This document discusses the principles of absolute and relative stability in fracture fixation, as well as locking compression plates. It describes how absolute stability aims to reduce strain below a critical level for primary healing without callus formation, while relative stability allows some motion and secondary bone healing through callus formation. Locking compression plates provide angular stability through locking head screws in the plate and bone, maintaining blood supply while providing fixation. They can be used for compression of reduced fractures or for splinting in multifragmentary fractures.
Screw and plates are most common used devices in orthopedics. However, sometimes we forget their principles, so this presentation hopes to review most their problems. Thank you for your attention!
Screw and plates are most common used devices in orthopedics. However, sometimes we forget their principles, so this presentation hopes to review most their problems. Thank you for your attention!
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
conventional plates including different functions of screws, modes of plate application, Compression Mode.
Neutralization Mode.
Buttress plate.
Antiglide plate.
Bridge plating or span plating.
Tension band.
prebending precountouring
working length
lag screw
AO principles
biological fixation
MIPO
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
conventional plates including different functions of screws, modes of plate application, Compression Mode.
Neutralization Mode.
Buttress plate.
Antiglide plate.
Bridge plating or span plating.
Tension band.
prebending precountouring
working length
lag screw
AO principles
biological fixation
MIPO
Cervical Disc Replacement, Cervical Disc Arthroplasty, Adjacent Segment Disease, Recent Advances, Discusses about the cervical disc replacement or arhroplasty for cervical spine disease
requires certain indication such as level from c3-c7, single or maximum 2 level, Mechanical loading of disc cause of degeneration
Treatment: Conservative magment to surgery +/- fusion
fusion associated with ASD, pseudoarthrosis, donor site mobility, restricted motion,altered physiology Depends on implant based parameters:
wear
material
kinetics
Depends on Patient based parameters:
Age, Sex, gender
Weight, BMI
Depends on Surgeon based parametes:
Precision, skill
soft tissue and bone handling
single-level,
myelopathic, or radiculopathic cervical disease
between C3 and C7
All of above in symptomatic patient
failing 6 weeks of conservative management
Osteoporosis
Significant kyphosis
Instability, greater than 50% loss of disc height
Facet arthropathy
Ossification of PLL
Inflammatory arthropathy
Multilevel disease
Translation > 3.5 mm on flexion extension X-rays
ACDF with CDR:
for multilevel cervical Degen Disc Disease(DDD)
Combination of fusion and nonfusion tailored to each level
allowing segmental motion preservation at index levels
minimizing hypermobility at adjacent levels
Composite:
two metal endplates with poly in between, Ball and socket
Viscoelastic:
with or without endplates
Mechanical:
A mechanical artificial disc is usually comprised of two articulating pieces, all of which are the same material (e.g. metal) or a composite metal and ceramic
Doesnot replicate mechanics of spine
Simple design
based on concept of synovial joint arthroplasty(hip, knee)
accelerated dgeneration of surrounding structure:
facets, UV joint, ligaments
Prodisc-C® Cervical Disc:
2 cobalt chromium endplates and
1 ultra-high molecular weight polyethylene inlay
Inlay technically separate from the endplate,
but it locks into the lower metal, function as a single after installation
Upper endplate has a highly polished divot
plastic dome fits and moves
metal surfaces coated with a titanium plasma spray
helps hold the artificial disc in place and promote bony growth.
Endplate sandwiched:
eg: Bryan Cervical disc
polycarbonate urethane nucleus
rests between two titanium alloy “shells”
Saline innucleus adds compression to disc
Prestige cervical disc:
made of a titanium ceramic composite and titanium carbide
“ball and socket” design,
This design and composition make highly durable and give spine outstanding motion at one- and two-disc levels in cervical spine
Endplates each have two low profile keels to help secure it to bone
Artificial disc permits spine to flex, extend, side bend, and rotate while maintaining alignment, height, and curvature
Unconstrained:
Excess ROM, cost of instability
Semiconstrained:
Constrained:
Limits movement via Keel
pressure on Facet joints
Stable
3mm disc space required prior to CDR
Avoid overstuffing of implant:
Facet joint distraction,
Slide 35
References
Tornetta P. Rockwood and Green's fractures in adults. Philadelphia: Wolters Kluwer; 2020.
Buckley R, Moran C, Apivatthakakul T. AO principles of fracture management. Davos Platz, Switzerland: AO Foundation; 2017.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. Absolute and relative stability and
locking plate principles
Presenter: DR SOUVIK PAUL
2. Goal of this seminar
• AO Principles(Martin Allgöwer, Robert Schneider, and
Hans Willenegger)
• Elaboration of absolute and relative stability
• Discuss about locking compression plates
2
3. AO Principles
1. # reduction and fixation to restore anatomical
relationships
2. Stability by fixation or splintage , as personality of
fracture and injury requires.
