Flow properties of powders can be classified as free flowing or cohesive and are influenced by particle size, shape, density, moisture content, and electrostatic charge. Flow properties impact tabletting and encapsulation processes. Factors like nature, size distribution, shape, moisture, and surface morphology of particles affect powder flow. Larger, more spherical particles with narrow size distribution and low moisture content exhibit better flow than smaller, irregular particles. Common tests to evaluate flow include angle of repose, compressibility index, and cohesion. Flow can be improved by increasing particle size, producing spherical particles, or adding glidants or lubricants.
Decomposition and stabilization of pharmaceutical productsArshad Khan
Drug stability:Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention.
Decomposition and stabilization of pharmaceutical productsArshad Khan
Drug stability:Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention.
Preformulation Studies: Introduction to preformulation, goals and objectives, study of
physicochemical characteristics of drug substances.
a. Physical properties: Physical form (crystal & amorphous), particle size, shape, flow
properties, solubility profile (pKa, pH, partition coefficient), polymorphism.
b. Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs & its significant
Application of preformulation considerations in the development of solid, liquid oral and
parenteral dosage forms and its impact on stability of dosage forms.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the tablets and its excipients and Ideal properties of tablet and the methods and equipment for there for manufacturing.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
Tablets are solid dosage forms usually obtained by single or multiple compression of powders or granules. In certain cases tablets may be obtained by molding or extrusion techniques. They are uncoated or coated. Tablets are normally right circular solid cylinders, the end surfaces of which are flat or convex and the edges of which may be bevelled. They may have lines or break-marks (scoring), symbols or other markings.Tablets contain one or more active ingredients. They may contain excipients such as diluents, binders, disintegrating agents, glidants, lubricants, substances capable of modifying the behaviour of the dosage forms and the active ingredient(s) in the gastrointestinal tract, colouring matter authorized by the appropriate national or regional authority and flavouring substances. When such excipients are used it is necessary to ensure that they do not adversely affect the stability, dissolution rate, bioavailability, safety or efficacy of the active ingredient(s); there must be no incompatibility between any of the components of the dosage form.
Tablets are single-dose preparations intended for oral administration. Some are intended to be swallowed whole, some after being chewed and some after being crushed, some are intended to be dissolved or dispersed in water before being taken and some are intended to be retained in the mouth where the active ingredient(s) is/are liberated.
Direct compression is the most advanced technology. It involves only blending and compression. Thus offering advantage particularly in terms of speedy production. Because it requires fewer unit operations, less machinery, reduced number of personnel and considerably less processing time along with increased product stability.
Preformulation Studies: Introduction to preformulation, goals and objectives, study of
physicochemical characteristics of drug substances.
a. Physical properties: Physical form (crystal & amorphous), particle size, shape, flow
properties, solubility profile (pKa, pH, partition coefficient), polymorphism.
b. Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs & its significant
Application of preformulation considerations in the development of solid, liquid oral and
parenteral dosage forms and its impact on stability of dosage forms.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the tablets and its excipients and Ideal properties of tablet and the methods and equipment for there for manufacturing.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
Tablets are solid dosage forms usually obtained by single or multiple compression of powders or granules. In certain cases tablets may be obtained by molding or extrusion techniques. They are uncoated or coated. Tablets are normally right circular solid cylinders, the end surfaces of which are flat or convex and the edges of which may be bevelled. They may have lines or break-marks (scoring), symbols or other markings.Tablets contain one or more active ingredients. They may contain excipients such as diluents, binders, disintegrating agents, glidants, lubricants, substances capable of modifying the behaviour of the dosage forms and the active ingredient(s) in the gastrointestinal tract, colouring matter authorized by the appropriate national or regional authority and flavouring substances. When such excipients are used it is necessary to ensure that they do not adversely affect the stability, dissolution rate, bioavailability, safety or efficacy of the active ingredient(s); there must be no incompatibility between any of the components of the dosage form.
Tablets are single-dose preparations intended for oral administration. Some are intended to be swallowed whole, some after being chewed and some after being crushed, some are intended to be dissolved or dispersed in water before being taken and some are intended to be retained in the mouth where the active ingredient(s) is/are liberated.
Direct compression is the most advanced technology. It involves only blending and compression. Thus offering advantage particularly in terms of speedy production. Because it requires fewer unit operations, less machinery, reduced number of personnel and considerably less processing time along with increased product stability.
Mixing: Objectives, applications & factors affecting mixing,
Difference between solid and liquid mixing,
mechanism of solid mixing, liquids mixing and semisolids mixing.
Principles, Construction, Working, uses, Merits and Demerits of Double cone blender
Principles, Construction, Working, uses, Merits and Demerits of twin shell blender
Principles, Construction, Working, uses, Merits and Demerits of ribbon blender
Principles, Construction, Working, uses, Merits and Demerits of Sigma blade mixer
Principles, Construction, Working, uses, Merits and Demerits of planetary mixers
Principles, Construction, Working, uses, Merits and Demerits of Propellers
Principles, Construction, Working, uses, Merits and Demerits of Turbines
Principles, Construction, Working, uses, Merits and Demerits of Paddles
And
Principles, Construction, Working, uses, Merits and Demerits of Silverson Emulsifier.
characterization of ceramic green body for specific objectivesabebewolelaw6
characterization is mandatory for ceramic green bodies in order to identify there relative density, pore size and pore distribution, there morphology and thier microstructure as well
Amidst the verdant foliage, a **lush bush** unfurls its vibrant petals, each a crimson stroke against the canvas of the sky. The gentle sunlight** weaves through leaves, illuminating this botanical masterpiece. 🌼
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
3. Flow property are employed as the flow measurements of the
effect that the interparticulate forces acting at once
Based on flow property, powders are classified as
Free flow powders
Cohesive powders
Flow property are effected by changes in particle size, shape,
density, electrostatic charge and absorb moisture
Flow property of solids have great impact on the tabletting and
encapsulation process
Weight variation and uniform content properties depends upon the
uniform & rapid flow of powders
3
4. FACTORS INFLUENCING THE FLOW
PROPERTIES
Nature of powders and granulation
Particle size and size distribution
Shape factors and surface morphology
Moisture and static charge
Powder cohesion and storage conditions
Effect of temperature.
