The document discusses various laboratory tests used to evaluate liver function and disease. It describes tests for hepatocellular damage like ALT and AST, tests for cholestasis like alkaline phosphatase, and tests for liver synthetic function like albumin. Common causes of abnormal liver enzymes are also summarized, along with risk factors for liver disease.
Liver function tests (LFT’s) are groups of laboratory blood assays designed to give information about the state of patients liver
They include
Liver enzymes (SGOT, SGPT, ALP, GGT etc.,)
Bilirubin(Direct and indirect)
Albumin
Prothrombin time / INR
Liver Function Test | A must needed precautionary actBMS_health
Liver Function Tests help determine the health of your liver by measuring the levels of proteins, Liver enzymes, or Bilirubin in your blood. Commonly used tests to check liver function are the alanine transaminase (SGPT), aspartate aminotransferase (SGOT), alkaline phosphatase (ALP), albumin, and bilirubin tests. The SGPT and SGOT tests measure enzymes that your liver releases in response to damage or disease. The albumin and bilirubin tests measure how well the liver creates albumin, a protein, and how well it disposes of bilirubin, a waste product of the blood. BookMyScans offers 11 test at just Rs.400/-. Get the inexpensive cost for Liver Function Tests at 40-50% discount in Bangalore, Chennai, Mumbai, Delhi, Hyderabad, Jaipur.
Urinary Stone analysis
A kidney stone is a hard mass developed from crystals that separate from the urine and build up on the inner surfaces of the kidney.
Liver function tests (LFT’s) are groups of laboratory blood assays designed to give information about the state of patients liver
They include
Liver enzymes (SGOT, SGPT, ALP, GGT etc.,)
Bilirubin(Direct and indirect)
Albumin
Prothrombin time / INR
Liver Function Test | A must needed precautionary actBMS_health
Liver Function Tests help determine the health of your liver by measuring the levels of proteins, Liver enzymes, or Bilirubin in your blood. Commonly used tests to check liver function are the alanine transaminase (SGPT), aspartate aminotransferase (SGOT), alkaline phosphatase (ALP), albumin, and bilirubin tests. The SGPT and SGOT tests measure enzymes that your liver releases in response to damage or disease. The albumin and bilirubin tests measure how well the liver creates albumin, a protein, and how well it disposes of bilirubin, a waste product of the blood. BookMyScans offers 11 test at just Rs.400/-. Get the inexpensive cost for Liver Function Tests at 40-50% discount in Bangalore, Chennai, Mumbai, Delhi, Hyderabad, Jaipur.
Urinary Stone analysis
A kidney stone is a hard mass developed from crystals that separate from the urine and build up on the inner surfaces of the kidney.
Biochemical kidney function tests with their clinical applicationsrohini sane
An illustrative presentation on Biochemical kidney function tests with their clinical applications for medical ,dental, pharmacology and biotechnology student to facilitate easy-learning.
Importance of enzymes : The two aminotransferases that are checked are the alanine aminotransferase (ALT or SGPT) and aspartate aminotransferase (AST or SGOT). These liver enzymes form a major constituent of the liver cells. They are present in lesser concentration in the muscle cells.
ALT is an enzyme present in liver, heart skeletal muscles, highest concentration is present in Liver. it value increases when there is abnormality in liver, ALT is an amino transferase which transfer one amino group from an amino acid and transfer to another substance for production of non essential amino acid
biological characteristics of the enzyme. How it works, what it is, how it is measured, interferences to the tests and applications in clinical pathology
The slides show the gastric and pancreatic function test along with the significance of these tests and the conditions in which the values of which increase.
Biochemical kidney function tests with their clinical applicationsrohini sane
An illustrative presentation on Biochemical kidney function tests with their clinical applications for medical ,dental, pharmacology and biotechnology student to facilitate easy-learning.
Importance of enzymes : The two aminotransferases that are checked are the alanine aminotransferase (ALT or SGPT) and aspartate aminotransferase (AST or SGOT). These liver enzymes form a major constituent of the liver cells. They are present in lesser concentration in the muscle cells.
