The document summarizes palmitate synthesis from acetyl-CoA and malonyl-CoA. Specifically, it notes that palmitate synthesis requires 8 acetyl-CoA molecules, 7 ATP molecules, 14 NADPH molecules, and 14 hydrogen ions to produce palmitate, 8 CoA molecules, 7 ADP molecules, 7 phosphate ions, and 6 water molecules. It further explains that in palmitate, only 2 carbon atoms come from acetyl-CoA, while the remaining 14 carbon atoms are from malonyl-CoA, which is produced from acetyl-CoA.

1. De novo fatty acid
synthesis
Lecture by
S.Mathivanan.,M.Pharm
Asst Professor
Pharmacy

31. Summary of Palmitate synthesis
8 acetyl CoA + 7ATP + 14NADPH + 14H+
Palmitate + 8CoA + 7ADP + 7Pi + 6H2O
In palmitate, out of 16C only 2C comes from
acetyl CoA and 14 are from malonyl CoA that
in turn, is produced by acetyl CoA.

38. Thank you my dear students..!!!!