The document discusses formalizing systems biology models using ontologies. It describes how biological models are specified using the Systems Biology Markup Language (SBML) with semantic annotations from ontologies. These annotated models are then converted into formal ontological representations using the Web Ontology Language (OWL) to enable automated reasoning and knowledge discovery from the models. This allows validating annotations, inferring new knowledge, and querying simulation results in a biologically meaningful way.
SWISS-PROT- Protein Database- The Universal Protein Resource Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins.
The Protein Data Bank (PDB) is a database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids. This presentation deals with what, why, how, where and who of PDB. In this presentation we have also included briefing about various file formats available in PDB with emphasis on PDB file format
This presentation entitled 'Molecular phylogenetics and its application' deals with all the developmental ideas and basics in the field of bioinformatics.
SWISS-PROT- Protein Database- The Universal Protein Resource Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins.
The Protein Data Bank (PDB) is a database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids. This presentation deals with what, why, how, where and who of PDB. In this presentation we have also included briefing about various file formats available in PDB with emphasis on PDB file format
This presentation entitled 'Molecular phylogenetics and its application' deals with all the developmental ideas and basics in the field of bioinformatics.
Cyclic conformation and nucleic acid sugar puckeringDaniel Morton
Cyclic systems are ubiquitous, in nature and synthetic chemistry. Establishing an understanding of the shape preferences (e.g., strain and energetics) regarding representative cyclic models is a powerful tool in conformational analysis. The expanded review of fundamental cycloalkanes can further assist in preferential conformational analysis of associated derivatives.
Contributed by: Roland Jones, Dane Brankle, and Peter Stevenson, University of Utah, 2015
This presentation gives you a detailed information about the swiss prot database that comes under UniProtKB. It also covers TrEMBL: a computer annotated supplement to Swiss-Prot.
Cyclic conformation and nucleic acid sugar puckeringDaniel Morton
Cyclic systems are ubiquitous, in nature and synthetic chemistry. Establishing an understanding of the shape preferences (e.g., strain and energetics) regarding representative cyclic models is a powerful tool in conformational analysis. The expanded review of fundamental cycloalkanes can further assist in preferential conformational analysis of associated derivatives.
Contributed by: Roland Jones, Dane Brankle, and Peter Stevenson, University of Utah, 2015
This presentation gives you a detailed information about the swiss prot database that comes under UniProtKB. It also covers TrEMBL: a computer annotated supplement to Swiss-Prot.
Darwin’s Magic: Evolutionary Computation in Nanoscience, Bioinformatics and S...Natalio Krasnogor
In this talk I will overview ten years of research in the application of evolutionary computation ideas in the natural sciences. The talk will take us on a tour that will cover problems in nanoscience, e.g. controlling self-‐organizing systems, optimizing scanning probe microscopy, etc., problems arising in bioinformatics, such as predicting protein structures and their features, to challenges emerging in systems and synthetic biology. Although the algorithmic solutions involved in these problems are different from each other, at their core, they retain Darwin’s wonderful insights. I will conclude the talk by giving a personal view on why EC has been so successful and where, in my mind, the future lies.
Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...Varij Nayan
“Organisms function in an integrated manner-our senses, our muscles, our metabolism and our minds work together seamlessly. But biologists have historically studied organisms part by part and celebrated the modern ability to study them molecule by molecule, gene by gene. Systems biology is critical science of future that seeks to understand the integration of the pieces to form biological
systems”
(David Baltimore, Nobel Laureate)
Systems Biology and Genomics of Microbial PathogensRamy K. Aziz
Talk at SCITA-BIOFANS (02 Feb 2016), entitled
"Systems Biology and Genomics of Microbial Pathogens:
From virulence gene discovery to vaccine development and therapeutic intervention"
Computational Approaches to Systems BiologyMike Hucka
Presentation given at the Sydney Computational Biologists meetup on 21 August 2013 (http://australianbioinformatics.net/past-events/2013/8/21/computational-approaches-to-systems-biology.html).
