Erythropoiesis
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This document defines and describes the process of erythropoiesis, or red blood cell formation. It outlines the stages of development from pleuripotent stem cell to mature red blood cell over 7-9 days. Key stages include proerythroblast, basophilic erythroblast, polychromic erythroblast, and reticulocyte. Erythropoiesis occurs primarily in red bone marrow and is regulated by factors like erythropoietin and oxygen levels to maintain normal red blood cell counts.
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erythropoieses
Red blood cells are formed through the process of erythropoiesis, where hemopoietic stem cells in the bone marrow differentiate into mature red blood cells. This process is regulated by erythropoietin, which is released by the kidneys in response to low oxygen levels in the blood and promotes the production and release of reticulocytes from bone marrow. Other factors like iron, vitamin B12, and folic acid are also necessary for hemoglobin production and the maturation of red blood cells. Mature red blood cells are biconcave disks that transport oxygen and carbon dioxide throughout the body and have a lifespan of approximately 120 days before being destroyed by the spleen and liver.
Erythropoiesis
Erythropoiesis is the process where red blood cells develop from stem cells in the bone marrow. It proceeds through several stages, starting with stem cells that differentiate into progenitor cells and then normoblasts as the cells mature. Key changes occur like decreasing size, loss of nucleus and organelles, and increasing hemoglobin content. Erythropoietin is the main hormone that stimulates and regulates red blood cell production in response to hypoxia. Other factors like iron, vitamin B12, and folic acid are also necessary for erythropoiesis.
Erythropoiesis 150731072608-lva1-app6891
Erythropoiesis is the process where primitive stem cells in the bone marrow develop into mature red blood cells. In fetal life, red blood cells are initially produced in the yolk sac, then the liver, and finally the bone marrow. After birth, erythropoiesis occurs primarily in the bone marrow of long bones and skull. Stem cells differentiate through several stages, reducing in size and losing organelles, as hemoglobin production increases and the cells mature from reticulocytes to biconcave erythrocytes ready for circulation.
Rbc Structure and Physiology
This document provides an overview of red blood cell structure and physiology. It discusses that blood volume is calculated based on weight, and lists the functions of blood. It describes hematopoiesis, the process of blood cell formation, and focuses on erythropoiesis, the development of red blood cells. Key aspects of red blood cell structure are summarized, including the lipid bilayer membrane, cytoskeleton, integral and peripheral proteins. Hemoglobin structure and function in oxygen transport is also covered. The roles of erythropoietin and iron metabolism in red blood cell production are highlighted.
Blood physiology
Erythropoietin (EPO) secreted by kidney
Inhibitor: High concentration of O2 in kidney
Life span of RBC: 120 days
RBC metabolism: anaerobic glycolysis [reason for
Heinz body and G6PD deficiency anemia]
RBC destruction: spleen and macrophage in liver,
bone marrow [reason for spherocytosis and
elliptocytosis]
RBC regeneration: bone marrow
RBC reserve: about 25% of total RBC
RBC production: 2.4×1011/day
Erythropoiesis
Erythropoiesis is the process where red blood cells are produced in the bone marrow. It begins with pluripotent stem cells that differentiate through several stages into reticulocytes over 5 days, then mature into erythrocytes over 2 more days. The key stages include pronormoblast, basophilic normoblast, polychromatophilic normoblast, orthochromatic normoblast, and reticulocyte. Erythropoiesis is regulated by erythropoietin and requires various vitamins and minerals to produce hemoglobin and allow the red blood cells to mature fully.
Red blood cell - Erythropoiesis
This document discusses erythropoiesis, the process of red blood cell formation. It outlines the stages of erythropoiesis from pluripotent hematopoietic stem cells to mature red blood cells, including proerythroblasts, basophilic erythroblasts, polychromatophilic erythroblasts, orthochromatic erythroblasts, reticulocytes, and mature red blood cells. It also describes the key factors that regulate erythropoiesis, particularly erythropoietin produced by the kidneys in response to tissue oxygen levels. Vitamin B12 and folic acid also support red blood cell formation.
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White blood cells, or leukocytes, are nucleated blood cells that play an important role in the immune system. Compared to red blood cells, white blood cells are larger in size and fewer in number. The main types of white blood cells are neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Each type has a distinct shape and granule composition and serves different immune functions, such as phagocytosis of pathogens by neutrophils and antibody production by B lymphocytes. White blood cell counts can vary in different physiological and pathological conditions to help fight infection and disease.
