Cryptococcosis also called as Torulosis is a subacute or chronic fungal infection caused by Cryptococcus neoformans. It leads to compications such as fatal meningoencephalitis. It is an opportunistic infection in HIV-infected patients. The PPT discuss on the morphology of the fungus, pathogenesis, laboratory diagnosis and treatment.
Cryptococcosis also called as Torulosis is a subacute or chronic fungal infection caused by Cryptococcus neoformans. It leads to compications such as fatal meningoencephalitis. It is an opportunistic infection in HIV-infected patients. The PPT discuss on the morphology of the fungus, pathogenesis, laboratory diagnosis and treatment.
The PPT is mainly all about Mycobacterium Tuberculosis. Agents causing the disease Tuberculosis, pathogenesis, laboratory diagnosis, treatment and prophylaxis. It was made for both BSc and MSc students.
Cholera is a serious bacterial disease that usually
causes severe diarrhea and dehydration. The disease is typically spread through contaminated water.
Modern sewage and water treatment have effectively eliminated cholera in most countries. It’s still a problem in countries like Asia, America and Africa. Mostly in India.
Countries affected by war, poverty, and natural disasters have the greatest risk for a cholera outbreak.
Taxonomy:
class : Gamma Proteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: v.cholerae, v.parahaemolyticus,
v. vulnificus, v. alginolyticus
MORPHOLOGY:
Gram negative, actively motile, short, rigid curved bacilli
Resembling letter “V”
about 34 genus
most common in water
1.5µ X 0.2 -0.4 µ in size
polar flagellum , strongly aerobic
Smear – fish in stream appearance
PATHOGENESIS:
Source: Ingestion of contaminated water, food,
fruits and vegetables etc.,
Incubation periods: 1-5 days
Symptoms: Watery diarrhoea, vomiting, thirst, dehydration, muscle cramps
Complications: muscular pain, renal failure, pulmonary edema, cardiac arrhythrnias
DIAGNOSIS:
Specimen: stool sample, water sample(envt)
Microscopy: a) Hanging drop : +ve
b) Gram stain :-ve
Culture: Mac conkey Agar :colourless to light pink
TCBS : yellow colonies
Serology: serological tests are no diagnostic value
TREATMENT:
Adequate replacement of fluids and electrolytes.
Oral tetracycline reduces the period of vibrio excreation.
PREVENTION:
Drink and use bottled water
Frequent washing
Sanitary environment
Defecate in water
Cook food thoroughly
The PPT is mainly all about Mycobacterium Tuberculosis. Agents causing the disease Tuberculosis, pathogenesis, laboratory diagnosis, treatment and prophylaxis. It was made for both BSc and MSc students.
Cholera is a serious bacterial disease that usually
causes severe diarrhea and dehydration. The disease is typically spread through contaminated water.
Modern sewage and water treatment have effectively eliminated cholera in most countries. It’s still a problem in countries like Asia, America and Africa. Mostly in India.
Countries affected by war, poverty, and natural disasters have the greatest risk for a cholera outbreak.
Taxonomy:
class : Gamma Proteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: v.cholerae, v.parahaemolyticus,
v. vulnificus, v. alginolyticus
MORPHOLOGY:
Gram negative, actively motile, short, rigid curved bacilli
Resembling letter “V”
about 34 genus
most common in water
1.5µ X 0.2 -0.4 µ in size
polar flagellum , strongly aerobic
Smear – fish in stream appearance
PATHOGENESIS:
Source: Ingestion of contaminated water, food,
fruits and vegetables etc.,
Incubation periods: 1-5 days
Symptoms: Watery diarrhoea, vomiting, thirst, dehydration, muscle cramps
Complications: muscular pain, renal failure, pulmonary edema, cardiac arrhythrnias
DIAGNOSIS:
Specimen: stool sample, water sample(envt)
Microscopy: a) Hanging drop : +ve
b) Gram stain :-ve
Culture: Mac conkey Agar :colourless to light pink
TCBS : yellow colonies
Serology: serological tests are no diagnostic value
TREATMENT:
Adequate replacement of fluids and electrolytes.