Dr. Leroy Hood lectured to a group of Ohio State University College of Medicine students and faculty on May 13, 2010 in advance of an announcement of a partnership between the Ohio State University Medical Center and the Institute for Systems Biology. The partnership will be known as
The Sociology of Nothingness: Challenges of Big DataEugen Glavan
The Sociology of Nothingness: Challenges of Big Data
Presentation at Towards the Good Society – European Perspectives Conference, Bucharest, 2013
Eugen Glăvan
Abstract
The recent evolution of the internet caught attention of the social researchers through increased interaction among individuals in various aspects of life mediated by electronic devices. The boundaries between digital and real life become blurred and we are witnessing the accumulation of abundant, detailed and comprehensive information about a wide range of behaviours, choices, opinions and artefacts of Internet users. Whether we are talking about images on Flickr, short texts on platform Twitter, search log files generated by Google, millions of megabytes of information form databases on which the issue is not capability of computing, but how to analyse such data methodologically. In my presentation I will describe the latest information concerns the definition and use of „Big Data”, showing the applications and theories developed so far and possible directions for use and development of digital sociology through these types of information.
Keywords: big data, internet, digital sociology
Cyclops™ is an ergonomically designed wireless keyboard/mouse/controller combination created to interact with a new generation of consumer electronics (CE) and computer devices.
www.genos.tv
Managing Diversity:Using the CLAS Standards to guide organizational changediversityRx
Reviews the evolution of the National Standards on Culturally and Linguistically Appropriate Services in health care, with discussion of three case studies.
Biochemical ontologies aim to capture and represent biochemical entities and the relations that exist between them in an accurate manner. A fundamental starting point is biochemical identity, but our current approach for generating identifiers is haphazard and consequently integrating data is error-prone. I will discuss plausible structure-based strategies for biochemical identity whether it be at molecular level or some part thereof (e.g. residues, collection of residues, atoms, collection of atoms, functional groups) such that identifiers may be generated in an automatic and curator/database independent manner. With structure-based identifiers in hand, we will be in a position to more accurately capture context-specific biochemical knowledge, such as how a set of residues in a binding site are involved in a chemical reaction including the fact that a key nitrogen atom must first be de-protonated. Thus, our current representation of biochemical knowledge may improve such that manual and automatic methods of bio-curation are substantially more accurate.
Scaling up semantics; lessons learned across the life sciencesChris Mungall
Semantic modeling is key to understanding the biological processes underpinning the health of humans and the health of ecosystems on this planet. There are a number of different approaches to semantic modeling, varying from modeling of *things* in the form of knowledge graphs, modeling of *data structures* in the form of semantic schemas, and modeling of *words* in the form of ultra-large language models. Taking the metaphor of modeling paradigms as planets in a semantic solar system, I will take us on a tour through the solar system, exploring the strengths of each approach, and looking through a historic lens at how we keep iterating over similar solutions with each rotation around the sun. As an alternative to the dichotomy of either resisting change, or starting afresh I urge an approach were we embrace change and adapt with each revolution. I will look specifically at how the OBO community have built powerful knowledge graphs of biological concepts, how the LinkML modeling language incorporates aspects of both frame languages and shape languages, and how language models can be integrated with semantic ontological approaches through the OntoGPT framework
SBML FOR OPTIMIZING DECISION SUPPORT'S TOOLS cscpconf
Many theoretical works and tools on epidemiological field reflect the emphasis on decisionmaking tools by both public health and the scientific community, which continues to increase.
Indeed, in the epidemiological field, modeling tools are proving a very important way in helping to make decision. However, the variety, the large volume of data and the nature of epidemics
lead us to seek solutions to alleviate the heavy burden imposed on both experts and developers. In this paper, we present a new approach: the passage of an epidemic model realized in BioPEPA to a narrative language using the basics of SBML language. Our goal is to allow on one hand, epidemiologists to verify and validate the model, and the other hand, developers to
optimize the model in order to achieve a better model of decision making. We also present some preliminary results and some suggestions to improve the simulated model.
Demonstration of the applicability of the Linked Data Modeling Language and CHEMROF ( https://chemkg.github.io/chemrof/) for semantic chemical sciences. Presented at MADICES 2022. https://github.com/MADICES/MADICES-2022
SBML FOR OPTIMIZING DECISION SUPPORT'S TOOLScsandit
Many theoretical works and tools on epidemiological field reflect the emphasis on decisionmaking
tools by both public health and the scientific community, which continues to increase.
Indeed, in the epidemiological field, modeling tools are proving a very important way in helping
to make decision. However, the variety, the large volume of data and the nature of epidemics
lead us to seek solutions to alleviate the heavy burden imposed on both experts and developers.
In this paper, we present a new approach: the passage of an epidemic model realized in Bio-
PEPA to a narrative language using the basics of SBML language. Our goal is to allow on one
hand, epidemiologists to verify and validate the model, and the other hand, developers to
optimize the model in order to achieve a better model of decision making. We also present some
preliminary results and some suggestions to improve the simulated model.
