Flexor tendon repair requires protecting the tendon repair while allowing early controlled motion to minimize adhesions. This involves splinting the fingers in flexion after primary repair or tendon grafting, followed by progressive range of motion exercises. Complications can include infection, scarring and joint contractures, but good outcomes are achieved with protocols emphasizing early motion like Duran or Kleinert methods.
At the end of this lecture, you should be able to:-
Understand and describe the anatomy of the flexor tendon system in the hand and its relevance in surgery
Describe and relate the normal physiology of the tendon and its implications in injury
Understand the reaction of tendon to injury and its healing process and its implications in surgery and rehabilitation
A fingertip injury is defined as any soft tissue, nail or bony injury distal to the dorsal and volar skin creases at the distal interphalangeal joint and insertions of long flexor and extensor tendons of a finger or thumb.
The fingertips are exposed to all aspects of daily living,
recreation and work and it is perhaps no surprise they
are the most commonly injured part of the hand
Surgical Approaches to Acetabulum and PelvisBijay Mehta
Important surgical approaches to acetabulum and pelvis are described.
Ilioinguinal approach, Modified Stoppa Approach, Kocher lagenbeck Approach, Ilifemoral approach and extensile approaches are well illustrated and described.
At the end of this lecture, you should be able to:-
Understand and describe the anatomy of the flexor tendon system in the hand and its relevance in surgery
Describe and relate the normal physiology of the tendon and its implications in injury
Understand the reaction of tendon to injury and its healing process and its implications in surgery and rehabilitation
A fingertip injury is defined as any soft tissue, nail or bony injury distal to the dorsal and volar skin creases at the distal interphalangeal joint and insertions of long flexor and extensor tendons of a finger or thumb.
The fingertips are exposed to all aspects of daily living,
recreation and work and it is perhaps no surprise they
are the most commonly injured part of the hand
Surgical Approaches to Acetabulum and PelvisBijay Mehta
Important surgical approaches to acetabulum and pelvis are described.
Ilioinguinal approach, Modified Stoppa Approach, Kocher lagenbeck Approach, Ilifemoral approach and extensile approaches are well illustrated and described.
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Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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2. Flexor tendon function depends on
• tendon excursion,
• intact pulley system,
• joint motion,
• presence of lubricating synovial fluid
3.
4.
5. If bowstringing is present, to close fingertip
greater amplitude of muscle contraction and
greater amount of tendon excursion
6.
7. •Digital flexor tendons receive
nutrition:-
1.intrinsic
longitudinal vessels
entering the palm in the
endotendinous channel,
vessels that enter at the
osseous insertion,
vincula (two short and
two long).
2.extrinsic
synovial fluid
8.
9. Incidence
• 33.2 per 100,000:- hand & wrist injuries
• <1% of all hand injuries:- Flexor tendon
injuries
11. Musculoskeletal Examination.
• angular or rotational deformity of the digit
• Realignment of a fracture
• Reduction of a dislocation
• Tenodesis effect
• Partial tendon injuries: pain on resisted flexion
19. Historically
recommendations of Sterling Bunnel in 1922 for
the treatment of cut flexor tendon injuries:
• 1. Close the skin,
• 2. Wait for the wound to heal,
• 3. Perform secondary procedures:
– (a) Excise both the flexor tendon.
– (b) Undertake tendon grafting of the flexor
digitorum profundus tendon only
20. Surgical exposure
• The standard midlateral incision or Bruner's
zigzag incision
• no study comparing the two methods of
surgical exposures
21.
22.
23. • midlateral incision
– prevents scar formation directly over the tendon,
– is less likely to breakdown during physiotherapy
– but requires surgical dissection directly over the
neurovascular bundle.
• Bruner's zigzag incision
– provides excellent surgical exposure
– scar formation directly over the tendon and may
break in case of infection thereby affecting the
physiotherapy
24.
25. Surgical repair
If digital perfusion is compromised
Urgent exploration and tendon repair with
microvascular digital artery and nerve repair
• Done promptly after injury, the wound is
easier to manage and the tendon ends are
fresh for the repair
26. zone 1 injuries (Gersey finger injury).
Flexor Digitorum
Profundis (FDP)
retracts to the
palm
Leddy type 1 the tendon must
be repaired
within 2 weeks.
retracted to the
PIP joint
Type 2 the repair must
be performed
within 6 weeks
When caught at
A4 pulley
Type 3 the repair can be
performed at any
time
27.