Oral tetracycline reduces the period of vibrio excreation.
PREVENTION:
Drink and use bottled water
Frequent washing
Sanitary environment
Defecate in water
Cook food thoroughly
Dermatophytes are molds (multicellular filaments of organisms) that require keratin for nutrition and must live on stratum corneum, hair, or nails to survive. Human infections are caused by Epidermophyton, Microspores, and Trichophyton species.
Clinical immunology is the study of diseases caused by disorders of the immune system (failure, aberrant action, and malignant growth of the cellular elements of the system). It also involves diseases of other systems, where immune reactions play a part in the pathology and clinical features.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. Dermatophytoses or cutaneous mycoses are diseases of
the skin, hair and nail
Generally called ringworm infections and tinea
These infections are caused by a homogenous group of
closely related fungi known as dermatophytes
These dermatophytes infect only superficial keratinised
structures such as skin, hair and nail but not deeper tissues
3. The most important dermatophytes that cause infection in
humans are classified into three genera
Trichophyton - infections on skin, hair, and nails.
Microsporum - infections on skin and hair
(not the cause of TINEA UNGUIUM)
Epidermophyton - infections on skin and nails
(not the cause of TINEA CAPITIS)
4. The dermatophytes on the basis of their natural habitat and
host preferences can be classified into following groups
1. Anthropophilic species
2. Zoophilic species
3. Geophilic species
5. Anthropophilic
Associated with humans only
Person -to-person transmission through contaminated
objects (fallen hairs, desquamated epithelium, combs,
hat, towel etc.)
Examples: Trichophyton rubrum, Microsporum audouinii and
Epidermophyton floccosum
6. Zoophilic
Associated with animals
Direct transmission to humans by close contact with
domestic animals (cat and dog) and occasionally wild
animals
Examples: Trichophyton violaceum and Microsporum canis
7. Geophilic
These are saprophytic fungi found in soil or in dead organic
substances
They occasionally cause infection in humans and animals
Examples: Microsporum gypseum and Trichophyton ajelloi
8. Dermatophytes usually grow only on keratinised skin and its
appendages and do not penetrate the living tissue
In some infected persons, hypersensitivity to fungus antigen
may cause secondary eruptions such as vesicles on the finger
This reaction is known as dermatophytid (Id) reaction
This reaction occurs as a result of hypersensitivity response
to circulating fungal antigen, and these lesions do not
contain any fungal hyphae
10. Clinical features
The skin infections caused by dermatophytes are chronic
infections of the skin often found in the warm humid areas
of the body
Typical ringworm lesions are circular , dry, erythematous,
scaly and itchy which have an inflamed border containing
papules and vesicles surrounding a clear area of relatively
normal skin
These lesions are associated with variable degrees of scaling
and inflammation
Nails are thickened, deformed, friable, discolored,
subungual debris accumulation
11. Dermatophytoses clinical classification
• Infection is named according to the
anatomic location involved:
a. Tinea barbae e. Tinea pedis
(Athlete’s foot)
b. Tinea corporis f. Tinea manuum
c. Tinea capitis g. Tinea unguium
d. Tinea cruris
(Jock itch)
12. Transmission
• Close human contact
• Sharing clothes, combs, brushes, towels,
bedsheets... (Indirect)
• Animal-to-human contact (Zoophilic)
13. Tinea capitis
This is the infection of the shaft of scalp hairs and presents
as the following clinical types
a) Inflammatory – Kerion, favus
b)Non-inflammatory – Black dot, Ectothrix and Endothrix
The infected hairs in tinea capitis appear dull and grey
The base of hair shaft as well as hair follicles is involved
There is breakage of hair at follicular orifice which creates
patches of alopecia with black dots of broken hairs
15. Ectothrix
The arthrospores appear as mosaic sheath
around hair or as chains on surface of hair
shaft
The cuticle of hair remains intact
Hyphae invade hair shafts at mid follicle