I gave this talk in the EDBT 2014 conference, which tool place in Athens, Greece.
I show how data examples can be used to characterize the behavior of scientific modules. I present a new methods that automatically generate the data examples, and show that such data examples are useful for the human user to understand the task of the modules, and that they can be used to assist curators in repairing broken workflows (i.e., workflows for which one or more modules are no longer supplied by their providers)
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
knowledge graphs are an emerging paradigm to represent information. yet their discovery and reuse is hampered by insufficient or inadequate metadata. here, the COST ACTION Distributed Knowledge Graphs had a first workshop to develop a KG metadata schema. In this presentation, the progress and plans are discussed with the W3C Community Group on Knowledge Graph Construction.
Data-Driven Discovery Science with FAIR Knowledge GraphsMichel Dumontier
Data-Driven Discovery Science with FAIR Knowledge Graphs
Despite the existence of vast amounts of biomedical data, these remain difficult to find and to productively reuse in machine learning and other Artificial Intelligence technologies. In this talk, I will discuss the role of the FAIR Guiding Principles to make AI-ready biomedical data, and their representation as knowledge graphs not only enables powerful ontology-backed semantic queries, but also can be used to predict missing information, as well as to check the quality of knowledge collected.
The main idea of the talk is to introduce the FAIR principles (what they are and what they are not), and how their application with semantic web technologies (ontologies/linked data) creates improved possibilities for large scale data integration, answering sophisticated questions using automated reasoners, and predicting new relations/validating data using graph embeddings. The audience will gain insight into the state of the art in a carefully presented manner that introduces principles, approaches, and outcomes relevant to Health AI.
The FAIR (Findable, Accessible, Interoperable, Reusable) Guiding Principles light a path towards improving the discovery and reuse of digital objects (data, documents, software, web services, etc) by machines. Machine reusability is a crucial strategic component in building robust digital infrastructure that strengthens scholarship and opens new pathways for innovation on a truly global scale. However, as the FAIR principles do not specify any particular implementation, communities have the homework to devise, standardize and implement technical specifications to improve the ‘FAIRness’ of digital assets. In this seminar, I will focus on the history and state of the art in the FAIRness assessment, including manual, semi-automated and fully automated approaches, and how these can be used by developers and consumers alike. This seminar will serve as a springboard for community discussion and adoption of these services to incrementally and realistically improve the FAIRness of their resources.
The Role of the FAIR Guiding Principles for an effective Learning Health SystemMichel Dumontier
he learning health system (LHS) is an integrated social and technological system that embeds continuous improvement and innovation for the effective delivery of healthcare. A crucial part of the LHS lies in how the underlying information system will secure and take advantage of relevant knowledge assets towards supporting complex and unusual clinical decision making, facilitating public health surveillance, and aiding comparative effectiveness research. However, key knowledge assets remain difficult to obtain and reuse, particularly in a decentralized context. In this talk, I will discuss the role of the Findable, Accessible, Interoperable, and Reusable (FAIR) Guiding Principles towards the realization of the LHS, along with emerging technologies to publish and refine clinical research and knowledge derived therein.
Keynote given for 2021 Knowledge Representation for Health Care http://banzai-deim.urv.net/events/KR4HC-2021/
CIKM2020 Keynote: Accelerating discovery science with an Internet of FAIR dat...Michel Dumontier
Biomedicine has always been a fertile and challenging domain for computational discovery science. Indeed, the existence of millions of scientific articles, thousands of databases, and hundreds of ontologies, offer exciting opportunities to reuse our collective knowledge, were we not stymied by incompatible formats, overlapping and incomplete vocabularies, unclear licensing, and heterogeneous access points. In this talk, I will discuss our work to create computational standards, platforms, and methods to wrangle knowledge into simple, but effective representations based on semantic web technologies that are maximally FAIR - Findable, Accessible, Interoperable, and Reuseable - and to further use these for biomedical knowledge discovery. But only with additional crucial developments will this emerging Internet of FAIR data and services enable automated scientific discovery on a global scale.
bio:
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research focuses on the development of computational methods for scalable and responsible discovery science. Dr. Dumontier obtained his BSc (Biochemistry) in 1998 from the University of Manitoba, and his PhD (Bioinformatics) in 2005 from the University of Toronto. Previously a faculty member at Carleton University in Ottawa and Stanford University in Palo Alto, Dr. Dumontier founded and directs the interfaculty Institute of Data Science at Maastricht University to develop sociotechnological systems for responsible data science by design. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon 2020, the European Open Science Cloud, the US National Institutes of Health and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
This presentation was given on October 21, 2020 at CIKM2020.
