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FundusFluorescein Angiography Dr. AnandSudhalkar Baroda
Purpose Highlight retinal and choroidal circulation Detect early vascular pathologies Confirm diagnosis
How does it work? Charateristics applications Absorbs 465-490nm, emits 520-530nm Binding to plasma proteins, espAlbumin Selective visualization of its passage Confined to natural blood retinal barrier
The sequence: passage of dye after inj. Visualization 10 to 15 sec : Short posterior ciliary arteries. Choroidal flush, optic nerve head, cilioretinal artery. 11-18 sec: Retinal circulatiion, arteries-capillaries-veins.  20-25 sec: juxtrafoveal and perifoveal capillaries Maximal fluorescence around FAZ. The best time for PEAK PHASE IMAGING. 30 sec: First passage completed. Recirculation starts After 10min: total disappearance of dye.
The Interpretation Hypo-fluorescence Hyper-fluorescence Blocked: Media opacity, Hem Vascular Filling Defects: Occlusions, capillary non perfusion Autofluorescence Transmitted fluorescence Hyperfluorescence:          1. Abnormal Vessels: Angiomas,  Tumours         2. Leakage: NV, Plebitis         3. Pooling: CSR, PED          4. Staining: Disc, drusen, chorioret. scar
Hypofluorescence Vascular filling defects Obstructions
Transmitted fluorescence
Blocked Fluorescence
Hyperfluorescence Vascular Leakage Pooling Staining
FFA reveals NV
FOCAL LEAKAGE

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