and as hair grows out of follicle, hyphae
burst out of shaft and cover hair surface
with mass of small arthrospores
Caused by T. mentagrophytes, M. canis,
M. audouinii, M. gypseum and
T. verrucosum
16. Endothrix
Hyphae form arthrospores within hair
shaft, which is severely weakened
Cuticle of hair is usually destroyed
The arthrospores are 3-4 µm in diameter
and are observed in chains filling inside
shortened hair stubs
Caused by T. schoenleinii, T. tonsurans
and T. violaceum
T. rubrum cause both ectothrix
as well as endothrix infections
17. Tinea corporis
This is disease of glabrous (non-hairy) skin of body and may
result from extension of infection from scalp, groin or beard
Characterised by erythematous scaly lesions, annular, sharply
marginated plaques with raised border which may be single,
multiple or confluent
19. Tinea Pedis
This is the infection of plantar aspect of foot, toes and
interdigital web spaces
It is frequently seen among individuals wearing shoes for
long hours and popularly known as Athlete’s Foot
In toe webs, scaling, fissuring, maceration and erythema may
be associated with an itching or burning sensation
Due to maceration and peeling, cracks appear which are prone
to secondary bacterial infections
When infection becomes chronic, sole becomes hyperkeratotic
and is often covered with fine scales
21. Tinea Barbae
Infection of beard and moustache areas of face with
invasion of coarse hairs
Also called as barber’s itch
There are erythematous patches on face which show scaling
24. Tinea Cruris
Dermatophytic infection of groin
Involves perineum, scrotum and perianal area and may
spread to inner third of buttock and occasionally to thigh
The appearance of Tinea Cruris can be seen in other
intertriginous areas such as axilla and around umblicus of
obese patients
25. Tinea Manuum
Dermatophyte infection of skin of palmar aspect of hands
The most common clinical manifestation is diffuse
hyperkeratosis of palms and fingers
26. Tinea Unguium
Dermatophyte infection of nail plates and is largely a
disease of adults
It begins under leading free edge of nail plate or along
lateral nail fold and may continue until entire nail plate
and nail bed are infected
There is accumulation of subungual debris in an opaque,
chalky or yellowish thickened nail
28. Laboratory diagnosis
Specimens
Scrapings of the skin and nail as well as short lengths of hair
plucked from the scalp. Scrapings are taken from the edges
of ringworm lesions
Direct microscopic examination
KOH wetmount
Branching hyaline septate (non-pigmented) hyphae is
considered positive for fungi; spores may also be seen
29. Wood’s lamp
In suspected Tinea capitis, plucked hair is examined by
using wood’s lamp
Infected hair will be fluorescent (yellow green)
30. Culture
Species identification is possible only by culture examination
Sabouraud’s dextrose agar containing chloramphenicol and
cycloheximide
The plates incubated aerobically at 25-300C for upto 21 days
Identification of dermatophytes in the laboratory is by
examing the macroscopic characteristics of the fungal
colonies (rate of growth, texture, colour on the observe and
reverse)
31. Microscopic examination
Trichophyton
Microconidia are abundant and arranged in clusters along
the hyphae
Macroconidia are relatively scanty generally elongated,
with blunt ends and have distinctive shapes in different
species
Some species possess special hyphal characters such as
spiral hyphae, raquet mycelium and favic chandeliers
32.
33. Microsporum
Microconidia are relatively scanty and not distinctive
Macroconidia, the predominant spore form, are large,
multicellular, spindle shaped structures, borne singly on
the ends of hyphae
Microsporum species infect the hair and skin but usually
not the nails
34.
35. Epidermophyton
Colonies are powdery and greenish yellow
Microconidia are absent
Macroconidia are multicellular, pear-shaped and typically
arranged in clusters
Epidermophyton attacks the skin and nails but not the hair
37. Treatment
This is by using topical preparations (ointments or gels)
containing azoles (miconazole, clotrimazole, econazole)
or terbinafine
Oral preparations of griseofulvin, azoles (ketoconazole,
itraconazole) or terbinafine