This ppt contains all information about epidemiology of Measles. It is useful for students of medical field learning preventive and social medicine, Swasthavritta (Ayurved), nursing and everyone who is interested in knowing about it.
This ppt contains all information about epidemiology of Measles. It is useful for students of medical field learning preventive and social medicine, Swasthavritta (Ayurved), nursing and everyone who is interested in knowing about it.
Tuberculosis infection is very common in the world and the disease manifest when ever either the virulence of the organism increases or the resistance of the host goes down.it can affect any part of the body.the best method of control of tuberculosis is early diagnosis and treatment.despite international cooperation the problem of resistance in tuberculosis is increasing and great efforts are being made to tackle this problem both in diagnostic tools as well as in treatment modalities. the social factors also play a big role in the causation as well as emergence of resistance is concerned . a participatory approach is required to combat the problem.
this ppt contains all information about epidemiology of chickenpox. It is useful for students of medical field learning preventive and social medicine, Swasthavritta (Ayurved) and everyone who is interested in it
Pertussis : Highly contagious respiratory infection caused by Bordetella pertussis
Outbreaks first described in 16th century
Bordetella pertussis isolated in 1906
Estimated >300,000 deaths annually worldwide
Before the availability of pertussis vaccine in the 1940s, public health experts reported more than 200,000 cases of pertussis annually.
Since widespread use of the vaccine began, incidence has decreased more than 75% compared with the pre-vaccine era.
In 2012, the last peak year, CDC reported 48,277 cases of pertussis.
Extremely contagious-attack rate 100%
Immunity is never complete
Protection begins to wane in 3-5 yrs after vaccination
Tuberculosis infection is very common in the world and the disease manifest when ever either the virulence of the organism increases or the resistance of the host goes down.it can affect any part of the body.the best method of control of tuberculosis is early diagnosis and treatment.despite international cooperation the problem of resistance in tuberculosis is increasing and great efforts are being made to tackle this problem both in diagnostic tools as well as in treatment modalities. the social factors also play a big role in the causation as well as emergence of resistance is concerned . a participatory approach is required to combat the problem.
this ppt contains all information about epidemiology of chickenpox. It is useful for students of medical field learning preventive and social medicine, Swasthavritta (Ayurved) and everyone who is interested in it
Pertussis : Highly contagious respiratory infection caused by Bordetella pertussis
Outbreaks first described in 16th century
Bordetella pertussis isolated in 1906
Estimated >300,000 deaths annually worldwide
Before the availability of pertussis vaccine in the 1940s, public health experts reported more than 200,000 cases of pertussis annually.
Since widespread use of the vaccine began, incidence has decreased more than 75% compared with the pre-vaccine era.
In 2012, the last peak year, CDC reported 48,277 cases of pertussis.
Extremely contagious-attack rate 100%
Immunity is never complete
Protection begins to wane in 3-5 yrs after vaccination
Cough in children.pptx by dr sayed ismailSayed Ahmed
causes of cough in children
acute and chronic cough
approach to cough in children
common causes of cough
treatment of cough
investigation of cough
neonatal cough
differntial diagnosis of cough
impact of cough
complications of cough
prolonged cough
persistent cough
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. PERTUSSIS
• It is also called as WHOOPING
COUGH.
• Is an acute infectious disease,
usually of young children caused
by Bordetella pertussis.
3. • It is clinically characterized by an
insidious onset with mild fever
and an irritating cough, gradually
becoming paroxysmal with
characteristic “whoop” (loud
crowing inspiration) often with
cyanosis and vomiting.
4. • The spectrum of the disease
varies from severe illness to
atypical and mild illness without
whoop.
• The Chinese call it a “Hundred
Day Cough”.
6. AGENT
• The causative
agent in large
proportion is
Bordetella
pertussis.
• In less than 5%
cases it is
B.parapertussis.
7.
8.
9. • Certain viruses such as
adenovirus, parainfluenza virus
are also implicated in the
whooping cough syndrome.
• Bordetella pertussis occurs in
smooth and rough phases,
capsulated and non capsulated
form.
10. • It elaborates an exo and
edotoxin.
• Clinical disease is associated
with encapsulated, phase I
strains.
11. SOURCE OF INFECTION
• B. pertussis infects only man.
• The source of infection is a case of
pertussis.
• A chronic carrier state does not
exist.
12. INFECTIVE MATERIAL
• The bacilli occurs abundantly in
the nasopharyngeal and
bronchial secretions, which are
infective.
• Objects freshly contaminated by
such discharges are also infective.
14. • The infective period may be
considered to extend from one
week after exposure to about 3
weeks after the onset of the
paroxysmal stage although
communicability diminishes.
rapidly after the catarrhal stage.
17. • AGE : Whooping cough is
primarily a disease of infants and
preschool children.