28. • patient presents
too late and the
FDS is intact can be
considered
• more than 1 cm of
FDP stump is
available
• stump is less than 1
cm long,
distal
interphalangeal joint
arthrodesis
primary tenorrhaphy
FDP tendon advancement and
primary repair to bone
29. tendon-to bone repair
• traditional pull-out suture methods
• internal suture methods
• “pull-out suture” removed approximately 6
weeks after the procedure
30.
31. Zone 2 repair
• important to preserve the critical A2 and A4
pulleys
• repair of both prevents hyperextension of the
PIP joint.
32. • Different options of treatment:
1. repair of the FDP tendon only with debridement
of the FDS stump;
2. repair of both tendons; or
3. repair of FDP with repair of one slip of FDS
tendon.
• Repair of both tendons in zone 2 is ideal
• Most hand surgeons prefer to repair the FDP
and one slip of FDS
33.
34. • number of core strands that cross the repair
site will increase the strength of the repair
• Increasing the number of strands to >4 leads
to more tissue handling, increase in the
surgical time.
35. Line diagram showing (a) conventional two strand suture
techniques (b) conventional four strand suture techniques
36. • Different suture techniques
• two-strand Kessler core with a simple
peripheral suture remains the most popular
flexor tendon suture technique
39. The MGH flexor tendon repair (modified Becker) technique
40.
41.
42. • Single knotted core suture techniques (e.g.,
Cruciate) have been shown to be
biomechanically superior to double-knotted
techniques (e.g., Double Kessler, modified
Becker, Tsuge)
45. Suture material for core suture
• nonabsorbable, 3/0 or 4/0 braided or
monofilament material.
• 4-0 Fibre Wire (Anthrex, Naples, FL)
46. For peripheral epitendinous suture
• 6/0 nonabsorbable suture
• contributes to the strength of the repair upto
50%
• makes repair neat (smoothes tendon and
decreases bulk)
47.
48.
49.
50.
51. • Tendons with repair site gaps less than 3 mm
acquire strength during the fourth to sixth
week postoperatively.
• ibuprofen at antiinflammatory doses (2400
mg/day) decrease peritendinous adhesions
following zone 2 flexor tendon repairs
53. Zone 3, 4, 5 repair
• repair of flexor tendon injuries proximal to the
A1 pulley are similar to injuries in zone 2
• improved prognosis
54. For the forearm
• arterial repairs first,
• tendon repairs second, and
• nerve repairs last.
Tendon repairs started from the deepest tendon
and then superficially
55. On exploration,
• if injury >60% of the tendon in diameter, it
should be repaired.
• If injury <60%, free edges are debrided to
prevent catching on the pulleys
56.
57. Postoperative dressing
• wrist in flexion (20 to 30 degrees),
• the MP joints in flexion (50 to 70 degrees),
• PIP and DIP joints at zero or slight flexion
58. Secondary flexor tendon
reconstruction
• Carroll first described the use of silicone rod
for use in two stage flexor tendon
reconstruction in 1963.
• The technique was modified by Hunter in
1970 and has been used extensively since
then with satisfactory results
59. indications:
1. failed primary repair,
2. neglected injuries,
3. segmental tendon loss and
4. complicated injuries (Boyes grade 2-5)
60. single stage reconstruction
Prerequisites:
1. supple joints,
2. wounds healed without contracture or much
scarring,
3. intact neurovascular structure,
4. willingness and understanding to participate
in rehabilitation programmes
61. • If excessive scarring is found in the tendon bed or
pulleys are contracted leading to constriction of the
graft; then two stage tendon reconstruction.
62. two stage tendon reconstruction
• Debridement of the cut tendons done
• silicone rod is placed with suturing the distal
end to the distal phalanx and the proximal end
is left free in the distal forearm
• pulleys are reconstructed over the silicone rod
63. • Materials for pulley:
1. Sheath of extensor retinaculam (advantage of
synovial lining leading to fewer chances of
adhesions)
2. Debrided tendons
3. Palmaris longus or Plantaris
64. Different surgical techniques.
• Making a double loop beneath the extensor
tendon encircling the proximal phalanx in its
proximal one third for reconstruction of the
A2 pulley.
• A4 Pulley is also reconstructed over the
middle phalanx by encircling around the
extensor apparatus.
• Using the remnants of the pulley
65.
66.
67. • Use of volar plate as the pulley by Karev; he
makes incisions distal and proximal in the
volar plate, and the tendon is passed through
it. Due to nonelasticity of the volar plate, the
tendon glide is impaired
• reconstruct the pulley as third stage
procedure under LA. Ensures proper tightness
68. • If nerve repair is indicated it is done at this
stage.
• The joints are mobilised in the postoperative
period.
