This document provides information on various tissue nematodes including filarial worms, Guinea worm, and Trichinella spiralis. It discusses the epidemiology, morphology, life cycles, pathogenesis and clinical features of Wuchereria bancrofti, Onchocerca volvulus, Loa loa, and Dracunculus medinensis. Key details include that W. bancrofti causes lymphatic filariasis and is transmitted by mosquitoes, O. volvulus causes river blindness and develops in humans after transmission via black flies, L. loa develops in humans after transmission via day biting flies and has diurnal periodicity, and D. medinensis causes dracuncul
Filarial worms are thread-like nematodes of which there are at least 8 species for which humans, especially in tropical regions, are the definitive host
Filariases is commonly known as Elephantiasis. it is a tropical disease which is caused by parasitic worm filariae. it is a microscopic roundworm that dwells in the blood and tissues of human. Its main causative agent is Wuchereria bancrofti and Brugia malayi. The host is man. This disease is most prominent in Africa and in India it is most prominent in the state Kerala. 90% of filariases is caused by Wuchereria bancrofti and only 10%-15% is caused by Brugia malayi.
Filarial worms are thread-like nematodes of which there are at least 8 species for which humans, especially in tropical regions, are the definitive host
Filariases is commonly known as Elephantiasis. it is a tropical disease which is caused by parasitic worm filariae. it is a microscopic roundworm that dwells in the blood and tissues of human. Its main causative agent is Wuchereria bancrofti and Brugia malayi. The host is man. This disease is most prominent in Africa and in India it is most prominent in the state Kerala. 90% of filariases is caused by Wuchereria bancrofti and only 10%-15% is caused by Brugia malayi.
Protozoa and Helminth Parasites ppt by Dr.Prince.C.PDR.PRINCE C P
PPT prepared by :Dr.Prince.C.P
Associate Professor & HOD , Department of Microbiology,
Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution)
Medical Parasitology is the subject which deals with the parasites that infect human being, the diseases caused by them, clinical feature and the response generated by human being against them. It's also concerned with the various methods of their diagnosis, treatment and finally their prevention & control.
An ova or cyst or egg is detected by microscopic evaluation of a stool sample that is used to look for parasites that may infect the lower digestive tract, causing symptoms such as diarrhoea. The parasites and their eggs (ova) are shed from the lower digestive tract into the stool
Stool examination (Microscopic) is performed for the diagnosis of following parasitic infections
1. Protozoa • Entamoeba histolytica • Giardia lamblia • intestinal coccidian parasites (i) Cryptosporidium parvum (ii) Cyclospora (iii) Isospora • Balantidium coli
2. Helminthes • nematodes: (i) Ascaris lumbricoides (ii) Trichuris trichuria
(Iii) hookworm • Ancylostoma duodenale • Nectar americans (iv) Strongyloides stercoralis
Cestodes: (i) Taenia spp • T. Saginata • T.Solium (ii) Hymenolepsis nana (iii) Enterobius vermicularis
this is power point presentation for ophthalmic assistant student regarding basic knowledge for ocular parasites like, LOA LOA, RIVER BLINDNESS , ONCHOCERCIASIS , TOXOPLASMOSIS & TOXOCARIASIS etc. which consist basic test , epidemiology, lab investigation, culture & management .
what is loa loa.
loa loa is eradicated mostly from from Asian country like India, Nepal, China etc. , the presentation is for 2nd year O.A students & EHW. which shows basic....knowledge
This is an overview about parasites infest or affect the human eyes & principles of the diseases thay cause
A medical-student-made presentation for Ain Shams University - Faculty of Medicine - Department of Parasitology
Hope it help you
Concise discussion on Fialrial worms including Morphology, Life cycle, pathogenesis, clinical manifestations and laboratory diagnosis including newer techniques for UG and PG students.
wuchereria bancrofti can causes serious diseases that attack our world . so this presentation gives us some information about this worm , methods of avoiding it and what are diagnostic tests that doctors ask .
Protozoa and Helminth Parasites ppt by Dr.Prince.C.PDR.PRINCE C P
PPT prepared by :Dr.Prince.C.P
Associate Professor & HOD , Department of Microbiology,
Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution)
Medical Parasitology is the subject which deals with the parasites that infect human being, the diseases caused by them, clinical feature and the response generated by human being against them. It's also concerned with the various methods of their diagnosis, treatment and finally their prevention & control.
