Pharmacy Pharmaceutical organic chemistry compounds Pyridine Quinoline Isoquinoline Acridine Indole Pyrimidine Purine Azepines

1. 1
Topics :
Pyridine,Quinoline,Isoquinoline,Acridine
Indole ,Pyrimidine ,Purine,Azepines.

2. Pyridine :
• Pyridine is a basic heterocyclic organic
compound with the chemical formula C5H5N. It is
structurally related to benzene, with one methine
group (=CH−) replaced by a nitrogen atom.

3. Uses :
It is also used to make many different products
such as medicines, vitamins, food flavorings,
paints, dyes, rubber products, adhesives,
insecticides, and herbicides.
Properties
Chemical formula C5H5N
Molar mass 79.10 g·mol
Appearance Colorless to yellow liquid
Odor Nauseating, fish-like
Melting point 41.6 °C
Boiling point 115.2 °C
Solubility in water Miscible

4. Quinoline
Properties
Chemical formula C9H7N
Molar mass 129.16 g/mol
Appearance yellowish oily liquid
Melting point 15 °C
Boiling point 237 °C
Solubility in water Slightly soluble
Solubility Soluble in alcohol, ether, and
carbon disulfide

5. Uses :
• Quinoline is used in the manufacture of dyes,
the preparation of hydroxyquinoline sulfate
and niacin. It is also used as a solvent for
resins and terpenes.

6. Isoquinoline
• Isoquinoline is a heterocyclic aromatic organic
compound. It is a structural isomer of quinoline.
Isoquinoline and quinoline are benzopyridines,
which are composed of a benzene ring fused to
a pyridine ring.

7. Uses :
Properties
Chemical formula C9H7N
Molar mass 129.16
Appearance yellowish oily liquid,
hygroscopic platelets
when solid
Melting point 26 to 28 °C
Boiling point 242 °C
Isoquinolines are used in the manufacture of dyes,
paints, insecticides and antifungals. It is also used as
a solvent for the extraction of resins and terpenes,
and as a corrosion inhibitor.

8. Acridine
• Acridine is an organic compound and a nitrogen
heterocycle with the formula C13H9N. Acridines are
substituted derivatives of the parent ring. It is a planar
molecule that is structurally related to anthracene with
one of the central CH groups replaced by nitrogen

9. Uses:
Acridine orange is an organic compound. It
is usedas a nucleic acid-selective fluorescent
cationic dye useful for cell cycle determination
Properties
Chemical formula C13H9N
Molar mass 179.22 g·mol
Appearance White powder
Odor Irritating
Melting point 106–110 °C
Boiling point 344.86 °C

10. Indole
(2,3Benzopyrrole)
Indole is an aromatic heterocyclic organic compound with
formula C8H7N. It has a bicyclic structure, consisting of a
six-membered benzene ring fused to a five membered
nitrogen-containing pyrrole ring.

11. Properties
Chemical formula C8H7N
Molar mass 117.15 g/mol
Appearance White solid
Odor Feces or jasmine like
Melting point 52 to 54 °C
Boiling point 253 to 254 °C

12. Uses :
• Indole regulates various aspects of bacterial physiology,
including spore formation, plasmid stability, resistance to
drugs, biofilm formation, and virulence. A number
of indole derivatives have important cellularfunctions,
including neurotransmitters such as serotonin.

13. Pyrimidine
• Pyrimidine is an aromatic heterocyclic organic
compound similar to pyridine.One of the
three diazenes (six-membered heterocyclics with
two nitrogen atoms in the ring), it has the nitrogen atoms at
positions 1 and 3 in the ring.
Chemical formula C4H4N2
Molar mass 80.088 g mol
Melting point 20 to 22 °C
Boiling point 123 to 124 °C

14. Uses :
• The presence of pyrimidine base in thymine,
cytosine, and uracil, which are the
essential building blocks of nucleic acids
DNA and RNA, is one possible reason for their
widespread therapeutic applications

15. Purine
• A purine is a heterocyclic aromatic organic compound that
consists of a pyrimidine ring fused to an imidazole ring.
Chemical formula C5H4N4
Molar mass 120.12 g·mol
Melting point 214 °C

16. Azepines
• Azepines are unsaturated heterocyclic of
seven atoms, with a nitrogen replacing
a carbon at one position.
Chemical formula C6H7N
Molar mass 93.13 gmol