Ag. Several synthesis method main emphasis on green method.
The main methods of producing nanoparticles are often cost effective and harmful to the environment. The green synthesis of nanoparticles has been proposed as a cost-effective and eco-friendly alternative of the previous methods. At present the metal nanoparticle synthesis using plant extracts has become a major focus of researchers.
This document summarizes the green synthesis of silver nanorods and wires using plant extracts from Zoysia japonica lawn grass, Azadarichta indica neem leaves, and Prunus dulcis almond. The aim was to produce silver nanoparticles using these plant extracts as reducing agents. Silver nanoparticles were synthesized by adding plant extracts to a silver nitrate solution and incubating for 24 hours, resulting in color changes. The synthesized nanoparticles were characterized using UV-visible spectroscopy, which showed absorption peaks varying between 300-500 nm depending on the plant extract used. Further analysis using techniques like iodometric titration, TEM, and FTIR were proposed to understand stabilization and structure of the synthesized silver nanoparticles.
Novel effects can occur in materials when structures are formed with sizes comparable to any one of many possible length scales, such as the de Broglie wavelength of electrons, or the optical wavelengths of high energy photons. In these cases quantum mechanical effects can dominate material properties. One example is quantum confinement where the electronic properties of solids are altered with great reductions in particle size. The optical properties of nanoparticles, e.g. fluorescence, also become a function of the particle diameter. This effect does not come into play by going from macrosocopic to micrometer dimensions, but becomes pronounced when the nanometer scale is reached.
Nanoparticles for magnetic resonance imagingAlex Chris
This document discusses the use of various types of nanoparticles for molecular imaging applications such as magnetic resonance imaging (MRI) and computer tomography (CT). It describes how gold nanoparticles, quantum dots, iron oxide nanoparticles, carbon nanotubes, dendrimers, and other nanoparticles are being investigated and developed as contrast agents for molecular imaging due to their tunable properties and potential for functionalization and targeted delivery. For example, one study demonstrated how antibody-conjugated gold nanorods could selectively target and image squamous cell carcinoma tumors using CT. Overall, the controlled properties of engineered nanoparticles show promise for improving molecular imaging techniques.
Advances in Diagnosis & Imaging Impacting Cancer Treatment Dr.Harsha Doddihal
This document discusses advances in cancer diagnosis and treatment. It covers new diagnostic techniques like advanced pathology using techniques like IHC, FISH, and genomic assays that provide more molecular information about tumors. Imaging techniques like PET scans are now able to more precisely define tumors and monitor treatment response. The document also discusses the shifting treatment paradigm towards personalized and targeted therapies that act on specific molecular pathways identified as disrupted in a patient's cancer. Several new targeted drugs approved in recent years are mentioned along with the biomarkers they target like HER2, BCR-ABL, MEK, PI3K, VEGF receptors.
The Molecular Imaging Laboratory at Howard University provides state-of-the-art imaging equipment including high resolution MRI systems for small animal and clinical research. The lab aims to train students and foster multidisciplinary research using imaging to study disease processes and investigate new treatments. Areas of research include in vivo MRI and optical imaging of disease models in small animals, as well as molecular imaging of biological processes and developing new imaging probes and nanoparticles.
Nanoparticles have shown promise for cancer therapy by taking advantage of their small size to selectively target tumors. Researchers are developing nanoparticles that can carry drugs, genes, or imaging agents directly into cancer cells while avoiding healthy tissues. Some nanoparticles under study use magnetic or optical properties to heat and destroy cancer cells from the inside or help locate tumors for more effective radiation therapy.
The engineered nanoparticles are effectively used for cancer treatment due to their targeted drug delivery approach. Download the Aranca report on Technology and Patent Research for current research trends and developments.
Nanoparticles for drug delivery by shreyaShreya Modi
This document discusses the advancement of nanotechnology and nanoparticles for cancer diagnosis and drug delivery. It outlines several challenges in developing effective nanoscale drug delivery systems, as well as properties of nanomaterials that make them suitable for drug delivery. Various nanodevices are described that could be used for targeted drug delivery, including liposomes, nanoshells, dendrimers, micelles, nanowires, nanotubes, quantum dots, and potential future nanorobots. Advantages of nanoparticle drug delivery systems include smaller size, higher bioavailability, and ability to target drugs directly to cells and nuclei. The only disadvantage mentioned is difficulty determining proper dosages.