• The mobilisation is started depending upon
the repair of the nerves. It may be started
immediately or after two weeks.
69. • second stage: replacement of the silicone rod
with the tendon graft
• A pseudosheath must be formed before
replacing the silicone rod with a graft.
• performed after 3 months as during this
period the scars mature and a suitable gliding
sheath forms around the implant
70. (a) Well placed silicone rod at zone 2 along with the reconstructed
pulleys (b) Silicone rod brought into proximal forearm (c) Silicone rod
is replaced by a free tendon using two minimal incisions and rail-road
technique
71. • proximal end of the graft is tied (with an
interweave fish mouth suture) to the adjacent
FDP tendon, if that is not suitable then the FDS is
selected.
• The graft is pulled through the pseudosheath by
stitching to the silicone rod at the proximal site
and pulling the rod at the distal end.
• The graft is stitched distally first with a Bunnel's
pull through suture over a button or with anchor
sutures
72.
73.
74. Tendon grafts:
• Palmaris longus (most commonly used graft).
absent in 25% of the population. useable length
is 16cm
• Plantaris (2nd most common). absent in 20%,
usable length is 35 cm. thin- can be passed
easily through the newly constructed tendon
sheath.
• The long extensors of foot (middle three
extensors). Very thick
75. • flexor digitorum longus of second toe. is the
only intrasynovial tendon. The chances of
adhesions are expected to be lower than
extrasynovial tendons. 12-13 cm long
• Extensor indicis proprius
76. Rehabilitation
Controversy:
• early/late mobilisation,
• position and type of the splint and
• mobilisation protocols (controlled passive
motion, active extension/passive flexion or
controlled active motion)
• old concept of 2-3 weeks of immobilisation in
splint and then starting the mobilisation has
been abandoned
77. • start mobilisation by the 3-5th postoperative
day
• no general consensus at present
• In original Duran and associates protocol, 3 to
5 mm of tendon excursion was sufficient to
prevent restrictive adhesions after repair
78. EARLY ACTIVE MOTION PROTOCOL
Day l
• Dorsal blocking splint with wrist neutral, MCPJ 70°,
and IPJ straight
• Digits strapped to splint
• Modified Duran passive flexion with active extension
to splint
• Place and hold exercises passively flex digits and
allow patient to actively contract muscles to hold
digits in fist, composite, and differential.
79. • hourly home exercise program that consists
initially of passive positioning of the fingers in
a fist for 3 minutes
• Therapist monitor the patient’s compliance,
attend therapy at least two times a week for
the first 6 to 8 weeks
81. In controlled passive motion regimen of Duran and
Houser
• dorsal splint to keep the PIP and DIP joints in
extension with no elastic band for passive flexion,
• Patient uses another hand to move the PIP, DIP,
and MCP joints passively
• active extension is also done by the patient.
• associated with a poor capacity for differential
gliding between the superficialis and profundus
tendons, particularly in Zone II
82. • Kleinert's classical description of controlled active
extension with passive flexion utilizing elastic
band traction has been used by most hand
surgeons who are proponents of immediate
controlled mobilization
• Strickland introduced an early active motion
protocol (Indiana Hand Centre) for a four-strand
repair with an epitendinous suture for which
good patient motivation and comprehension are
required
83. 3wk
• Gentle tenodesis exercises out of splint
• No active composite flexion
• Continue place and hold exercises
84.
85. 4wk
• Active composite flexion exercises out of splint
• Differential tendon gliding exercises
• No passive extension, no blocking
• Continue dorsal blocking splint between
exercises
88. 8wk
• May start light strengthening (putty)
12wk
• Normal activities
89. “high” physiologic response
• Accelerated wound healing, edema, and
dense scar resulting in the formation of
peritendinous adhesions
• significant loss of flexor tendon excursion.
• Hence are progressed through the pyramid of
exercises quickly to promote force and
prevent further adhesions
90. “low” physiologic response
• slower wound healing, limited edema, and
minimal discrepancy between the patient’s
active and passive finger flexion
measurements.
• have improved flexor tendon excursion
• less risk is required in therapy to maintain the
range of motion.
92. Outcomes
Boyes outcome scale that judged results based
on finger tip flexion measurement from palm
• poor being >6 cm,
• fair 4 to 6 cm,
• Good 2.S to 4 cm, and
• excellent 0 to 2.5 cm.
93. Strickland Modified outcome assessment scale
• poor is 0% to 24% motion (<44°).
• fair is 25% to 49% motion (44° to 87°)
• good is 50% to 74% motion (88° to 131°), and
• excellent is 7S% to 100% motion (>131°)