3. Preservation of blood supply to soft tissues and bone by
careful handling and gentle reduction techniques.
4. Early and safe mobilization of the part and patient.
3
4. • “Surfaces of the fracture do not displace under
functional load”
• No micromotion Reduction of strain to a level below
critical level primary healing without callus
•compressive preload and friction
•Rigid fixation , perfect alignment
Absolute stability
6. Relative stability
• Some motion secondary bone healing by callus
formation
• Better in multifragmentary fractures
• More fragments less strain between fragments
less rigid construct requirement
• “Stress distribution”
7. Biomechanics of callus formation
Post op interfragmentary mobility:-
• amount of external loading
• stiffness of the splints
• stiffness of the tissues bridging the fracture.
7
8. Perren's strain theory
• ε=d/G where ε-the inter-fragmentary strain, d-fracture ends
displacement, & G– gap between ends
16. Tension Band Plates
• Plate counteracts natural
bending moment seen wih
physiologic loading of bone
– tension side
– converts bending force
to compression
17. Buttress / Antiglide Plates
• Resist shear forces
– Used in metaphyseal areas
• Plate must match contour
• Buttress Plate
– intra-articular fractures
• Antiglide Plate
– diaphyseal fractures
19. DCP
• First introduced in 1969 by Danis
• Revolutionary concept of compression plating
• Featured a new hole designed for axial compression
• Compression depend on friction of plate over bone
20. • allow 1mm compression
• Additional compression with
1 more eccentric screw
before locking first screw
• Compression of several
fragments individually in
comminuted fractures
• Oval shape allows 25 deg
inclination in longitudinal &
7deg in transverse plane
21. Problems with DCP
• Unstable fixation leads to fatigue & failure
• Strict adherence to principles of compression
• Compromised blood supply
• “Refractures” after plate removal
23. Mechanics/biomechanics of
plate/screw fixation
Plate fixation with conventional screws
• Screws in tension
• Plate/bone friction
• Compression at fracture site
• Disturbed blood supply
Plate fixation with locking head screws (LHS)
• Screws in shear
• Noncontact plate
• No compression of fracture
• Preserved blood supply
24. Functions of LHS
• Always in combination with a plate
• Never as lag screw
• Never cross an unreduced fracture
• Fixation screw
– Fix the plate to the bone
• Position screw
– Keeps two fragments in correct
relative anatomical position
25. Features and advantages of LHS
• Axial and angular stability
• Not preloaded
• Cannot be over-tightened
• Higher resistance against bending loads
• Monocortical insertion is possible
• Lag first, lock second
• No primary/ secondary loss of reduction
26. Features and advantages of locked
plates
• Screw-plate system with angular and axial stability
• Locked internal fixator/noncontact plate
• Individual blade plate
• Anatomically contoured
• High pull out strength
27. Biological advantages
• Reduced compression of the periosteum
• Protects blood supply to the bone,less infection
• Callus formation/bone healing under the plate
bone after plating with a DCP bone after plating with a LCP
28. Technical/mechanical advantages
• Angular and axial stability
• No need for exact preshaping
• Good for osteoporotic bone—bicortical LHS
• Optimal predefined screw placement
• No need for drilling, measuring, or tapping
• MIPO is easier
29. Splinting with locked plates—prerequisites
• Indirect, closed, no precise reduction
• Long plate
• Fixation with LHS only on main fragments
• No screws in fracture zone
• Prebending not necessary
• Elastic fixation
30. Drawback of fixation with LHS
• Screw insertion is only possible in a 90° angle
• Possible loss of the feel for the quality of the bone
during screw insertion and tightening
• Screw jamming and difficult implant removal
31. Splinting with locked plates—shortcomings and
disadvantages
• Stability depends on rigidity of construct
• Plate takes over the entire load
• MIPO is a demanding/difficult technique
32. Combination of compression and splinting with
one plate
• A combination of both methods is only possible
when two different fractures occur in same bone.
Indications
• Segmental fractures
• Articular fracture with
additional metaphyseal/
diaphyseal fracture
35. conclusion
• Two different methods and principles:
– compression—absolute stability
– splinting—relative stability
• no mixture of principles/methods in same
fracture
36. • Compression plating after anatomical
reduction in articular and simple fractures.
• Splinting/bridge plating in multifragmentary
• Good for Osteoporotic ,Periprosthetic #