1. Flexor tendon injuries can occur in any of the 5 zones defined by Kleinert and Verdan and require different surgical approaches depending on the location and severity of the injury.
2. Primary repair within 12-24 hours of injury provides the best functional outcomes while delayed or secondary repairs have higher risks of adhesion formation.
3. Flexor tendon repair techniques aim to accurately approximate the tendon ends with core sutures while minimizing handling and restoring the normal gliding relationship between tendons. Postoperative rehabilitation is crucial.
4. Flexor tendon grafting is indicated for injuries with segment
Hand rehabilitation following flexor tendon injuriesAbey P Rajan
hand rehabilitation following flexor tendon injuries include introduction, clinical anatomy, tendon nutrition, tendon healing, post op. management, special cases, summary
Hand rehabilitation following flexor tendon injuriesAbey P Rajan
hand rehabilitation following flexor tendon injuries include introduction, clinical anatomy, tendon nutrition, tendon healing, post op. management, special cases, summary
ANATOMY
Meatcarpophalangeal joint- Condyloid joints
ROM at MCPJ- flexion and extension of the digits, as well as a very small degree of abduction and adduction when the digits are extended.
• Phalanges - has a base, shaft, neck and head that is formed from two condyles.
• PIPJ, DIPJ - Hinge joints,
ROM at PIP and DIP joint : flexion and extension.
VERDAN’S ZONES OF HANDS
VOLAR PLATE
Vinculum breve and Vinculum longum
MECHANISMS OF INJURY
ANATOMY
Meatcarpophalangeal joint- Condyloid joints
ROM at MCPJ- flexion and extension of the digits, as well as a very small degree of abduction and adduction when the digits are extended.
• Phalanges - has a base, shaft, neck and head that is formed from two condyles.
• PIPJ, DIPJ - Hinge joints,
ROM at PIP and DIP joint : flexion and extension.
VERDAN’S ZONES OF HANDS
VOLAR PLATE
Vinculum breve and Vinculum longum
MECHANISMS OF INJURY
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. Extrinsic flexors
• Superficial group
PT, FCR, FCU, PL
• Intermediate group
FDS
• Deep group
FPL –
FDP –
3. Condensations of the fibrous retinacular
sheath form the flexor pulleys
Cruciform pully:allow digital flexion to
occur without significant deformation of
annular pulley system
Annular pulley : stiffer and thicker
A1
A2
A3
A4
A5
4. Contains only one tendon-FDP
Tendon laceration occurs close to its insertion
Tendon to bone repair is required
Green DP, JBJS 2002
Kleinert and verdan classified into 5 anatomic
zones
5. From metacarpal head to middle phalanx
FDS n FDP within one sheath
Adhesion formation risk is amplified at campers chiasm
ZONE III
•B/W transverse carpal ligament and proximal margin of tendon
sheath formation
•Lumbricals origin here prevents profundus tendons from over acting
6. Lies deep to deep transverse ligament
Tendon injuries are rare
Lies proximal to transverse carpal ligament in the forearm
ZONE V
8. H/o trauma by sharp objects
completely transected :no active flexion
and loss of tenodesis effect
Loss of inherent flexor tone and
extended posture at PIP and DIP
Functional tests of FDS and FDP
light touch and static two-point discrimination
Capillary refill of the volar digital pulp and the nail bed
9. Types :
Primary: first 12-24 hours of injury
Delayed primary repair : 24 hours to 10 days
Secondary repair: 10 to 14 days,
Late secondary repair: after 4 weeks
Ref campbell 12 th ed
10. Emergency repair needed if altered digital perfusion present
Clean wound caused by sharp object.
11. Indicated if a/w
extensive crushing with bony comminution
severe neurovascular injury
severe joint injury and skin loss requiring a coverage procedure
Primary repair gives better functional outcomes than secondary
repairs
Ref: Tang JB :Injury. 2006 Nov
12. Incisions should not compromise viability of skin flaps shd not
create contractures or cosmetically unsightly scars
Zigzag (Brunner) or midaxial incisions and midlateral incisions
13. Core Non-absorbable 4/0 suture
4-0 or 3-0 prolene or mersilene suture may be used
5-0 or 6-0 monofilament running epitenon suture.
Ref: J Bone Joint Surg Am. 1998.
Singer G,
14. Direct repair (primary tenorraphy): laceration >1 cm from FDP
insertion
Entire A4 annular pulley preserved
proximal tendon
Retrieved by feeding
tube and passed
underneath A4 pulley
15. Traditional pull-out suture methods :
Free ends of sutures are passed through or around distal phalanx to be
tied over dorsum of fingernail by tie over button.
Removed after 6 weeks.
Internal suture methods: suture
anchors or other methods to affix
the tendon directly to the bone
16. Dissection proceeds with identification
and protection of the digital nerves and arteries
It is necessary to open either the C1 (between A2 and A3) or C2
(between A3 and A4) cruciate-synovial sheath
Always restore the normal relation between the two tendons
17. Pearls
Multistrand core suture method with running circumferential suture
preferred
Enter sheath between distal A2 and proximal A4.
Proximal stump retrieval by milking, feeding tube, or direct exposure
Deliver distal stump by passive DIP hyperflexion
Repair by transfixation using 25-gauge, 5/8 inch needle
Use two or four strand core suture technique
19. Core suture loops
When transverse component passes within tendon
superficial to the longitudinal component, suture “locks” a
bundle of tendon fibers.
When transverse component passes deep to longitudinal
component, but the suture does not “lock” a bundle of
tendon fibers, but pulls through the tendon by grasping it.