Nano particles are extremely small particles that are now being used in many products including sunscreen. There is ongoing research about whether nano particles in sunscreen are safe. While nano particles help sunscreen go on clear rather than white, some studies show they may penetrate the skin and cause harm. Alternative natural nano particles from ivy are being researched as potentially safer options. Overall, the risks of nano particles in sunscreen are still being evaluated.
This Presentation discuss about "Drug Development",it is mainly discuss about "Cancer" cure by "Nano Technology".In this Presentation explains how Nano Technology to cure a "Cancer".This Presentation will help for students to know about "Nano Technology".
The main aim deals with the eradication of cancer cells by providing a steady, possible method of destroying and curing the cancer in an efficient and safe way so that healthy cells are not affected in any manner. This technology also focuses on a main idea that the patient is not affected by cancer again. The purpose of using the RF signal is to save normal cells.
Use of Nanotechnology in Diagnosis and Treatment of CancerAnas Indabawa
The document discusses how nanotechnology can be used for cancer diagnosis and treatment. It describes several nanoscale devices such as nanopores, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, and nanorobots that can help detect genetic mutations associated with cancer, target delivery of drugs to cancer cells, and enable non-invasive cancer diagnosis and treatment with localized heat therapy. The manipulation of matter at the nanoscale allows more precise cancer detection and targeted therapy with fewer side effects than traditional approaches.
NANOTECHNOLOGY FOR CANCER THERAPY RECENT DEVELOPMENTSroshan telrandhe
This document discusses the use of nanotechnology for cancer therapy and recent developments. It describes how nanotechnology platforms can serve as targeted drug delivery vehicles, carrying therapeutic agents into malignant cells while avoiding healthy cells. The document then discusses several nanotechnology approaches for cancer treatment, including using nanoparticles loaded with anticancer drugs for targeted delivery and preventing DNA damage through coating skin cells with sunscreen-containing nanoparticles on the nanoscale. Overall, the document outlines the potential of nanotechnology to improve cancer treatment by more precisely targeting cancer cells and reducing side effects.
Current and future techniques for cancer diagnosisNitin Talreja
This document discusses various nanotechnology approaches for cancer diagnosis, including the use of gold nanoparticles, quantum dots, carbon nanotubes, and nanoflares. Gold nanoparticles can be used for detection through techniques like dynamic light scattering and surface plasmon coupling. Quantum dots and carbon nanotubes can also be functionalized for ultrasensitive detection of cancer biomarkers. Emerging tools like nanoflares allow for detection of genetic targets associated with cancer within living cells. Overall, nanotechnology enables low detection limits and early cancer diagnosis.
Nanotechnology for cancer therapy recent developmentsroshan telrandhe
1. The document discusses recent developments in using nanotechnology for cancer therapy. It describes how nanoparticles can be used to target delivery of drugs specifically to tumor cells, reducing side effects on healthy cells.
2. Various nanotechnology platforms for drug delivery are reviewed, including polymeric nanoparticles, liposomes, dendrimers, and nucleic acid-based nanoparticles. The targeted delivery allows for higher drug doses to be used against cancer cells.
3. The review discusses both preventative and treatment applications of nanotechnology. Preventatively, nanoparticles could deliver sunscreen agents directly to skin cells. In treatment, nanoparticles are being used to more effectively deliver drugs like paclitaxel for prostate cancer therapy.
Nanotechnology for Cancer therapy: Recent developmentsroshan telrandhe
Nanotechnology shows promise for targeted cancer treatment. It can deliver drugs, genes, and proteins specifically to tumor tissues to treat cancer without harming healthy tissues. Nanoparticles can be engineered for both diagnosis and therapy of cancer. Nanotechnology approaches help address challenges with conventional cancer treatments like toxicity. Nanoparticles allow targeted drug delivery to tumors via leaky blood vessels and can be functionalized for long circulation times and tissue recognition to maximize exposure of drugs to cancer sites. However, more research is still needed to overcome challenges like an immune response and optimize nanotechnology cancer platforms.