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Red blood cells are formed through the process of erythropoiesis, where hemopoietic stem cells in the bone marrow differentiate into mature red blood cells. This process is regulated by erythropoietin, which is released by the kidneys in response to low oxygen levels in the blood and promotes the production and release of reticulocytes from bone marrow. Other factors like iron, vitamin B12, and folic acid are also necessary for hemoglobin production and the maturation of red blood cells. Mature red blood cells are biconcave disks that transport oxygen and carbon dioxide throughout the body and have a lifespan of approximately 120 days before being destroyed by the spleen and liver.
Erythropoiesis
Erythropoiesis is the process where red blood cells develop from stem cells in the bone marrow. It proceeds through several stages, starting with stem cells that differentiate into progenitor cells and then normoblasts as the cells mature. Key changes occur like decreasing size, loss of nucleus and organelles, and increasing hemoglobin content. Erythropoietin is the main hormone that stimulates and regulates red blood cell production in response to hypoxia. Other factors like iron, vitamin B12, and folic acid are also necessary for erythropoiesis.
Erythropoiesis 150731072608-lva1-app6891
Erythropoiesis is the process where primitive stem cells in the bone marrow develop into mature red blood cells. In fetal life, red blood cells are initially produced in the yolk sac, then the liver, and finally the bone marrow. After birth, erythropoiesis occurs primarily in the bone marrow of long bones and skull. Stem cells differentiate through several stages, reducing in size and losing organelles, as hemoglobin production increases and the cells mature from reticulocytes to biconcave erythrocytes ready for circulation.
Rbc Structure and Physiology
This document provides an overview of red blood cell structure and physiology. It discusses that blood volume is calculated based on weight, and lists the functions of blood. It describes hematopoiesis, the process of blood cell formation, and focuses on erythropoiesis, the development of red blood cells. Key aspects of red blood cell structure are summarized, including the lipid bilayer membrane, cytoskeleton, integral and peripheral proteins. Hemoglobin structure and function in oxygen transport is also covered. The roles of erythropoietin and iron metabolism in red blood cell production are highlighted.
Blood physiology
Erythropoietin (EPO) secreted by kidney
Inhibitor: High concentration of O2 in kidney
Life span of RBC: 120 days
RBC metabolism: anaerobic glycolysis [reason for
Heinz body and G6PD deficiency anemia]
RBC destruction: spleen and macrophage in liver,
bone marrow [reason for spherocytosis and
elliptocytosis]
RBC regeneration: bone marrow
RBC reserve: about 25% of total RBC
RBC production: 2.4×1011/day
Erythropoiesis
Erythropoiesis is the process where red blood cells are produced in the bone marrow. It begins with pluripotent stem cells that differentiate through several stages into reticulocytes over 5 days, then mature into erythrocytes over 2 more days. The key stages include pronormoblast, basophilic normoblast, polychromatophilic normoblast, orthochromatic normoblast, and reticulocyte. Erythropoiesis is regulated by erythropoietin and requires various vitamins and minerals to produce hemoglobin and allow the red blood cells to mature fully.
Red blood cell - Erythropoiesis
This document discusses erythropoiesis, the process of red blood cell formation. It outlines the stages of erythropoiesis from pluripotent hematopoietic stem cells to mature red blood cells, including proerythroblasts, basophilic erythroblasts, polychromatophilic erythroblasts, orthochromatic erythroblasts, reticulocytes, and mature red blood cells. It also describes the key factors that regulate erythropoiesis, particularly erythropoietin produced by the kidneys in response to tissue oxygen levels. Vitamin B12 and folic acid also support red blood cell formation.
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White blood cells, or leukocytes, are nucleated blood cells that play an important role in the immune system. Compared to red blood cells, white blood cells are larger in size and fewer in number. The main types of white blood cells are neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Each type has a distinct shape and granule composition and serves different immune functions, such as phagocytosis of pathogens by neutrophils and antibody production by B lymphocytes. White blood cell counts can vary in different physiological and pathological conditions to help fight infection and disease.