ALT is an enzyme present in liver, heart skeletal muscles, highest concentration is present in Liver. it value increases when there is abnormality in liver, ALT is an amino transferase which transfer one amino group from an amino acid and transfer to another substance for production of non essential amino acid
biological characteristics of the enzyme. How it works, what it is, how it is measured, interferences to the tests and applications in clinical pathology
The slides show the gastric and pancreatic function test along with the significance of these tests and the conditions in which the values of which increase.
Liver Function Tests - An Approach for Primary CareJarrod Lee
This presentation is aimed at primary care physicians. It covers the fundamentals of liver function tests, including the basic principles of interpretation, and the key patterns of abnormalities. The focus is on how to approach liver function tests in a primary care setting.
Correlation liver disfunction and infection disease (dengue typhoid fever)01mataharitimoer MT
Correlation Liver Disfunction and Infection Disease (Dengue and Typhoid Fever)
Dr Erwin, SpPD, FINASIM
Disampaikan pada acara PIT VI IDI Kota Bogor | 9 Nopember 2013
The liver function tests typically include alanine transaminase (ALT) and aspartate transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), serum bilirubin, prothrombin time (PT), the international normalized ratio (INR), total protein and albumin.
INTERPRETATION OF COMMON BIOCHEMICAL TESTS INCLUDING LFT & RFT.pptxDr Debasish Mohapatra
Biochemical tests are commonly used in day-to-day practices for diagnosis of diseases. Liver function test and renal function tests are common tests done.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
For Better Surat #ℂall #Girl Service ❤85270-49040❤ Surat #ℂall #Girls
Chapter31.liver
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11. ENZYME ELEVATIONS IN LIVER DISEASE Hepatocellular injury (hepatitis in all types) Cholestasis (Biliary obstruction, hepatic infiltration)
12.
13.
14.
15.
16. Additional test to identify the cause of elevated aminotransferase in asymptomatic patient
17.
18.
19. Hemoglobin (1-2 X 10 8 eryhtrocytes /hr) globin heme Iron of heme is degraded in the reticuloendothelial cells of the liver, bone marrow and spleen amino acids ( reutilized or catabolized )
30. ALK + AMA is positive: primary biliary cirrhosis. If: the AMA (-) ultrasonography (-), alkaline phosphatase level remains >50% :liver biopsy ERCP, MRCP. If the increase in the alkaline phosphatase level is <50%: observation
31.
32.
33. Graduated chemical laboratory program for the diagnosis or differential diagnosis of hepatobiliary diseases Minimum Necessary Maximum 1.Enzymatic activity: GPT, -GT GOT, GLDH LDH 2.Synthesis output ChE, Quick value Albumins Ammonia, galactose 3.Excretory output: AP, bile pigments in urine Bilirubin, LAP Bile acids, iron, copper, cholesterol, indocyanine green, LP-X Enzyme tracing grid Enzyme quotients 4.Mesenchymal activity: -Globulins Immunoglobulins, A, G, M Copper, procollagen III peptide 5.Immunological activity: HBs-Ag, HBc-Ab, AMA, HA-Ab HBs-Ab, ANA HBe-Ag, Hbe-Ab, HBV-DNA, HDV, HCV-Ab, SMA, LMA, 1 -fetoprotein
34. TESTS WHEN IS IT LIKELY ABNORMAL SPECIFICITY FOR LIVER DISEASE OTHERS Hepatitis (viral, autoimmune, drug induced, NAFLD, iron overload) Hepatitis (particularly alcoholic), hepatitic fibrosis, cirrhosis Sensitive and specific Less sensitive And specific than ALT Acute obstructive jaundice (within first 24 hours) Cardiac or skeletal muscle injury ALT AST Enzyme elevations in liver disease Hepatocellular injury
35. TESTS WHEN IS IT LIKELY ABNORMAL SPECIFICITY FOR LIVER DISEASE OTHERS More specific than GGT More sensitive than ALP May not indicate significant liver disease Bone disease, pregnancy Medications, hepatic congestion ( CHF ) ALK GGT Enzyme elevations in Liver Disease Cholestasis Cholestasis Cholestasis, Alcohol
38. Screening and Early Diagnosis of Primary Liver Cancer Yang B et al. National Medical Journal of China (Zhonghua Yi Xue Za Zhi) 1999 AFP US AFP w/ or w/o US SENSITIVITY 69% 84% 92% SPECIFICITY 95% 97.1% 92.5% PPV 3.3% 6.6% 3.0% NPV 99.9% 99.9% 100%
Editor's Notes