• The highest incidence is found
below the age of 5 years.
18. • In adults pertussis is often
unrecognized because of it’s
atypical course.
• However the older age groups
represent an important source of
infection for susceptible infants.
19. GENDER
• Incidence and fatality are
observed to be more among
female than male children.
21. ENVIRONMENTAL FACTORS
• Pertussis occurs throughout the
year, but the disease shows a
seasonal trend with more cases
occurring during winter and
spring months, due to
overcrowding.
22. • Socio economic conditions and
ways of life also play a role in the
epidemiology of the disease.
• Thus the exposure of risk is
greater in the lower social
classes living in overcrowded
conditions.
23. MODE OF TRANSMISSION
• Whooping cough is mainly spread
by droplet infections and direct
contact.
• Each time the patient coughs,
sneezes or talks the bacilli are
spread into the air.
24. • Most children contract infection
from their playmates who are in
the early stages of the disease.
• The role of fomites appears
small, unless they are freshly
contaminated.
26. CLINICAL COURSE
• B pertussis produces a local infection;
the organism is not invasive.
• It multiplies on the surface
epithelium of the respiratory tract
and causes inflammation and
necrosis of the mucosa leading to
secondary bacterial infection.
27. • Three stages can be seen in the
clinical course of the disease.
• 1.CATARRHAL STAGE.
• 2. PAROXYSMAL STAGE.
• 3. CONVALESCENT STAGE.
28.
29. CATARRHAL STAGE
• Lasts for 10 days.
• It is characterized by its insidious
onset, lacrimation, sneezing and
coryza, anorexia, malaise and
general hacking night cough that
becomes diurnal.
30.
31. PAROXYSMAL STAGE
• Lasts for 2-4 weeks.
• It is characterized by bursts of
rapid, consecutive coughs
followed by a deep, high pitched
inspiration (whoop).
32. • It is usually followed by
vomiting.
• In young infants it may cause
cyanosis and apnoea.
33. • In adults and adolescents,
uncharacteristic, persistent
cough may be the only
manifestation .
36. COMPLICATIONS
• Complications occur in 5-6 percent
cases, most frequently in infants
aged less than 6 months.
• The chief complications are;
bronchitis, bronchopneumonia and
bronchietasis.
37. • The violence of the paroxysms
may precipitate subconjunctival
haemorrhages, epistaxis,
haemoptysis and punctate
cerebral haemorrhages which
may cause convulsions and
coma.
38. • Bronchopneumonia occurs in
about 5.2 % cases.
• The incidence of pertussis
related encephalopathies is 0.9%
/100,000.
40. CASES
• The general principles of control
includes early diagnosis,
isolation and treatment of cases,
and disinfection of discharges
from nose and throat.
41. • Early diagnosis is possible only
by bacteriological examination of
nose and throat secretions
(obtained from nasopharyngeal
secretions - swabs).
• Erythromycin is the drug of
choice.
42. • A dose of 30-50mg/kg of body
weight in 4 divided doses for 10
days has been recommended.
• Possible alternatives are
ampicillin, septran or
tetracycline.
43. • Antibiotics may prevent or
moderate clinical pertussis when
given during incubation period
or in early catarrhal stage.
44. • During paroxysmal phase of
disease, antimicrobial drugs will
not change the clinical course
but may eliminate the bacterium
from the nasopharynx and thus
reduce the transmission of the
disease.
45. CONTACTS
• Infants and young children should
be kept away from cases.
• Close contacts may be given
prophylactic antibiotics
(erythromycin or ampicillin) for 10
days to prevent the infecting
bacteria to become established.
46. • The best protection is to
administer a booster dose of
DPT/DT to his siblings.
47. ACTIVE IMMUNIZATION
• The vaccine is usually
administered in the national
immunization programme as
combined DPT.
48.
49. • In India, the National Policy is to
immunize against diptheria,
pertussis and tetanus
simultaneously, by administering
3 doses (each dose about 0.5 ml)
of DPT vaccine intramuscularly-
at 1 month interval, starting at
the age of 6 weeks.
50. • A booster dose is given at 18-24
months.
• Children whose vaccination
series has been interrupted
should have their series
resumed, without repeating
previous doses.
51.
52. UNTOWARD REACTIONS
• Pertussis vaccines may give rise
to local reactions at the site of
injection, mild fever, irritability.
53. • The rare vaccine reactions are
persistent (more than 3 hours)
include inconsolable screaming,
seizures, hypotonic hypo
responsive episodes,
anaphylactic reaction and very
rarely encephalopathy.
54. CONTRAINDICATIONS
• Pertussis vaccine is
contraindicated in anaphylactic
reaction, encephalopathy, a
personal or strong family history
of epilepsy, convulsions or
similar CNS disorders or reaction
to one of the previously given
triple antigen injection.