An emulsion is a two-phase system consisting of two immiscible liquids, where one liquid is dispersed as globules in the other. Emulsions can be oil-in-water or water-in-oil depending on the dispersed and continuous phases. Emulsions are used pharmaceutically for oral, rectal, topical, and injectable drug delivery to mask tastes/odors and enhance absorption. Emulsion stability depends on the emulsifying agent and preventing effects like creaming, flocculation, coalescence, cracking, and phase inversion.
PHYSICAL PHARMACEUTICS II COARSE DISPERSION VijayaKumarR28
R. VIJAYAKUMAR., M Pharm,
Research Scholar
department of Pharmaceutical Technology.
Anna university- BIT
Tiruchirappalli.
As per PCI syllabus for B Pharm / 2nd Year ,III Semester.
UNIT-III / Coarse dispersion
R. VIJAYAKUMAR., M Pharm,
Research Scholar
department of Pharmaceutical Technology.
Anna university- BIT
Tiruchirappalli
III Semester.
UNIT-IV / Micromeritics
R. VIJAYAKUMAR., M Pharm,
Research Scholar
department of Pharmaceutical Technology.
Anna university- BIT
Tiruchirappalli
B Pharm / 2nd Year ,III Semester.
UNIT-I / Colloidal dispersion's
PHYSICAL PHARMACEUTICS II COARSE DISPERSION VijayaKumarR28
R. VIJAYAKUMAR., M Pharm,
Research Scholar
department of Pharmaceutical Technology.
Anna university- BIT
Tiruchirappalli.
As per PCI syllabus for B Pharm / 2nd Year ,III Semester.
UNIT-III / Coarse dispersion
R. VIJAYAKUMAR., M Pharm,
Research Scholar
department of Pharmaceutical Technology.
Anna university- BIT
Tiruchirappalli
III Semester.
UNIT-IV / Micromeritics
R. VIJAYAKUMAR., M Pharm,
Research Scholar
department of Pharmaceutical Technology.
Anna university- BIT
Tiruchirappalli
B Pharm / 2nd Year ,III Semester.
UNIT-I / Colloidal dispersion's
4th (30.10.2014) on eutectic mixture by Diptarco SinghaDiptarco Singha
this ppt is very simple and has immence importance in physical pharmacy. it has been prepared based on the syllabus of WBUT & consists of informations of elimentary label...
Suspension, type of suspension, interracial property of suspended particles Dheeraj Saini
Here you find
Suspension , types of suspension, difference between flocculated and deflocculated suspension and interfacial properties of suspended particles
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
4th (30.10.2014) on eutectic mixture by Diptarco SinghaDiptarco Singha
this ppt is very simple and has immence importance in physical pharmacy. it has been prepared based on the syllabus of WBUT & consists of informations of elimentary label...
Suspension, type of suspension, interracial property of suspended particles Dheeraj Saini
Here you find
Suspension , types of suspension, difference between flocculated and deflocculated suspension and interfacial properties of suspended particles
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
Current Compensations in Emulsion Type Pharmaceutical Formulation: An OverviewBRNSS Publication Hub
In modern years, the quantity of medicine and drug treatments has larger extremely which are moderately often more strong. Pharmacy research reveals exclusive data which is growing day by day. Emulsion are important dosage formulation they are continuously used from ancient time. In this overview we discuss the development of emulsion technology also focused on properties of emulsion & formulation methods by different equipment used for this consideration. With different identification tests. Multiple emulsion, Microemulsion, Non-aqueous emulsion, Liposome emulsion, Emulsion polymerization, Nanoemulsion are new trends in emulsion technology.
Similar to Pharmacy#Emulsion#Physical Pharmaceutics II (20)
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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2. Definition
Type of Emulsion
Pharmaceutical Application of
Emulsion
Formulation of Emulsion
Theory of Emulsion
Stability of Emulsion
3. An emulsion is a two phase system consisting of two
incompletely miscible liquids, one of which is dispersed as
finite globules in the other. The particle size of the globules
range from 0.25 to 25 µm.
Types of Emulsion
Based on dispersed phase
Oil in Water (O/W): Oil droplets dispersed in water.
Water in Oil (W/O): Water droplets dispersed in oil.
Multiple emulsions (e.g. w/o/w emulsions).
5. 0.2 – 50 mm Macroemulsions
0.01 – 0.2 mm Microemulsions
50 – 1000 nm Nanoemulsions
Oil in water emulsion (o/w) Water in oil emulsion (w/o)
Water is the dispersion medium
and oil is the dispersed phase.
quickly released from
Water soluble drugs are more
o/w
emulsions.
They are preferred for
formulations meant for internal
use as bitter taste of oils can be
masked.
• Oil is the dispersion medium and
water is the dispersed phase.
• Oil soluble drugs are more
quickly released from w/o
emulsions .
• They are preferred for
formulations meant for external
use like creams.
6. Oral, rectal and topical administration of oils and oil-soluble
drugs.
The unpleasant taste or odor can be masked by
emulsification.
The absorption and penetration of medicament are enhanced
by emulsification.
Intramuscular injections of water-soluble drugs or vaccine to
provide slow release.
The use of sterile stable i.v emulsion containing fats,
carbohydrates and vitamins as a potential nutrition.
7. Selection of Emulsifying agents
(emulsifiers):
An emulsifying agent is any material that enhances the stability of an
emulsion (i.e. Prevention of coalescence and reducing creaming).
The ideal emulsifying agent is colourless, odourless, tasteless, non- toxic,
non-irritant and able to produce stable emulsions at low concentrations.