20. Postoperative POP and dressing applied with wrist
flexed (20 to 30 degrees) and MP joints flexed (50 to 70
degrees), and PIP and DIP joints at zero or slight flexion
Graded rehabilitation protocol(Duran ,Kleinert)
Unrestricted activity at 4 to 6 months after surgery
21. If both tendons are lacerated, both are repaired, end to end with
circumferential re-enforcing sutures
May affect lumbricals inaddition to flexor tendons
Damaged lumbrical is either repaired or excised depending on
severity of injury and the location of the laceration
Lumbricals muscle bellies usually are not sutured, cause lumbrical
plus finger
22. A/w median ,ulnar nerve or ulnar or radial vessel injury.
Here vessels and nerves should be repaired first and the tendons
last
23. Partially severed tendon should not be repaired if at least 40% of
the tendon remains intact
J Hand Surg 2000;25A:1118-1121 :
24. Extensile exposure in a controlled setting with optical
magnification allows the extent of the injury to be defined.
▪ Tendon retrieval is done using atraumatic techniques and
windows through noncrucial areas of the flexor tendon sheath.
▪ Handling of the tendon should be minimal.
▪ The tendon must be accurately oriented.
▪ The core tendon sutures should be placed to allow for
accurate coaptation of the tendon ends. The suture method
should provide a stable, smooth repair that is freely gliding
within the tendon sheath.
▪ Circumferential suture is used to “finish” the repair and
add strength to the repair.
▪ Sheath closure is necessary only if it improves tendon
gliding.
Acknowledgments
25.
26.
27. Indications: 1.Injuries resulting in segmental tendon loss.
2. Neglected >3 to 6 weeks with tendon degeneration and scar
within the tendon sheath.
3. Large section of tendon has been damaged in zone 2 injury
4.Delayed presentation of FDP avulsion injuries associated with
significant tendon retraction.
28. Grade 1 Good: Minimal scar with mobile joints and no trophic
changes
Grade 2 Cicatrix: because of injury , failed primary repair or
infection
Grade 3 Joint damage: with restricted range of motion
Grade 4 Nerve damage: resulting in trophic changes
Grade 5 Multiple damage: Involvement of multiple fingers with
combination of above problems
From Boyes JH: J Bone Joint Surg Am 32:489-499, 1950.
29. One graft in each finger.
Never sacrifice intact flexor digitorum superficialis (FDS).
Graft of small caliber.
Perform the junctions outside of the tendon sheath.
Ensure adequate graft tension.
30. Palmaris longus[1] tendon present in approximately 85%
of all individuals of sufficient length and size .
Plantaris [2] when graft length is important.
present in about 93% of population
EDL[3]
EI [3]
EDM[3]
FDS of unaffected finger[4]
Ref: 1. MARTIN I. BOYER.JBJS 2002
2.Morrison WA J Hand Surg [Br] 1992
3. Harvey FJ, J Hand Surg [Am] 1983
4.Snow JW: Plast Reconstr Surg 1968
31. Tendon weave in any area outside the flexor sheath
Stronger than the end-to-end suture techniques
Allow to modulate graft tension
Ref:Pulvertaft RG: JBJS Am 1980; 42:1363-
1371.
Rank BK: 2nd ed. Edinburgh, E & S
Livingstone, 1988.
33. ▪ 1 cm FDP stump ,1 to 2 cm FDS tendon near insertion
▪ Obtaining flexor graft
▪ Graft threaded under pulleys with suture passer(pediatric
feeding tube/red rubber catheter
▪ Distal juncture created
▪ Proximal juncture into the FDP tendon just distal to the
lumbrical origin. (≥3 interweaves)
Sourmelis SG: J Hand Surg Br 1987;
34. ▪ In patients with DIP joint hyperextension, tenodesis
or arthrodesis can be offered.
Postoperative Care
▪ Static dorsal blocking splint (4 to 6 weeks) with the
wrist neutral, MP joints at 45 degrees, and IP joints
neutral.
▪ Treat flexion contractures with passive stretching
and splinting (6 to 8 weeks).
35. Passive tendon implants at first surgery, placement of
tendon graft at second surgery
Indications ▪ Crushing injuries a/w # or skin damage
▪ Damaged pulley system
▪ Excessive scarring of the tendon bed
▪ Failure of previous operations
▪ Contracted joints
36. 1-cm FDP stump kept & proximal FDP tendon
transected at the level of the lumbrical origin.
Through distal forearm incision identify the involved
FDS tendon, draw it into the wound, and transect it
near the musculotendinous junction
Appropriate size of the silicone implant.
Assess pulley system
37. Pass implant from proximal palm to distal forearm
between the FDP and FDS
Distal juncture suture applied
ROM checked
If implant assumes bowstring posture, pulley
reconstruction done by Bunnell encircling
method/ Kleinert technique
38. Postoperative Care :Splint with wrist in 35 degrees of
flexion, MP joints at 60 to 70 degrees of flexion, and IP
joints extended.
▪Start passive motion on first postoperative visit
▪Contracture releases may benefit from dynamic splinting
(6 to 8 weeks).
39. Indication: Patient who underwent stage I of flexor reconstruction
process
Interval between stages I and II :2-3 months.
Hand must be soft, and joints well mobilized.
40. Surgical principles:
Implant distal and proximal ends located
Tendon graft obtained
Graft sutured to proximal end
of implant, and pull it distally
through sheath.
Fix distal juncture and
proximal juncture.(in palm or
distal forearm)
41. Proper tension of graft maintaining necessary
Postoperative Care
▪ Apply a short arm dorsal blocking splint
▪ Protected passive range of motion early
▪ Dynamic splinting for contractures.