Erythropoiesis
Erythropoiesis is the process of formation of red blood cells (erythrocytes) through maturation of stem cells in the bone marrow. In fetal life, erythropoiesis occurs in the yolk sac, liver, and later the bone marrow. In adults, erythropoiesis takes place primarily in the bone marrow. The process involves the maturation of stem cells into pro-erythroblasts, normoblasts, reticulocytes, and finally mature erythrocytes over the course of approximately 7 days as the cells reduce in size, lose their nuclei, and accumulate hemoglobin in their cytoplasm.
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This document discusses erythropoiesis, the process of red blood cell formation. It covers the sites of hematopoiesis, blood cell precursors, the stages of erythropoiesis from pronormoblast to reticulocyte, and the factors that regulate and are necessary for erythropoiesis. Key factors discussed include erythropoietin, which stimulates red blood cell production; vitamin B12 and folic acid, which are required for DNA synthesis and cell maturation; and intrinsic factor, which is needed for vitamin B12 absorption.
Erythropoiesis
Erythropoiesis is the process where red blood cells are produced. It occurs in multiple stages starting with stem cells in the bone marrow that differentiate into erythroid progenitor cells and progress through normoblast stages as the cells take up hemoglobin and lose their nuclei to become reticulocytes and then mature red blood cells. Key regulators of erythropoiesis include erythropoietin, iron, vitamin B12 and folic acid which promote red blood cell production and maturation. Hypoxia is the main stimulant for increased erythropoietin secretion from the kidneys which then acts to accelerate the production of red blood cells from progenitor cells in the bone marrow.
Erythropoiesis
dimensions, normal count and functions of RBC.
list of abnormal forms of RBCs
define erythropoiesis, give the different steps.
details of regulation of erythropoiesis =
- erythropoietin
- Vit.B12
- Folic acid
-Factors for Hb
Erythropoiesis
Erythropoiesis is the process of red blood cell formation that occurs in bone marrow. It involves stem cells maturing through several stages over 7-9 days to become reticulocytes and then erythrocytes. The cytoplasm changes color as maturation occurs and cell size decreases as the nucleus is lost. Erythropoietin produced by kidneys is the major hormonal regulator of erythropoiesis, stimulating stem cell development and red blood cell maturation. A variety of nutritional and environmental factors can also influence erythropoiesis.
erythropioesis
Erythropoiesis is the process where red blood cells are produced. It occurs in multiple stages starting with hematopoietic stem cells in the bone marrow. The stem cells differentiate into progenitor cells and then normoblasts as they mature. The stages include the proerythroblast, basophilic, polychromatophilic, and orthochromatic normoblasts. Reticulocytes are released without a nucleus and circulate for a few days before becoming mature erythrocytes. Key regulators of erythropoiesis include erythropoietin, iron, vitamin B12, and folic acid which influence proliferation and maturation of red blood cells.
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This document provides an overview of erythropoiesis, the process of red blood cell formation. It discusses the stages of erythropoiesis from stem cells to mature red blood cells, including proerythroblast, normoblast, reticulocyte, and mature red blood cell. It also outlines the key sites of erythropoiesis in fetal life (yolk sac, liver, bone marrow) and the general, maturation, and hemoglobin formation factors required for successful erythropoiesis, such as erythropoietin, vitamins, vitamin B12, and iron.
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This document discusses red blood cells (RBCs), including their definition, morphology, size, shape, counts, functions, nutritional requirements, hemoglobin structure and function, oxygen dissociation curve, production, metabolic pathways, and fate. RBCs, also known as erythrocytes, are biconcave discs that lack a nucleus and transport oxygen from the lungs to tissues via hemoglobin. Hemoglobin is an iron-containing protein made of globin and heme. RBC production occurs primarily in the bone marrow and is regulated by erythropoietin. RBCs undergo glycolysis and the pentose phosphate pathway for energy and biosynthesis.
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By: Ms. S. ANGELINE OLIVE
M.Sc. Hematology & Blood Transfusion
HEMATOPOIESIS
Hematopoiesis is the formation of blood cells in the bone marrow. Hematopoietic stem cells originate in the yolk sac and migrate to the liver, spleen and bone marrow where they differentiate into various blood cell types. The major sites of hematopoiesis change throughout development - the liver is dominant during the fetal stage while the bone marrow becomes the permanent site of hematopoiesis after birth. In the bone marrow, stem cells differentiate through several stages into mature red blood cells, white blood cells or platelets through the action of growth factors and cytokines.
