Onchocerca volvulus is a filarial worm that causes onchocerciasis, also known as river blindness. It has a life cycle involving microfilariae that infect blackflies which transmit the larval forms to humans. The microfilariae develop into adult worms in human subcutaneous tissue, producing more microfilariae that can cause skin disease and blindness. Onchocerciasis is treated and prevented through ivermectin treatment programs and avoiding blackfly bites in endemic regions, mainly in rural Africa and some parts of Central and South America.