This document defines benign and malignant tumors and compares their key differences. It begins by introducing tumors and their classification into two main types: benign and malignant. Benign tumors are slow-growing and self-contained, while malignant tumors are usually fast-growing and can invade nearby tissues and spread to other parts of the body. The document then discusses in more detail the causes, symptoms, treatments and examples of both benign and malignant tumors.
Delve into the complex world of tumors with our insightful presentation. From benign growths to malignant masses, we'll navigate through the intricacies of tumor biology, diagnosis, and treatment. Through a comprehensive exploration of key concepts and cutting-edge research, discover how tumors develop, evade the body's defenses, and influence health outcomes. Join us as we decode the language of oncology, examining tumor types, classifications, and the latest advancements in therapeutic interventions. Whether you're a healthcare professional, researcher, or simply curious about the science behind tumors, this presentation promises to enlighten and inspire.
Delve into the complex world of tumors with our insightful presentation. From benign growths to malignant masses, we'll navigate through the intricacies of tumor biology, diagnosis, and treatment. Through a comprehensive exploration of key concepts and cutting-edge research, discover how tumors develop, evade the body's defenses, and influence health outcomes. Join us as we decode the language of oncology, examining tumor types, classifications, and the latest advancements in therapeutic interventions. Whether you're a healthcare professional, researcher, or simply curious about the science behind tumors, this presentation promises to enlighten and inspire.
Cancer is disease where cells grows out of control and invade, erode and destroy normal tissues
Normal body cells grow, divide and die in orderly fashion
Cancer cell does not obey this path
Cancer cells don't die (Immortality). They just continue to grow and divide in disorderly fashion
This makes it hard for the body to work the way it should
CANCER
•
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A tumor marker is a substance found in your blood, urine, or body tissue. The term "tumor markers" may refer to proteins that are made by both healthy
....
This lecture power point gives the basic and fundamental understanding and management of cancer and its diseases.
And as well as some remedies and recommendations
Medooc is a search engine for researching medical information.It has been built by medical
professionals to help others in the community to research and share credible health information.
Doctors, Physcials and medical professionals participate in Medooc.com on day to day basis to help
each other.
For more information you can visit:-http://www.medooc.com/
Here you will get about glycolysis its regulation and energetics.Further updates like and follow my slideshare account
Click on below link to get presentation on Properties of cancer cell.
https://www.slideshare.net/PratikshaPuranik5/properties-of-cancer-cells
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
1. Benign And Malignant Tumor
Presented by
Miss. P
. G. Puranik
M.Sc. Zoology B.Ed. Ph.D Pursuing
P
. G. Department Of Zoology
Shri Shivaji Science College, Amravati
2021 - 2022
3. INTRODUCTION
• Tumor is an abnormal growth of tissue
• Also known as Neoplasm
• Means the new formation
• Oncology (oncos = tumor) is the study of tumors or neoplasm
4. DEFINITION OF TUMOR
• A tumor is a mass of tissue that's formed by an accumulation of abnormal cells.
• Normally, the cells in your body age, die, and are replaced by new cells. With
cancer and other tumors, something disrupts this cycle. Tumor cells grow, even
though the body does not need them, and unlike normal old cells, they don't
die.
• As this process goes on, the tumor continues to grow as more and more cells
are added to the mass.
5. CLASSIFICATION OF TUMOR
1. Benign tumor – A slow growing, self contained tumor that is not seriously harmful.
2. Malignant Tumor – A usually fast growing, often fatal tumor that invades
surrounding tissue and sheds cells that spread throughout the body, creating new
tumor.
6. BENIGN TUMOR
• Benign tumor are non Malignant or non cancerous tumor.
• A benign tumor is usually localized, and does not spread (metastasize) to other
parts of the body.
• Benign tumors are typically slow growing.
• Most benign tumors respond well to treatment and they often have well defined
borders, so surgical removal can be an effective treatment.
• However, if left untreated, some benign tumors can grow large and leads to serious
disease because of their size.
• Eg : fibroid in the uterus, lipomas in skin
8. SYMPTOMS
Depending on the location, possible symptoms of a benign tumor include:
• Headache
• Vision trouble
• Fuzzy memory
• Chills
• Discomfort or pain
• Fever
• Weight loss
• Night sweats
9. TREATMENT
• In many cases, benign tumors need no treatment.
• Doctors may simply use “watchful waiting” to make sure they cause no problem.
• But treatment may be needed if symptoms are a problem.
• Surgery is a common type of treatment for benign tumors.
• The goal is to remove the tumor without damaging surrounding tissues.
10. EXAMPLES
• Lipomas grow from fat cells. They are the most common benign tumor in adults, often found
in the neck, shoulder, back or arm.
• Myomas are tumors that grow from muscle.
• Nevi (moles) are growths on the skin.
• Osteochondromas are the most common type of benign bone tumor.
• Adenomas: cancer of glandular epithelial cell: colon brest tumor, liver
12. MALIGNANT TUMOR
• A Malignant Tumor is a cancerous tumor.
• Malignant tumors have cells that are abnormal and divide uncontrollably
without order.
• Some tumors are caused by the genetic mutation.
• These cells are often spread to and damage nearby tissue and may spread to
other parts of the body, which is known as metastasis.
13. CAUSES
• Genetic mutation
• Radiation
• Bacteria and viruses also can cause cancer
• Lifestyle and many more
14. SYMPTOMS
• Severe, persistent headache
• Seizures (brain disturbed) epilepsy
• Vomiting
• Mental or behavioural changes, such as memory problems or changes in
personality
• Vision problems
16. EXAMPLES
• Carcinomas :covers internal and external parts of the body.
• Sarcomas: located in bone, cartilage, muscles and etc.
• Lymphomas: In lymph nodes and immune system response.
• Adenoma: In the thyroid gland, adrenal gland and other glands.
• Osteosarcoma : It is a type of bone cancer that begins in the cells that form bones .
19. REFERENCES
• 1) Kumar P
., Mina U., 2015 Life sciences fundamentals and practice- I Fith edition
,Pathfinder Publication New Delhi India.
• 2) https://www.mayoclinic.org