An ova or cyst or egg is detected by microscopic evaluation of a stool sample that is used to look for parasites that may infect the lower digestive tract, causing symptoms such as diarrhoea. The parasites and their eggs (ova) are shed from the lower digestive tract into the stool
Stool examination (Microscopic) is performed for the diagnosis of following parasitic infections
1. Protozoa • Entamoeba histolytica • Giardia lamblia • intestinal coccidian parasites (i) Cryptosporidium parvum (ii) Cyclospora (iii) Isospora • Balantidium coli
2. Helminthes • nematodes: (i) Ascaris lumbricoides (ii) Trichuris trichuria
(Iii) hookworm • Ancylostoma duodenale • Nectar americans (iv) Strongyloides stercoralis
Cestodes: (i) Taenia spp • T. Saginata • T.Solium (ii) Hymenolepsis nana (iii) Enterobius vermicularis
this is power point presentation for ophthalmic assistant student regarding basic knowledge for ocular parasites like, LOA LOA, RIVER BLINDNESS , ONCHOCERCIASIS , TOXOPLASMOSIS & TOXOCARIASIS etc. which consist basic test , epidemiology, lab investigation, culture & management .
what is loa loa.
loa loa is eradicated mostly from from Asian country like India, Nepal, China etc. , the presentation is for 2nd year O.A students & EHW. which shows basic....knowledge
This is an overview about parasites infest or affect the human eyes & principles of the diseases thay cause
A medical-student-made presentation for Ain Shams University - Faculty of Medicine - Department of Parasitology
Hope it help you
Concise discussion on Fialrial worms including Morphology, Life cycle, pathogenesis, clinical manifestations and laboratory diagnosis including newer techniques for UG and PG students.
wuchereria bancrofti can causes serious diseases that attack our world . so this presentation gives us some information about this worm , methods of avoiding it and what are diagnostic tests that doctors ask .
This comprehensive program covers essential aspects of performance marketing, growth strategies, and tactics, such as search engine optimization (SEO), pay-per-click (PPC) advertising, content marketing, social media marketing, and more
The Impact of Artificial Intelligence on Modern Society.pdfssuser3e63fc
Just a game Assignment 3
1. What has made Louis Vuitton's business model successful in the Japanese luxury market?
2. What are the opportunities and challenges for Louis Vuitton in Japan?
3. What are the specifics of the Japanese fashion luxury market?
4. How did Louis Vuitton enter into the Japanese market originally? What were the other entry strategies it adopted later to strengthen its presence?
5. Will Louis Vuitton have any new challenges arise due to the global financial crisis? How does it overcome the new challenges?Assignment 3
1. What has made Louis Vuitton's business model successful in the Japanese luxury market?
2. What are the opportunities and challenges for Louis Vuitton in Japan?
3. What are the specifics of the Japanese fashion luxury market?
4. How did Louis Vuitton enter into the Japanese market originally? What were the other entry strategies it adopted later to strengthen its presence?
5. Will Louis Vuitton have any new challenges arise due to the global financial crisis? How does it overcome the new challenges?Assignment 3
1. What has made Louis Vuitton's business model successful in the Japanese luxury market?
2. What are the opportunities and challenges for Louis Vuitton in Japan?
3. What are the specifics of the Japanese fashion luxury market?
4. How did Louis Vuitton enter into the Japanese market originally? What were the other entry strategies it adopted later to strengthen its presence?
5. Will Louis Vuitton have any new challenges arise due to the global financial crisis? How does it overcome the new challenges?
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15385-LESSON PLAN- 7TH - SS-Insian Constitution an Introduction.pdf
2.3. TISSUE NEMATODE BY ADERAW.doc
1. 0
AMBO UNIVERSITY WOLISO
CAMPUS
INDIVIDUAL ASSIGNMENT OF
MEDICAL PARASITOLOGY
DEPARTMENT OF NURSING
NAME: ADERAW ALEMIE
ID NO: UGR/35168/12
Submitted to:Mr.Amsalu
Submission date:5/12/2014 E.C
2. 1
2.3. TISSUE NEMATODES
Introduction
♦Tissue nematodes includes:-
1 The filarial worms. A. Wuchereria bancrofti C. Loa loa
B. Onchocerca volvulus
2. Guinea worm (Dranculuculus medinensis) and
3. Trichinella spiralis.
1. FILARIAL WORMS
♦Nematodes belonging to the superfamily Filarioidea are slender thread-like
worms (latin, filum and thread), which are transmitted by the bite of blood-
sucking insects The filarial worms reside in the subcutaneous tissues, lymphatic
system, or body cavities of humans
♦The filarial worms have complex life cycles involving a developmental stage in
an insect vector. They require an arthropod vector for their transmission. The
worms inhabit either the lymphatic system or the subcutaneous tissues of man.
