Generic Dexamethasone Tablets (Dexona) are used to treat symptoms such as inflammation, certain immune disorders and in replacement therapy of an inactive or underactive adrenal gland. Dexamethasone may be prescribed for skin allergies, asthma, leukaemia, blood disorders, selected rheumatic disorders, gastrointestinal disorders, skin problems, certain abnormal growths (cancers) and excessive calcium in the blood.

1. Generic Dexamethasone Tablets
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Generic Dexamethasone Tablets (Dexona) are used
to treat symptoms such as inflammation, certain immune
disorders and in replacement therapy of an inactive or
underactive adrenal gland. Dexamethasone may be
prescribed for skin allergies, asthma, leukaemia, blood
disorders, selected rheumatic disorders, gastrointestinal
disorders, skin problems, certain abnormal growths
(cancers) and excessive calcium in the blood.

2. Dexona Tablets
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Dexona Tablets are manufactured by
Zydus Cadila Healthcare Ltd., India,
(Website: www.zyduscadila.com)

3. Dexamethasone Tablets – Brand Names
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Dexamethasone tablets are available
as Dexona, Demisone, Dexamag,
Dexasone and Dexane.

4. Active Ingredient
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The active ingredient contained in Dexona
tablets is Dexamethasone Sodium
Phosphate. Each Dexona tablet contains 0.5
mg of Dexamethasone.

5. Chemical Structure
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The structure of Dexamethasone Sodium
Phosphate is given below:

6. Uses of Dexona Tablets
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Dexona tablets, manufactured by Zydus
Cadila Healthcare Ltd., India is a synthetic
corticosteroid exhibiting both anti-
inflammatory and immuno-suppressant
properties. This medicine is used for
replacement therapy in secondary adrenal
insufficiency arising from insufficient
corticotrophin secretion.

7. Uses of Dexona Tablets
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It is also indicated for allergic disorders such as
bronchial asthma and allergic skin reactions, blood
disorders such as leukaemia, thrombocytopoenia
and haemolytic anaemias, selected collagen and
rheumatic disorders (only rarely in rheumatoid
arthritis), gastrointestinal disorders such as
inflammatory bowel disease, connective tissue
disorders such as arteritis, systemic lupus
erythematosus (but not scleroderma), some skin
diseases such as pemphigus, oedema, some eye
disorders, certain neoplastic disorders such as
cerebral neoplasm, secondary hypercalcaemia, and
acute leukaemia in children.

8. Dexona Dosage
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➢The starting Dexona dosage varies from 0.75
mg to 9 mg a day depending on the disease
being treated.
➢The duration of the treatment is dependent
on the clinical response of the patient and as
soon as improvement is observed, the dosage
must be adjusted to the minimum required to
maintain the desired response. Withdrawal
of Dexamethasone tablets at completion of
treatment should be gradual.
The dosage of Dexona tablets (Dexamethasone
Sodium Phosphate) is given below:

9. Storage Instructions
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Generic Dexamethasone Tablets
(Dexona) have to be stored at controlled
room temperature i.e. from 20°C to 25°C
(68°F to 77°F). Protect from light.
Keep this as well as all other medicines
away from children and pets.

10. Warnings
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Precautions is necessary when oral corticosteroids are
used in patients with the following conditions and frequent
monitoring is necessary: Hypertension, Hypothyroidism,
Congestive Heart failure or recent myocardial infarction,
Liver failure, Renal insufficiency, Diabetes mellitus or in
those with a family history of diabetes, Osteoporosis,
Glaucoma, Patients with a history of severe affective
disorders particularly of steroid induced psychoses,
Epilepsy and/or seizure disorder Peptic ulceration,
Previous steroid myopathy, Tuberculosis, patients with
myasthenia gravis receiving anticholinesterase
therapy since corticosteroid use may decrease plasma
anticholinesterase activity, Patients with Cushing's
disease and Patients with thromboembolic disorders.

11. Warnings
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This medicine has to be administered
with caution in patients with
Duchenne’s muscular dystrophy since
transient rhabdomyolysis and
myoblobinuria have been reported
following strenuous physical activity.

12. Dexona Tablets
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Contraindications
Dexona is contraindicated in patients with a
hypersensitivity to Dexamethasone Sodium
Phosphate or any other component of this
medication.
This medicine is also contraindicated in cases of
systemic infection unless specific anti-infective
therapy is employed.
Avoid live vaccines in patients receiving immuno
suppressive doses (serum antibody response
diminished).

13. Generic Dexamethasone Side Effects
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➢Generic Dexamethasone Tablets (Dexona) side
effects can include slowed growth in children,
bloating or rounding of the face,cramps or
weakness in the muscles of the arms and legs,
water retention leading to swollen legs and feet,
irregular heartbeat or breathlessness, weight gain,
headache, tiredness, irregular menstrual periods,
leg pains, tingling in hands and feet, painful joints,
an increased frequency of infections, nausea,
vomiting, indigestion (burning sensation), weight
loss, mood swings, euphoria, personality changes,
severe depression, insomnia (inability to sleep),
abnormal thoughts, headaches and fits. Other side
effects not listed above may also occur in certain
patients.

14. Generic Dexamethasone Overdose
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Treatment of Generic Dexamethasone
overdosage is by supportive and
symptomatic therapy. In the case of acute
Dexona overdosage, according to the
patient's condition, supportive therapy may
include gastric lavage or emesis.

15. Dexamethasone During Pregnancy
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Dexamethasone (Dexona tablets) has been classified by
the US FDA as Pregnancy Category C.
During animal studies, corticosteroids have been
found to cause malformations of various kinds (cleft
palate, skeletal malformations).
Reduced placental and birth weight have been observed
in animals and humans after long-term treatment. Since
the possibility of suppression of the adrenal cortex in the
newborn baby after long-term treatment must be
considered, the needs of the mother must be carefully
weighed against the risk to the fetus when
prescribing corticosteroids. However, the short-term
use of antepartum corticosteroids for the prevention of
respiratory distress syndrome, when necessary, does not
seem to pose a risk.

16. Dexona Tablets
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Dexona (Generic Dexamethasone tablets)
by Zydus Cadila Healthcare Limited, India.