4
5. NATURE OF POWDERS AND
GRANULATION
Powders are two phase assemblies of discrete particles with
interactions b/w gas & solid internal phases
Powders differ from other physical states of matter, no-
homogeneous…consists discrete solid particles of diff sizes & shapes
Powders expand / contract when stresses and don’t flow…..on too
small stresses…..stresses are not dependent on rate of flow.
Solids handling properties are influenced by factors that have effect on
particle particle interactions
Factors associated with nature of particles and their surfaces such as..
Size, Shape, Surface morphology, Packing conditions, Interparticulate
forces 5
6. PARTICLE SIZE AND SIZE
DISTRIBUTION
Dimensions of particles increases and particles changes in nature and forces acting on them
also changes
Fine powder particles
Less than 100μm -governed by surface forces
Above 1000μm -governed by gravitational forces
Flow through an orifice – restricted by small particles…. Cohesive forces b/w particles are
same as gravitational forces
As particle size increases, flow facilitated….if too large…arching...blocks flow
Finest fraction of powders….poorest flow, larger fraction…best flow
Increase in fines, increases the flow rate…further increase , decreases the flow rate
Flow rate increases as diameter of fines increases to 90μm
Decrease in particle size and its distribution decreases the angle of internal flow
6
7. SHAPE FACTORS AND SURFACE
MORPHOLOGY
•Various shape factors includes sphericity, circularity, surface
shape coefficient, volume shape coefficient and surface volume
shape coefficient
•Flowability of powders decreases as shape of particles becomes
more irregular
•Flowability of powders increases with increasing spericity
•Shape of components has great impact on mixing rate and
physical stability
7
8. MOISTURE AND STATIC CHARGE
Adsorbed moisture in solids exists in unbound state or part of the crystal struct
Moisture effects flow prop’s indirectly and permanently through formation of
granules, which are held together by solid bridges generated by hydration and
dehydration of powder / binder
Moisture influences powder flowability by forming liquid bridges
Effect of moisture varies depending on degree of packing and porosity of powder
bed
For cohesive & porous materials flowability is effected by moisture, since it
penetrates
Increased moisture content ( exceeding 5%) decreases flow prop’s and even very
low moisture hinders flow prop’s
8
9. FLOW PROPERTIES & THEIR
MEASUREMENT
Various flow properties determined for
powders and granules are :
Cohesion
Angle of Repose ( Ø )
Powder Bulk Density
Particle Density
Compressibility Index ( I )
9
10. COHESION
Defined as Stress necessary to shear a bed of powder
under conditions or zero normal load
Measurement of cohesion is done by various methods…
Using Shear Cell - (Quantitative method)
Rate of Sieving - (Qualitative method)
Mobility Test - (Qualitative method)
10
11. Mobility Test
Fine particles are more cohesive than coarser, cohesion of
bulk powder reduced by adding coarser fraction
Mobility test finds the minimum quantity of a coarse
component that is trequired for free flowing properties of
cohesive powder
11
12. ANGLE OF REPOSE
The maximum angle possible between surface of a pile of powder
and horizontal plane is known as Angle of Repose
It is the common way of expressing the flow characteristics of
powders and granules
Through this, frictional forces of powders / granules are measured
Tan Ø = h / r
Ø = Tan -1 h / r
12
13. Angle of repose is determined by various
methods…
Funnel Method
Open Cylinder method
Pilpel method
ANGLE OF REPOSE FLOW PROPERTY
0 – 25O Excellent
25 -35O Good
35 - 45O Moderate
> 45O Poor
13
14. COMPRESSIBILITY INDEX
The simple indication of ease with which a material can be induced to flow is given
by application of Compressibility Index.
C.I is denoted by….
I = [1 – V / Vo] × 100
Problems Occurring in Determining I
In case of powders containing non- isometric particles, they take more time for
packing due to…
Arches & Bridges are formed by the interlocking of particles, which need to break
down and disperse
Smaller particles have to move into voids between the larger particles, hence this
movement needs time to occur.
14
15. I VALUES FLOW PROPERTY
Below 15% Good
15-25% Moderate
Above 25% Poor
15
16. METHODS OF IMPROVING FLOW
PROPERTIES
Increasing the average particle size
By producing the powder in the form of spherical particles
By use of additives.
16
17. INCRESING THE AVERAGE PARTICLE SIZE
The larger particles are less cohesive than smaller ones and the optimium size
for free flow exists and also a distinct disadvantages in using a finer grade is
noted.
Hence granules are used in many cases than powder forms and also the
addition of coarser fraction to fine powder improves its flow property.
BY PRODUCING THE POWDER IN THE FORM OF SPHERICAL
PARTICLES
By using this type of powder, it packs down and flows wasily since particles
roll over one another.
17
18. BY USE OF ADDITIVES
Commonly used additives to increase the flow properties of the
powders are flow enhancers
They are generally used in low conc. and the optimum conc.of all
glidants varies from 1% to 2% and above this conc., the flow
properties of powders decreases.
18