The role of the FAIR Guiding Principles in a Learning Health SystemMichel Dumontier
The learning health system (LHS) is a concept for a socio-technological system that continuously improves the delivery of health care by coupling biomedical research with practice- and evidence- based medicine. Key aspects of the LHS are collecting, integrating, and analyzing data from different sources. While the increased digitalisation of healthcare is creating new data sources, these remain hard to find and use, let alone make use of as part of intelligent systems for the benefit of patients, healthcare providers, and researchers. This talk will examine recent developments towards making key parts of the LHS, such as clinical practice guidelines, Findable, Accessible, Interoperable, and Reusable (FAIR).
Acclerating biomedical discovery with an internet of FAIR data and services -...Michel Dumontier
With its focus on improving the health and well being of people, biomedicine has always been a fertile, if not challenging domain for computational discovery science. Indeed, the existence of millions of scientific articles, thousands of databases, and hundreds of ontologies, offer exciting opportunities to reuse our collective knowledge, were we not stymied by incompatible formats, overlapping and incomplete vocabularies, unclear licensing, and heterogeneous access points. In this talk, I will discuss our work to create computational standards, platforms, and methods to wrangle knowledge into simple, but effective representations based on semantic web technologies that are maximally FAIR - Findable, Accessible, Interoperable, and Reuseable - and to further use these for biomedical knowledge discovery. But only with additional crucial developments will this emerging Internet of FAIR data and services, which is built on Semantic Web technologies, be well positioned to support automated scientific discovery on a global scale.
Accelerating Biomedical Research with the Emerging Internet of FAIR Data and ...Michel Dumontier
ith its focus on improving the health and well being of people, biomedicine has always been a fertile, if not challenging domain for computational discovery science. Indeed, the existence of millions of scientific articles, thousands of databases, and hundreds of ontologies, offer exciting opportunities to reuse our collective knowledge, were we not stymied by incompatible formats, overlapping and incomplete vocabularies, unclear licensing, and heterogeneous access points. In this talk, I will discuss our work to create computational standards, platforms, and methods to wrangle knowledge into simple, but effective representations based on semantic web technologies that are maximally FAIR - Findable, Accessible, Interoperable, and Reuseable - and to further use these for biomedical knowledge discovery. But only with additional crucial developments will this emerging Internet of FAIR data and services enable automated scientific discovery on a global scale.
Are we FAIR yet? And will it be worth it?
The FAIR Principles propose essential characteristics that all digital resources (e.g. datasets, repositories, web services) should possess to be Findable, Accessible, Interoperable, and Reusable by both humans and machines. The Principles act as a guide that researchers and data stewards should expect from contemporary digital resources, and in turn, the requirements on them when publishing their own scholarly products. As interest in, and support for the Principles has spread, the diversity of interpretations has also broadened, with some resources claiming to already “be FAIR”.
This talk will elaborate on what FAIR is, what it entails, and how we should evaluate FAIRness. I will describe new social and technological infrastructure to support the creation and evaluation of FAIR resources, and how FAIR fits into institutional, national and international efforts. Finally, I will discuss the merits of the FAIR principles (and what we ask of people) in the context of strengthening data-driven scientific inquiry.Are we FAIR yet? And will it be worth it?
The FAIR Principles propose essential characteristics that all digital resources (e.g. datasets, repositories, web services) should possess to be Findable, Accessible, Interoperable, and Reusable by both humans and machines. The Principles act as a guide that researchers and data stewards should expect from contemporary digital resources, and in turn, the requirements on them when publishing their own scholarly products. As interest in, and support for the Principles has spread, the diversity of interpretations has also broadened, with some resources claiming to already “be FAIR”.
This talk will elaborate on what FAIR is, what it entails, and how we should evaluate FAIRness. I will describe new social and technological infrastructure to support the creation and evaluation of FAIR resources, and how FAIR fits into institutional, national and international efforts. Finally, I will discuss the merits of the FAIR principles (and what we ask of people) in the context of strengthening data-driven scientific inquiry.
Keynote given at NETTAB2018 - http://www.igst.it/nettab/2018/
The future of science and business - a UM Star LectureMichel Dumontier
I discuss how data science is affecting our way of life and how we at Maastricht University are preparing the next generation of leaders to address opportunities and challenges in responsible manner.