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Hematopoiesis or haemopoiesis is a process of formation of blood cellular components, i.e. formation, development, and differentiation of blood cells, which are derived from haematopoietic stem cells (HSC).
Erythropoiesis
This document discusses erythropoiesis, the production of red blood cells. It describes the stages of red blood cell development from stem cells to reticulocytes to mature red blood cells. Erythropoiesis is regulated by factors like erythropoietin and tissue oxygen levels. Erythropoietin is produced mainly in the kidneys and stimulates red blood cell production. Vitamins like B12 and folic acid are also essential for red blood cell maturation.
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Erythropoiesis
Erythropoiesis is the process of red blood cell formation. It occurs in the yolk sac in embryos, the liver and spleen in fetuses, and the red bone marrow after birth. Factors that affect erythropoiesis include oxygen supply, the state of hematopoietic organs like the bone marrow and liver, hormones, and diet. Erythropoietin is the key hormone that stimulates erythropoiesis by acting on stem cells in the bone marrow to speed up red blood cell development.
The erythrocyte
1. Red blood cells (erythrocytes) constitute 99% of blood cells and function to transport oxygen to tissues and carbon dioxide from tissues to the lungs.
2. Erythrocytes contain hemoglobin which gives blood its red color and allows for oxygen transport. They are biconcave discs that are able to deform to pass through small blood vessels.
3. The erythrocyte membrane is selectively permeable and regulates ion content. It contains proteins, lipids, and carbohydrates that maintain the biconcave shape and cellular integrity of erythrocytes.
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INTRODUCTION-ERYTHROCYTES
STRUCTURE
NORMAL COUNT
COMPOSITION
ERYTHROPOIESIS- PROCESS
HEMOGLOBIN
FUNCTIONS
Monophyletic theory of hematopoiesis. Stem cells.
There are three main theories of hematopoiesis or blood cell formation: monophyletic, dualistic, and polyphyletic. The monophyletic or unitary theory, first proposed over 100 years ago, suggests that all blood cells originate from a common stem cell. Stem cells are classified based on their differentiation potential as totipotent, pluripotent, multipotent, or unipotent. Hematopoiesis occurs primarily in the bone marrow and is regulated by growth factors. The process involves the proliferation, differentiation, and maturation of stem cells into the various mature blood cell types through multiple cellular stages. A complete blood count provides indicators of normal or abnormal hematopoiesis. Stem cells
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Erythropoiesis for bs mlt
Erythropoiesis is the process of red blood cell production that occurs in multiple stages within the bone marrow. It begins with pluripotent stem cells that differentiate into erythroid progenitor cells and progress through normoblast stages as the cells take on hemoglobin and lose their nuclei to become reticulocytes and finally mature red blood cells. Key regulators of erythropoiesis include erythropoietin, which is produced mainly in the kidneys in response to hypoxia and promotes red blood cell production, and various vitamins and minerals that support cell maturation and hemoglobin synthesis.
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This document summarizes erythropoiesis, the production of red blood cells. It describes the stages of maturation from pluripotent stem cells to erythrocytes. Key stages include burst forming units and colony forming units that give rise to erythroblast precursors. Erythropoietin is the main growth factor that stimulates and regulates erythropoiesis. The bone marrow is typically the main site of erythropoiesis in adults, though the liver and spleen can also produce red blood cells early in development.
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Erythropoiesis
Erythropoiesis is the process of formation of red blood cells (erythrocytes) through maturation of stem cells in the bone marrow. In fetal life, erythropoiesis occurs in the yolk sac, liver, and later the bone marrow. In adults, erythropoiesis takes place primarily in the bone marrow. The process involves the maturation of stem cells into pro-erythroblasts, normoblasts, reticulocytes, and finally mature erythrocytes over the course of approximately 7 days as the cells reduce in size, lose their nuclei, and accumulate hemoglobin in their cytoplasm.
ERYTHROPOIESIS
This document discusses erythropoiesis, the process of red blood cell formation. It covers the sites of hematopoiesis, blood cell precursors, the stages of erythropoiesis from pronormoblast to reticulocyte, and the factors that regulate and are necessary for erythropoiesis. Key factors discussed include erythropoietin, which stimulates red blood cell production; vitamin B12 and folic acid, which are required for DNA synthesis and cell maturation; and intrinsic factor, which is needed for vitamin B12 absorption.