Nanotechnology involves controlling and manipulating matter at the atomic and molecular scale from 1-100 nm. It allows the production of materials and devices with special properties not seen in bulk materials. Nanoparticles can be synthesized through various methods and engineered into different structures. Nanomedicine applies nanotechnology for health and medicine, enabling early disease detection and more targeted treatment through nano-sized materials and biosensors. In cancer treatment, nanoparticles can be engineered to target and deliver chemotherapeutics directly to tumor cells to minimize side effects.
Mrs. Archana Morey discusses how nanotechnology can be used as a multi-tasking weapon for oral cancer treatment. Nanoparticles can be engineered to target cancer cells specifically and deliver higher concentrations of drugs directly to tumors, overcoming challenges of current cancer therapies. Applications include using gold nanorods conjugated to antibodies for early cancer detection, quantum dots for enhanced imaging, and polymersomes to more efficiently deliver therapies directly into tumor cells. The precise targeting of cancer cells and ability to diagnose and treat at the earliest stages makes nanotechnology a promising approach for improving oral cancer outcomes.
Improvisation of Conventional Techniques: The Future of Oncology Researchasclepiuspdfs
This document discusses two advanced techniques that may improve future oncology research: resonant harmonic excitation and low-intensity pulsed ultrasound. Resonant harmonic excitation uses ultrasound at specific frequencies to rupture the nucleolar envelopes of cancer cells without harming healthy cells. Low-intensity pulsed ultrasound bombards a mixture of cancer and normal cells with short pulses of low-intensity ultrasound at various frequencies and durations, killing cancer cells through microbubble oscillations while leaving normal cells unharmed. These techniques offer targeted cancer cell destruction with less damage to surrounding tissue compared to conventional chemotherapy and may provide new avenues for cancer treatment if validated in human studies.
Positron Emission Tomography (PET) is a nuclear imaging technique that allows measurement of brain function while the patient is conscious. Unlike CT or X-rays, PET shows metabolic activity rather than just anatomical structure. A radioactive tracer is injected and detected as it decays, allowing reconstruction of images showing metabolic processes like glucose use in different brain regions. Myocardial Perfusion Imaging (MPI), a type of nuclear medicine imaging, uses radioactive tracers to demonstrate heart muscle function and blood flow. It can diagnose coronary artery disease and is often more sensitive than other tests, particularly for women.
Gold Nano Particles Of Cancer Treatment: A ReviewShrikant Shirole
Gold nanoparticles are emerging as promising agents for cancer
therapy and are being investigated as drug carriers, photothermal
agents, contrast agents and radiosensitisers. Cancer is the disease
caused by an uncontrolled division of abnormal cells in a part of the
body.In this review some various nanotechnology is found the 10 new
technique and treated with all the cancer treatment is beneficial
compare to other cancer therapy.Will the synthesis of various gold
nano particles and find out the gold nano shells, gold nano cages, gold
colloidal nano spheres. Then Nanoparticles can be used to target bio markers or antigens that
are highly specific to Cancer cells.This gold nano particles using the therapy Rheumatoid
arthritis, Alzheimer's disease, Cancer detection. The introduces to the cancer diseases,nano
particles techniques, cancer therapy, then various types of the gold nano particles, propertices
of cancer cells, future scope of cancer treatment, applications, background of cancer
treatment will be discussed.
KEYWORDS: Gold nano particles techniques, cancer treatment, clinical trials.
Nanorobotics is the emerging technology field of creating machines or robots ...Amit Srivastav
Nanobots have the potential to revolutionize cancer treatment by targeting cancer cells precisely without harming healthy cells. Researchers envision swarms of nanobots that can be injected into the bloodstream to locate and destroy cancer tumors through mechanisms like laser zapping or injecting toxic payloads. This approach could reduce the side effects of current treatments like chemotherapy and radiation therapy. However, developing functional nanobots faces challenges from technical debates around the feasibility of molecular manufacturing at the nanoscale.
Nanotechnology has aided cancer treatment development in several ways:
1) It has enabled earlier cancer detection through highly sensitive nanoscale devices that can detect rare molecular signals associated with malignant cells.
