Generic Selegiline Tablets (Selgin)

Generic Selegiline Tablets
© Clearsky Pharmacy
Generic Selegiline HCl Tablets (Selgin) is used to treat
movement disorders caused by Parkinson's disease.
Selgin does not cure Parkinson's disease, but it may
improve shakiness (tremor), muscle stiffness, loss of
normal movement as your dose of other Parkinson's
medication wears off, and sudden changing between
normal movement and stiffness ("on-off" problems).

Selgin Tablets
Selgin Tablets are manufactured by
Intas Pharmaceuticals Ltd. , India.
(Website: www.intaspharma.com)

Selegiline Hydrochloride Tablets – Brand Names
Selegiline Hydrochloride tablets are
available as Elegelin, Selerin,
Eldepryl, Jumax, Jumex, Selgin and
Selerin.

Active Ingredient
The active ingredient contained in Selgin
tablets is Selegiline Hydrochloride.
Each Selgin tablet contains 5 mg of
Selegiline.

Chemical Structure
The structure of Selegiline Hydrochloride is
given below:

Uses of Selgin Tablets
Selgin tablets, manufactured by Intas
Pharmaceuticals Ltd., India is a monoamine
oxidase type B (MAO-B) inhibitor, is used
in the management of patients with
Parkinson’s disease being treated with
Levodopa/Carbidopa who exhibit
deterioration in the quality of their response
to this therapy.
A transdermal patch which is marketed
under the brand name, Emsam is used to
treat depression.

Generic Selegiline Tablets Dosage
➢Generic Selegiline Tablets (Selgin) is
administered as monotherapy in the early
phase of the disease, or as adjunctive
therapy with Levodopa (with / without a
peripheral decarboxylase inhibitor) with a
dose of 10 mg per day administered as divided
doses.
➢In each case the initial dose is 5 mg
taken at breakfast and lunch.
The dosage of Selgin tablets (Selegiline
Hydrochloride) is given below:

Selgin Dosage
➢After two to three days of adjunctive therapy,
an attempt may be made to reduce the dose
of levodopa (10% to 30%) in case Levodopa-
related adverse reactions occur. Further dosage
reductions of Levodopa may be possible during
continued Selegiline therapy.
➢Taking Generic Selegiline late in the day could
cause trouble sleeping. Dosage is based on your
medical condition and response to therapy. Do not
increase your dose or take it more often than
directed.
The dosage of Generic Selegiline Tablets
(Selgin) is given below:

Storage Instructions
Selgin (Generic Selegiline tablets )
have to be stored at controlled room
temperature i.e. from 25°C (77°F) with
excursions permitted between 15° to
30°C (59° to 86°F).
Keep this as well as all other medicines
away from children and pets.

Selgin Tablets
Contraindications
Selgin is contraindicated in patients with a
hypersensitivity to Selegiline Hydrochloride or any other
component of this medication.
Generic Selegiline Tablets (Selgin) is contraindicated in
patients using the following medicines: Meperidine,
Tramadol, Methadone, Propoxyphene, Mao Inhibitors
Including Selective Mao-B Inhibitors, Dextromethorphan,
St. John’s Wort, and Cyclobenzaprine.
Pethidine is contraindicated in combination with
MAOIs like Selgin because of reports of serious,
sometimes fatal, reactions in patients receiving this
combination and in patients who have discontinued
MAOI therapy and are then started on Pethidine within
two weeks of discontinuation.

Selgin Tablets
Contraindications
Generic Selegiline Tablets (Selgin) is
contraindicated in patients using Selective
Serotonin Reuptake Inhibitors (SSRIs) or within
five weeks of stopping a SSRI.
There have been reports of serious, sometimes
fatal, reactions in patients receiving SSRIs in
combination with Selegiline tablets and in
patients who have recently discontinued SSRIs
and are then started on a MAOI.
At least five weeks should be allowed
between discontinuation of, for example,
Fluoxetine, Sertraline or Paroxetine and
starting treatment with Selegiline tablets.

Warnings
May cause hypertension above 2.5 mg/day
The recommended dose of 10 mg /day should not
be exceeded because of the risks associated with
non-selective inhibition of MAO i.e. 'cheese reactions'.
May cause Serotonin syndrome when used with
antidepressants
May cause falling asleep during activities of daily living
May cause hypotension/orthostatic hypotension
May cause or exacerbate dyskinesia
May cause hallucinations and psychotic-like behavior
May cause problems with impulse control and
compulsive behaviors
Abrupt discontinuation could cause hyperpyrexia and
confusion.
Increased risk of melanoma

Warnings
May cause irritation of the buccal mucosa
Increased risk for phenylketonuric patients
Some patients on adjunctive therapy may experience
exacerbation of Levodopa-associated side effects,
presumably due to the increased amounts of
dopamine reacting with super-sensitive postsynaptic
receptors.
These effects may often be mitigated by reducing the dose
of Levodopa by approximately 10% -30%.
Selegiline should be used cautiously in patients with
severe liver or kidney dysfunction, as there is no
pharmacokinetic information available on Selegiline or it's
metabolites in these patients.
Selegiline should be given cautiously to patients with
peptic or duodenal ulcer, labile hypertension, cardiac
arrhythmias, severe angina pectoris, or psychosis as
selegiline may exacerbate these conditions.

