Computers can be classified into five types according to the generations i.e. time period:
First Generation Computers: vacuum tubes
Second Generation Computers: transistors
Third Generation Computers: integrated circuits (ICs)
Fourth Generation Computers: large scale integration (LSI)
Fifth Generation Computers: very large scale integration (VLSI)
Computer has become a part of our life. Today along with calculations, their work area is very wide-supermarket scanners scan and calculate our grocery bill and also keep store inventory, automatic teller machines(ATM) helps us in banking transaction how the technology has developed and what its future course is To understand this first we should know about the different generations of computers.
The First electronic computer was designed and built at the university of pennsylvania based on vaccum tube technology. Vaccum tubes were used to perform logic operations and to store data. Generations of computers has been divided into five according to the development of technologies used to fabricate the processors, memories and I/O units.
The History of computer development is often referred to in reference to the different generations of computing devices. Each generation of computer is characterized by a major technological development that fundamentally changed the way computers operates, resulting in increasingly smaller, cheaper, more powerful and more efficient and reliable devices.
Computers can be classified into five types according to the generations i.e. time period:
First Generation Computers: vacuum tubes
Second Generation Computers: transistors
Third Generation Computers: integrated circuits (ICs)
Fourth Generation Computers: large scale integration (LSI)
Fifth Generation Computers: very large scale integration (VLSI)
Computer has become a part of our life. Today along with calculations, their work area is very wide-supermarket scanners scan and calculate our grocery bill and also keep store inventory, automatic teller machines(ATM) helps us in banking transaction how the technology has developed and what its future course is To understand this first we should know about the different generations of computers.
The First electronic computer was designed and built at the university of pennsylvania based on vaccum tube technology. Vaccum tubes were used to perform logic operations and to store data. Generations of computers has been divided into five according to the development of technologies used to fabricate the processors, memories and I/O units.
The History of computer development is often referred to in reference to the different generations of computing devices. Each generation of computer is characterized by a major technological development that fundamentally changed the way computers operates, resulting in increasingly smaller, cheaper, more powerful and more efficient and reliable devices.
Generation in computer terminology is a change in technology
With each new generation, the circuitry has gotten smaller and more advanced than the previous generation
Generation in computer terminology is a change in technology a computer is/was being used. Initially, the generation term was used to distinguish between varying hardware technologies. But nowadays, generation includes both hardware and software, which together make up an entire computer system.
Generation in computer terminology is a change in technology
With each new generation, the circuitry has gotten smaller and more advanced than the previous generation
Generation in computer terminology is a change in technology a computer is/was being used. Initially, the generation term was used to distinguish between varying hardware technologies. But nowadays, generation includes both hardware and software, which together make up an entire computer system.
General features of computer – Evolution of computers; Computer Applications – Data Processing – Information Processing – Commercial – Office Automation – Industry and Engineering – Healthcare – Education – Disruptive technologies.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. Contents:
Introduction
Brief History of Computer.
Generation of Computer
Advantages and disadvantages of Computers
Computer Types
3. Introduction:
A computer is an electronic device that can
process data and produce output as per a set of
instructions called as program and display output
through various output devices such as printer and
monitor etc.
4. Brief History of Computer
1. Pascal’s Adding Machine.
2. Leibniz's Reckoning Machine.
3. Colmar’s multiplying Machine.
4. Babbage’s Difference Engine.
5. Babbage’s Analytical Engine.
6. The first Computer
5. Dr. Howard Aiken of Harvard university in
association with IBM in 1944,constructed an electro
mechanical machine capable of processing a series of
instructions in the form of a program. It was named as
Mark-I. This is considered to be the first operational
computer .It was around 15.24m long and 2.44m high
compromising of more than 750,000 parts. It can
complete one arithmetic operation on 23 digit
numbers in around 3 seconds
8. First Generation(1946-1955)
The first computers used vacuum tubes for circuitry and
magnetic drums for memory, and were often enormous,
taking up entire rooms. First generation computers relied on
machine language to perform operations, and they could only
solve one problem at a time.
The Mark-I, EDSAC, EDVAC, UNIVAC-I and ENIAC
computers are examples of first-generation computing
devices.
IBM-650 was another first generation computer by IBM
corporation.
9.
10. Advantages:
the 1G computers were able to process any tasks in
milliseconds.
The hardware designs are functioned and
programmed by machine languages.
Vacuum tube technology is very much important
which opened the gates of digital world
communication
11. Disadvantages:
Size of that machines are very big.
Required large amount of energy for processing.
Heat generated and need air conditioning.
Expensive.
In order to get proper processing, maintenance is
required continuously
12. Second Generation(1955-1965)
Transistors replaced vacuum tubes in the second
generation computer. Transistor is a device composed of
semiconductor material that amplifies a signal or opens or
closes a circuit. Invented in 1947 at Bell Labs, transistors
have become the key ingredient of all digital circuits,
including computers.
Today's latest microprocessor contains tens of millions of
microscopic transistors.
The first computers of this generation were developed for
the atomic energy industry. • Ex-IBM 7074 series, CDC 164,
IBM 1400 Series
13.
14. Advantages:
1.less expensive and smaller in size as compared to first generation
computers.
2.Fast in speed.
3.Low power consumption and less heat generated.
4.Vacuum tube technology is very much important which opened
the gates of digital world communication.
5.Language after machine language for programming, in G2
assembly language (COBOL, FORTRON) is introduced for
programming.
15. Disadvantages:
Maintenance of Machine is required.
Air conditioning required still as heat causes to process
slowly.
These computers are not used as personal system.
Preferably used for commercial purpose
16. Third Generation(1965-1975)
The development of the Integrated Circuit was the
hallmark of the third generation of computers.
Transistors were miniaturized and placed on silicon
chips, called semiconductors, which drastically
increased the speed and efficiency of computers.
Instead of punched cards and printouts, users
interacted with third generation computers through
keyboards and monitors and interfaced with an
operating system, which allowed the device to run
many different applications at one time with a central
program that monitored the memory.
17.
18. Advantages:
Smaller in size.
Low power consumption and easy to operate.
High reliability.
OS for user interactions.
Disadvantages:
IC chips are still difficult to maintain.
Need complex technology.
19. Fourth Generation(1976-1988)
Use of microprocessor in mid seventies marked the
advent of fourth generation computers. Medium to
very large scale IC’s technology packed about 1,00,000
transistors in a single chip.
The Intel corporation in 1971 packed the complete
CPU in a single chip. This is known as microprocessor.
What in the first generation filled an entire room
could now fit in the palm of the hand.
Ex-Intel processors, AMD processor based machines
20.
21. Advantages:
Smaller in size.
Microprocessor based Technology.
Semiconductor Memory.
Low cost of production.
High speed.
High reliability.
Efficient OS.
22. Fifth Generation(1988 onwards)
Fifth generation computing devices, based on Artificial
Intelligence, are still in development, though there are
some applications, such as voice recognition, that are
being used today.
The goal of fifth-generation computing is to develop
devices that respond to natural language input and are
capable of learning and self-organization.
Ex-ULAIC Technology, Artificial intelligence etc.
23.
24. Advantages:
Program independent.
Have thinking and analysis by its own.
Voice reorganization & biometric devices.
Self organization and learning.
