NEOPLASM, NAMING, Ways to differentiate between BENIGN and MALIGNANT NEOPLASM, Differentiation and ANAPLASIA, FEATURES OF ANAPLASTIC CELLS, DYSPLASIA, Features of DYSPLASTIC cell, LOCAL INVASION, Rate of growth, Malignant Neoplasm , CUT SECTION OF INVASIVE DUCTAL CARCINOMA OF BREAST, Metastasis, Tendency to METASTASIZE, Ways of dissemination of malignant tumours, Seeding within the body , Lymphatic spread , SKIP METASTASES , Haematogenous spread , A LIVER STUDDED WITH METASTATIC CANCER, Summary
Neoplasia - Characteristics & Classification of Neoplasm Chhavi Singh
This power point presentation take a detail note on neoplasm (cancer), types of neoplasm, stages of neoplasm, various kinds of carcinogens. This presentation also take interest in the classification and characteristics of the tumor & difference between the normal cells and tumor cells.
Neoplasia - Characteristics & Classification of Neoplasm Chhavi Singh
This power point presentation take a detail note on neoplasm (cancer), types of neoplasm, stages of neoplasm, various kinds of carcinogens. This presentation also take interest in the classification and characteristics of the tumor & difference between the normal cells and tumor cells.
Bordetella (Gram-Negative Rod Related to the Respiratory Tract)Syeda Maryam
In this presentation, we are discussing Bordetella Pertussis, its important properties, EPIDEMIOLOGY, PATHOGENESIS, Several factors that play a role in the pathogenesis, Pertussis toxin production,
adenylate cyclase production, Tracheal
cytotoxin, Whooping cough, its CLINICAL FINDINGS, THE CLASSIC PICTURE OF WHOOPING
COUGH IN YOUNG CHILDREN, it's LABORATORY DIAGNOSIS, TREATMENT, PREVENTION, KILLED VACCINE, and ACELLULAR VACCINE.
CAMPYLOBACTER & HELICOBACTER (Curved Gram-Negative Rods affecting the GIT)Syeda Maryam
In this presentation, I have discussed the following topics:
Curved Gram-Negative Rods affecting the GIT
CAMPYLOBACTER
HELICOBACTER
ENTEROCOLITIS
Guillain-barre Syndrome
Important Properties of these bacteria
their Epidemiology, Pathogenesis, Laboratory Diagnosis, Treatment, and Prevention.
MALT lymphomas
Mucosal-associated lymphoid tissue lymphomas
Gastric carcinoma
This presentation is about STREPTOCOCCI, GRAM POSITIVE STTREPTOCOCCI, BROWN’S CLASSIFICATION, ALPHA HEMOLYTIC STREP.,BETA HEMOLYTIC STREPTOCOCCI, LANCIFIED CLASSIFICATION, GROUP A ( S. PYOGENS) , GROUP – B ( S. AGLACTIA ), GROUP - D, DISEASES, PEPTOSTREPTOCOCCI
TRANSMISSION, PATHOGENESIS,STREPTOCOCCUS PNEUMONIAE, IMPORTANT PROPERTIES, C - SUBSTANCE, TRANSMISSION, CONSOLIDATION OF LUNGS, FACTORS THAT PREDISPOSE PERSON TO PNEOMCOCCAL INFECTIONS, CLINICAL FINDINGS, LABORATORY DIAGNOSIS, TREATMENT
a brief description on morphology and pathogenesis caused by Staphylococcus Aureus, Staphylococcus Epidermidis, Staphylococcus Saprophyticus, toxic shock syndrome toxin (tsst) and it's treatment, enterotoxin , exfoliatin , pyogenic infections, abscess etc
contact me via my email: maryamhy95@gmail.com
Rh typing and its technique , BLOOD TYPING , Rhesus (Rh) typing , procedures of rh typing, process of Rh typing, Test limitations, Sources of Error in Rh Antigen Typing, False positive reactions' reason, False negative reactions' reasons
MECHANISM of ACTION of some GRAM positive BACTERIA’s exotoxinSyeda Maryam
exotoxin, MECHANISM of ACTION of some GRAM positive BACTERIA’s exotoxin, DIPHTHERIA TOXIN produced by CORYNEBACTERIUM DIPHTHERIA, TETANUS TOXIN (TETNOSPASMIN) produced by CLOSTRIDIUM TETANI, BOTULINUM TOXIN produced by CLOSTRIDIUM BOTULINUM , EXOTOXIN PRODUCED BY CLOSTRIDIUM PREFRENGIS AND OHER SPECIES OF CLOSRIDIA, EXOTOXIN produced by CLOSTRIDIUM DEFICILE, EXOTOXIN OF BACILIS ANTHRACUS,
TSST (toxic shock syndrome toxin), SAPHYLOCOCCAL ENTEROTOXIN, EXFOLIATIN, PANTONE-VALENTINE (leukocidin) , ERYTHROGENIC TOXIN,
a brief description on division of nervous system,SOMATIC NERVOUS SYSTEM and working, SENSORY DIVISION and MOTOR DIVISION, SENSORY RECEPTORS, CATEGORIZATION OF SENSORY RECEPTORS, TYPES OF NERVES, SPINAL NERVES, CRANIAL NERVES, REFLEX ARCS, AUTONOMIC NERVOUS SYSTEM and it's properties and division, PARASYMPATHETIC NERVOUS SYSTEM, SYMPATHETIC NERVOUS SYSTEM
SOCIOLOGY & HEALTH ,SOCIOLOGY, DETERMINANTS OF HEALTH AND DISEASE ,FAMILY ,types of family, SOCIAL GROUPS,
TYPES OF SOCIAL GROUP, SOCIAL CLASS, WESTERN WAY OF DIVIDING SOCIETY ,OUR WAY OF DIVIDING SOCIETY,
GENDER ,CHILD REARING PRACTICE ,TYPES OF PARENTING,
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
2. NEOPLASM:
literally means new
growth.