The female worm gives rise to a young worm called microfilaria.
♦The microfilariae, when taken by the arthropod intermediate host during biting,
develop into filariform larvae, which are the infective stages. Humans get infected
when bitten by the infected arthropod intermediate host.
A. Wuchereria bancrofti
♦This is a parasite of lymph nodes and lymphatic vessels- causing lymphatic
filariasis. This filarial worm is transmitted by the bite of various species of
mosquitoes.
Epidemiology
♦W. bancrofti is strictly a human pathogen and is distributed in tropical areas
worldwide, whereas B. malayi infects a number of wild and domestic animals and
is restricted to South-East Asia. Mosquitoes are vectors for both parasites.
3. 2
♦W. bancrofti infection is not reported in higher altitudes of Ethiopia, but limited
to lowlands of Gambella. The epidemic area covers a long distance along the Baro
River.
♦It is believed that over 100 million people are infected.
Habitat
♦ The adult worms reside in the lymphatic system of man. The microfilariae are
found in blood.
Life cycle
♦Filariform larvae enter the human body during a mosquito bite and migrate to
various tissues. There, they may take up to a year to mature and produce
microfilaria which migrate to lymphatics and, at night, enter the blood circulation.
♦Mosquitos are infected during a blood meal. The microfilaria grow 4 to 5 fold in
the mosquito in 10 to 14 days and become infective for man.
Mode of transmission and pathogenesis
♦Humans get infection by bite of mosquito carrying filariform larva
♦Intermediate host: Female mosquito, of different species
♦Definitive host: Man. No animal host or reservoir is known for W. bancrofti.
♦Infective form: Actively motile third-stage filariform larva is infective to man.
♦The filariform larvae are introduced through the skin by the bite of the
arthropod intermediate host. The larvae invade the lymphatics, usually the lower
limb, where they develop into adult worms.
♦The microfilariae are librated into the blood stream. They remain in the
pulmonary circulation during day, emerging into the peripheral circulation only
during night, to coincide with the biting habit of the vector.
♦Presence of the adult worms causes lymphatic blockage and gross lymphedema,
which sometimes lead to elephantiasis.
4. 3
Pathogenecity and clinical features:
♦The adult worm obstructs the flow of lymph in the lymph nodes and the
lymphatic vessels draining the lower limbs and the external genitalia.
♦The lower limbs and external genitalia become swollen. The skin becomes thick
and fissured. The disease is called bancroftian elephantiasis.
♦The major symptoms and findings include: lymphangitis, lymphedema, fever,
headache, myalgia, hydrocele and chyluria.
Diagnosis
♦Blood film examination after staining by Giemsa or Leishman stain to detect
microfilaria. The film should be taken by night.
Treatment
♦Diethyl carbamazine (DEC): 2 mg/kg 3x daily for 2 weeks.
Prevention and control
strategy:
B. Onchocerca volvulus (Blinding filariasis; river blindness)
Onchocerca volvulus, the ‘convoluted filaria’, or the ‘blinding filaria’ producing
onchocerciasis or ‘river blindness’was first described by leuckart in 1893
Epidemiology
♦Infection by this filarial worm is common in Ethiopia. Endemic foci are found in
Bebeka, Gojeb valley, Dedessa valley, Agaro, Metekel, and in Northwestern
5. 4
Ethiopia around Gondar. Onchocerciasis is prevalent throughout eastern, central
and western Africa.
♦In the Americas, it is found in Guatemala, Mexico, Colombia and Venezuela
Habitat
♦The adult worms are seen in nodules in subcutaneous connective tissue of
infected persons.
Morphology:
♦Male: Similar to that of Wuchereria bancrofti.