Examples of Emulsifying agent
1. Carbohydrate Materials:
- Acacia, Tragacanth, Agar, Pectin. o/w emulsion.
2. Protein Substances:
- Gelatin, Egg yolk, Caesin o/w emulsion.
3. High Molecular WeightAlcohols:
stearate o/w emulsion,- Stearyl Alcohol, Cetyl Alcohol, Glyceryl
Mono cholesterol w/o emulsion.
9. IDENTIFICATION TEST FOR
EMULSIONS:
By using Naked eye, it is very difficult to differentiate
between o/w or w/o emulsions. Thus, the following
methods have been used to identify the type of
emulsions.
1) Dye Test
2) Dilution Test
3) Electrical conductivity Test
4) Fluorescence Test.
5) Cobalt Chloride Test.
10. 1) DYE TEST:
Water-soluble dye will dissolve in the aqueous
phase.
Oil-soluble dye will dissolve in the oil phase.
Microscopic View
Oil-soluble dye (e.g. Scarlet) Water-soluble dye (e.g. Amaranth dye)
O/W W /OO/WW /O
11. 2) DILUTION TEST:
Based on the solubility of external phase of emulsion.
O/W emulsion can be diluted with water.
W/O emulsion can be diluted with oil.
Fewdrops
ofemulsion
Fewdrops
ofwater Waterdistribute
uniformly
Waterseparate
outaslayer
O/Wemulsion
W/Oemulsion
12. 3) ELECTRICAL CONDUCTIVITY TEST:
Electrode
As we know water is good conductor of electricity
whereas oil is non-conductor. Therefore, continuous
phase of water runs electricity more than continuous
phase of oil.
Bulb
Emulsion
Bulb glows with O/W
Bulb doesn’t glow with W/O
13. 3) FLUORESCENCE
TEST:
Oils give fluorescence under UV light, while
water doesn’t.
Therefore, O/W emulsion shows spotty
pattern when observed under UV.
while W/O emulsion fluoresces.
14. 4) COBALT CHLORIDE
TEST:
Principle:
Cobalt Chloride solution is used for identification
of Emulsion. It is water soluble so it changes
colour when encountered by O/W emulsion.
Procedure:
Filter paper is Dipped in Emulsion.
Filter paper changes its color from blue to Pink
Result:
Emulsion is O/W otherwise not.
15. Film theory or adsorption theory
Viscosity theory
Wedge theory
Interfacial tension theory
Film theory or adsorption theory
As per this theory, the added emulsifying agent forms a
mechanical film by getting adsorption at the interface of the
liquid and offers stability to the emulsion. However, this theory
could not explain the formation of type of emulsion.
Viscosity theory
As per this theory, an increase in viscosity of an emulsion will
lead to an increase in stability. This theory failed to explain about
the milk which shows considerable stability even though its
viscosity is less.
16. According to this theory, monovalent soap like sodium
stearate give o/w type emulsion and divalent soap like calcium
stearate give w/o type emulsion. This was explained by
successful accommodation of the soap molecules to give the
type of emulsion.
Interfacial tension theory
In accordance with this theory the added emulsifying agent
reduces the interfacial tension between the oil and water
phases and thus a stable emulsion is formed. This theory could
not explain the formation of type of emulsion.
17. An HLB number (1-20) represents the relative proportions of
the lipophilic and hydrophilic parts of the molecule.
High numbers (8-18) indicate a hydrophilic molecule, and
produce an o/w emulsion.
Low numbers (3-6) indicate a lipophilic molecule and produce
a w/o emulsion.
Oils and waxy materials have a 'required HLB number' which
helps in the selection of appropriate emulsifying agents when
formulating emulsions.
Liquid paraffin, for example, has a required HLB value of 4 to
obtain a w/o emulsion and 10.5 for an o/w emulsion.
18. HLB ca. 1 to 3.5:Antifoams
HLB ca. 3.5 to 8: Water-in-Oil Emulsifiers
HLB ca. 7 to 9: Wetting and spreading agents
HLB ca. 8 to 16: Oil-in-Water Emulsifiers
HLB ca. 13 to 16: Detergents
HLB ca. 15 to 40: Solubilizers
19. An emulsion is said to be stable if it remains as such after its
preparation , that is the dispersed globules are uniformly
distributed through out the dispersion medium during its
storage. The emulsion should be chemically stable and there
should not be any bacterial growth during it shelf life.
Emulsion instability may either reversible or irreversible and
manifest in the following ways:-
1) Cracking (irreversible instability)
2) Flocculation
3) Creaming
4) Phase inversion
20. Cracking means the separation of two layers of disperse and
continuous phase , due to the coalescence of disperse phase
globules which are difficult to redisperse by shaking.
Cracking may occurs due to following reasons:-
i. By addition of emulsifying agent of opposite type
ii. By decomposition or precipitation of emulsifying agent
iii. By addition of common solvent
iv. By microorganisms
v. Change in temperature
vi. By creaming
21.
22. In flocculated state the secondary interaction (van der
waals forces) maintain the droplets at a defined distance of
separation.
Application of shearing stress to the formulation (shaking)
will redisperse these droplets to form a homogeneous
formulation.
Although flocculation may stabilise the formulation, there is
also possibility that the close location of droplets would
enable droplet coalescence to occur if the mechanical
properties of the interfacial film are compromised.
23. Creaming may be defined as the upward movement of
dispersed globules to form a thick layer at the surface of
emulsion.
Creaming is temporary phase because it can be re-
distributed by mild shaking or stirring to get again a
homogenous emulsion.
24. 4) Phase inversion:-
Phase inversion means the change of one type of
emulsion into other type, that is oil in water
emulsion changes into water in oil type and vice-
versa.