The FAIR Principles propose key characteristics that all digital resources (e.g. datasets, repositories, web services) should possess to be Findable, Accessible, Interoperable, and Reusable by people and machines. The Principles act as a guide that researchers should expect from contemporary digital resources, and in turn, the requirements on them when publishing their own scholarly products. As interest in, and support for the Principles has spread, the diversity of interpretations has also broadened, with some resources claiming to already “be FAIR”. This talk will elaborate on what FAIR is, why we need it, what it entails, and how we should evaluate FAIRness. I will describe new social and technological infrastructure to support the creation and evaluation of FAIR resources, and how FAIR fits into institutional, national and international efforts. Finally, I will discuss the merits of the FAIR principles (and what we ask of people) in the context of strengthening data-driven scientific inquiry.
A talk prepared for Workshop Working on data stewardship? Meet your peers!
Datum: 03 OKT 2017
https://www.surf.nl/agenda/2017/10/workshop-working-on-data-stewardship-meet-your-peers/index.html
Towards metrics to assess and encourage FAIRnessMichel Dumontier
With an increased interest in the FAIR metrics, there is need to develop tools and appraoches that can assess the FAIRness of a digital resource. This talk begins to explore some ideas in this space, and invites people to participate in a working group focused on the development, application, and evaluation of FAIR metric efforts.
A presentation to the New Year's Event for Maastricht University's Knowledge Engineering @ Work Program. https://www.maastrichtuniversity.nl/news/kework-first-10-students-academic-workstudy-track-graduate
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Unit 8 - Information and Communication Technology (Paper I).pdf
Formal representation of models in systems biology
1. Formal representation of models in systems biology 1 Michel Dumontier, Ph.D. Associate Professor of Bioinformatics, Department of Biology, School of Computer Science, Institute of Biochemistry, Carleton University Professeur Associé, Département d’informatique et de génielogiciel, Université Laval Ottawa Institute of Systems Biology Ottawa-Carleton Institute of Biomedical Engineering INRIA2011::Dumontier
5. efficient software to execute computationally demanding simulationsISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 2
6. Repressilator: A self-regulating system 3 INRIA2011::Dumontier A synthetic oscillatory network of transcriptional regulators. Elowitz MB, Leibler S. (2000). Nature 403: 335-338.
18. Are generally used for semantic annotation of data, which when reused, facilitate integration across domains (granularity, species, experimental methods)
20. Can be used to obtain explanations for inferencesdrawn
21. Can be efficiently processed by algorithms and softwareISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 6
22. Additional annotations are specified using the Resource Description Framework (RDF) Implicit subject and xml attributes <species metaid="_525530" id="GLCi" compartment="cyto" initialConcentration="0.097652231064563"> <annotation> <rdf:RDFxmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Descriptionrdf:about="#_525530"> <bqbiol:is> <rdf:Bag> <rdf:lirdf:resource="urn:miriam:obo.chebi:CHEBI%3A4167"/> <rdf:lirdf:resource="urn:miriam:kegg.compound:C00031"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> The annotation element stores the RDF subject predicate object The intent is to express that the species represents a substance composed of glucose molecules We also know from the SBML model that this substance is located in the cytosol and with a (initial) concentration of 0.09765M ISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 7
41. discover biological implications inherent in the models and the results of simulations.ISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 9
42. Approach We formally represent semantically annotated biomodelssuch that it becomes possible to: Capture the semantics of models and the biological systems they represent Check the consistency of biological knowledge represented through automated reasoning query the results of simulations in the context of the biological knowledge 10 INRIA2011::Dumontier
69. in general: P(C1, C2), where P is an OWL axiom (template)ISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 14
70. INRIA2011::Dumontier 15 Conceptualization:Models and their components represent physical entities (material entities, processes) Formalization: every element E of the SBML language represents a class Rep(E) and we assert that E subClassOf: represents some Rep(E)
71. Top-level ontologies can make additional commitment by enforcing disjointnessamong basic types Material object, Process, Function and Quality are mutually disjoint. ISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 16
72. Relations impose additional constraints, such that inconsistencies arise when incorrectly used ISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 17
73. For each model annotation, we make a commitment to what it represents OWL Axiom: Model SubClassOf: represents some MaterialEntity Conversion rule: a Model annotated with class C represents: If C is a SubClassOfMaterialEntity then M SubClassOf: represents some C If C is a SubClassOfFunction then M SubClassOf: represents some (has-function some C) If C is a SubClassOfProcess then M SubClassOf: represents some (has-function some (realized-by only C))
76. F1 is realized by processes of the type heterotrimeric G-protein complex cycleM SubClassOf: represents some O1 O1 SubClassOf: (has-function some (realized-by only GO:0031684)
92. Model verification After reasoning, we found 27 models to be inconsistent reasons our representation - functions sometimes found in the place of physical entities (e.g. entities that secrete insulin). better to constrain with appropriate relations SBML abused – e.g. species used as a measure of time constraints in the ontologies themselves mean that the annotation is simply not possible ISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 25
93.
