The document discusses extinction and biodiversity loss. It defines extinction as occurring when the last member of a species dies. The passenger pigeon is provided as an example, with the last one dying alone in a zoo in 1914 after the species was already functionally extinct in the wild. Major causes of extinction discussed include habitat degradation and destruction from human activities like pollution, climate change, and overpopulation. Statistics are given on current extinction rates from human impacts being 1500 times the natural rate, with many species projected to be lost in the coming centuries if trends continue. The major impacts of biodiversity loss on human concerns like medicine, agriculture, ecosystem services, and moral obligations are also briefly touched on.
Community ecology, study of the organization and functioning of communities, which are assemblages of interacting populations of the species living within a particular area or habitat.
This is the 7th lesson of the course - Foundation of Environmental Management taught at the Faculty of Social Sciences and Humanities, Rajarata University of Sri Lanka
Ecosystem and Stability - Population Dynamics, Population density, Spatial Distribution patter, Population range, reproduction pattern,
Limiting population Growth - Dependent and independent Factor
Population Growth Rate
Ecosystem Stability - Resistance and Resilliance
Reference : Exploring Life Through Science 10
Community ecology, study of the organization and functioning of communities, which are assemblages of interacting populations of the species living within a particular area or habitat.
This is the 7th lesson of the course - Foundation of Environmental Management taught at the Faculty of Social Sciences and Humanities, Rajarata University of Sri Lanka
Ecosystem and Stability - Population Dynamics, Population density, Spatial Distribution patter, Population range, reproduction pattern,
Limiting population Growth - Dependent and independent Factor
Population Growth Rate
Ecosystem Stability - Resistance and Resilliance
Reference : Exploring Life Through Science 10
Biodiversity is variety…
of organisms in a given area
of genetic variation within a population
of species in a community
of communities in an ecosystem
Humans need to understand & preserve biodiversity for our own survival.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
2. What is Extinction?What is Extinction?
Extinction occurs when the last existingExtinction occurs when the last existing
member of a given species diesmember of a given species dies
In other words…there aren’t any more left!In other words…there aren’t any more left!
It is a scientific certainty when there areIt is a scientific certainty when there are
not any surviving individuals left tonot any surviving individuals left to
reproducereproduce
Functional ExtinctionFunctional Extinction
Only a handful of individuals are leftOnly a handful of individuals are left
Odds of reproduction are slimOdds of reproduction are slim
3. The passenger pigeonThe passenger pigeon
The last passenger pigeon inThe last passenger pigeon in
Wisconsin was shot in 1899.Wisconsin was shot in 1899.
This was reportedly the last passengerThis was reportedly the last passenger
pigeon shot in the wild.pigeon shot in the wild.
The last Passenger Pigeon, named Martha,The last Passenger Pigeon, named Martha,
died alone at Zoo in 1914.died alone at Zoo in 1914.
Even when Martha was still alive, the speciesEven when Martha was still alive, the species
was already functionally extinct – it wouldwas already functionally extinct – it would
never return to a sustainable population.never return to a sustainable population.
4. Causes of ExtinctionCauses of Extinction
GeneticsGenetics
Small populations = increased riskSmall populations = increased risk
MutationsMutations
• Causes a flux in natural selectionCauses a flux in natural selection
• Beneficial genetic traits are overruledBeneficial genetic traits are overruled
Loss of Genetic DiversityLoss of Genetic Diversity
• Shallow gene pools promote massive inbreedingShallow gene pools promote massive inbreeding
5. Extinctions occur when the environment ofExtinctions occur when the environment of
a species changes faster than the speciesa species changes faster than the species
can adapt.can adapt.
Extinctions can be local, widespread, orExtinctions can be local, widespread, or
global.global.
For example, the timber wolf was until recentlyFor example, the timber wolf was until recently
extinct in Wisconsin but not in Minnesotaextinct in Wisconsin but not in Minnesota
Wild elk and woodland caribou are now extinctWild elk and woodland caribou are now extinct
in Wisconsin but may be found on gamein Wisconsin but may be found on game
farms.farms.
6. Habitat DegradationHabitat Degradation
ToxicityToxicity
Kills off species directly through food/waterKills off species directly through food/water
Indirectly via sterilizationIndirectly via sterilization
Can occur in short spans (a single generation)Can occur in short spans (a single generation)
Can occur over several generationsCan occur over several generations
• Increasing toxicityIncreasing toxicity
• Increasing competition for habitat resourcesIncreasing competition for habitat resources
7. Habitat DegradationHabitat Degradation
Destruction of HabitatDestruction of Habitat
““Save the Rainforests!”Save the Rainforests!”