2) It has improved imaging techniques using nanoparticles and MRI to identify cancers that have spread.
3) It allows monitoring of environmental exposures to cancer risks and studying gene-environment interactions in cancer development.
Nanomedicines show promise for improving cancer treatment. Nanoparticles can be engineered to target cancer cells specifically and deliver toxic payloads or heat. Gold nanoparticles activated by laser light can hyperthermically destroy tumor cells from the inside. Challenges remain in developing nanoparticles that are safe and can effectively reach tumors. If these challenges can be addressed, nanomedicine may enable more precise cancer detection and treatments with fewer side effects than conventional therapies.
Nanotechnology involves processes at the molecular and nanoscale levels. It has applications in pharmacy including drug delivery, diagnostics, imaging, and biosensors. Nanoparticles show promise for cancer treatment through targeted drug delivery and hyperthermia. They can be engineered to selectively detect molecular markers of cancer cells through properties like high surface area and quantum dots for imaging. Challenges remain around reducing toxicity while ensuring nanoparticles reach tumors.
One way to alleviate the terrible side effects of chemotherapy is to find a way to better control what cells are needed
to be targeted by the drugs in cancer patients. By being able to target on ly the cancerous cells within the body, less
chemotherapy drugs would need to be injected into the patient for cancer treatment, thus reducing, if not completely
wiping away, the side effects of the chemotherapy drugs. Cancer researchers have figured out a method that better
delivers drugs, such as chemotherapy drugs, to cancer cells without damaging surrounding healthy ones, by
discovering a way to use single-walled carbon nanotubes (SWCNTs) as targeted medicinal delivery mediums. For
how small they are, their inner volumes are relatively large, leaving enough space to carry drugs into the body. Both
the inner and outer surfaces of SWCNTs can be easily modified for “functionalization”. Their small size nature
allows them to enter the nuclei of cells freely. Most importantly, single-walled carbon nanotubes are completely safe
and nontoxic and proven to be stable to use in inserting and transporting drugs into the body. Presently, carbon
nanotubes are not only being used as drug delivery systems, but as a means of directly killing malignant cells within
the body. All of these applications of CNTs makes it promising and would lead to great advances in medicine in the
future.
Nanotechnology shows promise for medical diagnosis and treatment. It involves constructing and engineering functional systems at the atomic or nanoscale level, where unique properties emerge. Various nanodevices like quantum dots, magnetic nanoparticles, nanoshells, and dendrimers can be used for cancer detection, DNA sequencing, and drug delivery. Challenges include safety concerns over nanoparticle interactions and the need for multidisciplinary collaboration to advance applications. Overall, the integration of nanotechnology into healthcare has potential to transform disease diagnosis, monitoring, and therapy.
Nanotechnology offers promising applications in diagnostic pathology through the use of nanoscale devices and materials. Some key applications discussed in the document include using cantilevers to detect cancer biomarkers, nanopores for efficient DNA sequencing, nanotubes to map DNA mutations, nanoshells that absorb light for cancer treatment, dendrimers for drug delivery, magnetic nanoparticles as MRI contrast agents, quantum dots as fluorescent probes, and graphene oxide sheets for attaching antibodies for medical diagnosis. Overall, nanotechnology enables detection, imaging, and analysis at the molecular level for early disease diagnosis and targeted treatment.
Nanotechnology and potential in Cancer therapy and treatmentladen12
this presentation focuses on new nanotechnology and it possible use in detection and therapy with cancer. it was prepared by final year biochemistry student at NCU.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Authoring a personal GPT for your research and practice: How we created the Q...Leonel Morgado
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
The cost of acquiring information by natural selectionCarl Bergstrom
This is a short talk that I gave at the Banff International Research Station workshop on Modeling and Theory in Population Biology. The idea is to try to understand how the burden of natural selection relates to the amount of information that selection puts into the genome.