94.
95. represents some (has-function some C) and represents some (has-function some (realized-by only C)) are unsatisfiableISMB2011::Dumontier|Hoehndorf::Formalizing Systems Biology with Biomedical Ontologies 27
96. Species are further described with ‘modifiers’ in the context of a reaction 28 INRIA2011::Dumontier essential activator <listOfModifiers> <modifierSpeciesReferencesboTerm="SBO:0000461" species="X"/> </listOfModifiers> partial inhibitor <listOfModifiers> <modifierSpeciesReferencesboTerm="SBO:0000536" species="PX"/> </listOfModifiers>
97. Roles are realized in the context of processes by material entities INRIA2011::Dumontier model sio: has proper part sio: represents sio: has direct part species ChEBI:molecule ChEBI:substance sio: role of SBO: participant role sio: has participant SBMLHarvester+ sio: realizes sio: represents GO:Process reaction Class role chain: realizes o role of -> has participant Individual Datatype 29
98. Semanticscience Integrated Ontology (SIO) OWL2 ontology 1000+ classes covering basic types (physical, processual, abstract, informational) with an emphasis on biological entities 183 basic relations (mereological, participatory, attribute/quality, spatial, temporal and representational) axioms can be used by reasoners to compute inferences for consistency checking, classification and answering questions about life science knowledge embodies emerging ontology design patterns specifies a data model dereferenceable URIs searchable in the NCBO bioportal Available at http://semanticscience.org/ontology/sio.owl 30 INRIA2011::Dumontier
100. SBML Reactions may be specified by mathematical expressions, which contain quantitative variables that denote quantities SBO:Reaction Quantity sio: is specified by sio:denotes sio: has proper part SBO: systems description parameter SBO:mathematical expression sio: has value Literal Class sio:derives from SBMLFarmer Individual Datatype INRIA2011::Dumontier 32
101. When running a simulation, some attributes change with time 33 INRIA2011::Dumontier species double sio:has attribute sio: has value sio: has unit uo:unit attribute sio: measured at sio: has value datetime time sio: result of sio: has agent simulation software sio: conforms to sio: has participant KISAO: algorithm parameter model expression Class Individual Datatype
104. Query Answering over RDF/OWL Find those concentration measurements for species that represent molecular entities that contain ribonucleotide residues ‘concentration’ and (‘measured at’ some double[>20.0, <40.0]) and ‘is attribute of’ some ( ‘species’ and ‘represents’ some (‘has part’ some ‘ribonucleotide residue’) ) 36 INRIA2011::Dumontier ChEBI ontology
112. Can be inflection pointsTEDDY_0000144 Point: Stationary Point (Maximum) B A C Curve Segment Overall Change (Slope) Constituent Points Concentration strictly increasing TEDDY_0000008 strictly decreasing Curve: Overall Change D TEDDY_0000009 Time INRIA2011::Dumontier
113. Queries ‘local maximum’ and ‘is attribute of’ some ( species and represents some ( ‘has function’ some ‘dna binding’ )) 38 INRIA2011::Dumontier Biomodel + UniProt + GO
114. Get the non-monotonic curves for protein species ‘non-monotonic curve’ and ‘has part’ some ( ‘concentration’ and ‘is attribute of’ some ( ‘species’ and ‘represents’ some ‘protein’)) ) 39 INRIA2011::Dumontier
115. Conclusion The SBML-derived ontologies can be i) checked for their consistency, thereby uncovering erroneous curations ii) infer attributes and relations of the substances, compartments and reactions beyond what was originally described in the models iii) answer sophisticated questions across a model knowledge base iv) extended with modifiers, mathematical expressions and parameters, simulation Results (from tab files) to answer questions about simulation results with reference to the semantic annotations (GO) in biomodels, UniProt 40 INRIA2011::Dumontier