This document provides an overview of European exploration and colonization between 1400-1600. It discusses major explorers like Zheng He, Vasco da Gama, Christopher Columbus, and Ferdinand Magellan who explored Asia, Africa, the Americas and new trade routes for Portugal and Spain. New technologies like the compass and caravel ships enabled these expeditions. Colonization of the Americas by Spain led to the destruction of the Aztec and Incan empires and the establishment of the first global economic system involving the triangular trade between Europe, Africa and the Americas, including the slave trade.