Elimination of living spaceElimination of living space
Change in habitatChange in habitat
• Rainforest to pasture landsRainforest to pasture lands
Leads to diminishing resourcesLeads to diminishing resources
• Increases competitionIncreases competition
Can be caused by natural processesCan be caused by natural processes
• Volcanoes, floods, drought, etc…Volcanoes, floods, drought, etc…
8. CoextinctionCoextinction
The loss of one species leads to the lossThe loss of one species leads to the loss
of anotherof another
Chain of extinctionChain of extinction
Can be caused by small impacts in theCan be caused by small impacts in the
beginningbeginning
A predator looses its food sourceA predator looses its food source
Affected by interconnectedness in natureAffected by interconnectedness in nature
9. Planned ExtinctionPlanned Extinction
Human controlledHuman controlled
Thought of to help humansThought of to help humans
Deadly virusesDeadly viruses
SmallpoxSmallpox
• Extinct in the wildExtinct in the wild
PolioPolio
• Near extinct (only in small parts of the world)Near extinct (only in small parts of the world)
12. Changes in Sea Level or CurrentsChanges in Sea Level or Currents
www.johnstonsarchive.net/spaceart/cylmaps.htmlwww.johnstonsarchive.net/spaceart/cylmaps.html
15. Disease/EpidemicsDisease/Epidemics
Can wipe out entireCan wipe out entire
speciesspecies
Frog with fungusFrog with fungus
diseasedisease
Killing frogs and otherKilling frogs and other
amphibiansamphibians
16. Natural factors usually occur at a slower
rate and therefore cause a low extinction
rate.
Human activities occur at a faster rate
and cause higher extinction rates.
Human activities are mostly responsible
for the present extinction rates.
http://www.gov.mb.ca/conservation/sustain/extinct.pdf
18. Top Human Causes of
Extinction:
Increased human population
Destruction/Fragmentation of
habitat
Pollution
Climate change/Global warming
19. Habitat Degradation
Habitat loss and degradation affect 86%
of all threatened birds, 86% of mammals and
88% of threatened amphibians
20. Current StatsCurrent Stats
9090% of all large fish have disappeared in the last 50 years due to% of all large fish have disappeared in the last 50 years due to
over-fishing.over-fishing.
Myers, Ransom. Worm, Boris. Biology Department, Dalhousie University, Halifax, Nova Scotia, Canada, RapidMyers, Ransom. Worm, Boris. Biology Department, Dalhousie University, Halifax, Nova Scotia, Canada, Rapid
Worldwide Depletion of Predatory Fish Communities. Nature. Volume 423. P. 280. May 2003Worldwide Depletion of Predatory Fish Communities. Nature. Volume 423. P. 280. May 2003
3030% of North American songbird species are in significant decline.% of North American songbird species are in significant decline.
One in eightOne in eight plant species are in danger of extinction within the nextplant species are in danger of extinction within the next
30 years (ICUN Red List)30 years (ICUN Red List)
The current rate of extinction isThe current rate of extinction is 15001500 times greater than the normal,times greater than the normal,
sustainable extinction rate.sustainable extinction rate.
Bjørn Lomborg, The Skeptical Environmentalist: Measuring the Real State of the World, Cambridge U. Press,Bjørn Lomborg, The Skeptical Environmentalist: Measuring the Real State of the World, Cambridge U. Press,
Cambridge, 2001.Cambridge, 2001.
““HalfHalf of bird and mammal species will be gone in 200 to 300 years”of bird and mammal species will be gone in 200 to 300 years”
Levin, Phillip and Levin, Donald. The Real Biodiversity Crisis. January, 2002.Levin, Phillip and Levin, Donald. The Real Biodiversity Crisis. January, 2002. American ScientistAmerican Scientist,, VolumeVolume
90, Number 1, Page 690, Number 1, Page 6
One species is going extinct every 20 minutes.One species is going extinct every 20 minutes.
Levin, Phillip and Levin, Donald. The Real Biodiversity Crisis. January, 2002. American Scientist, VolumeLevin, Phillip and Levin, Donald. The Real Biodiversity Crisis. January, 2002. American Scientist, Volume
90, Number 1, Page 690, Number 1, Page 6
21. Modern Causes of ExtinctionsModern Causes of Extinctions
Major current causes of extinctions include:Major current causes of extinctions include:
Habitat LossHabitat Loss: fragmentation, degradation, and: fragmentation, degradation, and
outright destruction of ecosystems that supportoutright destruction of ecosystems that support
native ecosystems (leading cause).native ecosystems (leading cause).
Invasive SpeciesInvasive Species: the introduction or: the introduction or
overpopulation of species that over-consumeoverpopulation of species that over-consume
natural resources and are uncontrolled bynatural resources and are uncontrolled by
predators (second leading cause).predators (second leading cause).
Over-harvestingOver-harvesting: the removal of species at rates: the removal of species at rates
that exceed reproductionthat exceed reproduction
PollutionPollution: introduction of harmful agents that: introduction of harmful agents that
reduce the effectiveness of a species’reduce the effectiveness of a species’
adaptationsadaptations
26. Biodiversity & Ecosystem ServicesBiodiversity & Ecosystem Services
Ecosystem services include air and waterEcosystem services include air and water
purification, detoxification and decomposition ofpurification, detoxification and decomposition of
wastes, climate regulation, regeneration of soilwastes, climate regulation, regeneration of soil
fertility, and the production and maintenance offertility, and the production and maintenance of
biological diversity.biological diversity.
These are the key ingredients of our agricultural,These are the key ingredients of our agricultural,
pharmaceutical, and industrial enterprises.pharmaceutical, and industrial enterprises.
Such services are estimated to be worth trillions ofSuch services are estimated to be worth trillions of
dollars annually.dollars annually.
We get these services for free…for now.We get these services for free…for now.
http://www.fws.gov/endangered/esa-http://www.fws.gov/endangered/esa-
library/pdf/Why_Save_Endangered_Species_Brochure.pdflibrary/pdf/Why_Save_Endangered_Species_Brochure.pdf