♦Female: The female measures 30-50 cm in length. It is present inside of a fibrous
nodule (onchocercomata or onchocerca tumor).
Life cycle
♦life cycle is completed in 2 hosts.
♦Definitive host: Humans are the only defi nitive host.
♦Intermediate hosts: Day-biting female black flies of the genus Simulium (black fl
ies)
♦Infective larvae are injected into human skin by the female black fly (Simulium
damnosum) where they develop into adult worms in 8 to 10 months.
♦The adults usually occur as group of tightly coiled worms (2 to 3 females and 1
to 2 males). The gravid female releases microfilarial larvae, which are usually
distributed in the skin. They are picked up by the black fly during a blood meal.
♦The larvae migrate from the gut of the black fly to the thoracic muscle where
they develop into infective larvae in 6 to 8 days.
Pathogenecity and clinical manifestations:
♦The disease, onchocerciasis or river blindness includes:
• Skin fibrous nodules (onchocercomata) enclosing female worms. The nodules
are common in neck, iliac crest and the coccyx.
6. 5
• Skin hypo- or hyper- pigmentation. Dermatitis is present. In advanced cases, the
skin becomes thickened and wrinkled, showing lizard or leopard skin appearance.
• Elephantiasis of the external genitalia and corneal opacity and optic atrophy
may finally cause blindness.
Diagnosis
♦Superficial biopsy (skin snip) is taken from the skin using sharp razor blade. The
specimen is allowed to stand for 30 minutes in saline before it is examined
microscopically for microfilariae.
Treatment
♦Ivermectin: 50 mg/kg bodyweight, given every 6 or 12 months. Because it kills
microfilariae but not adult worms, retreatment is necessary over a period of years.
Prevention
• Vector control
• Mass treatment
• Establishment of villages away from Simulium breeding places.
• Use of repellents
• Protective clothing
C. Loa loa
♦The eye worm, Loa loa, causes Loiasis. The insect vectors include mango flies of
Chrysops - Chrysops silacea, Chrysops dimidiata
Epidemiology
♦Loasis is limited to the areas of African equatorial rain forest
♦The eye worm, Loa loa, causes Loiasis. The insect vectors include mango flies of
Chrysops - Chrysops silacea, Chrysops dimidiata. Loiasis is endemic in Central and
West Equatorial Africa. The abundant rubber plantations provide a favorable
environment for the vector to transmit the disease.
Morphology
♦ Adult male worms: 30-34 mm in length
♦Adult female worms: 40-70 mm in length
7. 6
Life cycle
♦Life cycle is completed in 2 hosts.
♦Definitive host: Man
♦Intermediate host or vectors: Day biting flies (mango flies) of the genus
Chrysops, (C. dimidiata, C. silacea, and other species) in which the microfilariae
develop into the
♦infective third-stage larvae.Infection is transmitted to man through the bite of
infected Chrysops during their blood meal.
♦ The infective third stage larvae enter the subcutaneous tissue, moult, and
develop into mature adult worm over 6–12 months and migrate in subcutaneous
tissues.
♦Female worms produce sheathed microfilaria which have diurnal periodicity
♦The microfilaria are ingested by Chrysops during its blood meal.
♦They cast off their sheaths, penetrate the stomach wall
and reach thoracic muscles where they develop into infective larvae.
Pathogenesis
♦The microfilaria have a sheath. Their diurnal periodicity corresponds to the
feeding pattern of the insect vector, which bites humans from 10:00 AM to 4:00
PM.
Clinical Features
♦Incubation period is about one year. It causes calabar swelling beneath the skin
due to parasites. There is fever, pain, pruritus, urticaria, allergic reactions,
retinopathy, glomerulonephritis, meningo-encephalitis etc.
Laboratory diagnosis
• Detection of microfilaria in peripheral blood, urine, sputum, CSF - stained with
Giemsa or unstained
• Eosinophilia
Treatment
♦DEC, 6 to 10 mg per kilogram per day for 2 to 3 weeks: but has side effects -
allergic reactions
Prevention and control
8. 7
• Vector control • Mass treatmen
• Use of repellents. • Protective clothing
• Establishment of villages away from Simulium breeding places.