Bilirubin is a normal heme degradation product that is excreted from the body predominately via secretion into bile. Bilirubin is insoluble in water and requires conjugation (glucuronidation) into the water-soluble bilirubin mono- and di-glucuronide forms before biliary secretion. In the second decade of the twentieth century, van den Bergh and Muller16 used Ehrlich’s diazo reagent to determine that two types of bilirubin were present in the serum of jaundiced patients: one that reacted directly with the reagent (direct bilirubin) and a second form that required the addition of alcohol for color development (indirect bilirubin). Four decades later, independent work by Billing and Schmid demonstrated that unconjugated bilirubin was the indirect form, whereas the direct form was a combination of the bilirubin monoand di-glucuronides (conjugated bilirubin).17 Although the methodologies in serum bilirubin determination have advanced since this time, the terminology of direct and indirect bilirubin have remained virtually synonymous with conjugated and unconjugated bilirubin, respectively. To secrete bilirubin into bile, unconjugated bilirubin must be taken up into the hepatocyte and conjugated into the glucuronide form by the endoplasmic reticulum enzyme bilirubin UDP-glucuronyltransferase (bilirubin- UGT), and the water-soluble bilirubin glucuronides must be secreted across the canalicular membrane into bile. The molecular mechanisms of these processes recently have been delineated and reviewed18–20 but are beyond the scope of this document. Bilirubin-UGT, the enzyme that conjugates bilirubin, is expressed shortly after birth. However, once enzyme expression occurs, it continues to be highly expressed and active even in severe liver disease and cirrhosis.21,22 Diminished expression of this enzyme is one of the defects causing Gilbert’s syndrome, a benign, unconjugated hyperbilirubinemia occurring in up to 5% of the normal population.23–27 Unconjugated hyperbilirubinemia also may result from hemolysis (increased heme breakdown) or in rare genetic diseases such as the Crigler-Najjar syndrome.27,28 After the neonatal period, most hepatic conditions that result in a conjugated hyperbilirubinemia are caused by either extrahepatic obstruction of bile flow, intrahepatic cholestasis, hepatitis, or cirrhosis, with a resultant impairment of hepatocellular bilirubin secretion into bile. Because bilirubin-UGT expression and bilirubin conjugation typically are well preserved, these pathophysiological states usually result in a conjugated hyperbilirubinemia. When conjugated hyperbilirubinemia occurs, significant amounts of bilirubin may also be excreted via the urine.
alkaline phosphatase family of enzymes are zinc metalloenzymes that are present in nearly all tissues. In liver, the enzyme has been immunolocalized to the microvilli of the bile canaliculus. Under normal conditions, serum alkaline phosphatase predominantly is caused by liver and bone isoenzymes, with intestinal enzymes contributing up to 20% of total activity. The normal reference range is dependent on a host of factors including the method of determination, patient age and gender, and the postprandial state.29 During normal pregnancy, alkaline phosphatase activity begins to rise by the late first trimester (because of placental isoenzymes), may reach levels of twice normal by term, and can remain elevated for several weeks after delivery.4,5 Serum alkaline phosphatase levels can be elevated by cholestatic or infiltrative diseases of the liver and by diseases causing obstruction to the biliary system, as well as by bone diseases, numerous medications, and tumors of hepatic and nonhepatic origin. When evaluating serum liver chemistries, the important clinical issue is the determination of whether the alkaline phosphatase abnormality is of hepatobiliary or nonhepatic origin. Liver alkaline phosphatase is more heat stable than bone, and isoenzyme determination can be made based on heat sensitivity; however, this assay may be subject to considerable inaccuracy and therefore its clinical use may be “laboratory-specific.” Other isoenzyme determination methodologies may include assays using monoclonal antibodies or wheat germ lectin precipitation.
Gamma glutamyl transpeptidase (GGT) is a protein found in especially high levels in special cells (epithelium) lining the bile ducts of the liver. The GGT can be an especially sensitive test of biliary disease in the liver but an isolated elevated GGT in and of itself may have no meaning at all.