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Neoplasia   DR EJAZ WARIS ASSIS.PROF HISTOPATHOLOGY FMHC
Objectives of the lecture ,[object Object],[object Object],[object Object],[object Object]
What is a Neoplasm  ?
( Literally: New growth)   An abnormal tissue mass whose growth exceeds and is uncoordinated with that of adjacent normal tissue and persists after cessation of the stimuli that provoked it
 
Whats the main difference between a neoplastic & a nonneoplastic growth?
Neoplastic growths are uncontrolled & irreversible & non-neoplastic growths are controlled & reversible
Components of a tumor ,[object Object],[object Object]
Types of Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Benign tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
Malignant tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
Naming of neoplasms
ORIGIN BENIGN MALIGNANT I. EPITHELIAL Stratified squamous Squamous cell papilloma Squamous cell carcinoma Basal cells of skin Basal cell carcinoma Epithelial lining from glands or ducts Adenoma (e.g. of colon) Adenocarcinoma (e.g. of colon) Hepatocytes Hepatocellular adenoma Hepatocellular carcinoma (also called "hepatoma", a confusing Term that should be avoided) Melanocytes Nevus Melanoma (or malignant melanoma) Renal Renal cell adenoma Renal cell carcinoma Transitional Papilloma TCC
II. MESENCHYMAL A. Connective Tissue Bone Osteoma Osteosarcoma Cartilage Chondroma Chondrosarcoma Fibroblast Fibroma Fibrosarcoma B. Hematopoietic Erythroid Erythroid leukemia Myeloid Myelogenous leukemia Lymphoid Lymphocytic leukemia malignant lymphoma C. Muscle Smooth muscle Leiomyoma Leiomyosarcoma Striated (skeletal) muscle Rhabdomyoma Rhabdomyosarcoma D. Vascular Hemangioma Angiosarcoma III. GERM CELLS Teratoma (dermoid) teratocarcinoma
Other terms ,[object Object],[object Object],[object Object],[object Object]
Characteristics of tumors
1)Differentiation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Importance of differentiation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Carcinoma in situ ,[object Object]
 
 
desmoplasia ,[object Object]
2)Rate of growth ,[object Object],[object Object]
Local Invasion ,[object Object],[object Object],[object Object]
Metastasis ,[object Object],[object Object],[object Object],[object Object]
Routes of spread ,[object Object]
Routes of spread ,[object Object],[object Object]
 
 
Malignant cell
Charateristics  ,[object Object],[object Object],[object Object]
Characteristics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
GRADING AND STAGING OF TUMORS
Grading of tumors ,[object Object],[object Object]
Staging of tumors ,[object Object]
Staging systems ,[object Object]
TNM STAGING SYSTEM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Self Assessment Questions: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Self Assessment Questions: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Benign  Malignant: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Tumor Diagnosis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bilateral Cystadenoma Ovary:
Lipoma Intestine:
meningioma
Lung carcinoma
Hepatic Adenoma:
 
Carcinoma Breast:
Carcinoma Lung:
Osteo - sarcoma:
Biopsy – Slide preparation

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Neoplasia basics ! first lecture !