Erythropoiesis
Erythropoiesis is the process where red blood cells are produced. It occurs in multiple stages starting with stem cells in the bone marrow that differentiate into erythroid progenitor cells and progress through normoblast stages as the cells take up hemoglobin and lose their nuclei to become reticulocytes and then mature red blood cells. Key regulators of erythropoiesis include erythropoietin, iron, vitamin B12 and folic acid which promote red blood cell production and maturation. Hypoxia is the main stimulant for increased erythropoietin secretion from the kidneys which then acts to accelerate the production of red blood cells from progenitor cells in the bone marrow.
Erythropoiesis
dimensions, normal count and functions of RBC.
list of abnormal forms of RBCs
define erythropoiesis, give the different steps.
details of regulation of erythropoiesis =
- erythropoietin
- Vit.B12
- Folic acid
-Factors for Hb
Erythropoiesis
Erythropoiesis is the process of red blood cell formation that occurs in bone marrow. It involves stem cells maturing through several stages over 7-9 days to become reticulocytes and then erythrocytes. The cytoplasm changes color as maturation occurs and cell size decreases as the nucleus is lost. Erythropoietin produced by kidneys is the major hormonal regulator of erythropoiesis, stimulating stem cell development and red blood cell maturation. A variety of nutritional and environmental factors can also influence erythropoiesis.
erythropioesis
Erythropoiesis is the process where red blood cells are produced. It occurs in multiple stages starting with hematopoietic stem cells in the bone marrow. The stem cells differentiate into progenitor cells and then normoblasts as they mature. The stages include the proerythroblast, basophilic, polychromatophilic, and orthochromatic normoblasts. Reticulocytes are released without a nucleus and circulate for a few days before becoming mature erythrocytes. Key regulators of erythropoiesis include erythropoietin, iron, vitamin B12, and folic acid which influence proliferation and maturation of red blood cells.
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This document provides an overview of erythropoiesis, the process of red blood cell formation. It discusses the stages of erythropoiesis from stem cells to mature red blood cells, including proerythroblast, normoblast, reticulocyte, and mature red blood cell. It also outlines the key sites of erythropoiesis in fetal life (yolk sac, liver, bone marrow) and the general, maturation, and hemoglobin formation factors required for successful erythropoiesis, such as erythropoietin, vitamins, vitamin B12, and iron.
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This document discusses red blood cells (RBCs), including their definition, morphology, size, shape, counts, functions, nutritional requirements, hemoglobin structure and function, oxygen dissociation curve, production, metabolic pathways, and fate. RBCs, also known as erythrocytes, are biconcave discs that lack a nucleus and transport oxygen from the lungs to tissues via hemoglobin. Hemoglobin is an iron-containing protein made of globin and heme. RBC production occurs primarily in the bone marrow and is regulated by erythropoietin. RBCs undergo glycolysis and the pentose phosphate pathway for energy and biosynthesis.
Lymphoid tissue
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By: Ms. S. ANGELINE OLIVE
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HEMATOPOIESIS
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Hematopoiesis or haemopoiesis is a process of formation of blood cellular components, i.e. formation, development, and differentiation of blood cells, which are derived from haematopoietic stem cells (HSC).
Erythropoiesis
This document discusses erythropoiesis, the production of red blood cells. It describes the stages of red blood cell development from stem cells to reticulocytes to mature red blood cells. Erythropoiesis is regulated by factors like erythropoietin and tissue oxygen levels. Erythropoietin is produced mainly in the kidneys and stimulates red blood cell production. Vitamins like B12 and folic acid are also essential for red blood cell maturation.
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Erythropoiesis is the production of RBCs . This ppt contains general and concised information about RBC production in prenatal, neonatal and in young and adult life.
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Red blood cells, also known as erythrocytes, are biconcave discs that contain hemoglobin which transports oxygen and carbon dioxide throughout the body. Key functions of red blood cells include oxygen transport from the lungs to tissues and carbon dioxide transport from tissues back to the lungs. The document discusses normal red blood cell counts and dimensions in different age groups and gender. It also covers abnormal red blood cell shapes and conditions they are associated with, as well as factors that affect red blood cell sedimentation rate and hematocrit levels.
