Endodontic mishaps include procedural errors that can occur during root canal treatment such as ledge formation, canal perforation, separated instruments, and overfilling/underfilling of canals. It is important for practitioners to understand how to recognize, prevent, and treat these mishaps. Common causes include inadequate access, excessive force, or improper instrument use. Perforations require immediate sealing with materials like MTA to achieve the best prognosis. Separated instruments may be bypassed or retrieved, while ledges can sometimes be circumvented with smaller files. Overall, minimizing errors requires adherence to principles like conservative access, copious irrigation, and careful instrumentation.