Warnings
Transient increases in liver transaminases have been
reported during selegiline treatment.
Parkinson's disease patients treated with dopamine
agonists and other dopaminergic treatments such as
selegiline have been reported as exhibiting impulse
control disorders and compulsions like pathalogical
gambling, increased libido, hypersexuality, binge eating,
shopping and different kinds of compulsive/repetitive
activities (punding).
Treatment with heterogenous serotonergic drugs in
patients primarily with psychiatric illness taken alone or in
combination with other drugs such as MAOIs has been
uncommonly associated with symptoms of, myoclonus,
tremor, confusion, restlessness, ataxia and hyperreflexia.
While usually short-lived, it can lead to intensive care
admissions and is potentially fatal.

Warnings
Severe CNS toxicity has been reported in
patients when a combination of tricyclic
antidepressants and selegiline have been used.
Concomitant use of oral contraceptives (tablets
containing the combination of Gestodene/Ethinyl
Estradiol or Levonorgestrel/Ethinyl Estradiol)
and selegiline may cause an increase in the
oral bioavailability of Generic Selegiline.
Foods containing various exogenous amines such
as tyramine have not been reported to induce
hypertensive reactions during selegiline treatment
at doses used in the treatment of Parkinson's
disease.

Selgin Side Effects
➢Common Selgin (Selegiline HCl Tablets) side
effects with an incidence at least 3% greater than on
placebo are constipation, skin disorders, vomiting,
dizziness, dyskinesia, insomnia, dyspnea, myalgia,
and rash.
➢Since Selgin potentiates the clinical efficacy of
levodopa, the adverse reactions of Levodopa, e.g.
abnormal movements such as dyskinesias,
nausea, agitation, confusion, hallucinations,
headache, postural hypotension, cardiac arrhythmias
and vertigo, may worsen when Generic Selegiline
is added to the maximum tolerated levodopa dose.
Micturition difficulties and skin reactions have
also been reported during Selegiline treatment.

Generic Selegiline Overdose
No Generic Selegiline overdosage cases are known.
However, experience gained during Selegiline's
development reveal that some individuals exposed to
doses of 600 mg/day Selegiline suffered severe
hypotension and psychomotor agitation.
Signs and symptoms of overdosage of of non-selective
MAO inhibitor could include, alone or in combination,
any of the following: drowsiness, dizziness, faintness,
irritability, hyperactivity, agitation, severe headache,
hallucinations, trismus, opisthotonos, convulsions, and
coma; rapid and irregular pulse, hypertension,
hypotension and vascular collapse; precordial pain,
respiratory depression and failure, hyperpyrexia,
diaphoresis, and cool, clammy skin.

Selgin Overdose
There is no specific antidote to treat overdose
with non-selective MAO inhibitors like Selgin and the
treatment is symptomatic and supportive. Induction
of emesis or gastric lavage with instillation of charcoal
slurry may be helpful in early poisoning, provided the
airway has been protected against aspiration. Signs
and symptoms of central nervous system stimulation,
including convulsions, should be treated with
diazepam, given slowly intravenously.
Phenothiazine derivatives and central nervous
system stimulants should be avoided. Hypotension
and vascular collapse should be treated with
intravenous fluids and, if necessary, blood pressure
titration with an intravenous infusion of a dilute
pressor agent.

Selgin Overdose
It should be noted that adrenergic agents
could produce a markedly increased pressor
response.
Support respiration, including management of
the airway, use of supplemental oxygen, and
mechanical ventilatory assistance, as
required.
Body temperature should be monitored
closely.
Intensive management of hyperpyrexia may
be required. Maintenance of fluid and
electrolyte balance is essential.

Selegiline HCl During Pregnancy
Selgin (Selegiline HCl tablets) has been
classified by the US FDA as Pregnancy Category
C.
There are no adequate and well-controlled
studies conducted in pregnant women.
During animal studies, administration of
Selegiline during pregnancy was associated with
developmental toxicity which included decreased
embryofetal and postnatal offspring growth and
survival at doses greater than those used
clinically.
Selgin should be used during pregnancy only if
the potential benefit justifies the potential risk to
the fetus.

Selgin Tablets
For more details on
Selgin Tablets click here
Selgin (Selegiline Hydrochloride tablets)
by Intas Pharmaceuticals Limited, India.

Generic Selegiline Tablets (Selgin)

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