An abnormal tissue mass
that grows by cellular
proliferation more rapidly
than normal tissue mass ,
and continuous to grow after
the stimuli that initiated the
new growth cease
DEFINITION
3. NAMING
BENINGN
Use cell type and suffix “ oma”
E.g. fibroma
MALIGNANT
Use cell type and suffix
“sarcoma or carcinoma”
4. Ways to differentiate B/W BENIGN and
MALIGNANT NEOPLASM
There are four different features by
which benign and malignant
neoplasms can be distinguished
Differentiation and Anaplasia
Rate of growth
Local invasion
Metastasis
5. Differentiation and ANAPLASIA
Benign
Composed of well differentiated cell
e.g: lipoma, chondroma
Mitoses are rare and of normal
configuration.
6. MALIGNANT
Range from well
differentiated to
completely
undifferentiated
Adenocarcinomas is an
example of well
differentiated malignant
neoplasm.
8. FEATURES OF ANAPLASTIC CELLS
Show pleomorphism ( variation in size
and shape)
Nuclei are hyper chromatic ( dark
staining)
Increase nuclear to cytoplasmic ratio
1:1 ( 1:4 or 1:6 normal)
Giant cells ( considerably larger than
normal cells)
Mitoses are numerous
9.
10. DYSPLASIA
Disorderly but non-
neoplastic
proliferation is
called dysplasia...
Also called pre
malignant
11.
12. Features of DYSPLASTIC cell
They show pleomorphism
Nuclei are hyperchromatic
Mitoses abundant than normal figures
But not synonymous with cancer
because mild to moderate dysplasia
could be regressed if inciting causes
are removed.
13. EXCEPTIONS
Some malignant tumours grow
slowly
E.g.: Acute childhood
“leukaemia” initiate during
foetal development yet
manifest full blown cancer years
later
14. LOCAL INVASION
Benign
Remain localized
don’t have
capacity to
infiltrate, invade
or metastasize
They have capsule
(fibrous) that
separates them
from host tissues
15. Rate of growth
BENIGN
Most benign tumours grow
slowly
They are non-invasive
They don’t cause metastasis
MALIGNANT
They grow fast
They are invasive
They cause metastasis
*Rate of growth correlates
inversely with level of
differentiation...poorly
differentiated tumours grow more
rapidly*
16. NOTE
Lack of capsule does not always mean ,
tumour is malignant. Some benign
tumours lack capsule
E.g. Benign vascular neoplasm of dermis
19. Metastasis
“Spread of cancer from one part of
the body to other”
Metastases are secondary implants
of tumours that are discontinuous
with the primary tumours and
located in remote tissues
20. Tendency to METASTASIZE
Not all cancers have equal tendency to metastasize
E.g. Basal cell carcinomas of skin highly invasive
locally But rarely metastasize .
while
Osteogenic ( bones) sarcoma metastasize to lungs
at time of initial discovery
21. Ways of dissemination of
malignant tumours
There are 3 pathways of dissemination
1: seeding within the body
2: Lymphatic spread
3: Haematogenous spread
22. Seeding within the body
Spread by seeding occurs when
neoplasm invade a natural body
cavity e.g.: Cancers of ovary
23. Lymphatic spread
Primary tumour reaches at the
site of metastasis , where
secondary tumour is to be
formed by using lymphatic
system
Most common in carcinomas (
malignant tumour of epithelial
origin)
24. SKIP METASTASES
In some cases the cancer cells
seem to traverse the
lymphatic channels from
primary nodes to be trapped
in subsequent lymph nodes
producing so called skip
metastases.
25. Haematogenous spread
Primary tumour reaches at the site of metastasis
where secondary tumour is to be formed by using
Blood circulatory system
This spread is favoured by sarcomas ( malignant
cancer of parenchymal origin)
Liver and lungs are most frequently involved in
secondary site of haematogenous dissemination .
27. Summary
Benign and malignant tumours can be distinguished from one
another based on the degree of differentiation , rate of growth,
local invasiveness, and distant spread
Benign tumours resemble the tissue of origin and are well
differentiated; malignant tumours are poorly or completely
undifferentiated(anaplastic).
Benign tumours are slow growing ; Malignant tumours generally
grow faster
Benign tumours have capsule; Malignant tumours don't have
capsule .
Benign tumours remain localized to the site of origin ; Malignant
tumours are locally invasive and metastasize to distant sites.