Erythropoiesis
Erythropoiesis is the process of red blood cell formation. It occurs in the yolk sac in embryos, the liver and spleen in fetuses, and the red bone marrow after birth. Factors that affect erythropoiesis include oxygen supply, the state of hematopoietic organs like the bone marrow and liver, hormones, and diet. Erythropoietin is the key hormone that stimulates erythropoiesis by acting on stem cells in the bone marrow to speed up red blood cell development.
The erythrocyte
1. Red blood cells (erythrocytes) constitute 99% of blood cells and function to transport oxygen to tissues and carbon dioxide from tissues to the lungs.
2. Erythrocytes contain hemoglobin which gives blood its red color and allows for oxygen transport. They are biconcave discs that are able to deform to pass through small blood vessels.
3. The erythrocyte membrane is selectively permeable and regulates ion content. It contains proteins, lipids, and carbohydrates that maintain the biconcave shape and cellular integrity of erythrocytes.
RED BLOOD CORPOSULES(RBC)
INTRODUCTION-ERYTHROCYTES
STRUCTURE
NORMAL COUNT
COMPOSITION
ERYTHROPOIESIS- PROCESS
HEMOGLOBIN
FUNCTIONS
Monophyletic theory of hematopoiesis. Stem cells.
There are three main theories of hematopoiesis or blood cell formation: monophyletic, dualistic, and polyphyletic. The monophyletic or unitary theory, first proposed over 100 years ago, suggests that all blood cells originate from a common stem cell. Stem cells are classified based on their differentiation potential as totipotent, pluripotent, multipotent, or unipotent. Hematopoiesis occurs primarily in the bone marrow and is regulated by growth factors. The process involves the proliferation, differentiation, and maturation of stem cells into the various mature blood cell types through multiple cellular stages. A complete blood count provides indicators of normal or abnormal hematopoiesis. Stem cells
Blood (RBC, WBC, PLATELET)
Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. In vertebrates, it is composed of blood cells suspended in blood plasma.
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Hematopoiesis: Formation of Blood Cells - An Overview
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Erythropoiesis for bs mlt
Erythropoiesis is the process of red blood cell production that occurs in multiple stages within the bone marrow. It begins with pluripotent stem cells that differentiate into erythroid progenitor cells and progress through normoblast stages as the cells take on hemoglobin and lose their nuclei to become reticulocytes and finally mature red blood cells. Key regulators of erythropoiesis include erythropoietin, which is produced mainly in the kidneys in response to hypoxia and promotes red blood cell production, and various vitamins and minerals that support cell maturation and hemoglobin synthesis.
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This document summarizes erythropoiesis, the production of red blood cells. It describes the stages of maturation from pluripotent stem cells to erythrocytes. Key stages include burst forming units and colony forming units that give rise to erythroblast precursors. Erythropoietin is the main growth factor that stimulates and regulates erythropoiesis. The bone marrow is typically the main site of erythropoiesis in adults, though the liver and spleen can also produce red blood cells early in development.
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This document discusses erythropoiesis, the process of red blood cell production. It begins in the fetal liver and spleen and later continues primarily in the bone marrow. The process involves hematopoietic stem cells developing through several stages into reticulocytes and then mature erythrocytes. Key factors that regulate erythropoiesis include erythropoietin and various vitamins and minerals. Red blood cells circulate for about 120 days before being broken down and recycled by the spleen and liver.
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Blood 1
The document provides detailed information about blood and erythropoiesis. It discusses that blood is one of the largest organs and circulates throughout the body supporting other tissues. It transports oxygen, nutrients, waste and regulates temperature. Erythropoiesis is the process of red blood cell formation in the bone marrow from stem cells to reticulocytes over several stages taking around 5-6 days. Erythropoietin regulates erythropoiesis by stimulating red blood cell production.
