Lecture Objectives: After completion of the lecture, students will be able to: • Describe Quantitatively describe the relationship between drug, receptor, and the pharmacologic response. • Explain why the intensity of the pharmacologic response increases with drug concentrations and/or dose up to a maximum response. • Describe relationship of dose to pharmacologic effect Dose-Response Relationship: A drug's pharmacological effect is determined by its concentration at the site of action, which is determined by the dose administered. Such a relationship is called 'dose-response relationship’.