It's based on the first part of this research paper:
The cost of information acquisition by natural selection
Ryan Seamus McGee, Olivia Kosterlitz, Artem Kaznatcheev, Benjamin Kerr, Carl T. Bergstrom
bioRxiv 2022.07.02.498577; doi: https://doi.org/10.1101/2022.07.02.498577
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...PsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...Travis Hills MN
By harnessing the power of High Flux Vacuum Membrane Distillation, Travis Hills from MN envisions a future where clean and safe drinking water is accessible to all, regardless of geographical location or economic status.
The binding of cosmological structures by massless topological defectsSérgio Sacani
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
3. Nanotechnology will change the very foundations of cancer
diagnosis, treatment, and prevention.
If we take an imaginative approach. Of course, this is quite logical,
Since everything around us is made up of atomic and molecular
matter
All of our problems are ultimately rooted in atomic and molecular
arrangements. Nanotechnology has at last provided a way for us to
rearrange and restructure matter on an atomic scale, allowing us to
reach down to the very roots of any problem
4. Nano Particles
Nanotechnology is the
engineering of functional
systems at the molecular
scale.
Nano refers to the 10-9
power, or one billionth. .For
comparison, a human hair is
about 100,000 nanometers
thick.
The word itself is a
combination of nano, from
the Greek “nanos” (or Latin
“nanus”), meaning “Dwarf”,
and the word "Science”.
Relevant Comparisons
Water
molecule
White
blood cell
Tennis
ball
5. Most animal cells are
10,000 to 20,000
nanometers in diameter.
nanoscale devices (less
than 100 nanometers) can
enter cells and the
organelles inside them to
interact with DNA and
proteins. Tools developed
through nanotechnology
may be able to detect
disease in a very small
amount of cells or tissue.
They may also be able to
enter and monitor cells
within a living body.
NanoparticlesAre
SmallEnoughtoEnterCells
Cell
White blood
cell
Nanodevices
Nanoparticles
6. Cancer is a class of diseases characterized by out-of-control cell growth.
There are over 100 different types of cancer, and each is classified by the
type of cell that is initially affected.
Cancer harms the body when damaged cells divide uncontrollably to form
lumps or masses of tissue called tumors.
Tumor cells are basically two types.
A tumor cell is part of a tissue that is abnormally growing. It may be either
malignant or benign in nature
Liver
cancer
9. Gold nanoparticles (GNP) are emerging as
promising agents for cancer therapy and are
being investigated as drug carriers,
photothermal agents, contrast agents and
radiosensitisers. Due to its small size, high
surface area ratio and being chemically inert
gold acts as an active vehicle which binds
specifically to the tumor cell. The main
advantage of GNPs is that they minimize the
toxicity of the anti cancer drugs. Research
studies have sighted that gold nanoparticles
produce covalent bond with the cytotoxic drug
and don’t react with any other molecule.
Targeted cell therapy is achieved in GNP drug
delivery system and special interaction
between light matters at right wavelength
turns gold nanoparticle into precise cancer cell
killers. Infra red light is used to oscillate the
gold nanoparticles attached with the cancer
cell and the energy formed due to oscillation as
heat and at sudden temperature increase kills
the cancer cell. This review work displays the
applications of gold nanoparticles as targeted
drug delivery tools for the cancer therapy.
10.
11. Gold nanoparticle is simple for diagnosis.
It is less invasive.
It is provides increased contrast for diagnosis of oral
cancer.
It is nontoxic to human beings.
It does not photo bleaching or blinking which is
inherent to many other fluorophores.
14. Parvesh Sharma, Scott C Brown, NiclasBengtsson, et al. Gold-
nanoparticle.
Helcher, H. H.AurumPotabileoder Gold Tinstur; J.
HerbordKlossen: Breslau and Leipzig, 1718.
WeiboCai, Ting Gao, Hao Hong, et al. Applications of
goldnanoparticles in cancer nanotechnology. Nanotechnology,
Science and Applications 2008;1:17-32.
Huang X, El-Sayed IH, Qian W, El-Sayed MA. Cancer cell
imaging and photo thermal therapy in the nearinfraredregion by
using gold nanorods. J Am ChemSoc 2006;128:2115–20.Gold
Nanorod Antennas for Ultra selective Tumor Ablation.
Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases.
Nature 2000;407:249^57.
RisauW. Angiogenesis and endothelial cell
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