2. DRACUNCULUS MEDINENSIS (Guinea worm or Medina worm)
Epidemiology
♦Dracunculus medinensis causes dracunculiasis. The infection is endemic to Asia
and Africa: India, Nile Valley, central, western and equatorial Africa, lowlands of
Ethiopia and Eritrea.
Morphology
♦Gravid female worms measure 70-120 cm in length. Their body cavity is almost
fully occupied by a uterus greatly distended with rhabditiform larvae (250-750 μm
in length). A digestive tube and cuticular annulations distinguish the larvae from
microfilariae.
Habitat
♦The adult females of D. medinensis are usually found in the subcutaneous tissue
of the legs, arms and back in man
Mode of transmission
♦Humans get infected by drinking unfi ltered water containing infected cyclops.
Pathogenecity and life cycle
♦Definitive host: Man
♦Intermediate host: Cyclops, in which embryos undergo developmental changes.
There is no animal reservoir.
♦Infective form: Third-stage larva present in the hemocele of infected cyclops.
♦Infection is acquired by drinking unfiltered or not boiled water that contains
Cyclops species. The larvae are released in the stomach, penetrate the intestinal
wall and find their way to the subcutaneous tissue. Mating takes place in the
axillary or inguinal regions 3 months after infection.
9. 8
♦The male worms then die in the tissue and the female worms move down to the
limbs within 10 months. Inabout 1 year, female worms in the subcutaneous tissue
provoke the formation of a burning blister in the skin of the legs.
♦When in water, the blister bursts, and about 5 cm of the worm is extruded from
the resulting ulcer - thus releasing many thousands of first stage larvae. The
larvae swim in water and are ingested by the intermediate host - Cyclops species-
within about 4 days. Inside the Cyclops, the larvae molt twice and become
infective in 2 weeks
Clinical feature
♦The female parasites in the subcutaneous tissue release toxic byproducts of
histamine-like nature, which cause systemic allergic reactions, like erythema,
urticaria, pruritus, fainting, asthma, dyspnea, etc. This is followed by the
appearance of a blister on the legs, which ruptures on contact with water
releasing larvae into the water by the female worm. The wound may ulcerate.
♦The worms migrate into other tissues and may cause arthritis, pericarditis,
abscesses etc. It occasionally penetrates the eyeball and causes loss of the eye.
Diagnosis
1. Clinical: Observation of blister, worm or larvae
2. Histologic features of subcutaneous sinus tract
3. Eosinophilia and radiographic evidence
Treatment
♦Surgical excision when the worm is in the leg
♦Niridazole (Ambilhar) or DEC
Prevention
Health education on:
♦Boiling or filtering of drinking water
♦Treating of patients and educating them not to enter water bodies
♦Using insect larvicides to kill Cyclops in water.
3. TRICHINOSIS
10. 9
Trichinella spiralis - Etiologic agent
♦This is the only important species in this group. It causes trichinosis - a
cosmopolitan infection. More than 100 different animal species can be infected
with Trichinella species, but the major reservoir host for human infections is
swine.
Morphology
♦Adult female worm measures 3-4 mm in length and the adult male worm
measures 1.4-2.6 mm in length. The encysted larvae measure 800-1300 μm in
length.
Pathogenecity and life cycle
♦After ingesting infected meat, the capsule of the encysted larvae is digested by
gastric juice, and the larvae are released in the duodenum or jejunum where they
molt four times to become adult worm. After mating, the male worm dies and the
female worm begins to deliver the embryos 4-7 days after the infection. The
larvae penetrate the intestinal wall and migrate through the lymphatic vessels to
the blood stream, which carries them to various organs. Skeletal muscles and
diaphragm are most frequently parasitized. Others include the tongue, masseter
and ocular muscles.
Clinical features
♦There are two clinical phases.
1. The intestinal phase: lasting 1-7 days - asymptomatic; sometimes cause nausea,
vomiting, diarrhea, constipation, pain, etc, and
2. The muscle phase: which causes myalgia, palpabral edema, eosinophilia, fever,
myocarditis, meningitis, bronchopneumonia etc.
Diagnosis:
♦Muscle Biopsy
♦Detection of larvae in blood or CSF
♦Detection of larvae and adult worms in stool (rare).
♦ELISA
Treatment - Thiabendazol
Prevention
11. 10
♦Cooking of all meat before consumption
♦Inspection of pigs
♦Pork must be stored at -150C for 20 days.