This document discusses dose-response relationships and dose-response curves. It defines dose as the amount of drug administered and response as the effect on the body. The relationship between dose and response can be illustrated with a dose-response curve, which is typically a rectangular hyperbola. Dose-response curves are used to determine the appropriate dose of a drug and compare effects across doses and individuals. The document also discusses factors like potency, efficacy, thresholds, and how dose-response curves can be graded or quantal depending on the type of response measured.

1. DOSE RESPONSE RELATIONSHIP
SAURABH WANI
PGDPM 2013-2014
GARWARE COLLEGE
CLINICAL PHARMACOLOGY

2. SOME BASIC CONCEPTS
DOSE – amount of drug administered in the patient
E.G If 500 mg of paracetamol is taken dose is 500mg
RESPONSE - effect shown by the body to a particular
drug
E.G Paracetamol is antipyretic drug so response is it
should bring body temperature to normal

3. HOW DRUG RESPONSE IS OBTAINED
Drug Receptor Drug-Receptor Complex
Response

4. WHAT IS DOSE RESPONSE
RELATIONSHIP
A RELATIONSHIP USED TO ANALYZE A KIND OF
RESPONSE OBTAINED AFTER ADMINISTERING
SPECIFIC DOSE OF DRUG
E.G If 10mg of ILLAPRAZOLE [ppi] is administered
response is it should inhibit formation of proton pumps at
10mg specifically
Dose response relationship has two components
[1] DOSE PLASMA CONCENTRATION RELATIONSHIP
[2] PLASMA CONCENTRATION RESPONSE
RELATIONSHIP

5. WHAT IS DOSE RESPONSE CURVE
RELATIONSHIP OF DOSE TO RESPONSE CAN BE
ILLUSTRATED BY A GRAPH WHICH IS CALLED AS
DOSE RESPONSE CURVE
DOSE RESPONSE CURVE IS REQUIRED
{1} DECIDING DOSE OF DRUG
{2} COMPARING DOSSAGE TO PERCENTAGE OF
PEOPLE SHOWING DIFFERENT EFFECTS

6. DOSE RESPONSE CURVE
Intensity of response increases with increase in dose and
dose response curve is rectangular hyperbola

7. WHY DOSE RESPONSE CURVE IS
RECTANGULAR HYPERBOLA
This is because drug-receptor interaction obeys law
of mass action, accordingly
E = Emax [D]
Kd [D]
Where
E = Observed effect of dose of drug
Emax = maximal response
Kd = dissociation constant of drug receptor
complex

8. ADVANTAGES OF PLOTTING LOG DOSE RESPONSE
CURVES
[1] WIDE RANGE OF DRUG DOSES CAN BE DISPLAYED
ON GRAPH
[2] COMPARISON BETWEEN AGONIST AND
ANTAGONIST BECOMES EASIER

9. THRESHOLD
A dose below which there are no adverse effects
from exposure to chemicals

10. TYPES OF DOSE RESPONSE
CURVES
GRADED DOSE RESPONSE CURVES
QUANTAL DOSE RESPONSE CURVES

11. GRADED DOSE RESPONSE CURVES
Graded dose response curves are constructed for
response that are measured on continuous scale
E.G heart rate
GRADED dose response curves relates the intensity of
response to size of dose hence used in characterizing
actions of drug
Graded dose response means slight increase of drug
brings small increase in response
E.G increased dose of Histamine causes gradual
contraction of guinea pig ileum

12. • Very low dose of histamine has no effect and
response is obtained only beyond the threshold
dose of 20 mg
• Very high dose of more than 50 mg has no
additional effect and response remains constant at
this maximal levels
• Graded dose response means the pharmacological
effect of drug expressed in quality or number such
as heart rate by beat and blood pressure by mmHg

13. DOSE ERSPONSE CURVE STUDYING
THE EFFECT OF ASPIRIN
LINEAR PLOT SEMILOG PLOT

14. QUANTAL DOSE RESPONSE
CURVES
Quantal dose response curves are constructed for those
drugs that elicit all or none response
E.G presence or absence of epileptic seizures
Indicates that given dose of drug has or has not evoked a
certain effect in various subject under investigation that
is pharmacological effects are expressed in passive or
negative

15. Quantal dose response curves
An experiment performed
on 100 subjects
And the effective dose to
produce a quantal response
was determined for each
individual

16. DOSE RESPONSE CURVE
INFORMATION

17. Drug potency and efficacy
Drug potency refers to amount of drug needed to produce
a response.Relative potency is more meaningful than
absolute potency
E.G If 10 mg of morphine=100 mg of pethidine, morphine is
10 times more potent than pethidine
Drug efficacy refers to ability of drug to elicit a response
when it binds to a receptor
E.G Morphine produces a degree of analgesia not
obtainable with any dose of aspirin hence Morphine is
more efficacious than aspirin

18. Drug potency and efficacy curves
[1] Drug B is less potent but equally
efficacious as drug A
[2] Drug C is less potent and less
efficacious than drug A ,But equally
potent and less efficacious than
drug B
[3] Drug D is more potent than drug
A,B,& C but less efficacious than
drugs A&B and equally efficacious
as drug C

19. SLOPE AND VARIABLITY
Effect of incremental increase
in dose
Variability is reproductivity of
data different for different people

20. Therapeutic index
Therapeutic index is used for judging drug safety .
Therapeutic index is ratio of Ld50 to Ed50
Ed50 – Median effective dose at which 50% of individuals
exhibit a specific effect
Ld50 – Median lethal dose required to produce death in
50% individuals

21. Factors affecting drug response
[1] AGE
[2] WEIGHT
[3] GENDER
[4] ENVIRONMENT
[5] FEVER
[6] SHOCK

22. THANKYOU