Development anatomy and physiology of haematopoiesis, hematological copy
Hematopoiesis is the process by which blood cells are formed from hematopoietic stem cells in the bone marrow. There are four main stages of development: stem cells differentiate into progenitor cells, then precursor cells, and finally mature blood cells. The major types of blood cells produced are red blood cells, white blood cells, and platelets. During development in the embryo and fetus, hematopoiesis occurs first in the yolk sac, then liver, and later primarily in the bone marrow. Different types of hemoglobin are expressed at various developmental stages.
ppt.pptx
It is presentation which is based on stem cells
Which will help in many cure many biological deseases
Erythropoiesis.pptx
This document summarizes the process of erythropoiesis, or red blood cell formation. It begins with pluripotent stem cells in the bone marrow that differentiate over 7 days through several stages to mature red blood cells. Key stages include pronormoblast, normoblast, reticulocyte. Erythropoiesis is regulated by the hormone erythropoietin, which is produced by the kidneys in response to low oxygen levels and stimulates red blood cell production. Erythropoiesis requires adequate nutrition, hormones, growth factors and transcriptional factors to produce the daily replacement of red blood cells with a lifespan of 120 days.
Industrial production of recombinant Erythropoietin
This presentation briefs about introduction to Erythropoietin and industrial production of recombinant Erythropoietin
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The document discusses haemopoiesis (blood cell formation) and the histology of bone marrow. It describes how in fetal life, blood cells are formed in the yolk sac, liver, and later the bone marrow and liver. In newborns, children and adults, red bone marrow is found in all bones up to age 20, and later in flat bones and ends of long bones. Bone marrow contains hematopoietic stem cells that differentiate into the various blood cell lineages through progenitor and precursor cells in the bone marrow microenvironment.
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Development anatomy and physiology of haematopoiesis, hematological copy
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Erythropoiesis
- 1. GURUNANAK INSTITUTE OF PHARMACEUTICAL SCIENCE & TECHNOLOGY •
- 2. 1. INTRODUCTION-DEFINITION & SITE OF ERYTHROPOIESIS 2. STAGES OF ERYTHROPOIESIS 3. DESCRIPTION OF THE STAGES 4. DURATION 5. FACTORS EFFECTING ERYTHROPOIESIS 6. CONCLUSION 7. REFERENCE
- 3. DEFINITION: process by which the origin,development and maturatrion of RBCs occur. SITE: In intra uterian stage of RBCs are produced from mesodermal yolk sack, liver and spleen. After birth produced from Red bone marrow(RBM), skull,ribs and vertibrae.
- 4. Red bone marrow (RBM) Pleuripiotent haemopoitic stem cell (PHSC) Colony forming unit of erythroblast (CFU-E) Proerythroblast Erythroblast Basophilic erythroblast Polychromic erythroblast Reticulocytes (Diapedesis) Matured RBCs
- 5. PROERYTHROBLAST: Large cell , slightly alkaline in nature ,no haemoglobin. BASOPHILIC: Alkaline in nature , cell size smaller with no nucleus. POLYCHROMIC: Cell size smaller with small nucleus, haemoglobin starts to appear. ORTHOCHROMIC: Cell size more smaller with small nucleus ,more haemoglobin.
- 6. (contd...) RETICULOCYTES: Small cell,more stable haemoglobin,no nucleus. MATURED RBCs: Non-nucleated,alkaline,bi-concave in shape.
- 7. It takes total 7-9 days for formation of Mature Red Blood Cell. The duration is as follows- A. Red Bone Marrow → Proerythroblast- 3 Days B. Proerythroblast → Orthochromic ery- 2 Days C. Orthrochromic ery → Mature RBC- 2 Days
- 8. Tissue hypoxia → Kidney (JG cells) → REF → Erythropoietinogen → Erythropoietin → RBM → ↑ RBC production. ↑ BMR → Tissue hypoxia → Kidney (JG cells) → REF → Erythropoietinogen → Erythropoietin → RBM → ↑ RBC production.
- 9. OTHER FACTORS: Interleukin I T- lymphocytes ↑ RBC Androgen : ↑ Erythropoietin secretion → ↑ RBC production Oestrogen : ↓ Erythropoietin secretion → ↓ RBC production Vitamin B12, Intrinsic factor & Folic acid.
- 10. Life span of erythrocytes is 120 days! By the process , ERYTHROPOIESIS, development and maturation of new erythrocytes occurs . Thus the normal value of erythrocytes remain constant in human body.
- 11. 1.Haematology,Principles Of Physiology , Debasis Pramanik,4th Edition , Academic Publishers, page no.- 74-78 2.The blood , Ross And Wilson Anatomy & Physiology in Health and Illness,Anne Waugh;Allison Grant,12th Edition,Elsevier,page no.-66-67